Biomedical Science Letters (대한의생명과학회지)
- Volume 11 Issue 1
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- Pages.85-88
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- 2005
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- 1738-3226(pISSN)
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- 2288-7415(eISSN)
Refolding of Acid-Unfolded Globin to Hemoglobin
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Lee Jong-Woo
(School of Alternative Medicine and Health Science, Jeonju University)
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이종우
(전주대학교 의생명환경대학 대체건강관리학부)
- Published : 2005.03.01
Abstract
Hemoglobin is oxygen carrier protein within erythrocyte in blood. Apoprotein of this, globin, is synthesized in the cytosol but it's cofactor, heme, is synthesized in the mitochondria. It has not been known very well how globin receives the heme from mitochondria and folds to hemoglobin. In this folding process, the initial structure of globin seems to be very important. A small volume of globin at acid pH was added rapidly into the bulk of an egg phosphatidylcholine