• Title/Summary/Keyword: U-Factor

Search Result 1,474, Processing Time 0.027 seconds

3-(4′-hydroxyl-3′, 5′-dimethoxyphenyl) Propionic Acid Suppresses NO Production and Elevates GSH Levels in Murine Macrophages

  • Song, Young-Sun;Choi, Chun-Yeon;Suh, Hongsuk;Song, Yeong-Ok
    • Preventive Nutrition and Food Science
    • /
    • v.9 no.3
    • /
    • pp.270-275
    • /
    • 2004
  • Previous studies have shown that kimchi and kimchi-derived 3-(4'-hydroxyl-3', 5'-dimethoxyphenyl) propionic acid have anti-oxidative and hypolipidemic effects in rats and rabbits. This study was designed to investigate whether chemically synthesized 3-(4'-hydroxyl-3', 5' -dimethoxyphenyl) propionic acid (HDMPPA) may ameliorate oxidative stress through the regulation of nuclear factor KB (NFkB) activation in lipopolysaccharide (LPS)-stimulated RAW 264.7 murine macrophage cells. Treatment of RAW 264.7 cells with 400 uM of HDMPPA significantly reduced LPS-stimulated nitric oxide (NO) production. Treatments with HDMPPA at 100 uM to 400 uM concentrations significantly elevated glutathione (GSH) level. However, cell viability and thiobarbituric acid-reactive substances (TBARS) concentrations were not affected by the concentrations of HDMPPA used. The specific DNA binding activities of NFKB, a transcription factor which is sensitive to oxidative stress, were not down-regulated by HDMPPA treatments. These results suggest that HDMPPA may have weak anti-oxidative activity against LPS challenge by scavenging NO and stimulating GSH production.

The Effect of Interferon-${\alpha}$ and bFGF on the Proliferation of Cultured Leiomyoma and Myometrial Cells (자궁근종과 자궁평활근 세포분열에 있어 Interferon-${\alpha}$ 및 basic Fibroblast Growth Factor (bFGF)의 효과)

  • Lee, B.S.;Park, J.S.;Kim, J.Y.;Bae, S.W.;Park, K.H.;Cho, D.J.;Lee, K.d;Kim, J.W.;Song, C.H.
    • Clinical and Experimental Reproductive Medicine
    • /
    • v.24 no.3
    • /
    • pp.355-359
    • /
    • 1997
  • Leiomyomas, which are the commonest pelvic tumors in women, are originated from myometrial cells. Although the exact initial pathophysiologic event of the leiomyoma is not known, recent evidences suggested that the effects of sex steroid hormones in the process of tumor growth are mediated by local production of growth factors including epidermal growth factor (EGF), insulin-like growth factor-I (IGF-I) and insulin-like growth factor-II (IGF-II). If we look at the effects of other cytokines, it was suggested that basic fibroblast growth factor (bFGF) may stimulate the proliferation of myometrial and leiomyomas cells. And it was reported that interferon-${\alpha}$ inhibit the action of bFGF. Therefore, we examined the effect of bFGF and interferon-${\alpha}$ on the proliferation of leiomyoma and myometrial cells. bFGF stimulated the myometrial and leiomyoma cells significantly at the concentration of 1ng/ml (p<0.05) and 5ng/ml (p<0.05). However, Interferon-${\alpha}$ inhibited the cell proliferation of myometrial and leiomyoma cells significantly at the concentration of 100U/ml (p<0.05) and 1000U/ml (p<0.05). And the stimulated effects of bFGF with the various concentration on the myometrial and leiomyoma cells ware inhibited by interferon-${\alpha}$ with 100U/ml. Therefore, we concluded that bFGF may stimulate the myometrial and leiomyoma cell proliferation and interferon-${\alpha}$ may inhibit the myometrial and leiomyoma cell proliferation through blocking the effect of basic fibroblast growth factor.

  • PDF

The Effects of Shopping Value, Ease of Use, and Usefulness on Mobile Purchase Intention (쇼핑가치, 사용용이성, 유용성이 모바일 구매의도에 미치는 영향)

  • Chae, Jin Mie
    • Science of Emotion and Sensibility
    • /
    • v.20 no.2
    • /
    • pp.73-86
    • /
    • 2017
  • The purpose of this study was to investigate the influence of consumers' shopping value(SV), ease of use(EOU), and usefulness(U) on their purchase intention(PI) in mobile shopping mall. Path hypotheses in structural equation model which was constructed for this purpose were verified. In addition, the research model was analyzed according to the groups classified by the level of purchase experience in mobile shopping mall. The survey was limited to the respondents in their 20s and 30s living in Seoul and other metropolitan areas who had purchased fashion products in mobile shopping mall. 411 useful data collected from on-line survey were analyzed by descriptive statistics, exploratory factor analysis, confirmatory factor analysis, reliability analysis, and pearson's correlation analysis using SPSS 21 and AMOS 19. The results of verifying the hypotheses were as follows: First, SV was composed of two factors which included hedonic shopping value(HSV) and utilitarian shopping value(USV). Second, the research model was verified as an acceptable model in explaining the influence of consumers' SV, EOU, and U on PI. Third, seven hypotheses among nine hypotheses were accepted in high purchasers. HSV did not have a significant influence on PI, and EOU did not affect PI significantly. Fourth, five hypotheses were accepted in light purchasers. HSV affected U significantly while USV had a significant impact on EOU and PI. EOU affected U, and U affected PI significantly. In conclusion, USV was proven to be the factor affecting PI directly as well as indirectly. Eou and U also had a significant influnce on PI in mobile fashion shopping. These results will provide mobile marketers with the differentiated strategies to make consumers lead to mobile purchase.

A Study on Friction Welding of SM45C to SCM4 Steel Bars and the Fatigue Properties (SM45C와 SCM4의 마찰용접 및 피로특성에 관한 연구)

  • O, Se-Gyu;Kim, Bu-An;Kim, Seon-Jin;Nam, Sang-Hun
    • Journal of Ocean Engineering and Technology
    • /
    • v.2 no.2
    • /
    • pp.112-121
    • /
    • 1988
  • A study on friction welding of carbon steel bar (SM45C) to chrome molybedenum steel bar(SCM4) is examined experimentally through tensile test, hardness test, microstructure test and fatigue test. so, this paper deals with optimizing the welding concitions and analyzing various mechanical properties about friction welds of SM45C to SCM4 steel bars. The results obtained are summarized as follows; 1) For friction welded joints of SM45C to SCM4 steel bars, the total upset(U)increases linearly with an increase of heating time ($t_{1}$) till 6s. 2) The determined optimum welding conditions are heating time ($t_{1}$)2s, upsetting time($t_{2}$), 3s, heating pressure($p_{1}$), 4kgf/$mm^{2}$(39.2MPa), upsetting pressure($p_{2}$, 8kgf/mm$^{2}$(78.4MPa) and rotating speed(N), 2, 000rpm when the total upset(U) is 3.4mm, resulting in a computed relationship between the joint tensile strength .sigma.$_{t}$ (kgf/mm$^{2}$and the total upset U(mm); .sigma.$_{t}$ =$0.21U^{3}$ - $3.38U^{2}$ +17.03U + 66.00 3) As the elongation is increased more and more, the fracture position becomes away from weld interface and the fractures are similar to those of SM45C. Fracture is taken place on SM45C side. 4) The weld interface of two dissimilar materials is mixed strongly, and the heat affected zone is about 2.0mm at SM45C while about 2.7 mm at SCM4 side. Therefore, the welded zone and heat affected zone are very narrow, comparing with those of the joints welded by the other welding methods. 5) The fatigue strengths at N=10$^{6}$ cycles of SM45C, SCM4 and friction welded joints are 23kgf/$mm^{2}$, 33kgf/$mm^{2}$(220.5 MPa), and 22.5kgf/$mm^{2}$(220.5MPa) respectively, and fracture at friction welded joint takes place at the side of SM45C. 6) The hardness of the friction weld interface is 3 times higher than that of base metal. 7) Fatigue strength of friction welded joint is higher than that of base metal. 8) Notch sensitivity factor of friction welded joint is lower than that of base metal.

  • PDF

Bearing Capacity Characteristics of Shallow Foundation by Three Dimension FEM (3차원 유한요소해석에 의한 얕은 기초의 지지력 특성)

  • Park, Choon-Sik;Kim, Jong-Hwan
    • Journal of the Korean Geotechnical Society
    • /
    • v.35 no.3
    • /
    • pp.17-24
    • /
    • 2019
  • The purpose of this study is to understand the characteristics of bearing capacity of shallow foundation on the grounds. We made a comparative study of existing bearing capacity theory, based on the three-dimensional finite element analysis with a variety of conditions such as ground condition, foundation scale and foundation shape. In the finite element analysis, the ultimate bearing capacity showed a gradual convergence in the form of exponential function or logarithm function according to the foundation scale. Although the shear strength increased, the bearing capacity tended not to increase but change linearly. In the results of comparative study of existing bearing capacity theory, bearing capacity ratio ($q_{u(FEA)}/q_{u(theory)}$) of pure sand has the outcome closest to those of the Terzaghi method. Pure clay turned out to be about 0.4~0.6 while normal soil was changed in a range of 0.3~1.3. As shear strength is increased, the results turned out to be less than 1.0. Bearing capacity ratio ($q_u/q_{u(1.0)}$), normalized at 1.0m bearing capacity, was about 35%, 15% and 5% of theoretical formula under the condition of ${\phi}=25^{\circ}$, $30^{\circ}$ and $35^{\circ}$ of pure sand; no scale effect was found with pure clay and the normal soil with lower soil strength level showed less than 10% of the theoretical formula of pure sand. Bearing capacity ratio of each case, in accordance with, the shear strength increase, was largely influenced by the internal friction angle. Shape factor of bearing capacity ratios classified by foundation shapes have different results according to the shapes; the shape factor of circular foundation is 1.50, square foundation is 1.30, rectangular and continuous foundations are 1.1~1.0.

Rietveld Analysis of YBCO superconductor (YBCO 고온 초전도체의 Rietveld 해석 연구)

  • ;;;Fan Zhangguo
    • Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
    • /
    • 1995.05a
    • /
    • pp.182-186
    • /
    • 1995
  • In this pacer, it is examined and confirmed that the R factor which is compensated after analyzing the characteristics of superconductor resulted from this experimented theory with the computer simulation, is refined to R$\sub$WP/=8.83[%], R$\sub$P/=6.47[%], R$\sub$I/=10.08[%], RF=7.19[%], R/eub E/=3.76(%), and on the basis of these experimental data, the significant parameter such as the scale factor(s) and the zero point shift(Z) and FWHM value(U,V,W) are optimized as follows; S =72.0827E-3, Z=0.2146, U=4.2761E-2, V=1.7983E-2, and W=2.6768E-2

  • PDF

THE INVESTIGATION OF BURNUP CHARACTERISTICS USING THE SERPENT MONTE CARLO CODE FOR A SODIUM COOLED FAST REACTOR

  • Korkmaz, Mehmet E.;Agar, Osman
    • Nuclear Engineering and Technology
    • /
    • v.46 no.3
    • /
    • pp.407-412
    • /
    • 2014
  • In this research, we investigated the burnup characteristics and the conversion of fertile $^{232}Th$ into fissile $^{233}U$ in the core of a Sodium-Cooled Fast Reactor (SFR). The SFR fuel assemblies were designed for burning $^{232}Th$ fuel (fuel pin 1) and $^{233}U$ fuel (fuel pin 2) and include mixed minor actinide compositions. Monte Carlo simulations were performed using Serpent Code1.1.19 to compare with CRAM (Chebyshev Rational Approximation Method) and TTA (Transmutation Trajectory Analysis) method in the burnup calculation mode. The total heating power generated in the system was assumed to be 2000 MWth. During the reactor operation period of 600 days, the effective multiplication factor (keff) was between 0.964 and 0.954 and peaking factor is 1.88867.

Experimental Study on Measuring the Intermittency in the Transitional Boundary Layer (천이경계층에서의 간헐도 측정에 관한 실험적 연구)

  • 임효재;안재용;백성구;정명균
    • Korean Journal of Air-Conditioning and Refrigeration Engineering
    • /
    • v.15 no.1
    • /
    • pp.9-18
    • /
    • 2003
  • An experimental study was performed to investigate the turbulence intermittency measuring methods across the boundary layer in the transition region. A single type hot-wire probe was used to measure instantaneous streamwise velocities in laminar, transitional and turbulent boundary layer To estimate wall shear stresses on the flat plate, near wall mean velocities are applied to the principle of CPM. Distribution of intermittency factor is obtained by dual-slope method and compared to the results of four methods,$\'{u},\;\{U}$, TERA and M-TERA method. In these methods, M-TERA shows a good agreement in the near wall region. However, the result of M-TERA method shows that intermittency factor is underestimated in the outer part and outside of the boundary layer and the dimensional constant of M-TERA method should be changed appropriately depending on measuring point.

Fatigue crack growth and crack closure in 2017-T3 Aluminum alloy (2017 - T 3 알미늄 合金 의 勞龜裂進展 과 龜裂닫힘現象)

  • 송지호;김일현;신용승
    • Transactions of the Korean Society of Mechanical Engineers
    • /
    • v.4 no.2
    • /
    • pp.47-53
    • /
    • 1980
  • Kikukawa-Compliance method using a conventional clip-on gauge was employed to investigate fatigue crack growth and crack closure in 2017-T3 aluminum alloy. The crack growth rate plot against stress intensity range .DELTA.K on a log-log diagram exhibits a bilinear form with a transition at the growth rate of 10$\^$-4/ mm/cycle. The bilinear form appears still in the plot of growth rate versus effective stress intensity range .DELTA.K$\_$eff/. Fatigue crack growth rate could be well represented by .DELTA.K$\_$eff. The experimental results indicate that the effective stress intensity range ratio U depends on the maximum stress intensity factor K$\_$max/, but the stress ratio R does not affect U. The crack opening stress intensity factor K$\_$op/ tends to increase with increasing K$\_$max/ and decrease with increasing .DELTA.K.

A Cross-Cultural Study on the Consumer Satisfaction of Clothing between Korea and the United States - Focusing on Familiarity and Pursuited Image of Jeans (한국과 미국 대학생의 의류 제품 만족에 관한 비교 문화 연구 - 청바지에 대한 친숙도와 추구 이미지를 중심으로 -)

  • Park, Soo-Kyeong
    • The Research Journal of the Costume Culture
    • /
    • v.15 no.1 s.66
    • /
    • pp.169-178
    • /
    • 2007
  • The purpose of this study was to compare consumers' post acquisition behavior by analyzing the influence of familiarity of jeans, and pursued image. The data was collected by using survey, three stages of pre-tests, and main survey conducted in the U.S and Korea. A total of 520 participants from each country(260 males and 260 females) was used. The results of this study is as follows. Familiarity of jeans and pursued image of jeans wear were compared between Korean and American students. As a result, there was difference between the countries on familiarity that the U.S showed higher familiarity, frequence of wearing and owned quantity. Pursued image was consisted of unique factor and activity factor and Korean students showed higher score on pursuing individualistic image. The results of this study would provide marketing strategy for fashion marketers of global jean brands.

  • PDF