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Influence of Ethnicity on Survival of Breast Cancer Patients in Turkey

  • Kuzhan, Abdurahman;Adli, Mustafa;Buyukhatipoglu, Hakan
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.21
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    • pp.9199-9202
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    • 2014
  • Background: Kurdish women with breast cancer have more unfavorable prognostic factors than their Turkish and Arab counterparts. However, the effects of these factors on breast cancer survival among these ethnic groups remain unclear. We therefore investigated the impact of ethnicity on survival in breast cancer patients in Turkey. Materials and Methods: Ethnicity, age, stage at diagnosis, tumor characteristics, treatments given (surgery, chemotherapy, radiotherapy and hormone therapy), and survival times were recorded. Kaplan-Meier analysis was used to estimate the overall survival times and survival plots. Log-rank test was used to compare the survival curves.Results: Of the 723 breast cancer patients included in the study, 496 (68.7%) were Turkish, 189 (26.2%) were Kurdish, 37 (5.1%) were Arabic and 1 was Armenian. Kurdish women with breast cancer had larger tumor sizes and higher rates of hormone receptor negative tumors than Turkish and Arab patients. Mean follow-up time was 118.4 [95% Confidence Interval (CI): 95.4-141.3] months, and it was 129.9 (95% CI: 93.7-166.2), 124.2 (95% CI: 108.4-140.1) and 103.1 (95% CI: 85.9-120.4) months for Turkish, Arabic and Kurdish patients, respectively. Conclusions: Kurdish ethnicity is associated with higher rates of hormone receptor negative and triple-negative tumors and with worse survival. Clinical and epidemiological research is warranted to elucidate reasons underlying overall survival, variations in tumor biology, differences in treatment responsiveness, and effects of social factors among ethnic groups in Turkey.

A Cyclin D1 (CCND1) Gene Polymorphism Contributes to Susceptibility to Papillary Thyroid Cancer in the Turkish Population

  • Aytekin, Turkan;Aytekin, Alper;Maralcan, Gokturk;Gokalp, M. Avni;Ozen, Dogukan;Borazan, Ersin;Yilmaz, Latif
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.17
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    • pp.7181-7185
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    • 2014
  • Cyclin D1 is an important positive regulator of the G1/S phase of the cell cycle. We investigated the association between the CCND1 G870A polymorphism and susceptibility to papillary thyroid cancer in Turkish people. This study covered 102 patients with papillary thyroid cancer and 174 healthy controls. CCND1 genotyping was determined by the PCR-RFLP method. We found that the A allele frequency was higher in the cases than in the controls (p=0.042). On stratification analysis, papillary thyroid cancer risk was significantly elevated in individuals older than 45 years with the A allele (OR=1.91, 95% CI, 1.09-3.35, p=0.024) and in females with the A allele (OR=1.73, 95% CI, 1.06-2.84, p=0.029), compared to the G allele. According to the subject age, there was an increased papillary thyroid cancer risk for the individuals older than 45 years with the AA genotype (OR=2.28, 95% CI, 1.02-5.13, p=0.046) compared to the AG+GG combined genotypes. In conclusion, it is suggested that the CCND1 G870A polymorphism may contribute to the susceptibility to papillary thyroid cancer, especially in those who were older subjects ($45{\leq}$ years old) and female, in the Turkish population.

The Effects of Grape Seed Flour on the Quality of Turkish Dry Fermented Sausage (Sucuk) during Ripening and Refrigerated Storage

  • Kurt, Sukru
    • Food Science of Animal Resources
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    • v.36 no.3
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    • pp.300-308
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    • 2016
  • In this study, the effects of grape seed flour on the physical-chemical properties, microbiological and sensory properties of Turkish dry fermented sausage, sucuk, was investigated. After the sausages produced with beef, beef fat, sheep tail fat and spices, they were ripened for 14 d. Then they were vacuum-packaged and stored for 80 d at 4℃. The effects of grape seed flour (GSF; 0%, 0.75%, 1.5%, 3%) on the physical-chemical properties (pH, moisture, fat, protein, free fatty acids, thiobarbituric acids, diameter reduction, ripening yield, instrumental colour), microbiological properties (total aerobic mesophilic and lactic acid bacteria, Enterobacteriaceae, mould and yeast) and sensory properties of the sausages were investigated. Grape seed flour decreased moisture, TBA, diameter reduction, instrumental colour (a, b) values and sensory analysis scores during the ripening period; it also decreased TBA, instrumental colour (L, a, b) values, total aerobic mesophilic and lactic acid bacteria counts during the storage period. It was concluded that grape seed flour has a potential application as an additive in dry fermented sausages.

Morphological characterization of Korean and Turkish watermelon germplasm

  • Huh, Yun Chan;Choi, Hak Soon;Solmaz, Ilknur;Sari, Nebahat;Kim, Su
    • Korean Journal of Agricultural Science
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    • v.41 no.4
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    • pp.309-314
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    • 2014
  • A total of 67 watermelon accessions which include 37 accessions from Korean and 27 accessions from Turkish germplasm and 3 accessions of other related species from USA were investigated for morphological characteristics. The UPOV descriptor list for 56 characters (6 seedlings, 4 plants, 11 leaves, 5 flowers, 23 fruits and 7 seeds) was used in characterization. In addition, eight quantitative characters, hypocotyl length, cotyledon width, cotyledon length, fruit weight, fruit length, fruit width, thickness of outer layer of pericarp and soluble solid content were also measured. The 56 qualitatively scored characters were analyzed by principle coordinate analysis (PCoA) while the eight quantitative ones were subjected to principle component analysis (PCA). Morphological characterization result demonstrated that the accessions displayed high morphological diversity(how much percent?). A high level of phenotypic diversity was observed from the results of morphological characterization. However, plant growth habit and leaf blade flecking showed constant characters for all of the accessions. The Korean and Turkish watermelon genotypes are diverse groups and can be separated by both multivariate analysis of morphological characters although the grouping was more apparent in PCoS results.

A Comparisonal Study between Korean Po and Turkish Sultans′ Dress (우리나라 포(袍)와 터키 Sultans′의 의례용 외의 형태 비교 연구 - 1400∼1800년대를 중심으로 -)

  • 이상은;김영란
    • Journal of the Korea Fashion and Costume Design Association
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    • v.6 no.1
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    • pp.55-63
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    • 2004
  • The dress culture of Korea and Turkey should be necessary to study in view of a similar culture of Korea and Turkey due to similarity of oriental culture. Thus, as two nation's dress is investigated, cultural characteristics and dress form of two nations are analyzed with cultural background in detail. Also, comprehension is determinated for the dress color and texture as well as dress culture. In this paper, It is investigated theoretically for the function, type, and class of dress. Also, The form of Korean Po are compared to background of Turkish dress and Sulltans' dress form. To unify a cultural propagation and dress form, technical, inductive contents analytical method as well as literature review are used in positivism. Subject is limited to the Korean Po and Sultans' dress of Turkey. As a results, as the nation's dress reflect to culture and society of the nation, Korean dress have some similarity and differences comparing Turkish dress as followings. In dress form of two nation, rectangular Gil's shape was very similar. Mu's shape was similar too. However, Sultans' dress had outside shape of caftan type and Po had full or partial wrinkles by transforming Mu. Also, Sultans' dress did not have Sup. Korean Po have side slits or back side slits and Jun-Sam but Sultans' dress had only some side slits.

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Comparison of loads in Turkish earthquake code with those computed statistically

  • Firat, Fatih K.;Yucemen, M. Semih
    • Earthquakes and Structures
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    • v.8 no.5
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    • pp.977-994
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    • 2015
  • In this study, earthquake loads are investigated statistically and compared with the nominal earthquake loads calculated according to the Turkish Earthquake Code, namely: "Specifications for Structures to be Built in Earthquake Areas". For this purpose, the "actual" mean load values estimated from statistical methods and the nominal load values computed according the Seismic Code are compared, with respect to some variations in the basic parameters, such as the importance factor, building height, site coefficient, seismic zone and seismic load reduction factor. In addition to the data compiled from different regions of Turkey, the published data and information in the foreign literature are also used in the determination of the earthquake load statistics. Although the dead and live loads acting on a structure are independent of the geographical location of the structure, environmental loads, such as earthquake loads are highly dependent on the location of the structure. Accordingly, for the assessment of statistical parameters associated with earthquake loads, twelve different locations which can represent the different seismic zones of Turkey as accurately as possible are chosen. As a result of the code calibration procedure considered in this study, it is observed that the load values obtained from the Turkish Seismic Code may overestimate or underestimate the actual seismic loads in some of the seismic zones.

T-786C, G894T, and Intron 4 VNTR (4a/b) Polymorphisms of the Endothelial Nitric Oxide Synthase Gene in Bladder Cancer Cases

  • Polat, Fikriye;Diler, Songul Budak;Azazi, Irfan;Oden, Artun
    • Asian Pacific Journal of Cancer Prevention
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    • v.16 no.6
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    • pp.2199-2202
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    • 2015
  • The aim of the present study was to determine whether endothelial nitric oxide synthase (eNOS) gene polymorphisms play a role in development of bladder cancer in the Turkish population. The study was performed on 75 patients (64 men, 11 women) with bladder cancer and 143 healthy individuals (107 men, 36 women) with any kind of cancer history. Three eNOS gene polymorphisms (T-786C promoter region, G894T and intron 4 VNTR 4a/b) were determined with polymerase chain reaction and restriction fragment lenght polymorphism methods. In our study, GT and TT genotypes for eNOS G894T polymorphism were found to significantly vary among patients with bladder cancer and control group (OR: 0.185, CI: 0.078-0.439, p=0.0001 and OR: 0.324, CI: 0.106-0.990, p=0.026). Also, the frequency of the 894T allele was significantly higher in patients with bladder cancer (51%). No association was identified for eNOS T-786C and intron 4 VNTR 4a/b polymorphisms between patients with bladder cancer and control groups in our Turkish population.

Development of dental charts according to tooth development and eruption for Turkish children and young adults

  • Karadayi, Beytullah;Afsin, Huseyin;Ozaslan, Abdi;Karadayi, Sukriye
    • Imaging Science in Dentistry
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    • v.44 no.2
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    • pp.103-113
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    • 2014
  • Purpose: In this study, we aimed to develop dental charts for Turkish children and young adults of both genders within the age group of 4.5-22.5 years according to tooth mineralization and eruption in a format similar to that proposed by AlQahtani et al. Materials and Methods: In total, 753 digital panoramic radiographs from 350 males and 403 females were assessed. The permanent teeth were evaluated according to the classification system described by Demirjian et al. The eruption stage was assessed with Bengston's system, which was modified by AlQahtani et al at four points. Results: Teeth generally developed earlier in females than in males. This was particularly notable in the age group of 5-14 years. However, this difference was usually visible in only one stage, not in all teeth. It has been determined that the mixed dentition period ended with the shedding of the second deciduous molars in both genders. Conclusion: The dental charts presented here included information that could be beneficial to dental clinicians in making appropriate diagnosis and planning orthodontic and surgical procedures. These charts also provided datasets for preliminary dental age estimation in Turkish children and young adults.

Patients' knowledge and awareness of dental implants in a Turkish subpopulation

  • Tomruk, Ceyda Ozcakir;Ozkurt-Kayahan, Zeynep;Sencift, Kemal
    • The Journal of Advanced Prosthodontics
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    • v.6 no.2
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    • pp.133-137
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    • 2014
  • PURPOSE. The purpose of this study was to evaluate the patients' knowledge on dental implants in a Turkish subpopulation. MATERIALS AND METHODS. Five hundred twenty seven Turkish adults referred to Yeditepe University Faculty of Dentistry, Istanbul, Turkey, were presented with a questionnaire including 20 questions regarding the level of information and awareness about the dental implants. The data were collected and statistical analyses were performed with Chi square test to compare the descriptive data. RESULTS. Among 527 subjects, 54% were female and 46% were male with a mean age of 42.2 years. The rate of patients' implant awareness was 27.7%. When the patients were questioned about the treatment options for rehabilitation of tooth missing, 60.9% of patients were informed about fixed partial denture, followed by conventional complete denture (32.5%) and removable partial denture (24.9%). Six percent reported that they were very well informed about the dental implants whereas 48.2% were poorly informed. The information sources of the implants were from the dentist (44.5%), printed media (31.6%) and friends and acquaintances (17.3%), respectively. Sixteen percent of the population believed that their implants would last forever. CONCLUSION. The dentists should give more detailed information to the patients about dental implants and tooth-supported fixed partial dentures in the future.

Breast Cancer Risk Assessment Using the Gail Model: a Turkish Study

  • Erbil, Nulufer;Dundar, Nursel;Inan, Cigdem;Bolukbas, Nurgul
    • Asian Pacific Journal of Cancer Prevention
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    • v.16 no.1
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    • pp.303-306
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    • 2015
  • Purpose: This study was conducted to determine risk of developing of breast cancer among Turkish women. Materials and Methods: Using a descriptive and cross-sectional approach, data were collected from 231 women. Breast cancer risk was calculated using the National Cancer Institute's on-line verson of called as the Breast Cancer Risk Assessment Tool or the Gail Risk Assesment Tool. Results: The average age of women was $45.0{\pm}8.06$ years. It was revealed that 6.1% of participants reported having first degree relatives who had had breast cancer, with only four women having more than one first-degree relative affected (1.7%). The mean five-year breast cancer risk for all women was $0.88{\pm}0.91%$, and 7.4% of women had a five-year breast cancer risk >1.66% in this study. Mean lifetime breast cancer risk up to age 90 years was $9.3{\pm}5.2%$. Conclusions: The breast cancer risk assessment tool can help in the clinical management of patient seeking advice concerning screening and prevention. Healthcare providers in Turkey can use this approach to estimate an individual's probability of developing breast cancer.