• 한국기계가공학회지
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• 제19권11호
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• pp.23-28
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• 2020

In general, lithography techniques are applied when machining single-crystal silicon in nanoscale applications; however, these techniques involve low degrees of freedom for the vertical shapes. By applying mechanical techniques to machine silicon, nanopatterns having various types of vertical shapes can be manufactured. In this study, we determined the ductile-brittle machining transition point and analyzed the- variation of the specific cutting resistance within the ductile machining region in nanoscale applications. When brittle fracture occurred during the nanoscale cutting, the depth of cut and cutting force increased and decreased rapidly, respectively. The first point of rapid increase in the depth of cut was defined as the ductile-brittle machining point. Subsequently, the shape of the machining tool was observed using a scanning electron microscope to calibrate the machining area, considering the tip blunting. The specific cutting resistance decreased continuously and converged to a certain value during the nanoscale cutting. The decrease and convergence in the value can be attributed to the decrease in the ratio of the arc length to the area of the machining tool and silicon.

• 융합정보논문지
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• 제11권2호
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• pp.181-187
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• 2021

본 연구는 치과 임플란트 시술 환자의 만족도에 미치는 요인을 확인하고 시술 후 만족도 향상을 위해 시행된 연구이다. 일개 치과병원에 내원한 임플란트 환자 178명을 대상으로 조사한 결과, 임플란트 시술 전·후의 저작 기능은 1.07점, 사회적 기능 만족도 점수는 0.7점, 심리적 기능 만족도 점수 0.97점 높게 나타났다. 따라서, 임플란트 시술 만족도 향상을 위해서는 임플란트 시술 환자를 대상으로 하는 장기간 추적관찰 연구가 진행되어야 하고 환자의 만족도 변화를 분석하고 평가하기 위한 지속적인 후속연구의 필요성을 제안하며, 임플란트 최종 보철물 장착 후 구강보건교육과 상담 등 지속적인 관리가 필요할 것이다.

• 대한두경부종양학회지
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• 제24권2호
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• pp.162-168
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• 2008

Purpose：To know the results after induction chemotherapy followed by curative radiation therapy for locally advanced hypopharyngeal cancer Methods and Materials：From August 1990 to December 2003, forty patients who were treated with induction chemotherapy and curative radiation therapy were analyzed retrospectively. Median age of patients was 60 years(range：40-78 years) and clinical stage was wholly stage 3 or 4. Induction chemotherapy used cisplatin with 5-FU or docetaxel, and its interval was 3 weeks. Irradiated radiation dose was 70 to 78Gy (median：70.8Gy). Results：Median follow-up time was 39.4 months(range：8-115 months). Treatment failures were observed in 52.5% patients, and main failure pattern was local recurrence in 16 patients. 3 and 5 year disease free survival were 52.6%, 48.2% respectively and values of overall survival were 60.0, 43.9% and median survival time was 44.7 months. Treatment response was only a prognostic factor for survival. Laryngeal preservation was observed in twenty-four(60.0%) patients. Conclusion：Initial primary tumor stage was a significant prognostic factor for laryngeal preservation, and response after radiation therapy was a prognostic factor for long-term survival after induction chemotherapy followed by curative radiation therapy for locally advanced hypopharyngeal cancer.

• Molecules and Cells
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• 제38권2호
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• pp.138-144
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• 2015

Raloxifene is a selective estrogen receptor modulator (SERM) that binds to the estrogen receptor (ER), and exhibits potent anti-tumor and autophagy-inducing effects in breast cancer cells. However, the mechanism of raloxifene-induced cell death and autophagy is not well-established. So, we analyzed mechanism underlying death and autophagy induced by raloxifene in MCF-7 breast cancer cells. Treatment with raloxifene significantly induced death in MCF-7 cells. Raloxifene accumulated GFP-LC3 puncta and increased the level of autophagic marker proteins, such as LC3-II, BECN1, and ATG12-ATG5 conjugates, indicating activated autophagy. Raloxifene also increased autophagic flux indicators, the cleavage of GFP from GFP-LC3 and only red fluorescence-positive puncta in mRFP-GFP-LC3-expressing cells. An autophagy inhibitor, 3-methyladenine (3-MA), suppressed the level of LC3-II and blocked the formation of GFP-LC3 puncta. Moreover, siRNA targeting BECN1 markedly reversed cell death and the level of LC3-II increased by raloxifene. Besides, raloxifene-induced cell death was not related to cleavage of caspases-7, -9, and PARP. These results indicate that raloxifene activates autophagy-dependent cell death but not apoptosis. Interestingly, raloxifene decreased the level of intracellular adenosine triphosphate (ATP) and activated the AMPK/ULK1 pathway. However it was not suppressed the AKT/mTOR pathway. Addition of ATP decreased the phosphorylation of AMPK as well as the accumulation of LC3-II, finally attenuating raloxifene-induced cell death. Our current study demonstrates that raloxifene induces autophagy via the activation of AMPK by sensing decreases in ATP, and that the overactivation of autophagy promotes cell death and thereby mediates the anti-cancer effects of raloxifene in breast cancer cells.

• 자원리싸이클링
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• 제20권4호
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• pp.58-64
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• 2011

고온에서 PCB 처리를 통한 Au, Ag와 같은 귀금속뿐 아니라 Ni과 같은 주요 회유금속을 회수하기 위한 기초연구로서 CaO-$Al_2O_3$(-$SiO_2$) 및 CaO-$SiO_2$-$CaF_2$ 슬래그를 이용하여 Au, Ag, Ni의 회수거동올 관찰하였다. 슬래그 투입 없이 PCB만으로 용융실험을 수행한 결과 PCB는 거의 용융되지 않았으며, 이로부터 유도전류를 이용한 용융을 촉진할 뿐 아니라 유가금속의 회수를 위해서는 Cu와 갇은 적절한 base metal이 필요함을 확인하였다. 본 연구결과, PCB/Cu ratio는 1 이하가 바람직할 것으로 생각된다. CaO-$Al_2O_3$(-$SiO_2$) 및 CaO-$SiO_2$-$CaF_2$ 슬래그를 투입한 결과, $CaF_2$를 함유하는 fluorosilicate계 슬래그가 calcium aluminate계 슬래그보다 융점과 점도가 낮게 제어되었으며, 이로부터 Au, Ag, Ni의 높은 분배비를 얻을 수 있었다. 점도가 낮은 $CaF_2$ 함유 슬래그 적용 시 높은 유가금속 회수율은 슬래그 내에서 각 금속입자의 등속침강속도가 상승하기 때문인 것으로 평가되었다.

• 한국정밀공학회지
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• 제32권10호
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• pp.891-896
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• 2015

In order to protect the environment, using light material is becoming more and more attractive within the automobile industry. Aluminum alloys are the best and lightest metallic materials used in the automotive, electron, and aerospace industries. Al alloy and SGARC were joined by cold metal transfer (CMT) welding, using AlSiMn4 as a filler. Results showed that dissimilar metals from the Al 6000 series/SGARC could be successfully joined by CMT under proper processing parameters. The micro-hardness value of 125Hv was obtained at an interface.

• 센서학회지
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• 제13권5호
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• pp.392-398
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• 2004

It is known that the conductivity of fullerite depends on the applied pressure. In this paper we compare the variation of conductivity of three different fullerite structure with pressure. We examined $C_{60}$ powder, filled into thin glass capillaries and also studied fullerite nanotubules produced within etched swift heavy ion tracks in polymer foils. These investigations are compared with the results of planar Si-$C_{60}$-Au structures.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 2005년도 ICCAS
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• pp.1624-1627
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• 2005

We proposed a design technique for auto-landing guidance and control system. This technique utilizes linear controller and neural network. Main features of this technique is to use conventional linear controller and compensate for the error coming from the model uncertainties and/or reference model mismatch. In this study, the multi-perceptron neural network with single hidden layer is adopted to compensate for the errors. Glide-slope capture logic for auto-landing guidance and control system is designed in this technique. From the simulation results, it is observed that the responses of velocity and pitch angle to commands are fairly good, which are directly related to control inputs of throttle and elevator, respectively.

• 대한조선학회논문집
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• 제48권4호
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• pp.317-324
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• 2011

When a ship proceeds in confined water, like canal, the water ahead of ship is pushed by hull. This pushed water returns to the side and under the hull, and this returned water will make fluid velocity higher at the side and under the hull, compared to the case in the infinite water depth. Due to the higher velocity, the pressure under the hull will decrease, resulting in the ship drop. This phenomenon is called "ship squat" and ship squat will result in various marine accidents. In this paper, for predicting ship squat, numerical calculation was carried out using commercial CFD code, FLUENT. To confirm wave pattern profile around the ship, VOF(Volume of Fluid) method was applied. The calculated results were compared with other paper's results and empirical methods.

• 전기학회논문지
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• 제67권8호
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• pp.1047-1054
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• 2018

This paper proposed the strategies for controlling both the heater temperature and the output voltage of a single-phase inverter for the heat treatment. The single-phase inverter system for the heat treatment controls the heater temperature to its reference one, and also it limits the inverter output voltage to 60 V for safety. The stability may be deteriorated due to the large time constant difference between the heater temperature and inverter output voltage. In order to ensure the stability, a hysteresis on/off control approach for the heater temperature control is adapted, and both the open-loop and the closed-loop control strategies of the output voltage are suggested. The performances for the proposed strategies are demonstrated with the experiments.