• Health Policy and Management
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• v.6 no.2
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• pp.91-114
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• 1996

In this research, the Data Envelopment Analysis(DEA) was applied to measure production efficiency of Public Corporation Medical Centers(PCMCs) operating in Korea. The focus of this research is triple. First, identifing convenience and usefulness of DEA to measure the relative efficiency among PCMCs. Second, assessing magnitudes of the relative efficiency for each PCMC. Third, adding insights into some factors resulting inefficiency in PCMCs. Then, in this paper technical efficiency and scale efficiency measured by DEA[introduced by Charnes, Cooper, and Rhoides(1978) and Banker, Charnes, and Cooper(1984)] were analyzed and a new separate variable was introduced which makes it possible to determine whether operations were conducted in regions of increasing, constant or decresing returns to scale(in multiple input and output situations). And a multi-factor Tobit analysis was conducted to see which variables are associated with PCMC's efficiency.

• BMB Reports
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• v.53 no.5
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• pp.266-271
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• 2020

Breast cancer encompasses a major portion of human cancers and must be carefully monitored for appropriate diagnoses and treatments. Among the many types of breast cancers, triple negative breast cancer (TNBC) has the worst prognosis and the least cases reported. To gain a better understanding and a more decisive precursor for TNBC, two major histone modifications, an activating modification H3K4me3 and a repressive modification H3K27me3, were analyzed using data from normal breast cell lines against TNBC cell lines. The combination of these two histone markers on the gene promoter regions showed a great correlation with gene expression. A list of signature genes was defined as active (highly enriched H3K4me3), including NOVA1, NAT8L, and MMP16, and repressive genes (highly enriched H3K27me3), IRX2 and ADRB2, according to the distribution of these histone modifications on the promoter regions. To further enhance the investigation, potential candidates were also compared with other types of breast cancer to identify signs specific to TNBC. RNA-seq data was implemented to confirm and verify gene regulation governed by the histone modifications. Combinations of the biomarkers based on H3K4me3 and H3K27me3 showed the diagnostic value AUC 93.28% with P-value of 1.16e-226. The results of this study suggest that histone modification analysis of opposing histone modifications may be valuable toward developing biomarkers and targets for TNBC.

• Parasites, Hosts and Diseases
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• v.47 no.3
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• pp.235-241
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• 2009

The aim of this study was to estimate the benefit from repeated examinations in the diagnosis of enterobiasis in nursery school groups, and to test the effectiveness of individual-based risk predictions using different methods. A total of 604 children were examined using double, and 96 using triple, anal swab examinations. The questionnaires for parents, structured observations, and interviews with supervisors were used to identify factors of possible infection risk. In order to model the risk of enterobiasis at individual level, a similarity-based machine learning and prediction software Constud was compared with data mining methods in the Statistica 8 Data Miner software package. Prevalence according to a single examination was 22.5%; the increase as a result of double examinations was 8.2%. Single swabs resulted in an estimated prevalence of 20.1% among children examined 3 times; double swabs increased this by 10.1%, and triple swabs by 7.3%. Random forest classification, boosting classification trees, and Constud correctly predicted about 2/3 of the results of the second examination. Constud estimated a mean prevalence of 31.5% in groups. Constud was able to yield the highest overall fit of individual-based predictions while boosting classification tree and random forest models were more effective in recognizing Enterobius positive persons. As a rule, the actual prevalence of enterobiasis is higher than indicated by a single examination. We suggest using either the values of the mean increase in prevalence after double examinations compared to single examinations or group estimations deduced from individual-level modelled risk predictions.

• Fashion & Textile Research Journal
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• v.20 no.1
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• pp.34-49
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• 2018

Sustainability in fashion pertains to all stages within the product lifecycle, starting with the procurement of raw materials and ending with the disposal of the product. To clarify, the Lifecycle Management (LCM) views the Triple Bottom Line (TBL) from the perspective of a product's lifecycle. Sustainable products are identified based on their lifecycle, causing public attention to turn towards Product Lifecycle Management (PLM). As of now, PLM is largely known to have a strong impact on New Product Development (NPD). As such, the objective of this research is to study how PLM-based sustainable NPD models, when applied to the fashion industry, can produce a wide understanding of sustainable fashion products from a variety of angles. In order to achieve the research objective, this study did a selective case study on 20 sustainable fashion brands; conducted 1:1 in-depth interviews with 24 fashion experts, including both sustainable and non-sustainable experts; and took part in participant observation of 5 sustainable fashion brands. The results of the study indicate that there are specific conditions that must be met at each stage of production for the development of sustainable products by fashion brands. However, due to the lack of technological skills and the dearth of sustainability experts within the organization, management, monitoring and systematic collection of data is not properly implemented - leading to problems with the quantification of crucial data. This study aims to further forward the debate regarding the development of sustainable fashion products and its future implications.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.39 no.12
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• pp.1033-1044
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• 2002

In this Paper, a new FRAM design technique utilizing grounded-plate PMOS-gate (GPPG) ferroelectric cell is proposed. A GPPG cell consists of a PMOS access transistor and a ferroelectric data storage capacitor. Its plate is grounded. The proposed architecture employs three novel methods for cell operation: 1) $V_{DD}$ -precharged bitline, 2) negative-voltage wordline technique and 3) negative-pulse restore. Because this configuration doesn't need the plate control circuitry, it can greatly increase the memory cell efficiency. In addition, differently from other reported common-plate cells, this scheme can supply a sufficient voltage of $V_{DD}$ to the ferroelectric capacitor during detecting and storing the polarization on the cell. Thus, there is no restriction on low voltage operation. Furthermore, by employing a compact column-path circuitry which activates only needed 8-bit data, this architecture can minimize the current consumption of the memory array. A 4- Mb FRAM circuit has been designed with 0.3-um, triple-well/1-polycide/2-metal technology, and the possibility of the realization of GPPG cell architecture has been confirmed.

• Proceedings of the KSME Conference
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• 2008.11a
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• pp.1467-1470
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• 2008

An upper tibial opening wedge osteotomy is an operation to cure a malalignment and a degenerate arthritis. To prevent the postoperative malalignment caused by the upper tibial opening wedge osteotomy, the research to define the relationship between a Hinge Axis Angle and a Posterior Slope Angle is needed. The effect of the relationship between the hinge axis angle and the gap angle on the posterior slope angle is studied. After 3-D Compute Tomography (CT) scanning image is reconstructed, the virtual surgery is performed by the reconstructed 3-D tibia model. It was proved that the relationship between the hinge axis angle and the gap angle were constant and the simple mathematical model could be derived. To verify the suggested mathematical model, it compared with the measured data from the virtual surgery. In conclusion, while the deviation between the data from the virtual surgery and ones of the mathematical model under the gap angle<$10^{\circ}$ was less than 1%.

• Journal of Convergence for Information Technology
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• v.10 no.1
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• pp.139-148
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• 2020

As the internet and computer technology are developed, there is a need for service of traditional culture that can effectively search and create culture, history, and tradition-related materials in online contents. In this paper, we developed an RDF-based ontology retrieval service platform and verified usability and validity. This platform is divided into triple search, keyword search, network graph search, story search and management, curation management module. Based on this, the search results can be visualized based on the relationship between data, network graph search and story search can be used to easily understand the relationship between the keywords. An platform evaluation was conducted for verification, and it was evaluated that an intelligent search that can easily identify the relationship between information and shorten the analysis and search time than the existing search function.

• Genomics & Informatics
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• v.19 no.2
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• pp.17.1-17.13
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• 2021

Breast cancer is one of the leading causes of cancer in women all over the world and accounts for ~25% of newly observed cancers in women. Epigenetic modifications influence differential expression of genes through non-coding RNA and play a crucial role in cancer regulation. In the present study, epigenetic regulation of gene expression by in-silico analysis of histone modifications using chromatin immunoprecipitation sequencing (ChIP-Seq) has been carried out. Histone modification data of H3K4me3 from one normal-like and four breast cancer cell lines were used to predict miRNA expression at the promoter level. Predicted miRNA promoters (based on ChIP-Seq) were used as a probe to identify gene targets. Five triple-negative breast cancer (TNBC)-specific miRNAs (miR153-1, miR4767, miR4487, miR6720, and miR-LET7I) were identified and corresponding 13 gene targets were predicted. Eight miRNA promoter peaks were predicted to be differentially expressed in at least three breast cancer cell lines (miR4512, miR6791, miR330, miR3180-3, miR6080, miR5787, miR6733, and miR3613). A total of 44 gene targets were identified based on the 3'-untranslated regions of downregulated mRNA genes that contain putative binding targets to these eight miRNAs. These include 17 and 15 genes in luminal-A type and TNBC respectively, that have been reported to be associated with breast cancer regulation. Of the remaining 12 genes, seven (A4GALT, C2ORF74, HRCT1, ZC4H2, ZNF512, ZNF655, and ZNF608) show similar relative expression profiles in large patient samples and other breast cancer cell lines thereby giving insight into predicted role of H3K4me3 mediated gene regulation via the miRNA-mRNA axis.

• Journal of Korea Water Resources Association
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• v.52 no.1
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• pp.11-19
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• 2019

In this study, the actual evapotranspiration products of Global Land Data Assimilation System (GLDAS), Global Land Evaporation Amsterdam Model (GLEAM) and MOD16, which are satellite- and reanalysis-based dataset, were validated at the flux tower sites (i.e., CFK and SMK) managed by Korea Institute of Hydrological Survey, and the uncertainty and correlation analysis were conducted using Triple Collocation (TC) method. The result of validation with the flux tower showed better agreement in the order of GLEAM> GLDAS>MOD16. At the result of three combinations (S1: flux tower vs. GLDAS vs. MOD16, S2: flux tower vs. GLDAS vs. GLEAM, S3: flux tower vs. GLEAM vs. MOD16), the order of best to worst is GLEAM, GLDAS, MOD16, and flux tower for CFK (GLDAS> GLEAM>MOD16>flux tower for SMK). Since the error variance and correlation coefficients of the flux tower show relatively worse performance in TC analysis than the other products, By applying TC method to three products (GLDAS vs. GLEAM vs. MOD16), the uncertainty of each dataset were evaluated at the Korean Peninsula, As a results, the GLDAS and GLEAM performed reasonable performance (low error variance and high correlation coefficient), whereas results of MOD16 showed high error variance and low correlation coefficient at the cropland.

• Journal of Contemporary Eastern Asia
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• v.17 no.2
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• pp.200-221
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• 2018

Open Science is an umbrella term that involves various movements aiming to remove the barriers to sharing any kind of output, resources, methods or tools at any stage of the research process. While the study of open science is relatively advanced in Western countries, we know of no scholarship that attempts to understand open science in Hong Kong. This paper provides a broad-based background on the major research data management organisations, policies and institutions with the intention of laying a foundation for more rigorous future research that quantifies the benefits of open access and open data policies. We explore the status and prospects for open science (open access and open data) in the context of Hong Kong and how open science can contribute to innovation in Hong Kong. Surveying Hong Kong's policies and players, we identify both lost research potential and provide positive examples of Hong Kong's contribution to scientific research. Finally, we offer suggestions regarding what changes can be made to address the gaps we identify.