• 제목/요약/키워드: Unfolding

검색결과 267건 처리시간 0.023초

일시적 거주개념을 적용한 1인용 소형주거공간의 유형 및 특성 (The Types and Characteristics of Temporary Small-Sized Housing Units for Single-Person Households)

  • 김미경;송애희
    • 한국주거학회:학술대회논문집
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    • 한국주거학회 2011년도 춘계학술발표대회 논문집
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    • pp.231-235
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    • 2011
  • The purpose of this study was to analyze the types and characteristics of temporary small-sized housing units for single-person households. A document research method and case studies were used to analyze and classified the spatial characteristics and types of the temporary dwelling spaces since 2000. Findings of this study were as follows: temporary and simplified dwelling spaces were developed by the concept of impermanence for single-person households in modern society. In order to conform the concept of temporary dwelling for small-sized housing units of single-person households, the characteristics were divided into three aspects. 'Transporting' by wheel and rotation and vehicles, 'Transforming' by adapting, assembling disassembling, and folding unfolding, and 'Wearing Carrying' by inflatable and tented types. It attempted to resolve the concept of temporarity through the experiment so that they might apply to the space of contemporary city.

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Effects of Protein Unfolding and Soluble Aggregates Formation on the Gel Strength of Whey Proteins

  • Park, Moon-Jung;Michael E. Mangino
    • Preventive Nutrition and Food Science
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    • 제2권4호
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    • pp.281-284
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    • 1997
  • Heat-induced gelation is an important functional property of whey proteins. Preheating of calcium reduced whey was reported to increase gel strength. 5% whey-protein solutions were preheated at pH7 and at various temperatures(60~8$0^{\circ}C$) for 15 minutes. The amount of soluble aggregates and denaturation enthalpy of preheated whey proteins were measured. Preheating temperature was negatively correlated with denaturation enthalpy($R^2$=0.857, P=0.08) and positive with the amount of soluble aggregates($R^2$=0.921, P=0.002). Denaturation enthalpy was negatively correlated with gel strength($R^2$=0.93, P=0.002). Soluble aggregates and gel strength were positively correlated($R^2$=0.972, P=0.0003). The formation of three dimensional gel network requires controlled protein denaturation and aggregation. Since preheating leads to the partial denaturation of proteins and the formation of soluble aggregates, preheated whey proteins have a higher gel strength than non-preheated one.

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Conformational Properties of Disulfide-Free Recombinant Chicken Ovalbumin

  • Jeoung, Yeon-Hee;Yu, Myeong-Hee
    • BMB Reports
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    • 제32권3호
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    • pp.247-253
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    • 1999
  • Chicken egg ovalbumin is a non-inhibitory member of the serpin (serine protease inhibitors) family whose members share a common tertiary fold. In the present study, we succeeded in high-level production of a disulfide-free form of refolded recombinant ovalbumin. Conformational characterization of the recombinant ovalbumim revealed that it is well-folded, following two-state unfolding transition with the midpoint of transition at 4.7 M at $25^{\circ}C$. This value is very close to that of the reduced form of authentic ovalbumin. The recombinant ovalbumin can serve as a model molecule of non-inhibitory serpins in comparative studies with inhibitory members of the serpin family.

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영광 원자력발전소 원자로 건물내 중성자 스펙트럼 측정

  • 손중권;신상운;조찬희
    • 한국원자력학회:학술대회논문집
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    • 한국원자력학회 1998년도 춘계학술발표회논문집(2)
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    • pp.594-599
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    • 1998
  • 출력 운전중 원자로 건물내의 중성자 에너지 스펙트럼의 분포를 살펴보기 위해 중성자 스펙트럼 측정을 수행하였다. 영광4흐기 원자로 건물내 100ft 상에서 4곳, 122ft 상에서 4곳, 144 ft 상에서 8곳을 Bonner Multisphere Spectrometer(BMS) 시스템을 이용하여 중성자 스펙트럼을 측정하였다. BMS는 Cf-252 선원으로 교정하였으며 측정된 데이터는 BUNKI 코드를 이용하여 unfolding 하여 에너지 스펙트럼을 얻었다 분석 결과 100 ft의 경우 평균 중성자 에너지는 0.100 ~ 1.954 MeV, Fluence는 4.913$\times$$10^2$ ~ 1.478$\times$$10^4$ n/$\textrm{cm}^2$, 선량율은 0.56 ~ 289.37 mrem/hr의 분포를, 122 ft의 경우 평균 중성자 에너지는 0.122 ~ 0.320 MeV, Fluence는 4.586$\times$$10^{0}$ ~ 7.743$\times$$10^3$ n$\textrm{cm}^2$, 선량율은 0.05 ~ 201.46 mrem/hr의 분포를, 144 ft의 경우 평균 중성자 에너지는 0.062 ~ 0.578 MeV, Fluence는 7.922$\times$$10^{0}$ ~ 1.703$\times$$10^2$ n/$\textrm{cm}^2$, 선량율은 0.10 ~ 45.58 mrem/hr의 분포를 보였다.

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Refolding of Acid-Unfolded Globin to Hemoglobin

  • 이종우
    • 대한의생명과학회지
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    • 제11권1호
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    • pp.85-88
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    • 2005
  • Hemoglobin is oxygen carrier protein within erythrocyte in blood. Apoprotein of this, globin, is synthesized in the cytosol but it's cofactor, heme, is synthesized in the mitochondria. It has not been known very well how globin receives the heme from mitochondria and folds to hemoglobin. In this folding process, the initial structure of globin seems to be very important. A small volume of globin at acid pH was added rapidly into the bulk of an egg phosphatidylcholine $60\%$ liposome, containing hemins, at neutral pH according to the Rapid Dilution method. It was observed that an acid-induced unfolding structure of globin is initially needed to receive hemins from the lipid bilayer of liposomes. Also, this conclusion was confirmed with the absorption spectrum of the refolded globin separated by centrifugation.

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항력리본이 장착된 자탄의 공력 해석 연구 (A STUDY ON AERODYNAMIC ANALYSIS OF A SUB-MUNITION WITH DRAG RIBBON)

  • 강승희;김진석;안성호
    • 한국전산유체공학회지
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    • 제16권4호
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    • pp.14-20
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    • 2011
  • The initial unfolding motion simulation of a sub-munition with drag ribbon for precision guidance and reliable operation has been investigated by analyzing its unsteady aerodynamic load and fluid structure interaction. The effects of change in the ribbon configuration and flow angle are numerically studied using a commercial software "XFLOW" based on Lattice-Boltzmann Method. It is shown that the motion is affect adversely by the separation bubble formed posterior part of the fuselage. The rolling moment for arming of the sub-munition is increased with angle of attack and rotational movement.

Designing Technology for Visualisation of Interactions on Mobile Devices

  • Deray, Kristine;Simoff, Simeon
    • Journal of Computing Science and Engineering
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    • 제3권4호
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    • pp.218-237
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    • 2009
  • Interactions are intrinsic part of what we do. We interact when we work, when we learn, when we visit a doctor, and when we play. With the advent of information and communications technology we can collect rich data (video, audio, and various transcripts including text chat) about such interactions. This opens an opportunity to monitor the dynamics of interactions and to get deeper insights of how they unfold and deliver this information to the interacting parties. This paper presents the design of a technology for visualising information about the dynamics of unfolding of interactions and presenting it in an ambient display on mobile devices. The purpose of this technology is the delivery of such information to the point of decision making.

Molecular Targeting Agents in Cancer Therapy: Science and Society

  • Shaikh, Asim Jamal
    • Asian Pacific Journal of Cancer Prevention
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    • 제13권4호
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    • pp.1705-1708
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    • 2012
  • The inception of targeted agents has revolutionized the cancer therapy paradigm, both for physicians and patients. A large number of molecular targeted agents for cancer therapy are currently available for clinical use today. Many more are in making, but there are issues that remain to be resolved for the scientific as well as social community before the recommendation of their widespread use in may clinical scenarios can be done, one such issue being cost and cost effectiveness, others being resistance and lack of sustained efficacy. With the current knowledge about available targeted agents, the growing knowledge of intricate molecular pathways and unfolding of wider spectrum of molecular targets that can really matter in the disease control, calls for only the just use of the agents available now, drug companies need to make a serious attempt to reduce the cost of the agents. Research should focus on agents that show sustained responses in preclinical data. More needs to be done in laboratories and by the pharmaceutical industries, before we can truly claim to have entered a new era of targeted therapy in cancer care.

분할 스케쥴링 알고리즘에 기반한 스케쥴러의 효율성 분석 (Efficiency Analysis of Scheduler based on the Division Scheduling Algorithm)

  • 송유진;이종근
    • 제어로봇시스템학회논문지
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    • 제10권1호
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    • pp.87-95
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    • 2004
  • We proposed the division algorithm that was aimed at dividing system models. It used a transitive matrix to express the relation between place and transition. And the division algorithm was applied to the scheduling problem, with the division-scheduling algorithm. The division-scheduling algorithm was able to calculate the divided subnet table. And it is able to reduce the analysis complexity. In this study, we applied the proposed division algorithm and division-scheduling algorithm to flexible manufacturing system models. We compared the efficiency and performance of the division-scheduling algorithm with the Hillion algorithm, Korbaa algorithm, and Unfolding algorithm proposed in previous researches.

Hydrophobic Core Variant Ubiquitin Forms a Molten Globule Conformation at Acidic pH

  • Park, Soon-Ho
    • BMB Reports
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    • 제37권6호
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    • pp.676-683
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    • 2004
  • The conformational properties of hydrophobic core variant ubiquitin (Val26 to Ala mutation) in an acidic solution were studied. The intrinsic tryptophan fluorescence emission spectrum, far-UV and near-UV circular dichroic spectra, the fluorescence emission spectrum of 8-anilinonaphthalene-1-sulfonic acid in the presence of V26A ubiquitin, and urea-induced unfolding measurements indicate this variant ubiquitin to be in the partially folded molten globule conformation in solution at pH 2. The folding kinetics from molten globule to the native state was nearly identical to those from the unfolded state to the native state. This observation suggests that the equilibrium molten globule state of hydrophobic core variant ubiquitin is an on-pathway folding intermediate.