Waterfront redevelopment is an element in the process of inner-city regeneration now widespread in many ports of the world. Academic interest in the processes involved has yielded a literature biased towards specific locations rather than towards the analysis of processes and issues. The redevelopment of urban waterfronts does not, of course, occur exclusively in port cities but is found as a continuous process in most places where settlement and water are juxtaposed, whether or not commercial port activity is or was present. Port cities, however, as a result of the concentration and juxtaposition of urban and maritime influences, generally present the major issues involved in waterfront redevelopment most clearly. In this context, the general aim is to explore Korean dimensions of waterfront redevelopment in a range of port cities in a context of inner-urban renewal; and a specific objective is to examine the views of decision-makers in Korean port cities on the processes involved by a questionnaire method. The focus is on comparative strategies, and in particular upon the factors affecting the balance between social goals and commercial interests. To test the response of four categories of decision-makers in Korean port cities on a number of issues perceived as underpinning the processes involved in waterfront redevelopment, four catergories of respondents-port authority representatives(PO), urban planners(UP), port specialists(PS) and city-government official(GO)-were asked to fill in a questionnaire form. In three out of ten cases, the overall result broadly confirmed the a priori expectation; in six cases the confirmation was partial; and in one other the view of respondent was generally contrary to those anticipated. In many, but by no means all, cases there was substantial agreement between the four categories of respondents, but the range of scores was generally much wider than expected.
Background: The relationship between risk factors and likelihood of occupational injury has been studied. However, what has been published has only provided a limited explanation of why some of the employees working in the same environment as other employees suffered a single-injury event, while other employees experienced multiple-injury events. This article reports on an investigation of whether artisanal and small-scale miners in Migori County of Kenya are susceptible to a single-injury or multiple-injury incidences, and if so, what underpinning parameters explain the differences between the single incident injured and the multiple incident injured group. Mine management commitment to safety in artisanal and small-scale mining (ASM) operations is also considered. Materials and methods: The research objectives were achieved by surveying 162 uninjured and 74 injured miners. A structured, closed-end questionnaire was administered to participants after the stratification of the study population and systematic selection of the representative samples. Results: The results showed that most injured miners suffer a single-injury incident rather than experiencing multiple-injury events, and laceration (28.40%) was the common injury suffered by the miners. The analysis showed that the risk factors for the single incident injured group were not similar to those in the multiple incident injured group. The research also found mine workers have low opinion about mine management/owners commitment to safety. Conclusion: The study concluded that mine management and miners need to be educated and sensitized on the dangers of this operation. Provision of safety gears and positive safety culture must be a top priority for management.
As information systems are implemented in business organizations, users and other stakeholders are known to resist changes incurred by information systems being implemented. For successful implementation, it is critical to manage changes overcoming resistance. Through literature review and expert panel, this study derives four underlying dimensions of resistance (anxiety, suspicion, imposition and self-centeredness) and five categories of change management activities (vision, leadership, communications, education and training, and organizational culture). A Survey was designed to measure the relationship between these dimensions and activities, and administered among information systems consultants. It is found that activities related to vision and leadership is underpinning other change management activities. Anxiety and imposition can be mitigated by education and training while suspicion is to be overcome by communications and self-centeredness by activities related to cultural changes. Implications are discussed and further researches are suggested.
An, Ji-Young;Kim, Kwang Kee;JeKarl, Jung;Moon, Hyunjung;Cha, Sun Kyung;Jeong, Eunha
Korean Journal of Health Education and Promotion
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v.30
no.5
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pp.47-59
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2013
Objectives: To investigate the current status and challenges of research methodology for health promotion research (HPR), this study analyzed HPR funded by the Korea Health Promotion Foundation (KHPF) from 2005 to 2011. Methods: All of the research reports funded by the KHPF for the period were included in this study. From the literature reviewed, a framework of this study was developed. Results: Quantitative research was 67.7%. The most common quantitative research design was cross-sectional survey (46.6%). Only 7.3% of quantitative research employed theoretical frameworks, and more than a half (53.4%) used primary data. For qualitative research (2.8%), most cases were conducted together with quantitative research. No qualitative research employed a philosophical underpinning. Only 7.0% of research received consent form, and 2.1% was approved by institutional review board. The results of this study indicate that there is a need to employ various research methods to study key concepts of HPR more in-depth. Efforts should be made to reduce statistical errors and also employ newly introduced statistical methods. Conclusions: Overall, a lack of scientific evidence from the HPR reports analyzed in this study was observed. Therefore, the KHPF and the academia should work together to solve the problems indicated from this study.
This study investigated the effects of smart phone usage motives and fashion brand app factors upon the intention to accept fashion brand applications. Data were collected from 250 female college students living in Seoul and Gyeonggi-do. 220 reliable data were analyzed by frequency, factor analysis, Cronbach's alpha, ANOVA,, Duncan test, paired t-test, chi-square analysis, regression. The results were as follows: Firstly, the 'information acquisition' and the'use of time' were considered to be the most important motive factors driving consumer's smart phone usage. Secondly, the motives underpinning smart phone user's intention to accept a fashion brand application were 'social relationships', 'entertainment', and 'information acquisition'. Thirdly, the frequently used factors during the usage of fashion brand application could be classified in order of frequency as follows: 'product information provision', 'store information provision', 'coordinated information provision', 'fashion information provision', 'entertainment provision', 'hobbies and life information provision', virtual wearing provision', 'SNS provision', and, 'events and coupons provision'. Fourthly, a factor analysis of these nine factors were classified into 'basic information type', and 'additional information type'. The influences of basic information type and the additional information type upon the intention to accept the fashion brand application showed the following significant result: The basic information type had a greater influence upon the intention to accept the fashion brand app.
Mechanized constructions have been frequently increased in soft ground below sea bed or river bed, for urban tunnel construction, and for underpinning the lower part of major structures in order to construct a safer tunnel considering various risk factors during the tunnel construction. However, it is difficult to estimate the subsidence behavior of the ground surface due to excavation and needs to be easily predicted. Thus, in this study, when a twin tunnel is constructed in the soft ground, it is proposed a simpler equation relating to the settlement behavior and a corrected formula applicable to soft ground and large diameter shield tunnels based on the previously proposed theory by Peck (1969). For this purpose, it was analyzed to long-term measurement values such as the amount of maximum settlement, the subsidence range by ground conditions, and interference volume loss due to the parallel construction, etc. As a result, a equation was suggested to predict the amount of maximum settlement in the soft sediment clay ground where is located at the upper part of the excavation site. It is turned out that the proposed equation is more suitable for measurement data in Korea than Peck (1969)'s.
KSII Transactions on Internet and Information Systems (TIIS)
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v.15
no.1
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pp.90-113
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2021
Electronic Records Management System (ERMS) is a computer program or set of applications that is utilized for keeping up to date records along with their storage. ERMS has been extensively utilized for enhancing the performance of academic institutions. The system assists in the planning and decision-making processes, which in turn enhances the competencies. However, although ERMS is significant in supporting the process of decision-making, the majority of organizations have failed to take an initiative to implement it, taking into account that are some implementing it without an appropriate framework, and thus resulted in the practice which does not meet the accepted standard. Therefore, this study identifies the factors influencing the adoption of ERMS among employees of HLI in Yemen and the role of such adoption in the decision-making process, using the Unified Theory of Acceptance and Use of Technology (UTAUT) along with Technology, Organization and Environment (TOE) as the underpinning theories. The study conducts a cross-sectional survey with a questionnaire as the technique for data collection, distributed to 364 participants in various Yemeni public Higher Learning Institutions (HLI). Using AMOS as a statistical method, the findings revealed there are significant and positive relationships between technology factors (effort expectancy, performance expectancy, IT infrastructure and security), organizational factors (top management support, financial support, training, and policy),environmental factors (competitiveness pressure, facilitating conditions and trust) and behavioral intention to adopt ERMS, which in return has a significant relationship with the process of decision-making in HLI. The study also presents a variety of theoretical and empirical contributions that enrich the body of knowledge in the field of technology adoption and the electronic record's domain.
Background: Diabetes-related neuropathic pain frequently occurs, and the underpinning mechanism remains elusive. The periaqueductal gray (PAG) exhibits descending inhibitory effects on central pain transmission. The current work aimed to examine whether inflammatory cytokines regulate mechanical allodynia and thermal hyperalgesia induced by diabetes through the phosphoinositide 3-kinase (PI3K)-mammalian target of rapamycin (mTOR) pathway in the PAG. Methods: Streptozotocin (STZ) was administered intraperitoneally to mimic allodynia and hyperalgesia evoked by diabetes in rats. Behavioral assays were carried out for determining mechanical pain and thermal hypersensitivity. Immunoblot and ELISA were performed to examine PAG protein amounts of interleukin-1β (IL-1β), IL-6, and tumor necrosis factor-α (TNF-α), as well as their corresponding receptors in STZ rats, and the expression of PI3K/protein kinase B (Akt)/mTOR signaling effectors. Results: Increased PAG p-PI3K/p-Akt/p-mTOR protein amounts were observed in STZ-induced animals, a PI3K-mTOR pathway inhibition in the PAG attenuated neuropathic pain responses. Moreover, the PAG concentrations of IL-1β, IL-6, and TNF-α and their receptors (namely, IL-1R, IL-6R, and tumor necrosis factor receptor [TNFR] subtype TNFR1, respectively) were increased in the STZ rats. Additionally, inhibiting IL-1R, IL-6R, and TNFR1 ameliorated mechanical allodynia and thermal hyperalgesia in STZ rats, alongside the downregulation of PI3K-mTOR signaling. Conclusions: Overall, the current study suggests that upregulated proinflammatory cytokines and their receptors in the PAG activate PI3K-mTOR signaling, thereby producing a de-inhibition effect on descending pathways in modulating pain transmission, and eventually contributing to neuropathic pain.
Gender sensitivity is a concept needs to be substantially count since early childhood when a child starts understanding and developing their gender role. As such UNESCO published the guideline on Comprehensive Sexuality Education(CSE) guidelines. In Korea, the Ministry of Women and Family selected the book called 'Nadaum children's book' in order to support children to better develop the gender sensitivity in their early childhood. This study aims for qualitative research on 101 books for low-grade children of Nadaum Children's Books. Content analysis and theme analysis were conducted based on UNESCO's CSE guidelines. This is to analyze the frequency rate of the CSE concepts and how the value of gender sensitivity is described throughout the books. The results shows that 'family member' and 'value of tolerance' were most frequently appeared while 'puberty' and 'sex and health' were not included. In addition, the results of theme analysis showed that this book well described the activities pursuing the value of gender sensitivity as well as process of being materialized it.
Piao, Mei Jing;Han, Xia;Kang, Kyoung Ah;Fernando, Pincha Devage Sameera Madushan;Herath, Herath Mudiyanselage Udari Lakmini;Hyun, Jin Won
Biomolecules & Therapeutics
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v.30
no.3
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pp.265-273
/
2022
Resistance to chemotherapeutic drugs is a significant problem in the treatment of colorectal cancer, resulting in low response rates and decreased survival. Recent studies have shown that shikonin, a naphthoquinone derivative, promotes apoptosis in colon cancer cells and cisplatin-resistant ovarian cells, raising the possibility that this compound may be effective in drug-resistant colorectal cancer. The aim of this study was to characterize the molecular mechanisms underpinning shikonin-induced apoptosis, with a focus on endoplasmic reticulum (ER) stress, in a 5-fluorouracil-resistant colorectal cancer cell line, SNU-C5/5-FUR. Our results showed that shikonin significantly increased the proportion of sub-G1 cells and DNA fragmentation and that shikonin-induced apoptosis is mediated by mitochondrial Ca2+ accumulation. Shikonin treatment also increased the expression of ER-related proteins, such as glucose regulatory protein 78 (GRP78), phospho-protein kinase RNA-like ER kinase (PERK), phospho-eukaryotic initiation factor 2 (eIF2α), phospho-phosphoinositol-requiring protein-1 (IRE1), spliced X-box-binding protein-1 (XBP-1), cleaved caspase-12, and C/EBP-homologous protein (CHOP). In addition, siRNA-mediated knockdown of CHOP attenuated shikonin-induced apoptosis, as did the ER stress inhibitor TUDCA. These data suggest that ER stress is a key factor mediating the cytotoxic effect of shikonin in SNU-C5/5-FUR cells. Our findings provide an evidence for a mechanism in which ER stress leads to apoptosis in shikonin-treated SNU-C5/5-FUR cells. Our study provides evidence to support further investigations on shikonin as a therapeutic option for 5-fluorouracil-resistant colorectal cancer.
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