• BMB Reports
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• v.34 no.5
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• pp.421-427
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• 2001

Osteoclasts, cells primarily involved in bone resorption, originate from the hematopoietic precursor cells of the monocyte/macrophage lineage and differentiate into multinucleated mature forms. We developed an in vitro osteoclast culture system using embryonic chicken bone marrow cells. This culture system can be utilized in studies on the differentiation and function of osteoclasts. Phosphatidylinositol 3-kinase (PI3-kinase) and mitogen-activated protein kinases (MAPKs) have been implicated in diverse cellular functions including proliferation, migration, and survival. Using the developed avian osteoclast culture system, we examined the involvement of these kinases in osteoclast differentiation by employing specific inhibitors of the kinases. We Found that the inhibition of the PI 3-kinase, p38, or ERK interfered with osteoclast formation, suggesting that the signaling pathways that involve these molecules participate in the process of chicken osteoclast differentiation.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.37
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• pp.10.1-10.5
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• 2015

Background: The aim of this study was to investigate the effect of a botulinum toxin type A (BTX-A) injection in the masseter muscle using electromyography (EMG) in an animal model. Methods: Ten male adult (>3 months of age) New Zealand white rabbits were used. Muscle activity was continuously recorded from 8 hours before to 8 hours after BTX-A injection. The rabbits received unilateral BTX-A injections of either 5 units (group 1, n = 5) or 20 units (group 2, n = 5). Results: The masseter muscle activity of the rabbits was significantly reduced immediately after BTX-A injection (P < 0.05 for both groups). When the results from group 1 were compared with those from group 2, only the peak voltage was significantly decreased in group 2 (P = 0.013). Conclusion: Masseter muscle activity measured by EMG was immediately decreased after a BTX-A injection.

• Proceedings of the Korea Society for Energy Engineering kosee Conference
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• 1996.04a
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• pp.88-96
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• 1996

The characteristic analysis of fly ash generated from a fired power plant using bunker-C oil has been investigated. Ash size distribution by an optical microscopy with image processing technique, morphological shape by a scanning electron microscope(SEM) and microscope, chemical composition by the inductively coupled plasma emission spectrometry(ICP), and resistivity measurement as a function of temperature and moisture content by the resistivity meter are performed. A study of physical, chemical and electrical characteristics of bunker-C fly ash plays an important role of improving the performance of an electrostatic precipitator and protecting air pollution. The samples of bunker-C fly ash for analysis were collected from the electrostatic precipitator hopper of Ulsan Power Plant Unit 1 and Pusan Power Plant Unit 1. Mass median diameter(MMD) of bunker-C fly ash was measured 12.7${\mu}{\textrm}{m}$, while MMD of fly ash generated from the mixture of bunker-C oil(40%) and domestic anthracitic coal(60%) was 25.7${\mu}{\textrm}{m}$. The morphological structure of bunker-C fly ash consisted of fine particles of non-spherical shape. The primary chemical components of bunker-C fly ash were composed of SiO2(2.36%), Al2O3(4.91%), Fe2O3(14.33%) and C(11.84%). Resistivity of bunker-C fly ash was found to be increased with increasing temperature at the range of 100~15$0^{\circ}C$ and was measured 103~104 ohm-cm.

• Journal of the Korean Society of Physical Medicine
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• v.4 no.4
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• pp.269-274
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• 2009

Purpose：The purpose of this study is an interval palmar width according to change of muscle activation under push-up movement. Methods：Three, this study participation normal young adult (male 3, mean age ; 24yaers). The subject performed maximum contraction under push-up movement. EMG activaty patterns is measured with three different width. The EMG activity of pectoralis major and latissimus dorsi were measured using surface electromyography. Results：EMG activation of pectoralis major and latissimus dorsi following of push-up was shown significant difference(p<.05). Also, experiment value was agree with calculation value and width of shoulder position was minimum of pectoralis major and latissimus dorsi muscle activity. Conslusion：RMS values in case of fretum and wide width of the hands on Latissimus Dorsi are shown muscle activity $132{\mu}V$ and $173.5{\mu}V$, respectively. Especialy, RMS value in terms of wide width of the hands on muscles is shown very enhanced muscle activity. It is suggest that interval palmar width of the hands on pectoralis major and latissimus dorsi in push-up movement was effective to intensify of the muscle activity.

• Proceedings of the Korea Information Processing Society Conference
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• 2019.10a
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• pp.199-200
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• 2019

최근 의료서비스에 ICT 기술이 도입되면서 의료서비스 패러다임이 병원중심에서 환자 중심으로 변화되고 있다. 특히, 사물인터넷 기술은 스마트헬스케어 서비스를 현실화하고 있다. 이로인하여 병원이 아닌 곳에서도 환자의 상태를 확인할 수 있고 이에 대한 적절한 조치를 취할 수 있는 다양한 서비스를 개발 연구가 활발히 진행되고 있다. 그러나 의료 사각지대의 환자는 여전히 신속하게 조치를 못하는 실정이며, 관리가 되고 있지 않아 사회적인 문제로 이슈화되고 있다. 본 논문은 의료사각지대의 환자에 대한 의료영상 진단 지원을 위한 클라우드환경 기반의 Connected Radiology Care System을 제안하고자 한다.

• Journal of Clinical Otolaryngology Head and Neck Surgery
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• v.29 no.2
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• pp.307-310
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• 2018

Sparganum is the larvae of a parasite called Spirometra. It usually lives in snakes or frogs, which are parasitic on the human who consume them raw. Sparganum is presented with a form of mobile subcutaneous nodule in various parts of human body. A 78 years old man with palpable neck mass visited our clinics. He had a history of eating snakes raw about 50 years ago. He was diagnosed with Sparganosis through a fine needle aspiration biopsy and underwent excisional biopsy. Sparganosis should be considered when dealing subcutaneous palpable neck mass with history of consuming raw snakes or frogs.

• Journal of Clinical Otolaryngology Head and Neck Surgery
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• v.29 no.2
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• pp.281-285
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• 2018

Columnar cell variant of papillary thyroid carcinoma (CCV-PTC) is a rare variant representing 0.15-0.2% of all PTCs. The CCV is aggressive, due to its rapid growth, high local recurrence rate, and frequent lung, brain and bone metastasis. Aggressive surgical and medical management are recommended for these neoplasias. The authors experienced a case of CCV-PTC in a 45-year-old man. We performed total thyroidectomy with neck dissection. The patient received radiation and radioactive iodine therapy. There were no recurrences or complications in the following 24 months after the operation. The patient will closely undergo continuous follow up. We present the clinical characteristics, pathology, treatment, and prognosis of the tumor with a review of the literature.

• Proceedings of the Korean Society of Computer Information Conference
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• 2020.07a
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• pp.609-612
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• 2020

최근 코로나 19에 대한 세계적인 팬데믹 선언에 의해 의료서비스의 변화가 오고 있다. 특히, 국내 법제도적으로 묶여 있던 원격 서비스에 대한 재검토가 되고 있는 실정이다. 본 논문에서 제안하는 커넥티드 라디올로지 케어 시스템은 모바일 의료영상진단기기를 기반으로 의료사각지대에 있는 환자들의 영상촬영과 이에 대한 판독 서비스를 제공하기 위한 시스템이다. 제안한 시스템은 의료환경에 적용하기 위해 환자의 개인정보 보호를 위한 방법과 절차가 반드시 포함되어야 한다. 이를 위해 전체 시스템 구조와 익명화 처리과정을 보인다. 그리고 끝으로 구축된 시스템의 수행과정을 보인다.

• Applied Chemistry for Engineering
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• v.32 no.3
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• pp.268-276
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• 2021

As wireless communication devices become more common, interests in how to control the electromagnetic waves generated from the devices are increasing. One of the most commonly used electromagnetic wave control materials is magnetic one, but due to the features that make the product heavy and thick when applied to the product, it is difficult to use them in curved electronic devices. Therefore, a polymer flexible meta electronic device has been presented to sort out the problem, which is thin and can have various curvatures. However, it requires an additional evaluation of curvature reliability. In this study, we developed a method to predict electromagnetic wave control characteristics through the resistance/length of the conductive ink line patterns of polymer flexible meta electronic devices, which is inversely proportional to the electromagnetic wave control characteristics. As the radius of curvature decreased, the resistance/length increased, and there was little variations with the duration times of curvature. We also found that both permanent and recoverable changes along with the removal of curvature were occurred when the curvature was applied, and that the cause of these changes was newly created vertical cracks in the conductive ink line pattern due to the tensile stress applied by applying curvature.

• Journal of Korean Neurosurgical Society
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• v.46 no.4
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• pp.389-396
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• 2009

Objective : Triptolide (TP) has been reported to suppress the expression of mitogen-activated protein kinase (MAPK) phosphatase-1 (MKP-1), of which main function is to inactivate the extracellular signal-regulated kinase-1/2 (ERK-1/2), the p38 MAPK and the c-Jun N-terminal kinase-1/2 (JNK-1/2), and to exert antiproliferative and pro-apoptotic activities. However, the mechanisms underlying antiproliferative and pro-apoptotic activities of TP are not fully understood. The purpose of this study was to examine whether the down-regulation of MKP-1 expression by TP would account for antiproliferative activity of TP in immortalized HT22 hippocampal cells. Methods : MKP-1 expression and MAPK phosphorylation were analyzed by Western blot. Cell proliferation was assessed by $^3H$-thymidine incorporation. Small interfering RNA (siRNA) against MKP-1, vanadate (a phosphatase inhibitor), U0126 (a specific inhibitor for ERK-1/2), SB203580 (a specific inhibitor for p38 MAPK), and SP600125 (a specific inhibitor for JNK-1/2) were employed to evaluate a possible mechanism of antiproliferative action of TP. Results : At its non-cytotoxic dose, TP suppressed MKP-1 expression, reduced cell growth, and induced persistent ERK-1/2 activation. Similar growth inhibition and ERK-1/2 activation were observed when MKP-1 expression was blocked by MKP-1 siRNA and its activity was inhibited by vanadate. The antiproliferative effects of TP, MKP-1 siRNA, and vanadate were significantly abolished by U0126, but not by SB203580 or SP600125. Conclusion : Our findings suggest that TP inhibits the growth of immortalized HT22 hippocampal cells via persistent ERK-1/2 activation by suppressing MKP-1 expression. Additionally, this study provides evidence supporting that MKP-1 may play an important role in regulation of neuronal cell growth.