• Physical Therapy Rehabilitation Science
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• v.12 no.3
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• pp.259-267
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• 2023

Objective: Rehabilitative ultrasound imaging is a safe and noninvasive technique for evaluating muscle thickness. A dual probe-fixing frame (DPF) can provide visual feedback during exercises targeting specific muscles. The purpose of this research was to verify the reliability and validity of the DPF for dual-probe ultrasound (DPU)-based visual feedback exercises, allowing users to use both hands freely. Design: This cross-sectional study used repeated measures to compare muscle thickness measurements obtained using the handheld device and DPF with DPU. Methods: Twenty healthy adults participated in the study. Measurements were taken over two sessions, with a two-day interval between the sessions. The thicknesses of the rectus abdominis (RA) and transverse abdominis (TrA) muscles were measured using DPU. The DPF with DPU developed by the research team, was used along with a laptop-based muscle viewer. Bland-Altman analysis and intraclass correlation coefficients (ICCs) calculations were used in statistical analyses to evaluate agreement and reliability, respectively. Results: The results of the Bland-Altman analysis showed small average differences between the handheld and DPF methods for both RA and TrA muscle thicknesses. Inter-rater reliability analysis showed high ICC values for DPF measurements of both RA (0.908-0.912) and TrA (0.892-741) muscle thicknesses. Intra-rater reliability analysis also showed good ICC values for measurements taken by a single examiner over two days. Conclusion: The findings of this study demonstrate that the DPF provides reliable and valid measurements of muscle thickness during visual feedback exercises using the DPU.

• Korean Journal of Digital Imaging in Medicine
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• v.6 no.1
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• pp.51-64
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• 2003

This thesis describes the effective interfacing methods of PACS Modality based on the system installation andoperating experiences. PACS(Picture Archiving and Communication Systems) is a system for medical image archiving and communication using large storage device and high-speed network. The standard communication protocol of PACS is DICOM(Digital Imaging and Communication in Medicine) based on TCP/IP and point-to-point protocol. However, there are many Non-DICOM Modalities and DICOM Modalities having problems. First, we had interfaced almost modalities. Fuji CR, GE CT, MRI, Angio, Fluoro, Phillips Angio, Shimadzu Fluoro. Ultrasound PACS, with the main PACS in the Seoul S Hospital as large scale hospital. And we manipulated the intelligent image distribution and the CT. MRI Interfaces never experienced beforein the Anyang J Hospital and the Chungju C Hospital as mid or small scale hospital. Technically, we developed both the DICOM Interface and the Non-DICOM Interface. At the last, the DICOM Worklist and the DICOM Print Interface were implemented in the Seoul B Hospital, the Bucheon SJ Hospital and the Seoul K Hospital independently with PACS. The Oracle, Sybase and MS-SQL are used as database, and UNIX, Macintosh, MS Windows as operating systems. And the Visual C++ and UNIX C are the main programming tools. We have used UTP, coaxial and fiber optic cable under 10/100 mbps LAN for networking.

• Korean Journal of Digital Imaging in Medicine
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• v.5 no.1
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• pp.46-63
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• 2002

This thesis describes the effective interfacing methods of PACS Modality based on the system installation and operating experiences. PACS(Picture Archiving and Communication Systems) is a system for medical image archiving and communication using large storage device and high-speed network. The standard communication protocol of PACS is DICOM(Digital Imaging and Communication in Medicine) based on TCP/IP and point-to-point protocol. However, there are many Non-DICOM Modalities and DICOM Modalities having problems. First, we had interfaced almost modalities, Fuji CR, GE CT, MRI, Angio, Fluoro, Phillips Angio, Shimadzu Fluoro, Ultrasound PACS, with the main PACS in the Seoul S Hospital as large scale hospital. And we manipulated the intelligent image distribution and the CT, MRI Interfaces never experienced before in the Anyang J Hospital and the Chungju C Hospital as mid or small scale hospital. Technically, we developed both the DICOM Interface and the Non-DICOM Interface. At the last, the DICOM Worklist and the DICOM Print Interface were implemented in the Seoul B Hospital, the Bucheon SJ Hospital and the Seoul K Hospital independently with PACS. The Oracle, Sybase and MS-SQL are used as database, and UNIX, Macintosh, MS Windows as operating systems. And the Visual C++ and UNIX C are the main programming tools. We have used UTP, coaxial and fiber optic Gable under 10/100 mbps LAN for networking.

• The Journal of the Convergence on Culture Technology
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• v.8 no.5
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• pp.1-7
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• 2022

Korean medical device industry has laid the foundation for full-fledged growth and development with the G7 medical engineering technology development project that started in 1995, and the medical device production in 2020 increased by 8.52 times and the export by 13.94 times, compared to those in 2001. In early years, electronic medical devices such as ultrasound imaging device contributed greatly to Korean medical industry, but top ranks in medical device production and export in Korea has shifted recently to in vitro diagnostic medical devices and dental implants. However, the share of imported medical devices in the Korean medical device market have not changed much; it still ranges in 60 to 70%, as the Korean medical device industry produces and exports mid- to low-priced medical devices, and technology-intensive and capital-intensive high-priced medical devices are mainly imported. In this paper, we compare the leading medical devices produced by major Korean companies and those by global top medical device companies to suggest strategies for the Korean medical device companies to enter the global market.

• Journal of the Korean Society of Radiology
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• v.11 no.4
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• pp.221-225
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• 2017

To evaluate the performance of ultrasound imaging system, we investigated the change of spatial resolution according to changing sonic velocity change parameter provided by ultrasound equipment. Ultrasound phantom images were obtained using a 3.0 ~ 5.0 MHz convex transducer in an ultrasound diagnostic device used at a medical institution located at Iksan. N-365 multi-purpose ultrasound phantom was used to measure longitudinal distance measurement accuracy and longitudinal and transverse resolution. In the same manner, the sonic velocity of the ultrasound equipment was changed from 1580 m/sec to 1400 m/sec in six steps, and the full width at half maximum(FWHM) was measured using the image J program to determine whether the measured values were different. As a result, lateral resolution was measured from 1.91 mm to 5.3 mm according to the speed change, and the smallest FWHM was 1.91 mm at 1420 m/sec. The axial resolution was measured from 1.03 mm to 1.14 mm according to the speed change, and the smallest FWHM was 1.03 mm at 1400 m/sec. The slower the sound velocity of the ultrasound equipment, the shorter the length of longitudinal measurement.

• Journal of Radiopharmaceuticals and Molecular Probes
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• v.9 no.1
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• pp.9-16
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• 2023

Liposomes as drug delivery system have proved useful carrier for various disease, including cancer. In addition, perfluorocarbon cored microbubbles are utilized in conjunction with high-intensity focused-ultrasound (HIFU) to enable simultaneous diagnosis and treatment. However, microbubbles generally exhibit lower drug loading efficiency, so the need for the development of a novel liposome-based drug delivery material that can efficiently load and deliver drugs to targeted areas via HIFU. This study aims to develop a liposome-based drug delivery material by introducing a substance that can burst liposomes using ultrasound energy and confirm the ability to target tumors using PET imaging. Liposomes (Lipo-DOX, Lipo-DOX-Au, Lipo-DOX-Au-RGD) were synthesized with gold nanoparticles using an avidin-biotin bond, and doxorubicin was mounted inside by pH gradient method. The size distribution was measured by DLS, and encapsulation efficiency of doxorubicin was analyzed by UV-vis spectrometer. The target specificity and cytotoxicity of liposomes were assessed in vitro by glioblastoma U87mg cells to HIFU treatment and analyzed using CCK-8 assay, and fluorescence microscopy at 6-hour intervals for up to 24 hours. For the in vivo study, U87mg model mouse were injected intravenously with 1.48 MBq of ⁶⁴Cu-labeled Lipo-DOX-Au and Lipo-DOX-Au-RGD, and PET images were taken at 0, 2, 4, 8, and 24 hours. As a result, the size of liposomes was 108.3 ± 5.0 nm at Lipo-DOX-Au and 94.1 ± 12.2 nm at Lipo-DOX-Au-RGD, and it was observed that doxorubicin was mounted inside the liposome up to 52%. After 6 hours of HIFU treatment, the viability of U87mg cells treated with Lipo-DOX-Au decreased by around 20% compared to Lipo-DOX, and Lipo-DOX-Au-RGD had a higher uptake rate than Lipo-DOX. In vivo study using PET images, it was confirmed that ⁶⁴Cu-Lipo-DOX-Au-RGD was taken up into the tumor immediately after injection and maintained for up to 4 hours. In this study, drugs released from liposomes-gold nanoparticles via ultrasound and RGD targeting were confirmed by non-invasive imaging. In cell-level experiments, HIFU treatment of gold nanoparticle-coupled liposomes significantly decreased tumor survival, while RGD-liposomes exhibited high tumor targeting and rapid release in vivo imaging. It is expected that the combination of these models with ultrasound is served as an effective drug delivery material with therapeutic outcomes.

• Journal of Veterinary Science
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• v.24 no.4
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• pp.34.1-34.12
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• 2023

Background: There has not been a thoroughly reported study of the comparison between spectral domain-optical coherence tomography (SD-OCT) with both ultrasound biomicroscopy (UBM) and gonioscopy on the evaluation of the iridocorneal angle (ICA) in dogs. Objectives: To investigate the diagnostic value of SD-OCT for the early detection of narrowing ICA by comparing and assessing inter-device agreement in anterior chamber angle (ACA) measurements obtained by SD-OCT and UBM, and ICA evaluations by gonioscopy. Methods: A total of 28 eyes from 28 client-owned dogs with normal intraocular pressure were included for examination. The ACA and angle opening distance (AOD) were measured from the SD-OCT and UBM images, and gonioscopy images were analyzed using the ICA grade and ZibWest angle index. Results: The mean ACA and AOD for SD-OCT were 28.31° ± 5.37° and 658.42 ± 219.90 ㎛, and for UBM, 28.34° ± 5.82° and 859.29 ± 221.80 ㎛, respectively. The mean difference in ACA between the average values of SD-OCT and UBM measurements was 0.03° with a 95% limit of agreement (LoA) span of 16.2°, indicating positive agreement; that in AOD was 200.85 ㎛ with a 95% LoA span of 1,110.95 ㎛, indicating poor agreement. The Pearson correlation coefficient of the ACA of SD-OCT and ZibWest indices of gonioscopy was 0.624, indicating strong agreement; that of UBM and gonioscopy was 0.43, indicating moderate agreement. Conclusions: SD-OCT is well tolerated by canine patients due to its non-contact method and might be an alternative option for early screening of ICA narrowing in clinical settings.

• The Journal of the Korean dental association
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• v.55 no.11
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• pp.800-807
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• 2017

Ultrasonography is one of the most common diagnostic tools in medical imaging with non-invasive and non-radiation loaded characteristics. In the field of dentistry, especially for periodontology, high frequency ultrasonic device can be used for several purposes such as evaluating gingival thickness, identifying the level of alveolar bone, measuring the volume of mucosa of donor site for soft tissue graft and so on. According to recent studies, it was demonstrated that ultrasonic diagnosis had both accuracy and repeatability comparable to conventional diagnostic tools. However, improvement and development of intra-oral probe suitable for adpatation to gingiva and palatal mucosa, are considered as prerequisites for diffusion of ultrasonic diagnosis in periodontology.

• The Korean Journal of Pain
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• v.33 no.3
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• pp.258-266
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• 2020

Background: The genicular nerve block (GNB) is demonstrated from several reports to alleviate pain and improve knee functionality in patients with chronic knee osteoarthritis (OA). Ultrasound (US)-guided GNB has been the most used imaging method. This study aimed to compare the effectiveness of US-guided versus blind GNB in the treatment of knee OA. Methods: This prospective, randomized clinical trial included patients with knee OA based on American College of Rheumatology diagnostic criteria. The patients were evaluated for clinical and dynamometer parameters at the baseline, 4 weeks after treatment, and 12 weeks after treatment. The patients underwent blind injection or US-guided injection. Results: When compared with the baseline, both groups showed significant improvement in pain, physical function, and quality of life parameters. Significant differences were observed between the groups for clinical parameters (30-second chair stand test, 6-minute walk test) in favor of the US-guided group. On the other hand, blind injection was more significantly effective on some parameters of the Nottingham Health Profile. There wasn't any significant improvement in isokinetic muscle strength for either group. Conclusions: This study demonstrated that both US-guided and blind GNB, in the treatment of knee OA, were effective in reducing symptoms and improving physical function. GNB wasn't an effective treatment for isokinetic muscle function. US-guided injections may yield more effective clinical results than blind injections.

• The Journal of the Korea Contents Association
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• v.13 no.8
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• pp.284-291
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• 2013

The importance of ultrasound examination in the field of medical imaging has been emphasized and the interest in sonographic image evaluation is growing. However image evaluations by the non-standardized criteria and methods, so establishment of legal provisions and objective evaluation criteria are needed. In this study, we used SNR to find out more quantitative way and supplement the limitations of the existing phantom image evaluation. The results of acquired 8 images using ATS-539 multipurpose phantom were compared in SNR of sensitivity and gray-scale dynamic range. In the result of the experiment, excellent equipment of existing phantom images are G1, S1 and G2 in regular sequence. In SNR of sensitivity, G1, S1 and G2 and in SNR of gray-scale dynamic range, S1 G1 and G2 in order. In the conclusion, all the experiment results did not show big difference and regular pattern neither. Therefore, the new evaluation measures should be used with the existing phantom image evaluation method for more objective and quantitative evaluation of the ultrasound imaging device.