• Asian Pacific Journal of Cancer Prevention
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• v.13 no.5
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• pp.1881-1886
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• 2012

Breast cancer is a heterogeneous disease that is affected by ethnicity of patients. According to hormone receptor status and gene expression profiling, breast cancers are classified into four molecular subtypes, each showing distinct clinical behavior. Lack of sufficient data on molecular subtypes of breast cancer in Iran, prompted us to investigate the prevalence and the clinicopathological features of each subtype among Iranian women. A total of 428 women diagnosed with breast cancer from 2002 to 2011 were included and categorized into four molecular subtypes using immunohistochemistry. Prevalence of each subtype and its association with patients' demographics and tumor characteristics, such as size, grade, lymph-node involvement and vascular invasion, were investigated using Chi-square, analysis of variance and multivariate logistic regression. Luminal A was the most common molecular subtype (63.8%) followed by Luminal B (8.4%), basal-like (15.9%) and HER-2 (11.9%). Basal-like and HER-2 subtypes were mostly of higher grades while luminal A tumors were more of grade 1 (P<0.001). Vascular invasion was more prevalent in HER-2 subtype, and HER-2 positive tumors were significantly associated with vascular invasion (P=0.013). Using muti-variate analysis, tumor size greater than 5 cm and vascular invasion were significant predictors of 3 or more nodal metastases. Breast cancer was most commonly diagnosed in women around 50 years of age and the majority of patients had lymph node metastasis at the time of diagnosis. This points to the necessity for devising an efficient screening program for breast cancer in Iran. Further, prospective surveys are suggested to evaluate prognosis of different subtypes in Iranian patients.

• Journal of Digital Convergence
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• v.14 no.4
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• pp.487-494
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• 2016

The purpose of this study was to examine the effect of Health exercise program on insulin resistant and blood lipid factor of elderly women for 12 weeks. The two groups were classified into one group(exercise group: EG) with aerobics exercise and band exercise both, the other group(control group: CG) controled. The group of EG was applied to doing aerobics exercise and band exercise 4 times for 60 minutes a week. The intensity of the exercise was ACSM. Each measurement variable was measured before and after 12 weeks to investigate the effect. During this study the result came out with this step. First, EG have shown interaction with blood lipid(TC, HDL, LDL, TG) and blood pressure(SBP, DBP)factor. Second, EG have shown interaction with insulin resistant(insulin, glucose). Therefore, this study gives us positive result to effect of health exercise program on blood lipid factor and insulin resistant factor of elderly women for 12 weeks.

• Archives of Pharmacal Research
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• v.27 no.12
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• pp.1220-1225
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• 2004

The overproduction of nitric oxide (NO) by inducible nitric oxide synthase (iNOS) is known to be responsible for vasodilation and hypotension observed in septic shock and inflammation. Inhibitors of iNOS, thus, may be useful candidates for the treatment of inflammatory diseases accompanied by overproduction of NO. In the course of screening oriental anti-inflammatory herbs for the inhibitory activity of NO synthesis, a crude methanolic extract of Curcuma zedoaria exhibited significant activity. The activity-guided fractionation and repetitive chromatographic procedures with the EtOAc soluble fraction allowed us to isolate three active compounds. They were identified as 1,7-bis (4-hydroxyphenyl)-1,4,6-heptatrien-3-one (1), procurcumenol (2) and epiprocurcumenol (3) by spectral data analyses. Their concentrations for the 50% inhibition of NO production $(IC_{50})$ in lipopolysaccharide (LPS)-activated macrophages were 8, 75, 77 ${\mu}M$, respectively. Compound 1 showed the most potent inhibitory activity for NO production in LPS-activated macrophages, while the epimeric isomers, compound 2 and 3 showed weak and similar potency. Inhibition of NO synthesis by compound 1 was very weak when activated macrophages were treated with 1 after iNOS induction. In the immunoblot analysis, compound 1 suppressed the expression of iNOS in a dose-dependent manner. In summary, 1,7-bis (4-hydroxyphenyl)-1,4,6-heptatrien-3-one from Curcuma zedoaria inhibited NO production in LPS-activated macrophages through suppression of iNOS expression. These results imply that the traditional use of C. zedoaria rhizome as anti-inflammatory drug may be explained at least in part, by inhibition of NO production.

• The Research Journal of the Costume Culture
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• v.13 no.2 s.55
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• pp.318-328
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• 2005

Our interest in human body is more and more increasing. Not only academic and art communities but also other social communities show a keen interest in the human body. Especially, the breast of women's body parts may be comparable to men's penis because it is protruded. The breast which sexually distinguishes women from men becomes an important topic in the fashion design community. Therefore, such designs which emphasize the breast are being introduced in a natural way. This paper aims at examining the reason and symbolism for the exposure of breast and analyzing the fashion design that breast is exposed. This study will help us grasp the meaning which the design has. The exposure's scope of breast in the design includes the partial exposure, total exposure and the concealment of breast. But these all have their effects in each scope. For this paper, some general things were investigated. They are as follows: the phases of breast exposure in the fashion design, the exposure of breast expressed in the works of fine art, and the alteration of breast-exposing phenomenon shown in apparels. Then, each type of breast-exposing design shown in the women's fashion was analyzed from the middle of 1980s' when the phenomenon of breast exposure occurred to the year 2004. These could be divided into 4 types. They include a suggestive type, an exaggerative type, an open type and a reproductive type. As the result of analysis of 4 types, such meanings of design as an emphasis of femininity, an expression of liberty, a symbol of maternity and a commercialization of sex could be analogized.

• Fashion & Textile Research Journal
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• v.21 no.4
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• pp.452-458
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• 2019

This study provides basic research for developing dress forms of women's wear making. This study compared the average body size of Korean women by investigating the shape, composition and size of 417 dress forms for pattern making, sold at Korean and international online malls. The results showed that Korean brands produced torso-type and torso-crotch-type (94.13%), torso-type was the most dominant type made by Japanese Ki and French St (${\geq}80%$), and all US Al products were whole-body-type. The most common used internal filler of the dress forms was urethane for South Korean companies and paper for Japanese Ki and French St. In most cases, cotton was used for outer materials. Alternatively, linen and rayon were used as outer materials. Al did not indicate the materials used for filler and outer layers. Additionally, the sizing system of dress forms was commonly presented as a Numeric type. In addition to Numeric type, Ki presented body type + usage and Al used character type. When the dress form size for the average bust size of each age group was evaluated, waist measurements were smaller than the corresponding bust measurements. Dress form was presented in the KS interval and was compared with the $mean{\pm}1{\sigma}$ interval of each age group. The majority of the dress forms produced in South Korea were for body shapes in their 20s.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.6
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• pp.245-253
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• 2019

This study was performed to emotional labors of the relationship between the emotional dis-harmory and life satisfaction to find if authenticity take a role as a mediator variable. For this study targeting the women counselors us 197 people general public institution based in Seoul, to emotional dissonance scale partially modified by Hyuck-gi Kwon and Bong-gyu Park(2006); authenticity scale by Wood at all (2008), and life satisfaction measurement(Satisfaction With Life Scale; SWLS) developed by Diener at all(1985), was subjected to multiple regression analysis was performed to verify sobel for the statistical significance of the mediating effect. As a result was showed that authenticity is fully mediated of emotional dis-harmory between life satisfaction. The results implies that improving life satisfaction on a women customer counselor with emotional dis-harmony may help reduce accepting external influence, self-alienation and increase authentic living. Finally, implication and limitation of study are discussed.

• Journal of Service Research and Studies
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• v.7 no.4
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• pp.139-150
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• 2017

Open economy tightly works with foreign economy. This paper investigates the effect of the shock of foreign bond yield on the credit spreads of domestic corporate bonds in Korea. Foreign bond is referred to as US treasury bond. Credit spreads are defined with the difference between log yields of domestic corporate bonds and log yield of Korea treasury bond. With the data of monthly three-year AA- and BBB- corporate bond yields- ratings, monthly three-year Korean treasury bond yields, monthly US dollar foreign exchange rates, and monthly three-year US Treasury bond yields during the period from October 2000 to September 2014 including global financial crisis period, the paper documents the results as follow. First of all, the yield of Korean treasury and the credit spreads are very sensitive to the increase in the level and the volatility of the yield of the US treasury bond. Changes in the level and the volatility little affect the change of the exchange rate. Second, the change in the level and the volatility negatively affect the level of Korean treasury bond yields but lead to the increase in the level of Korean treasury bond yields at the same time. Third, there exist time lags of the increases of credit spreads by the increase in the level and the volatility. These imply that credit spreads and bond yields are very sensitive to the change in the yields of foreign bonds such as US treasury bond.

• Asia Marketing Journal
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• v.14 no.4
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• pp.95-116
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• 2013

AMOREPACIFIC has rapidly grown to become a successful global brand by persistently seeking and achieving success in foreign markets. In 2011, AMOREPACIFIC was ranked as one of the global top 20 cosmetics companies. What makes AMOREPACIFIC's global success noteworthy is that AMOREPACIFIC challenged the France and the US market, where competition level is the toughest. Lolita Lempicka, AMOREPACIFIC's perfume brand, was chosen as one of the top seven most popular brands in the women's perfume market in France. In addition, Amorepacific, AMOREPACIFIC's namesake skincare brand, is currently recognized as a top prestige brand in the USA. Their success played a significant role as a bridgehead for AMOREPACIFIC in becoming a global cosmetics company. The main object of this case study is to analyze how AMOREPACIFIC became a global cosmetic company through building key brands such as Lolita Lempicka and Amorepafic, among others. Therefore, this study reviewed AMOREPACIFIC's unconventional approach in launching Lolita Lempicka in France, and Amorepacific in the US by focusing on how they foresaw the future opportunities and employed innovative marketing strategies. Specifically, we focused on Amorepacific's marketing strategy under the critical period when AMOREPACIFIC achieved great success in France with Lolita Lempicka (between 1997 and 2004) and in US with the brand, Amorepacific (2003-2008). The case of AMOREPACIFIC's success in the global markets can give valuable lessons to companies that want to extend their businesses to foreign countries and ultimately become global. One such lesson is the importance of building a successful pioneer brand in a powerful bridgehead market. While domestic competitors first entered into less competitive markets such as those in South-East Asia, AMOREPACIFIC challenged the toughest markets such as the French and US markets where the incumbent companies waged the most intensive and severe battles against Lolita Lempick and Amorepacific. Through the success in France and US market, however, AMOREPACIFIC built a powerful base for its successful global expansion. Another valuable lesson is the importance of foresight in uncovering great opportunities hidden behind the trends without losing focus on the brand's core character and values. Lolita Lempicka and Amorepacific showed excellence in foresight competition, which led them to succeed against the intense competition from Goliath companies. If Lolita Lempicka and Amorepacific had just followed the popular market trend at the time, they would have never succeeded.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.12
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• pp.6391-6395
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• 2012

Background: Ovarian cancer is ranked as the fifth most common cause of cancer death in women. In Malaysia, it is the fourth most common cancer in females. CA125 has been the tumor marker of choice in ovarian cancer but its diagnostic specificity in early stages is only 50%. Hence, there is a critical need to identify an alternative tumor marker that is capable of detecting detect ovarian cancer at an early stage. HE4 is a new tumor marker proposed for the early diagnosis of ovarian cancer and disease recurrence. Currently, none of the normal ranges of HE4 quoted in the literature are based on data for a multiethnic Asian population. Therefore, the aim of this study was to determine reference intervals for HE4 in an Asian population presenting in University Malaya Medical Centre, a tertiary reference hospital. Materials and Methods: 300 healthy women were recruited comprising 150 premenopausal and 150 postmenopausal women, aged from 20-76 years. All women were subjected to a pelvic ultrasonograph and were confirmed to be free from ovarian pathology on recruitment. Serum HE4 levels were determined by chemiluminescent microparticle immunoassay (CMIA, Abbott Architect). The reference intervals were determined following CLSI guidelines (C28-A2) using a non-parametric method. Results: The upper limits of the $95^{th}$ percentile reference interval (90%CI) for all the women collectively were 64.6 pmol/L, and 58.4 pmol/L for premenopausal) and 69.0 pmol/L for postmenopausal. The concentration of HE4 was noted to increase with age especially in women who were more than 50 years old. We also noted that our proposed reference limit was lower compared to the level given by manufacturer Abbott Architect HE4 kit insert (58.4 vs 70 pmol/L for premenopausal group and 69.0 vs 140 pmol/L in the postmenopausal group). The study also showed a significant difference in HE4 concentrations between ethnic groups (Malays and Indians). The levels of HE4 in Indians appeared higher than in Malays (p<0.05), while no significant differences were noted between the Malays and Chinese ethnic groups. Conclusions: More data are needed to establish a reference interval that will better represent the multiethnic Malaysian population. Probably a larger sampling size of equal representation of the Malay, Chinese, Indians as well as the other native ethnic communities will give us a greater confidence on whether genetics plays a role in reference interval determination.

• Journal of the Korean Society of Costume
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• v.2
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• pp.9-21
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• 1978

The object of this article is to examine the shapes and the development of the costume worn in the early and middle Yi Dynasty from the viewpoint of the history of customes with the excavated clothing from Chung-Ju (1530 A.D.), Wool-San (1650 A.D.), An-Dong (1650 A.D.) etc. The study of the history of costumes of the early years of the Yi Dynasty has been mainly dependent upon fiblirographical records sofar. So I have arranged in order some excavated clothing of the early Yi Dynasty, which gives us some means for the study of Korean historical costumes. It is noticeably remarkable that the daily wear of the early Yi Dynasty period was excavated for the first time from Chung-ju. The results drawn from this research are: It is argued that the original from of Chul-nik(天翼) has been excavated. This is the remnants Mongolian clothing of the Koryo Dynasty, and it is sketched in the Dai-Myong-jib-lei(大明集禮) as Yo-sun-o-ja which the lower classes usually put on. The similar clothing is also handed down as a Dan-po(緞袍) from the ming Dynasty, and we can presume that Chul-nik was a common clothing regardless of the social status of their wearer. It is also remarkable that even women at those times wore the Chul-nik. The length of the Cheo-go-ri of the early Yi Dynasty was the middle hip length, and the edge of the sleeves was very wide which called Cham-soo, and it was handed down to the middle period of the Yi Dynasty which can be seen in the coat (po) of women(直領袍). The systems of the straight-collar Po(袍) during the early Yi Dynasty were discovered for the first time. This Po(袍) which would represent the po-system of the early years of Yi Dynasty, is handed down even to the middle of Yi Dynasty. The collars of the Po(coat) of the early Yi Dynasty are mostly double collars(二重衿) and these give us the advantage in reconsidering of the cheo-go-ri(赤古里) of the Kingdom of Shin-la, or Koryo Dynasty. The edge of the women's Ba-ji(袴) of the early Yi Dynasty was wide and the Ba-ji had a shoulder belt which connect the front part with the back one, which showed the practical point of Ba-ji. The men's Ba-ji of the middle Yi Dynasty was the same as can be seen today and it is clear that the Mongolian Ba-ji dated to B.C. 1 was the same one also. In the system of the Chi-ma(常), there seems to be no differences between the ancient styles and those of these times.