• Korean Journal of Biological Psychiatry
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• v.5 no.2
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• pp.263-277
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• 1998

Conventional high-dose antipsychotics tend to result in more side effects, negative symptoms and dysphoria, and at the same time lower the cognitive function which is already impaired in most schizophrenics. Florid psychotic symptoms, negative symptoms and cognitive impairment greatly impede psychosocial performance and eventual reintegration into society. The reduction of symptom and the improvement of cognitive funtions and social skills are therefore central to the psychiatric rehabilitation process. The purpose of this study was to evaluate the dose-reduction effects of antipsychotics on chronic schizophrenics prescribed conventional high-dose antipsychotics more than 1,500mg equivalent of chlorpromazine. Fifty-one chronic schizophrenics who maintained high-dose antipsychotics for more than three months were randomly assigned to two groups : 20 patients comprised the dose-maintaining group and 31 patients made the dose-reduction group. Over a sixteen weekperiod Positive and Negative Syndrome Scale(PANSS), Extrapyramidal Symptom(EPS), Nurses' Observation Scale for Inpatient Evaluation(NOSIE-30), Continuous Performance Test(CPT), Quality of Life(QOL), and haloperidol/reduced haloperidol blood levels were determined at the base line and after 2, 4, 6, 8, 12, 16 weeks to evaluate the dose reduction effects of high-dose antipsychotics. The results were as follows : 1) Dose-reduction is highly effective in reducing positive and negative symptoms, and general psychopathology. Effects were most prominent at 8, 12, 16 weeks. Among the dose reduction group, positive symptoms in positive symptom group and negative symptoms in negative symptom group were more reduced. 2 Extrapyramidal symptoms showed no significant difference between two groups. But the EPS was reduced time after time within two groups. 3) Hit rates of Continuous Performance Test, which indicate attentional capacity, increased significantly after dose reduction. 4) Haloperidol and reduced haloperidol blood levels decreased until the 4th week, after which they were constant. 5) Total scores of Nurses' Observation Scale for Inpatient Evaluation were unchanged between the two groups. But among the indices, social interest and personal neatness were improved in the dose-reduction group and retardation was aggrevated in the dose-maintaining group. 6) Total quality of life scores were unchanged between two groups. But in the dose maintaining group, satisfaction scores of attention, autonomy, and interpersonal relationship decreased progressively. These findings suggest that the dose reduction of antipsychotics for chronic schizophrenics on programs of high-dose antipsychotics were effective. Dose reduction should therefore be implemanted to spread the rehabilitation and improve quality of life for chronic schizophrenics.

• Biomedical Science Letters
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• v.11 no.4
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• pp.493-501
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• 2005

Circadian rhythms, time on a scale of about 24 hours, are present in a number of organisms including animals, plants, and bacteria. The control of the biochemical, physiological and behavioral processes is regulated by endogenous clocks in the suprachiasmatic nucleus (SCN). At the core of this timing mechanism is molecular machinery that are present both in the brain and in the peripheral tissues throughout the body, and even in a single cultured cell. In this study, we performed two-dimensional gel electrophoresis to figure out any correlation between protein expression patterns and the requirement of two canonical clock proteins, either mPER1 or mPER2, by comparing global protein expression profiles in livers from wildtype or mPer1/mPer2 double mutant mice. We could identify several differentially expressed protein candidates with respect to time and genotypes. Further analysis of these candidate proteins in detail in vivo will lead us to the better understanding of how circadian clock functions in mammals.

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 2003.05a
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• pp.32-33
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• 2003

Mechanism of a periodic oscillation of shock-induced combustion over a two- dimensional wedges and axi-symmetric cones were investigated through a series of numerical simulations at off-attaching condition of oblique detonation waves(ODW). A same computational domain over 40 degree half-angle was considered for two-dimensional and axi-symmetric shock-induced combustion phenomena. For two-dimensional shock-induced combustion, a 2H2+02+17N2 mixture was considered at Mach number was 5.85with initial temperature 292 K and initial pressureof 12 KPa. The Rankine-Hugoniot relation has solution of attached waves at this condition. For axi-symmetric shock-induced combustion, a H2+2O2+2Ar mixture was considered at Mach number was 5.0 with initial temperature 288 K and initial pressure of 200 mmHg. The flow conditions were based on the conditions of similar experiments and numerical studies.[1, 3]Numerical simulation was carried out with a compressible fluid dynamics code with a detailed hydrogen-oxygen combustion mechanism.[4, 5] A series of calculations were carried out by changing the fluid dynamic time scale. The length wedge is varied as a simplest way of changing the fluid dynamic time scale. Result reveals that there is a chemical kinetic limit of the detached overdriven detonation wave, in addition to the theoretical limit predicted by Rankine-Hugoniot theory with equilibrium chemistry. At the off-attaching condition of ODW the shock and reaction waves still attach at a wedge as a periodically oscillating oblique shock-induced combustion, if the Rankine-Hugoniot limit of detachment isbut the chemical kinetic limit is not.Mechanism of the periodic oscillation is considered as interactions between shock and reaction waves coupled with chemical kinetic effects. There were various regimes of the periodicmotion depending on the fluid dynamic time scales. The difference between the two-dimensional and axi-symmetric simulations were distinct because the flow path is parallel and uniform behind the oblique shock waves, but is not behind the conical shock waves. The shock-induced combustion behind the conical shockwaves showed much more violent and irregular characteristics.From the investigation of characteristic chemical time, condition of the periodic instability is identified as follows; at the detaching condition of Rankine-Hugoniot theory, (1) flow residence time is smaller than the chemical characteristic time, behind the detached shock wave with heat addition, (2) flow residence time should be greater than the chemical characteristic time, behind an oblique shock wave without heat addition.

• Journal of Advanced Marine Engineering and Technology
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• v.34 no.2
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• pp.275-281
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• 2010

In this paper, a geometric similarity law is introduced to the performance test of a large-sized silencer used in ship engine or plant system. A test of scale-down model enable to yield the cost and time saving in developing large-sized silencer considerably. Two types of silencer, resonator and expansion chamber, were analyzed by a theoretical method and an acoustical FEM(finite element method) in order to obtain geometric similarity variables. A method is proposed to estimate the transmission loss of prototype model using the test results of scale-down model. Two actual large-sized silencer, which consist of resonator and expansion chamber, were analysed by an acoustical FE analysis. Consequently, the proposed method predicts effectively the performance of prototype silencers using those of scale-down models.

• Journal of The Korean Astronomical Society
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• v.36 no.3
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• pp.105-110
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• 2003

Recent observations of galaxy clusters in radio and X-ray indicate that cosmic rays and magnetic fields may be energetically important in the intracluster medium. According to the estimates based on theses observational studies, the combined pressure of these two components of the intracluster medium may range between $10\%{\~}100\%$ of gas pressure, although their total energy is probably time dependent. Hence, these non-thermal components may have influenced the formation and evolution of cosmic structures, and may provide unique and vital diagnostic information through various radiations emitted via their interactions with surrounding matter and cosmic background photons. We suggest that shock waves associated with cosmic structures, along with individual sources such as active galactic nuclei and radio galaxies, supply the cosmic rays and magnetic fields to the intracluster medium and to surrounding large scale structures. In order to study 1) the properties of cosmic shock waves emerging during the large scale structure formation of the universe, and 2) the dynamical influence of cosmic rays, which were ejected by AGN-like sources into the intracluster medium, on structure formation, we have performed two sets of N-body /hydrodynamic simulations of cosmic structure formation. In this contribution, we report the preliminary results of these simulations.

• Journal of Animal Environmental Science
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• v.6 no.2
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• pp.73-81
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• 2000

A two-phase anaerobic digestion system for the treatment of swine waste was constructed in a commercial hog farm. The digester system was composed of 4 major units; slurry storage pit, acidogenic digester, methanogenic digester and sedimentation pit. A biogas boiler unit was also attached to maintain the digester temperature of 37$^{\circ}C$. Substrate lading was made with 2hr-interval by pumping about 2.1$m^3$ of slurry type swine waste from the slurry pit into the acidogenic digester, which corresponds to hydraulic retention time of 4 days for the acidogenic digester and of 11 days for the methanogenic digester. Digester temperature were well maintained as the set temperature of 37$^{\circ}C$ in the methanogenic digester, while the temperature in the acidogenic digester showed around 34$^{\circ}C$. pH also showed a steady-state results of 7.3 in the acidogenic digester and of 7.6 in the methanogenic digester during the operation period. Average biogas production rate was 0.66$m^3$/$m^3$ digester volume. Reduction rate of total solid and volatile solid were 42.8% and 5.8%, respectively. Total nitrogen and ammonia nitrogen were not reduced during the anaerobic fermentation, however, most of VFAs seemed to be converted to the biogas,. These fermentation performance data may suggest that he newly developed a two-phase anaerobic digester for the swine waste treatment worked so successfully.

• The Bulletin of The Korean Astronomical Society
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• v.38 no.2
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• pp.43.2-43.2
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• 2013

AGN are known for irregular variability on all time scales, down to intra-day variability with relative variations of a few percent within minutes to hours. In the shortest time scale of AGN activity, unexplored territory still exists: first, the existence of a shortest time scale of AGN activity and secondly the shape of high frequency end of AGN power spectrum. Also the spectral variations at the shortest timescale. Here, we present the preliminary results of AGN fast photometry performed with Korean VLBI Network(KVN). Observations were done in a 'anti-correlated' mode using two antennas, with always either one antenna pointing at the target. This results in an effective time resolution of 3 minutes. We used all four KVN frequencies, 22, 43, 86, and 129 GHz, in order to trace spectral variability. We have been able to derive high-quality light curves for 3C111 and 3C279 at 22 and 86 GHz observed on 31st of May and 30th of Nov. in 2012. We are currently performing detailed statistical analysis in order to assess the levels of variability or the corresponding upper limits.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.26 no.10
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• pp.1427-1435
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• 2002

The main aim of the present article is numerically to investigate the micro-scale heat transfer phenomena in a silicon microstructure irradiated by picosecond-to-femtosecond ultra-short laser pulses. Carrier-lattice non-equilibrium phenomena are simulated with a self-consistent numerical model based on Boltzmann transport theory to obtain the spatial and temporal evolutions of the lattice temperature, the carrier number density and its temperature. Especially, an equilibration time, after which carrier and lattice are in equilibrium, is newly introduced to quantify the time duration of non-equilibrium state. Significant increase in carrier temperature is observed for a few picosecond pulse laser, while the lattice temperature rise is relatively small with decreasing laser pulse width. It is also found that the laser fluence significantly affects the N 3 decaying rate of Auger recombination, the carrier temperature exhibits two peaks as a function of time due to Auger heating as well as direct laser heating of the carriers, and finally both laser fluence and pulse width play an important role in controlling the duration time of non-equilibrium between carrier and lattice.

• Proceedings of the Korean Society for Agricultural Machinery Conference
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• 1997.12a
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• pp.255-262
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• 1997

A low-cost and precise metering device, which is suitable to automatic mixing of nutrient-solution for hydroponic culture, was developed for small-scale growers. The metering device was composed of three parts those were supply pumps, metering cylinders and venturi tube. Those parts were controlled by personal computer with time-based odoff control method. To verify the performance of the developed metering device, the relationship between operating time and discharge was examined and the accuracy of the developed metering device was compared with commercial metering pumps. The results of this study are as follows. 1. The correlation coefficient between the flow rate and operating time was 0.9999, and the linear regression equation computed was y=21.759x, where y is the discharge(g) and x is the operating time(s). 2. The developed device has greater accuracy than commercial metering pumps in terms of the full-scale error. Calculated errors for the developed metering device and two commercial pump were $\pm$0.3 %, $\pm$2.45 % and $\pm$1.38 % respectively. 3. Above results show developed metering device is a useful tool for nutrient-solution control system.

• Journal of Korea Multimedia Society
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• v.14 no.11
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• pp.1507-1515
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• 2011

As the first step in research for sound synthesis of Pyungjong, timbre was analyzed by FFT analysis. There was no significant difference in the pitch of scale between modern Pyungjong and western twelve-tone equal temperament scale. The timbre of Pyunjong chagnes over time. When striking Pyunjong, the noises to be generated across all frequencies will disappear in a short period of time, and a unique partial only is left. Then it disappear from the partial of high frequency components in order, and two partials remain at release time. At this time, the beating is occurring by the frequency of the remaining partial. Pyungjong used in this study is relatively a recently manufactured Pyungjong, and for original sound synthesis of Pyungjong, a study of ancient Pyungjong's timbre should be additionally conducted later.