• 한국생물정보학회:학술대회논문집
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• 한국생물정보시스템생물학회 2006년도 Principles and Practice of Microarray for Biomedical Researchers
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• pp.30-36
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• 2006

Tissue microarray (TMA) is an array-based technology allowing the examination of hundreds of tissue samples on a single slide. To handle, exchange, and disseminate TMA data, we need standard representations of the methods used, of the data generated, and of the clinical and histopathological information related to TMA data analysis. This study aims to create a comprehensive data model with flexibility that supports diverse experimental designs and with expressivity and extensibility that enables an adequate and comprehensive description of new clinical and histopathological data elements. We designed a Tissue Microarray Object Model (TMA-OM). Both the Array Information and the Experimental Procedure models are created by referring to Microarray Gene Expression Object Model, Minimum Information Specification For In Situ Hybridization and Immunohistochemistry Experiments (MISFISHIE), and the TMA Data Exchange Specifications (TMA DES). The Clinical and Histopathological Information model is created by using CAP Cancer Protocols and National Cancer Institute Common Data Elements (NCI CDEs). MGED Ontology, UMLS and the terms extracted from CAP Cancer Protocols and NCI CDEs are used to create a controlled vocabulary for unambiguous annotation. We implemented a web-based application for TMA-OM, supporting data export in XML format conforming to the TMA DES or the DTD derived from TMA-OM. TMA-OM provides a comprehensive data model for storage, analysis and exchange of TMA data and facilitates model-level integration of other biological models.

• 한국정보처리학회:학술대회논문집
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• 한국정보처리학회 2003년도 춘계학술발표논문집 (하)
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• pp.1551-1554
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• 2003

최근 다양한 의료정보 시스템이 개발되어, 그 사용이 급증하고 있다. 이 들 각각의 의료정보 시스템에서 발생, 축적된 의료정보는 분산 이질의 형태를 가지며, 또한 같은 의미를 갖는 의료정보가 각기 다른 구조와 용어로 기술되어 축적되는 것이 일반적이다. 이와 같이 개별적으로 개발, 활용되어 온 의료정보를 웹 상에서 통합하여, 단일화 된 의료정보 검색 기능을 제공하기 위해서는 이들 의료정보의 의미적 연관성을 고려한 정보의 통합, 검색 기술의 개발이 필수적이다. 본 논문에서는 의미적 의료정보의 통합을 위한 UMLS와 LOINC 데이터베이스 기반의 연관 값 지식베이스의 설계 및 개발 방식을 제안한다. 웹 상에 존재하는 각종 분산 이질 형태의 의료정보는 XML을 공통 데이터 구조로 하여 통합되며, 정보 통합의 과정에서 연관 값 지식베이스를 참조하여 의미적 관련도가 높은 의료정보(구조 정보와 내용 정보)는 상호 연결되어, 진정한 의미의 정보 통합을 구현하게 된다. 지식베이스는 용어별로 식별자, 요소명, 연관값, 복수형, 동의어, 한글 이름 등의 필드틀 가지며, 현재 상담, 처방, 보험, 의료용어, 증상, 임상결과 등 적용분야 별로 작성된 연관 값 지식베이스가 구현되어 있다.

• Journal of Information Science Theory and Practice
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• 제3권1호
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• pp.6-23
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• 2015

This study develops an effective method for sentiment analysis of user-generated content on drug review websites, which has not been investigated extensively compared to other general domains, such as product reviews. A clause-level sentiment analysis algorithm is developed since each sentence can contain multiple clauses discussing multiple aspects of a drug. The method adopts a pure linguistic approach of computing the sentiment orientation (positive, negative, or neutral) of a clause from the prior sentiment scores assigned to words, taking into consideration the grammatical relations and semantic annotation (such as disorder terms) of words in the clause. Experiment results with 2,700 clauses show the effectiveness of the proposed approach, and it performed significantly better than the baseline approaches using a machine learning approach. Various challenging issues were identified and discussed through error analysis. The application of the proposed sentiment analysis approach will be useful not only for patients, but also for drug makers and clinicians to obtain valuable summaries of public opinion. Since sentiment analysis is domain specific, domain knowledge in drug reviews is incorporated into the sentiment analysis algorithm to provide more accurate analysis. In particular, MetaMap is used to map various health and medical terms (such as disease and drug names) to semantic types in the Unified Medical Language System (UMLS) Semantic Network.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제18권4호
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• pp.881-902
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• 2024

Fast decision support systems and accurate diagnosis have become significant in the rapidly growing healthcare sector. As the number of disparate medical IoT devices connected to the human body rises, fast and interrelated healthcare data retrieval gets harder and harder. One of the most important requirements for the Healthcare Internet of Things (HIoT) is semantic interoperability. The state-of-the-art HIoT systems have problems with bandwidth and latency. An extension of cloud computing called fog computing not only solves the latency problem but also provides other benefits including resource mobility and on-demand scalability. The recommended approach helps to lower latency and network bandwidth consumption in a system that provides semantic interoperability in healthcare organizations. To evaluate the system's language processing performance, we simulated it in three different contexts. 1. Polysemy resolution system 2. System for hyponymy-hypernymy resolution with polysemy 3. System for resolving polysemy, hypernymy, hyponymy, meronymy, and holonymy. In comparison to the other two systems, the third system has lower latency and network usage. The proposed framework can reduce the computation overhead of heterogeneous healthcare data. The simulation results show that fog computing can reduce delay, network usage, and energy consumption.

• 대한산업공학회지
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• 제41권1호
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• pp.34-42
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• 2015

Modeling and control of human-involved manufacturing systems poses a huge challenge on how to model all possible interactions among system components within the time and space dimensions. As the manufacturing environment are getting complicated, the importance of human in the manufacturing system is getting more and more spotlighted to incorporate the manufacturing flexibility. This paper presents a formal modeling methodology of affordance-based MPSG (Message-based Part State Graph) for a human-machine collaboration system incorporating supervisory control scheme for flexible manufacturing systems in automotive industry. Basically, we intend to extend the existing model of affordance-based MPSG to the real industrial application of humanmachine cooperative environments. The suggested extension with the real industrial example is illustrated in three steps; first, the manufacturing process and relevant data are analyzed in perspectives of MABA-MABA and the supervisory control; second, the manufacturing processes and task allocation between human and machine are mapped onto the concept of MABA-MABA; and the last, the affordance-based MPSG of humanmachine collaboration for the manufacturing process is presented with UMLs for verification.

• 정보관리학회지
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• 제36권1호
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• pp.191-213
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• 2019

과학적 지식을 얻는 과정은 연구자의 연구를 통해 이루어진다. 연구자들은 과학의 불확실성을 다루고 과학적 지식의 확실성을 구축해나간다. 즉, 과학적 지식을 얻기 위해서 불확실성은 반드시 거쳐가야 하는 필수적인 단계로 인식되고 있다. 현존하는 불확실성의 특성을 파악하는 연구는 언어학적 접근의 hedging 연구를 통해 소개되었으며 컴퓨터 언어학에서 수작업 기반으로 불확실성 단어 코퍼스를 구축해왔다. 기존의 연구들은 불확실성 단어의 단순 출현 빈도를 기반으로 특정 학문 영역의 불확실성의 특성을 파악해오는데 그쳤다. 따라서 본 연구에서는 문장 내 생의학적 주장이 중요한 역할을 하는 생의학 문헌을 대상으로 불확실성 단어 기반 과학적 지식의 패턴을 시간의 흐름에 따라 살펴보고자 한다. 이를 위해 생의학 온톨로지인 UMLS에서 제공하는 의미적 술어를 기반으로 생의학 명제를 분석하였으며, 학문 분야의 패턴을 파악하는데 용이한 DMR 토픽 모델링을 적용하여 생의학 개체의 불확실성 기반 토픽의 동향을 종합적으로 파악하였다. 시간이 흐름에 따라 과학적 지식의 표현은 불확실성이 감소하는 패턴으로 연구의 발전이 이루어지고 있음을 확인하였다.