• Journal of Ginseng Research
• /
• v.45 no.2
• /
• pp.325-333
• /
• 2021

Background: Alzheimer's disease (AD) is one of the most prevalent neurodegenerative disorders. Enhancing hippocampal neurogenesis by promoting proliferation and differentiation of neural stem cells (NSCs) is a promising therapeutic strategy for AD. 20(S)-protopanaxadiol (PPD) and oleanolic acid (OA) are small, bioactive compounds found in ginseng that can promote NSC proliferation and neural differentiation in vitro. However, it is currently unknown whether PPD or OA can attenuate cognitive deficits by enhancing hippocampal neurogenesis in vivo in a transgenic APP/PS1 AD mouse model. Here, we administered PPD or OA to APP/PS1 mice and monitored the effects on cognition and hippocampal neurogenesis. Methods: We used the Morris water maze, Y maze, and open field tests to compare the cognitive capacities of treated and untreated APP/PS1 mice. We investigated hippocampal neurogenesis using Nissl staining and BrdU/NeuN double labeling. NSC proliferation was quantified by Sox2 labeling of the hippocampal dentate gyrus. We used western blotting to determine the effects of PPD and OA on Wnt/GSK3β/β-catenin pathway activation in the hippocampus. Results: Both PPD and OA significantly ameliorated the cognitive impairments observed in untreated APP/PS1 mice. Furthermore, PPD and OA significantly promoted hippocampal neurogenesis and NSC proliferation. At the mechanistic level, PPD and OA treatments resulted in Wnt/GSK-3β/β-catenin pathway activation in the hippocampus. Conclusion: PPD and OA ameliorate cognitive deficits in APP/PS1 mice by enhancing hippocampal neurogenesis, achieved by stimulating the Wnt/GSK-3β/β-catenin pathway. As such, PPD and OA are promising novel therapeutic agents for the treatment of AD and other neurodegenerative diseases.

• Journal of Practical Agriculture & Fisheries Research
• /
• v.12 no.1
• /
• pp.137-150
• /
• 2010

Traditionally, like many people in mountain region of the Himalaya, the Lwang communities depend on mix of subsistence agriculture, animal husbandry, and seasonal migrant labor for their livelihoods. These traditional systems are characterized by low productivity, diverse use of available natural resources (largely for home consumption), limited markets, and some aversion for innovation. The potential to generate wealth through commerce has largely been untapped by these mountain residents and thus is undervalued in local and national economies. Introduction of organic tea farming is a part of Lwang community's several initiatives to break the vicious poverty cycle Annapurna Conservation Area Project (ACAP) played facilitating roles in all their efforts since beginning. In five years, the tea plantation emerged as a new means for secured a livelihood. This study aims to analyze the current practices in tea farming both in terms of farm management and soil nutrient status(technical) and the prosperity of the tea farmers (social). The technical aspect covers the soil and tea leaf analysis of various nutrients contents in the soil and tea leaf. Originally, the technical aspect of the study was not planned but later during the consultation with the advisor it was taken into consideration which added value to the research study. The sample were collected from different locations and analyzed on the field itself. The other part of the study i.e. the social aspect was done through questionnaire survey and focus group discussion. the tea farming provided them not only a new opportunity but also earned an identity in the region. This initiative was undertaken as a piloting measure. Now that the tea is in production with processing unit established locally, more serious consideration has to be given for better yield and economic prosperity. This research finding will help the community to analyze their efforts and make correction measures in tea garden management and application of fertilizer. It is also expected to fill up the gaps of knowledge and information required to reduce economic stresses and enhance capacity of farmers to make the tea farming a sustainable and beneficial business. The findings are expected to Sustainability of organic tea farming has direct impacts on biodiversity conservation compared to the other traditional farming practices that are more resource intensive. The study will also contribute to identify key action points required for reducing poverty while conserving environment and enhancing livelihoods

• Asian-Australasian Journal of Animal Sciences
• /
• v.14 no.3
• /
• pp.432-444
• /
• 2001

In this manuscript, several effective feeding and management systems to reduce environmental pollution in swine production have been briefly introduced. It is logical that reducing the excretion of nutrients in manure should be the first step to reduce the environmental impact of pig production. it is evident that the excretion of nitrogen and phosphorus can be reduced when more digestible or available feedstuffs are used. Also, it is well known that proper feed processing can reduce anti nutritional factors (ANF) and improve nutrient digestibilities. Supplementation of effective feed additives can reduce excretion of nitrogen and phosphorus due to efficient feed utilization. These include enzymes (e.g., phytase), antibiotics, probiotics, organic acids and growth hormones ($\beta$-agonists and porcine somatotropin). One of the most effective ways to reduce pollutants from swine manure is to use synthetic amino acids in feed manufacturing. Many studies showed that reduction of 2 to 4% unit (U) of dietary protein with supplemental amino acid (AA) could dramatically reduce (15 to 20%) nitrogen excretion. Regarding feeding strategies, it has been recognized that phase feeding regimen could be used to reduce nitrogen and phosphorous excretion by feeding pigs in better agreement with age and physiological state. Feeding barrows and gilts separately, known as split sex feeding, can also decrease excretion of nitrogen and phosphorus. With the increasing concerns on the negative impact of animal production systems on the environment, animal nutritionists and producers should be aware that sustainability of animal agriculture is as important as high production performance. Therefore, some feeding and management strategies described in this manuscript will help to reduce environmental pollution in swine production. Proper combination of feeding regimen and environment-friendly diet formulation through nutritional approach will be more effective to reduce nutrient excretion in swine production system compared to single approach to do so.

• Korean Business Review
• /
• v.5
• /
• pp.241-274
• /
• 1992

General American English(=A.E.) has conservative elements as well as progressive elements. A.E. and B.E. are languages which have more similarities than differances. In this paper. I studied the process of English progress before the A.E. had come into being, and the historical background and the cahristics of A.E. coming into being. Considering the differences between A.E. and B.E. from spelling, pronunciation, vocabulary and grammar, I can give the outline as follows. A spelling 1. B.E. : au, ou $${\rightarrow}$$A.E. : a, o 2. B.E. : e $${\rightarrow}$$A.E. : i 3. B.E. : $${\ae}$$ oe $${\rightarrow}$$A.E. : e 4. B.E. : our $${\rightarrow}$$A.E. : or 5. B.E. : re $${\rightarrow}$$A.E. : er B. pronunciation 1. B.E. : [e] $${\rightarrow}$$A.E. : [i], [e], $$[\partial]$$ 2. B.E. : [a] $${\rightarrow}$$A.E. : 3. B.E. : [i(:)] $${\rightarrow}$$A.E. : [ai], $$[\partial]$$, $$[{\varepsilon}]$$ 4. B.E. : $$[{\ae}]$$ $${\rightarrow}$$A.E. : [e], [c] 5. B.E. : [ai] $${\rightarrow}$$A.E. : $$[{\ae}]$$, [e] 6. B.E. : [c] $${\rightarrow}$$A.E. : [e], [a], [o] 7. In case of "Vowel+[t]+Vowel", [t] is pronounced into [d] or [r] 8. In case of "-nt", [t] becomes a mute. 9. [t]+[j, l, m, n, r, u, or, w] $${\rightarrow}$$A.E. : [?] (=glottal stop) 10. B.E. : [w] $${\rightarrow}$$A.E. : [hw] 11. B.E. : [Voiceless consonants], [Voiced consonants] $${\leftarrow}$$A.E. : [Voiced consonants], [Voiceless consonants] C. Vocabulary The historical background and geographical conditions of those days caused lots of new compounds and neologies. D. Grammar Though we use "of" to indicate the possessive case of inanimate object, -s genitive is used in A.E. In the perfect tense, "have" is often omitted and also auxiliary verb "will" is used in any case

• Journal of computational fluids engineering
• /
• v.21 no.2
• /
• pp.54-61
• /
• 2016

When spent fuel assemblies from the reactor of nuclear power plants(NPPs) are transported, the assemblies are exposed to short-term operations that can affect the peak cladding temperature of spent fuel assemblies. Therefore, it needs to perform the analysis of heat transfer on spent fuel dry cask during the operation. For 3 dimensional computational fluid dynamnics(CFD) simulation, it is proposed that the short-term operation is divided into three processes: Wet, dry, and vacuum drying condition. The three processes have different heat transfer mode and medium. Metal transportation cask, which is Korea Radioactive Waste Agency(KORAD)'s developing cask, is evaluated by the methods proposed in this work. During working hours, the boiling at wet process does not occur in the cask and the peak cladding temperatures of all processes remain below $400^{\circ}C$. The maximum peak cladding temperature is $173.8^{\circ}C$ at vacuum drying process and the temperature rise of dry, and vacuum drying process occurs steeply.

• Proceedings of the Korean Society of Precision Engineering Conference
• /
• 2005.06a
• /
• pp.1918-1920
• /
• 2005

The color and structure of urban constructions is a factor of urban landscape and shows their characteristics. Hence the modern buildings with their materials and external appearance makes up the urban image. But still yet, it was not easy to evaluate the value of visual landscape of buildings with objective measuring method. Most of all, it depends on the subjective estimation of a few talented or high educated experts with a sense of beauty. In relation to this kind of problems, it was tried here in this study to analyse the human response of brain wave pattern (EEG) with use of SD method, while the tested persons watched the urban landscape constructed in a visual reality. The tested persons were 10 adult males and females with no color blindness and intact cognitive function. Light source with color filter was used for color environment in chamber room. The signal of EEG is analysed digitally and grouped into the $\alpha$ and $\beta$ waves. The result showed that relative power of $\alpha$ wave ratio increased in natural landscape scenary clearly. From these results it was possible to evaluate the human response, which was affected by urban color and structure stimulation and it might be useful as an indicator of visual cognition amenity toward the design of urban construction environment.

• Korean Journal of Weed Science
• /
• v.11 no.3
• /
• pp.159-166
• /
• 1991

Seven oxyfluorfen formulations were tested for control of 8 weed species and rice injury under four different water depths with various ages of rice seedlings. Among formulations tested, rice injury was slight by formulations of Elvan, Coal Slag, Chitosan and Bentonite B under 0 cm or shallow water depths, and by those of Elvan and Coal Slag under deep water conditions. Weed control was high by Bentonite A and B, and Chitosan, and was low by Elvan. Coal Slag and Sand coated oxyfluorfen, if the target weeds of oxyfluorfen are annual species, further development of Elvan, coal slag, chitosan and Bentonite A would be controlled to increase control efficacy or to decrease rice injury.

• Journal of Microbiology and Biotechnology
• /
• v.19 no.12
• /
• pp.1635-1643
• /
• 2009

The aim of this study was to provide new insight into the mechanism whereby the housekeeping enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH) locates to cell walls of Lactobacillus plantarum 299v. After purification, cytosolic and cell wall GAPDH (cw-GAPDH) forms were characterized and shown to be identical homotetrameric active enzymes. GAPDH concentration on cell walls was growth-time dependent. Free GAPDH was not observed on the culture supernatant at any time during growth, and provoked cell lysis was not concomitant with any reassociation of GAPDH onto the cell surface. Hence, with the possibility of cw-GAPDH resulting from autolysis being unlikely, entrapment of intracellular GAPDH on the cell wall after a passive efflux through altered plasma membrane was investigated. Flow cytometry was used to assess L. plantarum 299v membrane permeabilization after labeling with propidium iodide (PI). By combining PI uptake and cw-GAPDH activity measurements, we demonstrate here that the increase in cw-GAPDH concentration from the early exponential phase to the late stationary phase is closely related to an increase in plasma membrane permeability during growth. Moreover, we observed that increases in both plasma membrane permeability and cw-GAPDH activity were delayed when glucose was added during L. plantarum 299v growth. Using a double labeling of L. plantarum 299v cells with anti-GAPDH antibodies and propidium iodide, we established unambiguously that cells with impaired membrane manifest five times more cw-GAPDH than unaltered cells. Our results show that plasma membrane permeability appears to be closely related to the efflux of GAPDH on the bacterial cell surface, offering new insight into the understanding of the cell wall location of this enzyme.

• Tunnel and Underground Space
• /
• v.6 no.4
• /
• pp.335-341
• /
• 1996

This fundamental study analyzes the relationship between rock thermal properties and psychrometric properties in underground space and has a ultimate goal to develope technologies for predicting major environmental variables. The study is divided into 2 subjects (1) developement of a basic model for predicting temperature and humidity, (2) analysis of the validity of the model through application to a local underground storage space for military supplies. The basic model is built for the network of tunnel-shaped underground spaces. The model takes into account rock thermal properties and changes in moisture content in the air due to condensation/evaporation on the rock surface. Using lumped-parameter analytical method, heat flux from or to the surrounding rock is calculated and then the psychrometric properties(air quantity, pressure, temperature, humidity) are estimated through network simulation. The model can be utilized regardless of the tunnel type. The study site is a local storage space built in rock, mainly granite gneiss and quartz-porphyry. It is a U-shaped tunnel, 593.5m long and 6x6.5m wide. Relative humidity inside has to be strictly controlled under 55% to avoid erosion of a certain types of supplies stored in 6 chambers with the capacity of 300~1.000 ton. The thermal conductivity varies between 2.734 and 2.779W/m$^{\circ}C$ and the thermal diffusivity is in the range of 1.119 and $1.152{\times}10^{-6}\;m^2/s$ the specific heat between 910 and $920\;J/kg^{\circ}C$. Relative errors of the predicted values of dry/wet temperature and relative humidity are 0.8~3.0%, 0~7.5% and 0~7.0%, respectively. Apparent errors associated with the rock surface temperature seems to be partly due to the intrinsic limitations in the infrared thermometer used in this study.

• Korean Journal of Weed Science
• /
• v.12 no.4
• /
• pp.380-386
• /
• 1992

Among 19 reasonable followed-by crops of paddy rice, tomato, eggplant, cucumber and lettuce could be classified into the acute susceptible, water melon, carrot, kidneybean and tobacco into the chronic susceptible, red-papper, onion, garlic, spinach, chinese cabbage, cabbage, radish, crown-daisy and barley into the relative tolerant group, respectively. Even the susceptible crops showed different phytotoxic response to quinclorac by differing of seedling growth stages. Comparing of g followed-by species to 7 different paddy herbicides(include of quinclorac) at 120-180 days after soil application, the growth of tomato, garlic, rye-grass, and cucumber could be negatively influenced by one of other several commercialized herbicides than quinclorac, and tomato by quinclorac was the most serious among others.