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A Short Review on the Chemistry, Pharmacological Properties and Patents of Obovatol and Obovatal (Neolignans) from Magnolia obovata

  • Chan, Eric Wei Chiang;Wong, Siu Kuin;Chan, Hung Tuck
    • Natural Product Sciences
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    • v.27 no.3
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    • pp.141-150
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    • 2021
  • This short review on the chemistry, pharmacological properties and patents of obovatol and obovatal from Magnolia obovata is the first publication. Pharmacological properties are focused on anti-cancer, anti-inflammatory, anti-platelet and neuroprotective activities. Obovatol and obovatal were first isolated from the leaves of M. obovata. Also reported in the bark and fruits of M. obovata, obovatol and obovatal are neolignans i.e., biphenolic compounds bearing a C-O coupling. Other classes of compounds isolated and identified from M. obovata include sesquiterpene-neolignans, dineolignans, trineolignan, lignans, dilignans, phenylpropanoids, phenylethanoid glycosides, flavonoids, phenolic acids, alkaloids, sesquiterpenes, ketone and sterols. The anti-cancer properties of obovatol and obovatal involve apoptosis, inhibition of the growth, migration and invasion of cancer cell lines. However, obovatol displays cytotoxicity against cancer cells but not obovatal. Similarly, anti-inflammatory, anti-platelet, neuroprotective, anxiolytic and other pharmacological activities were only observed in obovatol. The disparity in pharmacological properties of obovatol and obovatal may be attributed to the -CHO group present in obovatal but absent in obovatol. From 2007 to 2013, eight patents were published on obovatol with one mentioning obovatal. They were all published at the U.S. Patent and Trademark Office by scientists of the Korea Research Institute of Bioscience and Biotechnology (KRIBB) as inventors and assignee, respectively. Some future research and prospects are suggested.

Consumer Animosity to Foreign Product Purchase: Evidence from Korean Export to China

  • Kim, Jin-Hee;Kim, Myung Suk
    • Journal of Korea Trade
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    • v.24 no.6
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    • pp.61-81
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    • 2020
  • Purpose - This paper examines how the consumer animosity of partner country influences the purchase of foreign products. We analyzed news sentiment to determine whether Chinese consumer's animosity affect the purchase of the products made in Korea around the time when the U.S. Terminal High Altitude Area Defense missile system was deployed in South Korea. Design/methodology - To measure the tone of Chinese consumer animosity more carefully, we utilized a text mining technique of the Chinese language to read the public's opinion. Using Chinese news paper's editorials of 2015.1-2018.10, we analyzed the sentiment toward Korea and regressed it with Korean export to China. Findings - Empirical results report that Chinese consumers tended to reduce their purchase of consumer goods from Korea when the animosity increased, that is, the sentiments of Chinese news editorials were negative. In contrast, the animosity did not affect the purchase of Korean intermediates or raw materials. We further analyzed the effect by dividing the animosity into three categories; politics, economics, and culture. Among these groups, political news exhibits a unique effect on Chinese purchase on consumer goods from Korea. Originality/value - Existing literature on animosity models has measured the animosity by collecting the consumers' opinions through survey at a given time point, whereas it is measured by analyzing the tone of the press release by sentiment analysis during the time period around the event occurrence in this study.

Evaluation of pulse effect on frequency content of ground motions and definition of a new characteristic period

  • Yaghmaei-Sabegh, Saman
    • Earthquakes and Structures
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    • v.20 no.4
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    • pp.457-471
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    • 2021
  • This study aims at providing a simple and effective methodology to define a meaningful characteristic period for special class of earthquake records named "pulse-like ground motions". In the proposed method, continuous wavelet transform is employed to extract the large pulse of ground motions. Then, Fourier amplitude spectra obtained from the original ground motion and the residual motion is simply compared. This comparison permits to define a threshold pulse-period (Tp∗) as the threshold period above which the pulse component has negligible contributions to the Fourier amplitude spectrum. The effect of pulse on frequency content of motions was discussed on the light of this definition. The advantage and superior features of the new definition were related to the inelastic displacement ratio (IDR) for single-degree-of-freedom systems with period equal to one half of the threshold period. Analyses performed for the proposed period at three ductility levels u=2,4,6 were compared with the results obtained at half of pulse period derived from wavelet analysis, peak-point method and the peak of product of the velocity and the displacement response spectra (Sv x Sd). According to the results, pulse effects on inelastic displacement ratio seem to be more important when $\frac{T_p^*}{T}=2$ (T is the fundamental vibration period of system). The results showed that utilizing of the proposed definition could facilitate an enhanced understanding of pulse-like records features.

Doris Lessing's Views on Evolution in The Sirian Experiments (『시리우스 제국의 실험』에 나타난 도리스 레싱의 진화에 관한 시각)

  • Min, Kyung Sook
    • Journal of English Language & Literature
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    • v.58 no.4
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    • pp.655-678
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    • 2012
  • Doris Lessing, who considers science and technology as instruments of capitalism, deals with the theme of 'biological evolution' in The Sirian Experiments, the third book in the Canopus in Argos: Archives series. One of her themes that repeats throughout is that of 'spiritual evolution,' and in The Four-Gated City she even used 'biological evolution' as its metaphor. This paper analyzes The Sirian Experiments using scientific knowledge such as the concept of 'biological evolution' from Charles Darwin's evolution theory and Edward O. Wilson's sociobiology. Lessing concludes that while 'biological evolution' not accompanied with 'spiritual evolution' puts humans in existential problems and mental breakdown, the one in equilibrium with the other can bring social and political revolution. Lessing's concept of 'spiritual evolution' is basically a product of her holistic view and her own philosophical view that human evolution is a necessary process following the Universal Order, which shows that she is influenced by Sufism. The basic tenet in Sufi philosophy is to achieve equilibrium between the rational and non-rational modes of consciousness. Lessing incorporates her rational and irrational ideas into The Sirian Experiments to make a field for confluence where the biological, the sociological, and the spiritual thinking converge.

A Comparative Study on FDI Attractiveness Index between Korea and the United States (한·미간 FDI 매력도 비교 연구)

  • Byung-Soo Ahn
    • Korea Trade Review
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    • v.46 no.2
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    • pp.141-160
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    • 2021
  • The scale of global FDI has been decreasing since 2016 due to the ongoing US-China trade dispute, the strengthening of FDI inflow screening regulations with concern over strategic technology leaks, and the spread of reshoring trends due to the reinforcement of national preferences. Eventually, the competition to attract FDI between countries is expected to become more intense. Therefore, in order to attract high-quality FDI for Korea that will contribute to the development of the national economy, it is pressing to evaluate and improve the domestic FDI attraction environment. This study aims to analyze which areas of Korea's economic and non-economic environments need improvement for gaining advantage amid the fierce competition to attract FDI between countries, by the relative comparison between Korea and the U.S., and based on the ranking indicated in key FDI attractiveness indices. As a result, improvement is needed in the following areas. First, according to IMD's "World Competitiveness Ranking 2020," Korea was inferior to the US in terms of business efficiency, productivity, finance and business legislation in terms of government efficiency. Second, according to INSEAD's "Global Talent Competitiveness Index 2020," Korea was inferior to the US in terms of internal openness, external openness, employability, lifelong learning, access to growth opportunity, and business and labor landscapes. Third, according to WEF's "Global Competitiveness Index 2019", Korea was inferior to the US in terms of product market, labor market, business dynamism and workforce skills.

Corrosion characteristics in stress and various environments with Sn addition to Cu pipe (구리 배관의 Sn 첨가에 따른 응력 및 다양한 환경에서의 부식 특성)

  • Serim Kim;Uijun Kim;Myeonghoon Lee;Seunghyo Lee
    • Journal of the Korean institute of surface engineering
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    • v.57 no.3
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    • pp.192-200
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    • 2024
  • Cu as a heat exchanger tube is an important component in thermal fluid transfer. However, Cu tubes are exposed to stress in certain environments, leading to stress corrosion cracking (SCC). In this study, the effect of Sn addition on microstructure and corrosion characteristics was examined. The microstructural examination revealed the presence of columnar crystal and a grain refinement due to the addition of Sn. Electrochemical measurements showed that the 5 wt.% NH3 environment was the most vulnerable environment to Cu corrosion, and the corrosion current density increased as stress increased. The immersion test exhibited the formation of Cu2O and Cu(OH)2 corrosion product in 3.5 wt.% NaCl and 5 wt.% NH3 environments, respectively. Results indicated that Sn addition to Cu was an important factor in improving the mechanical strength.

Effect of Magnetic Properties on the Zr contents of Sm(CO.688-xFe.242Cu.07Zr x)7.404 Sintered Magnets (Sm(CO.688-xFe.242Cu.07Zr x)7.404소결자석의 자기적 특성에 미치는 Zr의 영향)

  • Jung, Woo-Sang;Kim, Yoon-Bae;Jeung, Won-Young
    • Journal of the Korean Magnetics Society
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    • v.12 no.5
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    • pp.189-194
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    • 2002
  • Microstructure and magnetic properties of Sm-Co sintered magnet were investigated with the variation of Zr content and their solution treatment and aging temperatures. The fraction of eutectic structure and the size of eutectic area decreased with increasing x value of cast Sm(C $O_{.688-x}$F $e_{.242}$C $u_{.07}$Z $r_{x}$)$_{7.404}$ alloys. On the other hand, x=0.022 ingot had finer dendritic structure compared to the other alloys. The sintered magnet of Sm(C $O_{.688-x}$F $e_{.242}$C $u_{.07}$Z $r_{x}$)$_{7.404}$ had well defined cell structure which is composed of cell boundary Sm $Co_{5}$ and cell interior S $m_2$Co/ssub 17/ phase. Cell boundary Sm $Co_{5}$ phase has 20nm thickness and its relative angle was 120$^{\circ}$ in x=0.018 and 0.022 alloys. Cell size was decreased with increasing Zr contents. But, x=0.026 alloy has diffuse cell boundary and irregular shape compared to x=0.022 and 0.018 alloys. Maximum value of coercive force and maximum energy Product were obtained from x=0.022 alloys. Optimum solution treatment temperature of Sm(C $O_{.688-x}$F $e_{.242}$C $u_{.07}$Z $r_{x}$)$_{7.404}$ alloy was 1170 $^{\circ}C$ and 1st aging temperature of two step aging process for higher coercivity was 850 $^{\circ}C$.

Study on the determination methods of the natural radionuclides (238U, 232Th) in building materials and processed living products (실내 건축자재 및 생활 가공제품 중 천연방사성핵종(238U, 232Th)의 농도 평가를 위한 분석법 연구)

  • Lee, Hyeon-Woo;Lim, Jong-Myoung;Lee, Hoon;Park, Ji-Young;Jang, Mee;Lee, Jin-Hong
    • Analytical Science and Technology
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    • v.31 no.4
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    • pp.149-160
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    • 2018
  • A large number of functional living products are being produced for eco-friendly or health-promoting purposes. In the manufacturing process, such products could be adulterated with raw materials with high radioactivity, such as monazite and tourmaline. Thus, it is essential to manage raw materials and products closely related to the public living. For proper management, an accurate radioactivity data of the processed products are needed. Therefore, it is essential to develop a rapid and validated analytical method. In this study, the concentration of the radioactive $^{238}U$ and $^{232}Th$ in building materials (e.g., tile, cement, paint, wall paper, and gypsum board) and living products (e.g., health products, textiles, and minerals) were determined and compared by ED-XRF and ICP-MS. By comparing the results of both methods, we confirmed the applicability of the rapid screening and precise analysis of ED-XRF and ICP-MS. In addition, $^{238}U$ and $^{232}Th$ levels were relatively lower in building materials than in living products. Particularly, $^{232}Th$ content in 6 of 47 living products exceeded (maximum $8.2Bq{\cdot}g^{-1}$) the standard limit of $^{232}Th$ content in raw material ($1.0Bq{\cdot}g^{-1}$).

A study on the process of spatial reduction of cotton culture in Korea since 1945 (해방 이후 우리나라 면작농업 소멸의 지역적 전개과정)

  • ;Kim, Kihyuk
    • Journal of the Korean Geographical Society
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    • v.29 no.3
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    • pp.318-339
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    • 1994
  • U.S. had given large amount of cotton to Korea as food aid program since 1945. This cotton aid had negative impact on cotton culture in Korean agriculture. Korean government used counterparts funds (sale proceeds of food aid) not for investment to agriculture sector, but for military budgets. And food aid on program type had influenced general economic policies, which neglected agricultural sector too. Anti-agricultural policy which was helped by U.S. food aid, had caused cotton cultivator an economic loss. So this economic loss had made many farmers abandon cotton culture. But in our times, cotton is cultivated for the purpose of domestic consumption in a few rural villages. The purposes of this study are 1) to analyze the process of spatial reduction of cotton culture since 1945 in regional contexts in Korea, and 2) to identify the function and meaning of cotton culture which does not pay off in agricultural region. Materials for acreage of cotton culture are acquired through the agricultural statistical year book(1952-1989) and census. To clarify the meanings of cotton culture, field survey are conducted in a rural village which is identified as only one where cotton was cultivated in 1993. In these contexts, this study has come to the following conclusions. In the period of under the rule of Japanese Imperialism (1910-1945), G. arboreum, species of cotton which was traditionally cultivated since 1364, had been driven out. And G. hirustun species, which is suitable for the production of highly qualified textile, has been hierarchically diffused by policy. In these period, regional structure of Korean agriculture was reorganized for the provision with food to Japan. Crops leading this dependent spatial structure were rice and cotton. So agricultural region, specialized with cotton, were distributed in the hinterland of the area which is specialized with rice. U.S. cotton aid to Korea began in 1947. U.S. took an interest in agricultural export because of her domestic surplus of cotton. Cotton aid is one mechanism by which U.S government developed agricultural market in recipient countries, Specially in the exchange rates, up-valuation of won to the U.S. dollars made domestic cotton more expensive than cotton imported, Production cost of domestic cotton is higher than Government's purchasing price of cotton which was also more expensive than price of cotton imported. Korean farmer could not help abandoning the cultivation of cotton, and this gave rise to spatial reduction of cotton culture. Spatially, cotton culture was abandoned in early stage of reduction in regions where stand at a disadvantage climatically, and in next stage in regions where other up-land crops which paid off in urban market, eg, fruits, could be cultivated. In the stage of extinction, cotton was cultivated only in area where G. hirustun species was originated in Korean peninsula. This region is not only suitable climatically for cotton culture, but is far away from urban market. Use of cotton produced is not for spinning, but for fillings of comforter. The main purpose of cotton culture in rural village is not for cotton yields, but for increase of production of seasame, which is grown together with cotton as mixed crops. Cotton product are used for domestic consumption and sold out to gin house. Though cotton culture is not paid off, farmer wanted to cultivate continuously for the cultural purpose, and they wanted the cotton culture promotion policy with the goverment subsidy.

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Correlation of serum total hydroperoxide levels and diseases of prematurity (미숙아 합병증 발생과 혈중 활성 산화물 농도와의 관계)

  • Kim, Shin-Hye;Hur, Hae Young;Lee, Kyu Hyoung;Moon, Ja Young;Chae, Kyu Young
    • Clinical and Experimental Pediatrics
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    • v.50 no.8
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    • pp.746-752
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    • 2007
  • Purpose : Total hydroperoxide (TH), free radical-mediated oxidation product can be used as a measure of free radical injury. The aim of the present study was to see if preterm newborns are at increased risk for oxidative stress compared with term newborns, and to determine whether oxidative stress during postnatal first 1 week is associated with clinical outcomes in preterm infants. Methods : Serum TH levels of preterm infants (n=39) were compared with those of term infants (n=24) on the postnatal day 1. Among the preterm infants, serum TH levels of uncomplicated group (n=23) were also compared with those of complicated group (n=16) who developed oxygen radical related diseases on the postnatal day 1 and 7. Retrospective analysis was performed to find out risk factors for oxygen radical injuries based on birth history, laboratory data, neuroimaging findings and clinical progress in two preterm groups. Results : Serum TH levels on postnatal day 1 were higher in the preterm infant group than the term infant group. Serum TH levels on postnatal day 1 in the complicated preterm infant group were significantly higher compared with uncomplicated group, but there was no significant difference in serum TH levels on postnatal day 7. Also, there was no significant difference in serum TH levels between uncomplicated preterm infants and term infants. Serum TH level on postnatal day 1 was independently associated with higher morbidity after adjusting for gestational age, Apgar score (5 min), arterial blood gas analysis. Conclusion : Complicated preterm newborns are at increased risk for oxidative stress compared with uncomplicated newborns and term newborns. Oxidative injury during the prenatal or postnatal day 1 is associated with adverse outcomes in preterm infants. Elevated TH levels on postnatal day 1 may have a value to predict clinical outcomes in preterm infants.