• Bulletin of the Korean Chemical Society
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• v.34 no.4
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• pp.1131-1136
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• 2013

Parabens, the esters of p-hydroxybenzoic acid, have been widely used as antimicrobial preservatives in cosmetic products, drugs, and processed foods and beverages. However, some parabens have been shown to have weak estrogenic effects through in vivo and in vitro studies. Because such widespread use has raised concerns about the potential human health risks associated with exposure to parabens, we developed a simultaneous analytical method to quantify 4 parabens (methyl, ethyl, propyl, and butyl) in human urine, by using solid-phase extraction and high-performance liquid chromatography coupled with triple quadrupole mass spectrometry. This method showed good specificity, linearity ($R^2$ > 0.999), accuracy (92.2-112.4%), precision (0.9-9.6%, CV), and recovery (95.7-102.0%). The LOQs for the 4 parabens were 1.0, 0.5, 0.2, and 0.5 ng/mL, respectively. This method could be used for quick and accurate analysis of a large number of human samples in epidemiological studies to assess the prevalence of human exposure to parabens.

• Journal of Astronomy and Space Sciences
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• v.16 no.1
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• pp.11-20
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• 1999

In this paper all the photoelectric times of minimum for the triple star SW Lyn have been analyzed in terms of light-time effect due to the third-body and secular period decreases induced by mass transfer process. The light-time orbit determined recently by Ogloza et al.(1998) were modified and improved. And it is found that the orbital period of SW Lyn have been decreasing secularly. The third-body revolves around the mass center of triple stars every $5^y.77$ in a highly eccentric elliptical orbit(e=0.61). The third-body with a minimum mass of $1.13M_{odot}$ may be a binary or a white dwarf. The rate of secular period-decrease were obtained as ${Delta}P/P=-12.45{ imes}10^{-11}$, implying the mass-transfer from the massive primary star to the secondary. The mass losing rate from the primary were calculated as about $1.24{ imes}10^{-8}M_{odot}/y$. It is noticed that the mass-transfer in SW Lyn system is opposite in direction to that deduced from it's Roche geometry by previous investigators.

• Earthquakes and Structures
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• v.7 no.4
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• pp.511-525
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• 2014

The main object of this study is to determine and compare the structural behavior of base isolated long span highway bridge, $G\ddot{u}lburnu$ Highway Bridge, using single concave friction pendulum (SCFP) and triple concave friction pendulum (TCFP). The bridge is seismically isolated in the design phase to increase the main period and reduce the horizontal forces with moments using SCFP bearings. In the content of the paper, firstly three dimensional finite element model (FEM) of the bridge is constituted using project drawings by SAP2000 software. The dynamic characteristics such as natural frequencies and periods, and the structural response such as displacements, axial forces, shear forces and torsional moments are attained from the modal and dynamic analyses. After, FEM of the bridge is updated using TCFP and the analyses are performed. At the end of the study, the dynamic characteristics and internal forces are compared with each other to extract the TCFP effect. To emphasize the base isolation effect, the non-isolated structural analysis results are added to graphics. The predominant frequencies of bridge non-isolated, isolated with SCFP and isolated with TCFP conditions decreased from 0.849Hz to 0.497Hz and 0.338Hz, respectively. The maximum vertical displacements are obtained as 57cm, 54cm and 44cm for non-isolated, isolated with SCFP and isolated with TCFP conditions, respectively. The maximum vertical displacement reduction between isolated with TCFP bearing and isolated with SCFP bearing bridge is %23. Maximum axial forces are obtained as 60619kN, 18728kN and 7382kN, maximum shear forces are obtained as 23408kN, 17913kN and 16249kN and maximum torsional moments are obtained as 24020kNm, 7619kNm and 3840kNm for non-isolated, isolated with SCFP and isolated with TCFP conditions, respectively.

• Annals of Surgical Treatment and Research
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• v.95 no.5
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• pp.240-248
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• 2018

Purpose: This study aimed to validate the synergistic effect of ABT-737 on docetaxel using MDA-MB-231, a triple negative breast cancer (TNBC) cell line overexpressing B-cell lymphoma-2 (Bcl-2). Methods: Western blot analysis was performed to assess expression levels of Bcl-2 family proteins and caspase-related molecules. Cell viability was assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Cell cycle distribution was determined by flow cytometry analysis. Benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone (z-VAD-fmk) was used for pretreatment to assess the role of caspases. Results: Cell viability of MDA-MB-231 after combination treatment with ABT-737 and docetaxel was significantly lower than that after docetaxel or ABT-737 monotherapy based on MTT assay (both P < 0.001), with a combination index of 0.41. The proportion of sub-G1 population after combination treatment was significantly higher than that after docetaxel or ABT-737 monotherapy (P = 0.001, P = 0.003, respectively). Pretreatment with z-VAD-fmk completely restored cell viability of MDA-MB-231 from apoptotic cell death induced by combination therapy (P = 0.001). Although pro-caspase-8 or Bid did not show significant change in expression level, pro-casepase-9 showed significantly decreased expression after combination treatment. Cleaved caspase-3 showed increased expression while poly (ADP-ribose) polymerase cleavage was induced after combination treatment. However, hypoxia-inducible factor 1-alpha and aldehyde dehydrogenase 1 totally lost their expression after combination treatment. Conclusion: Combination of ABT-737 with docetaxel elicits synergistic therapeutic effect on MDA-MB-231, a TNBC cell line overexpressing Bcl-2, mainly by activating the intrinsic pathway of apoptosis. Therefore, adjunct of ABT-737 to docetaxel might be a new therapeutic option to overcome docetaxel resistance of TNBCs overexpressing Bcl-2.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.40 no.6
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• pp.442-446
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• 2003

This paper proposes a new two-stage two-phase VPP charge pump configured in such a manner that body effect and the threshold voltage loss are eliminated. The newly proposed circuit is fabricated using 0.18um triple-well CMOS process and the measurement result shows that the VPP level tracks 3VDD when VDD is above the threshold voltage.

• Korean Management Science Review
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• v.32 no.3
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• pp.119-130
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• 2015

Previous studies have demonstrated that the three dimensions of Triple Bottom Line (TBL : economic, social, and environmental responsibility) indirectly affect product/corporate evaluation through reciprocity perception and trust (expertize-based trust and benevolence-based trust). Different from the past studies, this study investigates on the indirect effects as well as the direct effects of the three dimensions on product/corporate evaluation. The empirical results can be summarized as follows. First, reciprocity perception affects benevolence-based trust but it does not expertize-based trust. Second, the effect of economic dimension on product/corporate evaluation is not affected by reciprocity perception and benevolence-based trust, however, the effects of social dimension and environmental dimension on product/corporate evaluation are affected by reciprocity perception and benevolence-based trust.

• Transactions on Electrical and Electronic Materials
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• v.17 no.6
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• pp.329-334
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• 2016

In this work, the temperature dependence of electrical parameters of nanoscale SOI (silicon-on-insulator) TG (triple gate) n-FinFET (n-channel Fin field effect transistor) was investigated. Numerical device simulator $ATLAS^{TM}$ was used to construct, examine, and simulate the structure in three dimensions with different models. The drain current, transconductance, threshold voltage, subthreshold swing, leakage current, drain induced barrier lowering, and on/off current ratio were studied in various biasing configurations. The temperature dependence of the main electrical parameters of a SOI TG n-FinFET was analyzed and discussed. Increased temperature led to degraded performance of some basic parameters such as subthreshold swing, transconductance, on-current, and leakage current. These results might be useful for further development of devises to strongly down-scale the manufacturing process.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2007.11a
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• pp.107-108
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• 2007

• Journal of Digital Convergence
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• v.19 no.5
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• pp.127-133
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• 2021

This study studies the effect of social welfare service quality on facility reuse for users of social welfare facilities. The purpose of this study is to study the effect of the parallel triple mediation effect of facility image user loyalty and facility satisfaction. To this end 219 users of social welfare facilities were analyzed using SPSS 23.0 for Windows and Process macro. As a result, first the variables of service quality facility image user loyalty facility satisfaction and facility reuse all formed significant positive relationships. Second facility image user loyalty and facility satisfaction had multiple mediating effects. This study presented a new model using multivariate in response to social welfare facilities in pandemic situations.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.34 no.3
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• pp.301-307
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• 2010

Actuation using a shape memory alloy (SMA) is considered to be an important technology that will play a leading role in market for next-generation medical devices because an SMA actuator can accurately imitate skillful and delicate hand movements. However, SMA actuators have not been successfully used because of problems in control design caused by the nonlinear hysteresis effect of SMA, which leads to inaccuracies in control systems. In order to overcome the effect, the authors invented a SMA actuator, which could actively and rapidly cool down and heat up, by combining a SMA catheter and a TE module using the Peltier effect. In order to evaluate the TE characteristics of our TE module system, the changes in the temperature with 1) incremental increases in a continuous electric current and 2) the appearance of a discontinuous constant or reverse current are discussed in this paper.