Maxillofacial Plastic and Reconstructive Surgery

  • Volume 37
  • /
  • Pages.10.1-10.5
  • /
  • 2015
  • /
  • 2288-8101(pISSN)
  • /
  • 2288-8586(eISSN)
Korean Association of Maxillofacial Plastic and Reconstructive Surgeons (대한악안면성형재건외과학회)
권호 표지
DOI QR코드

DOI QR Code

Effects of a botulinum toxin type A injection on the masseter muscle: An animal model study

  • Park, Si-Yeok (Department of Oral and Maxillofacial Surgery, College of Dentistry, Gangneung-Wonju National University) ;
  • Park, Young-Wook (Department of Oral and Maxillofacial Surgery, College of Dentistry, Gangneung-Wonju National University) ;
  • Ji, Young-Jun (Department of Biomedical Engineering, Ulsan University) ;
  • Park, Sung-Wook (Department of Electronic Engineering, Gangneung-Wonju National University) ;
  • Kim, Seong-Gon (Department of Oral and Maxillofacial Surgery, College of Dentistry, Gangneung-Wonju National University)
  • Received : 2015.01.01
  • Accepted : 2015.02.16
  • Published : 2015.12.31
Download PDF
⟨ Previous Next ⟩

Abstract

Background: The aim of this study was to investigate the effect of a botulinum toxin type A (BTX-A) injection in the masseter muscle using electromyography (EMG) in an animal model. Methods: Ten male adult (>3 months of age) New Zealand white rabbits were used. Muscle activity was continuously recorded from 8 hours before to 8 hours after BTX-A injection. The rabbits received unilateral BTX-A injections of either 5 units (group 1, n = 5) or 20 units (group 2, n = 5). Results: The masseter muscle activity of the rabbits was significantly reduced immediately after BTX-A injection (P < 0.05 for both groups). When the results from group 1 were compared with those from group 2, only the peak voltage was significantly decreased in group 2 (P = 0.013). Conclusion: Masseter muscle activity measured by EMG was immediately decreased after a BTX-A injection.

Keywords

References

  1. Yamaguchi T, Satoh K, Komatsu K, Kojima K, Inoue N, Minowa K (2002) Electromyographic activity of the jaw-closing muscles during jaw opening-comparison of cases of masseter muscle contracture and TMJ closed lock. J Oral Rehabil 29:1063-1068 https://doi.org/10.1046/j.1365-2842.2002.00965.x
  2. Schatz J, Tsimas P (1994) Cephalometric evaluation of surgical-orthodontic treatment of skeletal Class III malocclusion. Int J Adult Orthodon Orthognath Surg 10:173-180
  3. Williams JL, Rowe NL (1994) Rowe and Williams' Maxillofacial injuries, 2nd edn. Churchill Livingstone, Edinburgh
  4. Harkins S, Linford J, Cohen J, Kramer T, Cueva L (1990) Administration of clonazepam in the treatment of TMD and associated myofascial pain: a double-blind pilot study. J Craniomandib Disord 5:179-186
  5. Wessberg GA, Schendel SA, Epker BN (1982) The role of suprahyoid myotomy in surgical advancement of the mandible via sagittal split ramus osteotomies. J Oral Maxillofac Surg 40:273-277 https://doi.org/10.1016/0278-2391(82)90217-8
  6. Miloro M, Ghali GE, Larsen PE, Waite P (2004) Peterson's principles of oral and maxillofacial surgery. 2nd ed. Hamilton, Ont B.C Decker Inc., London
  7. Soboleva U, Laurina L, Slaidina A (2005) The masticatory system-an overview. Stomatologija 7:77-80
  8. Aoki KR (2001) Pharmacology and immunology of botulinum toxin serotypes. J Neurol 248:I3-I10 https://doi.org/10.1007/PL00007816
  9. Simpson LL (1980) Kinetic studies on the interaction between botulinum toxin type A and the cholinergic neuromuscular junction. J Pharmacol Exp Ther 212:16-21
  10. Cote TR, Mohan AK, Polder JA, Walton MK, Braun MM (2005) Botulinum toxin type A injections: adverse events reported to the US Food and Drug Administration in therapeutic and cosmetic cases. J Am Acad Dermatol 53:407-415 https://doi.org/10.1016/j.jaad.2005.06.011
  11. Crowner BE, Torres-Russotto D, Carter AR, Racette BA (2010) Systemic weakness after therapeutic injections of botulinum toxin a: a case series and review of the literature. Clin Neuropharmacol 33:243 https://doi.org/10.1097/WNF.0b013e3181f5329e
  12. Persaud R, Garas G, Silva S, Stamatoglou C, Chatrath P, Patel K (2013) An evidence-based review of botulinum toxin (Botox) applications in non-cosmetic head and neck conditions. JRSM Short Rep 4:10 https://doi.org/10.1177/2042533312472115
  13. Guarda-Nardini L, Manfredini D, Salamone M, Salmaso L, Tonello S, Ferronato G (2008) Efficacy of botulinum toxin in treating myofascial pain in bruxers: a controlled placebo pilot study. Cranio 26:126-135 https://doi.org/10.1179/crn.2008.017
  14. Lee SJ, McCall WD Jr, Kim YK, Chung SC, Chung JW (2010) Effect of botulinum toxin injection on nocturnal bruxism: a randomized controlled trial. Am J Phys Med Rehabil 89:16-23 https://doi.org/10.1097/PHM.0b013e3181bc0c78
  15. Brin MF, Fahn S, Moskowitz C, Friedman A, Shale HM, Greene PE et al (1987) Localized injections of botulinum toxin for the treatment of focal dystonia and hemifacial spasm. Mov Disord 2:237-254 https://doi.org/10.1002/mds.870020402
  16. Castro WH, Gomez RS, da Silva Oliveira J, Moura MD, Gomez RS (2005) Botulinum toxin type A in the management of masseter muscle hypertrophy. J Oral Maxillofac Surg 63:20-24
  17. Seok H, Park YT, Kim SG, Park YW (2013) Correction of post-traumatic anterior open bite by injection of botulinum toxin type A into the anterior belly of the digastric muscle: case report. J Korean Assoc Oral Maxillofac Surg 39:188-192 https://doi.org/10.5125/jkaoms.2013.39.4.188
  18. Lee CJ, Kim SG, Kim YJ, Han JY, Choi SH, Lee SI (2007) Electrophysiologic change and facial contour following botulinum toxin A injection in square faces. Plast Reconstr Surg 120:769-778 https://doi.org/10.1097/01.prs.0000271068.71399.ae
  19. Karsai S, Adrian R, Hammes S, Thimm J, Raulin C (2007) A randomized double-blind study of the effect of Botox and Dysport/Reloxin on forehead wrinkles and electromyographic activity. Arch Dermatol 143:1447-1449
  20. Kim JH, Shin JH, Kim ST, Kim CY (2007) Effects of two different units of botulinum toxin type a evaluated by computed tomography and electromyographic measurements of human masseter muscle. Plast Reconstr Surg 119:711-717 https://doi.org/10.1097/01.prs.0000239453.67423.99
  21. Herzog W, Stano A, Leonard T (1993) Telemetry system to record force and EMG from cat ankle extensor and tibialis anterior muscles. J Biomech 26:1463-1471 https://doi.org/10.1016/0021-9290(93)90097-X
  22. Ernberg M, Schopka J, Fougeront N, Svensson P (2007) Changes in jaw muscle EMG activity and pain after third molar surgery. J Oral Rehabil 34:15-26 https://doi.org/10.1111/j.1365-2842.2006.01695.x
  23. Gorgu M, Silistreli OK, Karantinaci B, Ayhan M, Ozdemirkiran T, Celebisoy M (2006) Interaction of botulinum toxin type A with local anesthetic agents: an experimental study with rabbits. Aesthetic Plast Surg 30:59-64 https://doi.org/10.1007/s00266-004-0015-7
  24. Benedetto AV (1999) The cosmetic uses of botulinum toxin type A. Int J Dermatol 38:641-655 https://doi.org/10.1046/j.1365-4362.1999.00722.x
  25. Klein AW (2004) Contraindications and complications with the use of botulinum toxin. Clin Dermatol 22:66-75 https://doi.org/10.1016/j.clindermatol.2003.12.026
  26. Van Eijden T, Blanksma N, Brugman P (1993) Amplitude and timing of EMG activity in the human masseter muscle during selected motor tasks. J Dent Res 72:599-606 https://doi.org/10.1177/00220345930720030801
  27. Chandu A, Suvinen T, Reade P, Borromeo GL (2004) The effect of an interocclusal appliance on bite force and masseter electromyography in asymptomatic subjects and patients with temporomandibular pain and dysfunction. J Oral Rehabil 31:530-537 https://doi.org/10.1111/j.1365-2842.2004.01377.x
  28. van Wessel T, Langenbach GE, Korfage JA, Brugman P, Kawai N, Tanaka E et al (2005) Fibre-type composition of rabbit jaw muscles is related to their daily activity. Eur J Neurosci 22:2783-2791 https://doi.org/10.1111/j.1460-9568.2005.04466.x
  29. Garcia A, Fulton JE (1996) Cosmetic Denervation of the Muscles of Facial Expression with Botulinum Toxin A Dose-Response Study. Dermatol Surg 22:39-43
  30. Kim HJ, Yum KW, Lee SS, Heo MS, Seo K (2003) Effects of botulinum toxin type A on bilateral masseteric hypertrophy evaluated with computed tomographic measurement. Dermatol Surg 29:484-489
  31. Winn BJ, Sires BS (2013) Electromyographic Differences Between Normal Upper and Lower Facial Muscles and the Influence of Onabotulinum Toxin A. JAMA Facial Plast Surg 15:211-217 https://doi.org/10.1001/jamafacial.2013.692
  32. Rafferty KL, Liu ZJ, Ye W, Navarrete AL, Nguyen TT, Salamati A et al (2012) Botulinum toxin in masticatory muscles: Short-and long-term effects on muscle, bone, and craniofacial function in adult rabbits. Bone 50:651-662 https://doi.org/10.1016/j.bone.2011.11.015
  33. Kim MJ, Kim SG, Park YW (2002) Positional stability following intentional posterior ostectomy of the distal segment in bilateral sagittal split ramus osteotomy for correction of mandibular prognathism. J Craniomaxillofac Surg 30:35-40 https://doi.org/10.1054/jcms.2001.0272
  34. Korfage JA, Wang J, Lie SH, Langenbach GE (2012) Influence of botulinum toxin on rabbit jaw muscle activity and anatomy. Muscle Nerve 45:684-691 https://doi.org/10.1002/mus.23229

Cited by

  1. Early effect of Botox-A injection into the masseter muscle of rats: functional and histological evaluation vol.37, pp.None, 2015, https://doi.org/10.1186/s40902-015-0049-6
  2. S100 and p65 expression are increased in the masseter muscle after botulinum toxin-A injection vol.38, pp.None, 2016, https://doi.org/10.1186/s40902-016-0079-8
  3. Authors' response vol.149, pp.4, 2015, https://doi.org/10.1016/j.ajodo.2016.01.008
  4. Apoptotic action of botulinum toxin on masseter muscle in rats: early and late changes in the expression of molecular markers vol.5, pp.1, 2016, https://doi.org/10.1186/s40064-016-2680-9
  5. Botulinum Toxin Conjugated With Silk Fibroin and 4-Hexylresorcinol vol.28, pp.4, 2015, https://doi.org/10.1097/scs.0000000000003763
  6. Correction of Malocclusion by Botulinum Neurotoxin Injection into Masticatory Muscles vol.10, pp.1, 2018, https://doi.org/10.3390/toxins10010027
  7. Correction of facial asymmetry using a patient-specific three-dimensional printed polycarprolactone/beta tricalcium phosphate scaffold: a case report vol.45, pp.3, 2015, https://doi.org/10.21851/obr.45.03.202109.143