• 한국식품조리과학회지
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• 제21권1호
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• pp.64-74
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• 2005

To develop the diet for Korean type 2 diabetic patients, a consumer survey was conducted (N=35) and was analyzed statistically. The survey compared the results of a questionnaire, somatometry, and blood parameters before and 8 weeks after the experiment. It was divided into Diabetic diet enforcement group (DDE) vs. Non diabetic diet enforcement group (NDDE). There was no significant difference in body weight, body mass index (BMI), body fat, triglyceride (TG) and low density lipoprotein cholesterol (LDL-C) of the subjects before and 8 weeks after the experiment. DDE's average fasting glucose (FBG) and post prandial 2 hours blood glucose (PP2) were significantly decreased before and after the experiment (p<0.05). NDDE's average FBG and PP2 showed no significant difference. In terms of Hemoglobin $A_lC\;(HbA_1C)$ content, DDE's had significantly decreased level both before and after the experiment (p<0.05), while there was no significant difference in the NDDE group. Cholesterol and High density lipoprotein cholesterol (HDL-C) were significantly different in DDE (p<0.05) both before and after the experiment. Whereas in the case of NDDE, there was no significant difference on the cholesterol and HDL-C, while DDE's showed a significant difference before and after the experiment. In terms of patients distribution depending on their treatment (p<0.05), NDDE had no significant difference before and after the experiment. For an item asking blood glucose control, DDE had significant difference before and after the experiment (p<0.01), while NDDE had no significant difference. For program satisfaction (p<0.05) and health (p<0.001), both the groups changed significantly after the experiment. But there was no significant difference in applying it to their real life after the experiment. Based on these results, DDE had the decreased blood glucose levels, $HbA_1C$, and cholesterol and increased HDL-C, with decreased rate of the patients taking oral hypoglycemic agents. In addition, many of the patients who participated in the experiment were found to be satisfied with the program, in terms of having less trouble in glucose control and exhibited improvement in health. Hence, based on the above results it was concluded that program was a very successful one for the treatment of diabetes.

• The Korean Journal of Physiology and Pharmacology
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• 제25권2호
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• pp.167-175
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• 2021

Far-infrared rays (FIR) are known to have various effects on atoms and molecular structures within cells owing to their radiation and vibration frequencies. The present study examined the effects of FIR on gene expression related to glucose transport through microarray analysis in rat skeletal muscle cells, as well as on mitochondrial biogenesis, at high and low glucose conditions. FIR were emitted from a bio-active material coated fabric (BMCF). L6 cells were treated with 30% BMCF for 24 h in medium containing 25 or 5.5 mM glucose, and changes in the expression of glucose transporter genes were determined. The expression of GLUT3 (Slc2a3) increased 2.0-fold (p < 0.05) under 5.5 mM glucose and 30% BMCF. In addition, mitochondrial oxygen consumption and membrane potential (ΔΨm) increased 1.5- and 3.4-fold (p < 0.05 and p < 0.001), respectively, but no significant change in expression of Pgc-1a, a regulator of mitochondrial biogenesis, was observed in 24 h. To analyze the relationship between GLUT3 expression and mitochondrial biogenesis under FIR, GLUT3 was down-modulated by siRNA for 72 h. As a result, the ΔΨm of the GLUT3 siRNA-treated cells increased 3.0-fold (p < 0.001), whereas that of the control group increased 4.6-fold (p < 0.001). Moreover, Pgc-1a expression increased upon 30% BMCF treatment for 72 h; an effect that was more pronounced in the presence of GLUT3. These results suggest that FIR may hold therapeutic potential for improving glucose metabolism and mitochondrial function in metabolic diseases associated with insufficient glucose supply, such as type 2 diabetes.

• 한국방사선학회논문지
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• 제14권3호
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• pp.319-336
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• 2020

미만성 긴 병변이 있는 급성심근경색증 환자에서 장기적인 임상 결과에 대해 중첩된 약물용출스텐트와 긴 단일 약물용출스텐트라는 두 가지 중재 방법으로 시술한 환자의 관상동맥조영술 결과와 임상결과를 비교·분석하였다. 2008년 6월부터 2019년 3월까지 급성심근경색환자 (65.9±11.0세, 남성 306명)가 미만성 긴 관상동맥 병변 30 mm이상 병변에 대해서 두 그룹으로 나뉘었습니다. 그룹I (중첩 약물용출스텐트 그룹; n=140) 및 그룹II (긴 단일 약물용출스텐트 그룹; n=298). 주요심장사건의 발생률을 비교하였다[주요심장사건; 두 그룹 사이에서 12개월 동안 심장사망률, 심근경색, 표적병변 재개통술 및 스텐트 혈전증]. Everolimus-용출 스텐트는 그룹I보다 그룹II에서 더 일반적으로 사용되었고(28.1% vs. 51.8% p<0.001), 시술 전 평균 병변직경은 그룹II에서 약간 굵었고 (3.1±0.3mm vs. 3.2±0.3mm, p=0.042), ACC / AHA 병변 유형C의 유병률은 그룹I에서 더 높았다(41.7% vs. 25.4%, p<0.001). 12개월 동안 주요심장사건의 발생률은 그룹II보다 그룹I에서 더 높았고(18.5% vs. 14.4%, p=0.034), 심장 사망률 (2.1% vs. 4.4%, p=0.667), 심근경색 (5.0% vs. 2.7%, p=0.260) 및 스텐트 혈전증률 (0.7% vs. 1.7%, p=0.669)은 두 그룹 차이가 없었다. 그러나 표적병변 재개통술 비율은 그룹I에서 더 높았다(10.7% vs. 5.6%, p=0.041). 다변량 로지스틱 회귀 분석에서 당뇨병의 존재[위험률 2.383, 95 % 신뢰 구간 1.332-4.260, p=0.003]과 파클리탁셀-용출 스텐트[위험률 2.367, 95 % 신뢰 구간 1.371-4.086), p=0.002]는 12개월 주요심장사건의 독립적 예측인자였으며, 두 그룹 사이의 유병률에 큰 차이가 없었다. 미만성 병변이 있는 급성심근경색 환자에서 12개월의 추적 관찰 기간 동안 중첩 약물용출스텐트 그룹에서 표적병변 재개통술 비율이 더 높았고 당뇨병의 존재 및 파클리탁셀-용출 스텐트의 사용은 주요심장사건의 독립적인 예측인자였다.

• 한국식품영양과학회지
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• 제44권4호
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• pp.475-482
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• 2015

본 연구에서는 STZ 유발 당뇨 쥐에서 고혈당 및 산화적 스트레스 관련 간 손상 기전에 oligonol의 영향에 대해 살펴보고자 하였다. 10일 동안 oligonol을 투여한 결과 20 mg/kg oligonol 투여군에서 당뇨대조군에 비해 간 무게 및 간조직의 glucose, ROS, peroxynitrite, 지질과산화물 농도가 유의적으로 감소하였다. 간조직의 항산화 효소 단백질 발현을 측정한 결과 정상군에 비해 당뇨대조군에서 발현 정도가 낮아졌지만 oligonol 투여군에서는 유의적으로 증가하였다. 또한 caspase-3 효소의 단백질 발현은 당뇨대조군에서 증가하였으나 oligonol 투여군에서 그 발현이 억제되었다. 따라서 oligonol의 투여는 STZ-유발 당뇨 모델에서 ROS 및 지질과산화물 생성 억제와 항산화효소 작용의 증가 및 세포 사멸 작용이 있는 caspase-3 발현 억제를 통해 고혈당 및 산화적 스트레스에 의해 유발되는 간 손상에 대한 보호 효과가 있는 것으로 사료된다.

• 대한간호학회지
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• 제30권5호
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• pp.1219-1229
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• 2000

The purpose of this study was to describe and understand how diabetics dealt with the result of the various changes of lifestyle. The grounded theory approach of qualitative research methods was used for building a substantive theory about that. The subjects of this study were 10 clients who experienced diabetes from 4 to 30 years. The data was collected from August 1999 to November 1999 through in-depth interviews utilizing home visitation and telephone interview technique then it was and analyzed simultaneously by a constant comparative method in which the new data was continuously coded into categories and properties according to Strauss & Corbin,s methodology. One hundred six concepts were found and they were grouped into 35 categories and then into 14 categories. The results were as follows difficulty, unable to overcome the changes, disposition, disease process, tiredness, supportive environment, perception, handling, concent- ration, mastering, endurance, avoidance, giving up and tailoring. The core phenomenon was 'tiredness' and these categories were synthesized into one core concept, the process of tailoring. The process of tailoring in diabetics consisted of : 1) going through difficulty of disease management 2) experiencing tiredness from the difficulty of disease management 3) perception of disease from tiredness 4) undergoing various self-management 5) controlling the process of tailoring by one's own method. Six hypotheses were derived from the relation of these concepts and four types were from intensity of tiredness, direction of disposition, type of disease process and the level of supportive environment and perception. This study offers better understanding on diabetic experiences and may facilitate more appropriate interventive strategies to provide support, information and knowledge. The nurses should utilize the results to help diabetics enjoy their lives without any trouble and must continuously develop nursing knowledges and skills.

• 동의생리병리학회지
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• 제25권5호
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• pp.816-822
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• 2011

Kaempferol, a component of Polygonati rhizoma, is one of the herbal flavonoids, which is used in therapeutic agent for anti-hypercholesterol, anti-hypertension and anti-diabetes. And it is also known to be effective in anti-cancer therapy for breast, prostate and other type of cancers. However, the anti-cancer therapeutic mechanisms are pooly understood. To address molecular mechanism underlying kaempferol-induced anti-cancer effects, we determined the effect of kaempferol on cell growth of the lung cancer cell lines, A549, H1299 and H460. From the FACS analysis, measurement of caspase activity, DAPI and tryptophan blue staining, and DNA fragmentation assay, we found that kaempferol induces apoptosis and H460 cells are most sensitive among the tested cell lines. In addition, we performed microarray to identify the genome-wide expression profiling regulated by kaempferol. Lots of cell cycle-related genes were under-expressed, whereas the genes related to TGF-beta/SMAD pathway were over-expressed in kaempferol-treated H460 cells. Additionally, kaempferol also increased expression levels of apoptosis related genes such as death receptors, FAS, TRAIL-R and TNF-R, and casepase-8 and caspase-10. Overall, our results suggest that kaempferol promotes anti-lung cancer therapeutic effects by inducing G1 arrest and apoptosis through TGF-beta/SMAD pathway and death receptors/caspase pathway, respectively.

• 대한방사선기술학회지:방사선기술과학
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• 제31권1호
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• pp.33-39
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• 2008

복부비만은 2형 당뇨병과 고지혈증, 고혈압, 관상동맥질환 등의 심혈관계 질환의 주요 위험인자이며 특히 내장형 복부 비만인 경우 위험도가 더 크다고 알려져 있다. 이 연구에서는 2006년 4월부터 2007년 9월까지 일개 대학병원 비만 클리닉을 방문한 BMI 23 이상의 성인 여성 25명을 대상으로 하여 복부지방 CT를 실시하여 지질대사지표와의 상관성 및 내장지방 분포에 영향을 주는 요인을 분석하였다. 8시간 공복 후 채취한 정맥혈액을 이용하여 Glucose, TC, TG, HDL의 농도를 분석하였고, 안정시의 이완기 혈압과 수축기 혈압을 측정하였다. 연구결과 내장지방량은 TC와 TC/HDL과 음의 상관관계를 보였다. 통계적으로는 BMI, TAF, VSR이 통계적으로 유의한 차이가 있는 것으로 나타났다(p < .001). 내장지방량을 가장 잘 반영하는 지질대사지표는 TC와 TG, HDL인 것으로 나타났으며, 이 회기분석모델은 47%의 설명도를 가지고 있는 것으로 나타났다.

• 지역사회간호학회지
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• 제13권2호
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• pp.260-271
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• 2002

Objectives: The purpose of this study was to identify basic health needs of adult clients to develop a community nursing center model in Seoul. Methods: Data were collected using a questionnaire survey from 894 adults registered at a public health center who were health management members, and visiting 4 community nursing centers, University of Wisconsin, Milwaukee during the period from July 1999 to January 2000. The data were analyzed using frequency, percentile, t-test, and ANOVA. Results: 1) The University of Wisconsin- Milwaukee School of Nursing has a long tradition of developing 4 community nursing centers with innovative health care programs. CNCs integrate the ability to implement and test effective intervention strategies with education, research, and practices of nursing students and faculty. They were designed to enhance the health status and quality of life for urban communities through the development of productive, outcome focused, collaborative partnerships among UWM-Nursing faculties and staff, other health and human service providers, consumers, and policy makers. It links the financial resources between UWM and 9 voluntary agencies and 12 public funding organizations including federal. state, and local governments. 2) Of the total health management members, 37.4% were reported to have at least one type of chronic disease such as hypertension, diabetes, and arthritis. Ten percent of them reported having obesity, and 44.2% reported lack of exercise. The health status of the subjects was within normal range in laboratory tests. However, female subjects showed more significant differences in obesity and cholesterol levels than male subjects. The subjects, who were in their 50s, showed more significant differences in obesity, SGOT, SGPT, and cholesterol levels than the subjects in other age groups. Conclusion: A community nursing center needs to be developed, that has a link between the nursing college and the public health center, with partnerships and a multidisciplinary approach. Based on the study results, exercise programs for middle aged adults are considered necessary. In particular, specific exercise programs for pre-menopausal women needs to be implemented in the future to prevent them from developing osteoporosis.

• Nutrition Research and Practice
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• 제8권5호
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• pp.544-549
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• 2014

BACKGROUND/OBJECTIVES: Obesity-associated insulin resistance is a strong risk factor for type 2 diabetes mellitus. The aim of this study was to investigate the effect of myricetin on adiposity, insulin resistance, and inflammatory markers in mice with diet-induced insulin resistance. MATERIALS/METHODS: Five-week-old male C57BL/6J mice were fed a basal diet, a high-fat, high-sucrose (HFHS) diet, or the HFHS diet containing 0.06% myricetin or 0.12% myricetin for 12 weeks after a 1-week adaptation, and body weight and food intake were monitored. After sacrifice, serum lipid profiles, glucose, insulin, adipocyte-derived hormones, and proinflammatory cytokines were measured. The homeostasis model assessment for insulin resistance (HOMA-IR) was determined. RESULTS: Myricetin given at 0.12% of the total diet significantly reduced body weight, weight gain, and epidydimal white adipose tissue weight, and improved hypertriglyceridemia and hypercholesterolemia without a significant influence on food intake in mice fed the HFHS diet. Serum glucose and insulin levels, as well as HOMA-IR values, decreased significantly by 0.12% myricetin supplementation in mice fed the HFHS diet. Myricetin given at 0.12% of the total diet significantly reduced serum levels of leptin, tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$) and interleukin-6 (IL-6) in mice fed the HFHS diet. CONCLUSIONS: These findings suggest that myricetin may have a protective effect against diet-induced obesity and insulin resistance in mice fed HFHS diet, and that alleviation of insulin resistance could partly occur by improving obesity and reducing serum proinflammatory cytokine levels.

• Archives of Plastic Surgery
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• 제45권5호
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• pp.418-424
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• 2018

Background Complication rates after flap coverage for pressure ulcers have been high historically. These patients have multiple risk factors associated with poor wound healing and complications including marginal nutritional status, prolonged immobilization, and a high comorbidities index. This study utilizes the National Surgical Quality Improvement Program (NSQIP) to examine perioperative outcomes of flap coverage for pressure ulcers. Methods Data from the NSQIP database (2005-2015) for patient undergoing flap coverage for pressure ulcers was identified. Demographic, perioperative information, and complications were reviewed. One-way analysis of variance and Pearson chi-square were used to assess differences for continuous variables and nominal variables, respectively. Multivariate logistic regression was performed to identify independent risk factors for complications. Results There were 755 cases identified: 365 (48.3%) sacral ulcers, 321 (42.5%) ischial ulcers, and 69 (9.1%) trochanteric ulcers. Most patients were older male, with some degree of dependency, neurosensory impairment, high functional comorbidities score, and American Society of Anesthesiologists class 3 or above. The sacral ulcer group had the highest incidence of septic shock and bleeding, while the trochanteric ulcer group had the highest incidence of superficial surgical site infection. There was an overall complication rate of 25% at 30-day follow-up. There was no statistical difference in overall complication among groups. Total operating time, diabetes, and non-elective case were independent risk factors for overall complications. Conclusions Despite patients with poor baseline functional status, flap coverage for pressure ulcer patients is safe with acceptable postoperative complications. This type of treatment should be considered for properly selected patients.