• 한국임상약학회지
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• 제25권3호
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• pp.138-144
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• 2015

Objective: It is to evaluate the drug interaction monitoring program as a pilot project to develop a pharmaceutical care model in a medical intensive care unit and to analyze the influencing factors of drug interactions. Method: Electronic medical records were retrospectively investigated for 116 patients who had been hospitalized in a medical intensive care unit from October to December in 2014. The prevalence of adverse reaction with risk rating higher than 'D' was investigated by Lexi-$Comp^{(R)}$ Online database. The factors related with potential drug interaction and with treatment outcomes were analyzed. Results: The number of patients with a potential interaction of drug combination was 92 (79.3%). Average ages, the length of stay in the intensive care unit and the numbers of prescription drugs showed significant differences between drug interaction group and non-drug interaction group. Opioids (14.4%), antibiotics (7.2%), and diuretics (7.2%) were most responsible drug classes for drug interactions and the individual medications included furosemide (6.4%), tramadol (4.9%), and remifentanil (4.5%). There were 950 cases with a risk rating of 'C' (84.6%), 142 cases with a risk rating of 'D' (12.6%), and 31 cases with a risk rating of 'X' (avoid combination) (2.8%). The factors affecting drug interactions were the number of drugs prescribed (p < 0.0001) and the length of stay at intensive care unit (p < 0.01). The patients in intensive care unit showed a high incidence of adverse reactions related to potential drug interaction. Therefore, drug interaction monitoring program as a one of pharmaceutical care services was successfully piloted and it showed to prevent adverse reaction and to improve therapeutic outcomes. Conclusion: Active participation of a pharmacist in the drug management at the intensive care unit should be considered.

• Nuclear Engineering and Technology
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• 제51권1호
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• pp.104-115
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• 2019

Since the Fukushima Daiichi accident, there has been an emphasis on the risk resulting from multi-unit accidents. Human reliability analysis (HRA) is one of the important issues in multi-unit probabilistic safety assessment (MUPSA). Hence, there is a need to properly identify all the human and organizational factors relevant to a multi-unit incident scenario in a nuclear power plant (NPP). This study identifies and categorizes the human and organizational factors relevant to a multi-unit incident scenario of NPPs based on a review of relevant literature. These factors are then analyzed to ascertain all possible unit-to-unit interactions that need to be considered in the multi-unit HRA and the pattern of interactions. The human and organizational factors are classified into five categories: organization, work device, task, performance shaping factors, and environmental factors. The identification and classification of these factors will significantly contribute to the development of adequate strategies and guidelines for managing multi-unit accidents. This study is a necessary initial step in developing an effective HRA method for multiple NPP units in a site.

• Bulletin of the Korean Chemical Society
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• 제34권12호
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• pp.3591-3596
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• 2013

The enantioselective aza-Morita Baylis Hillman reaction of nitroalkene and N-tosylimine catalyzed by thiourea-tertiary amine has been investigated using density functional theory. Enantioselectivity is dominated by the cooperative effect of non-covalent and weak covalent interactions imposed by different units of catalyst. As Lewis base, the tertiary amine unit activates nitroalkene via weak covalent bond. The weak covalent interaction orients the reaction in a major path with smaller variations of this bond. The aromatic ring unit activates N-tosylimine via ${\pi}-{\pi}$ stacking. The non-covalent interaction selects the major path with smaller changes of the efficient packing areas. Thiourea unit donates more compact H-bonded network for species of the major path. The calculated ee value in xylene solution phase (97.6%) is much higher than that in N,N-Dimethylformamide (27.2%). Our conclusion is also supported by NBO analysis.

• Nuclear Engineering and Technology
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• 제45권7호
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• pp.839-846
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• 2013

This paper describes a finite element model of the microstructure of dispersion type nuclear fuels, which can be used to determine the effective thermal conductivity of the fuels during irradiation. The model simulates a representative region of the fuel as a prism shaped unit cell made of brick elements. The elements within the unit cell are assigned material properties of either the fuel or the matrix depending on position, in such a way as to represent randomly distributed fuel particles with a size distribution similar to that of the as manufactured fuel. By applying an appropriate heat flux across the unit cell it is possible to determine the effective thermal conductivity of the unit cell as a function of the volume fraction of the fuel particles. The presence of a fuel/matrix interaction layer is simulated by the addition of a third set of material properties that are assigned to the finite elements that surround each fuel particle. In this way the effective thermal conductivity of the material may also be determined as a function of the volume fraction of the interaction layer. Work is on going to add fission gas bubbles in the fuel as a fourth phase to the model.

• Genomics & Informatics
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• 제1권1호
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• pp.7-19
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• 2003

The latest measure of the relative evolutionary age of protein structure families was applied (based on taxonomic diversity) using the protein structural interactome map (PSIMAP). It confirms that, in general, protein domains, which are hubs in this interaction network, are older than protein domains with fewer interaction partners. We apply a hypothesis of 'biological network evolution' to explain the positive correlation between interaction and age. It agrees to the previous suggestions that proteins have acquired an increasing number of interaction partners over time via the stepwise addition of new interactions. This hypothesis is shown to be consistent with the scale-free interaction network topologies proposed by other groups. Closely co-evolved structural interaction and the dynamics of network evolution are used to explain the highly conserved core of protein interaction pathways, which exist across all divisions of life.

• 한국당과학회:학술대회논문집
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• 한국당과학회 2006년도 제1회 연례학술대회
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• pp.6-7
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• 2006

• 대한지리학회지
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• 제46권2호
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• pp.197-211
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• 2011

공간 상호작용의 복잡성, 공간적 재현과 모델링의 필요성에 의해서 공간 상호작용 데이터의 합역이 불가피하다. 이러한 상황에서 본 연구의 목적은 공간 상호작용 데이터를 스케일을 달리하여 합역하거나 혹은 동일 스케일에서 합역 방식을 달리하여 합역하였을 때, 공간 상호작용 모델의 결과가 어떻게 달라지는지 평가하는 것이다. 공간 상호작용 데이터의 합역은 공간단위 수정가능성의 문제(Modifiable Areal Unit Problem: MAUP)를 야기한다. 공간 상호작용 데이터의 합역을 위하여 무작위로 구역 시드를 선정한 후 인접한 공간단위를 할당하는 방법, 구역 시드와 공간단위 사이의 연구 가중 거리를 최소화하는 방법, 구역 내 상호작용 비율을 최대화하는 방법, 구역 내 상호작용 비율을 최소화하는 방법을 사용하였다. MAUP의 영향을 평가하기 위한 공간 상호작용 모텔로 기원지-목적지 제약 포아송 회귀 모델을 이용하였다. 분석 결과는 모델 잔차의 공간적 특성뿐만 아니라 파라미터 추정값, 적합도 등이 MAUP의 영향을 받는다는 것을 보여주었다. 모델은 합역 방식 보다는 합역 수준에 더 민감하게 반응하였고, 모델에 대한 스케일 효과는 구획 방식에 따라 상이하게 나타났다.

• 한국산업정보학회논문지
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• 제22권3호
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• pp.63-76
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• 2017

전통적으로 군수지원체제 구축과 결과품질에 관심이 집중되는 환경 속에서도 군수현장에서는 상호작용 품질에 대한 사용부대의 니즈가 나타나기 시작했다. 군수 기능 중 보급, 정비, 급양부대가 제공하는 군수지원 서비스품질 차원 중에서 상호작용 품질이 사용부대의 만족에 더 큰 영향을 미친 것으로 나타났는데, 특히 정비기능의 상호작용 품질이 가장 영향력이 크게 나타났다. 설문조사를 통한 실증분석 결과와 현장 군수종사자의 인터뷰가 이를 잘 증명하고 있으며, 고객과 상호작용 활동이 두드러지는 정비 기능의 특성이 이를 뒷받침하고 있다. 또한 상대적으로 직무만족이 높은 정비부대 종사자가 제공하는 서비스가 사용부대의 만족을 향상시키는 결과를 가져왔다.

• 대한인간공학회지
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• 제35권4호
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• pp.277-291
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• 2016

Objective: The aim of this study is to propose a unit touch gesture model, which would be useful to predict the performance time on mobile devices. Background: When estimating usability based on Model-based Evaluation (MBE) in interfaces, the GOMS model measured 'operators' to predict the execution time in the desktop environment. Therefore, this study used the concept of operator in GOMS for touch gestures. Since the touch gestures are comprised of possible unit touch gestures, these unit touch gestures can predict to performance time with unit touch gestures on mobile devices. Method: In order to extract unit touch gestures, manual movements of subjects were recorded in the 120 fps with pixel coordinates. Touch gestures are classified with 'out of range', 'registration', 'continuation' and 'termination' of gesture. Results: As a results, six unit touch gestures were extracted, which are hold down (H), Release (R), Slip (S), Curved-stroke (Cs), Path-stroke (Ps) and Out of range (Or). The movement time predicted by the unit touch gesture model is not significantly different from the participants' execution time. The measured six unit touch gestures can predict movement time of undefined touch gestures like user-defined gestures. Conclusion: In conclusion, touch gestures could be subdivided into six unit touch gestures. Six unit touch gestures can explain almost all the current touch gestures including user-defined gestures. So, this model provided in this study has a high predictive power. The model presented in the study could be utilized to predict the performance time of touch gestures. Application: The unit touch gestures could be simply added up to predict the performance time without measuring the performance time of a new gesture.

• 대한건축학회논문집:구조계
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• 제34권3호
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• pp.95-102
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• 2018

In order to understand interaction between building users' occupant performance and building maintenance performance of maintenance management personnel, actual data from maintenance activities of buildings were analyzed. Also, using building defect customer complaint data reported by building user, satisfaction data on building maintenance services of building users and service response time of maintenance management personnel, a method for evaluating interaction of buildings with the same purpose and same size was proposed. Throughout analysis, average number of occurrences per unit area per year for the mechanical complaints in complex building were presented. In addition, using building users' satisfaction with facility management services, attitude of responding to business obstacles, number of occurrences per unit area per year of mechanical complaints and complaint processing speed, interaction was comprehensively identified and compared.