• BMB Reports
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• v.34 no.5
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• pp.391-394
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• 2001

The balance between life and death of a cell regulates essential developmental processes in multicellular organisms. Apoptotic cell death is a complex, stepwise program involving multiple protein components that trigger and execute the demise of the cell. Of the many triggers of apoptosis, most are not well understood, but some key components have been identified, such as those of the Bcl-2 family, which function as anti-apoptotic or proapoptotic factors. Bax, a pro-apoptotic member of this family, has been shown to serve as a component of many apoptotic triggering cascades and its mechanism of action is the focus of intense study. Herein we discuss current, differing ideas on the function of Bax and its structure, and suggest novel mechanisms for how this death protein targets mitochondria, triggering apoptosis.

• Journal of the Korean Geotechnical Society
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• v.31 no.5
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• pp.47-58
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• 2015

Triggering rainfall and geologic conditions with the state of slope hazard were investigated based on the field investigation and collected data on the slope hazard during the period between 2011 and 2014 in Korea. Analysis results showed that most of slope hazards occurred in metamorphic rock and debris flow was the most frequent type of slope hazard. Slope hazard increased when the higher monthly mean rainfall was recorded. However, most of slope hazard occurred when certain time elapsed after the moment of maximum hourly rainfall. Finally, more than one month of long-term rainfall was shown to be related to the frequency of slope hazard in the period.

• The Journal of Korea Institute of Information, Electronics, and Communication Technology
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• v.12 no.2
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• pp.150-154
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• 2019

In the design of semiconductor integrated circuits, ESD is one of the important issues related to product quality improvement and reliability. In particular, as the process progresses and the thickness of the gate oxide film decreases, ESD is recognized as an important problem of integrated circuit design. Many ESD protection circuits have been studied to solve such ESD problems. In addition, the proposed device can modify the existing SCR structure without adding external circuit to effectively protect the gate oxide of the internal circuit by low trigger voltage, and prevent the undesired latch-up phenomenon in the steady state with high holding voltage. In this paper, SCR-based novel ESD(Electro-Static Discharge) device with the high holding voltage has been proposed. The proposed device has the lower triggering voltage without an external trigger circuitry and the high holding voltage to prevent latch-up phenomenon during the normal condition. Using TCAD simulation results, not only the design factors that influence the holding voltage, but also comparison of conventional ESD protection device(ggNMOS, SCR), are explained. The proposed device was fabricated using 0.35um BCD process and was measured electrical characteristic and robustness. In the result, the proposed device has triggering voltage of 13.1V and holding voltage of 11.4V and HBM 5kV, MM 250V ESD robustness.

• 한국연소학회:학술대회논문집
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• 2012.04a
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• pp.77-78
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• 2012

To predict combustion instability in actual full-scale combustion chamber of rocket engines, air-injection test is proposed with scaling techniques. From the data, damping factors have been obtained as a function of hydraulic parameter and the data give us instability map. Two instability regions are presented and it is found that they coincide reasonably with them from hot-fire test with full-scale flow rates. Accordingly, the proposed approach can be applied cost-effectively to stability rating of jet injectors when mixing of fuel and oxidizer jets is the dominant process in instability triggering.

• Proceedings of the KSMRM Conference
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• 2002.11a
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• pp.67-72
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• 2002

Real-time techniques are motivated by a number of factors including the potential for direct acquisition of diagnostic quality images, facilitation of patient-specific imaging parameters, and reduced examination time. Real-time MRI includes not only a rapid pulse sequence but also high speed image reconstruction and easy interactivity. The frame rate of the real-time technique used should be matched to the physiological timeframes under study. Principal applications thusfar have been in localization, fluoroscopic triggering, guidance of other processes, and potentially in the generation of diagnostic images of moving structures.

• Proceedings of the KIEE Conference
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• 2006.04a
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• pp.279-281
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• 2006

In this paper, we study an approach to design a self-tuning Fuzzy-PI controller in HVDC(High Voltage Direct Current) system. In the rectifier of conversional HVDC system, turning on, turning off, triggering and protections of thyristors have lots of problems that can make the dynamic instability and cannot damp the dynamic disturbance efficiently. The above problems are solved by adapting Fuzzy-PI controller for the fire angle control of rectifier.[7] The performance of the Fuzzy-PI controller is sensitive to the variety of scaling factors. The design procedure dwells on the use of evolutionary computing(Genetic Algorithms, GAs). Then we can obtain the optimal scaling factors of the Fuzzy-PI controller by Genetic Algorithms. In order to improve Fuzzy-PI controller, we adopt FIS to tune the scaling factors of the Fuzzy-PI controller on line. A comparative study has been performed between Fuzzy-PI and self-tuning Fuzzy-PI controller, to prove the superiority of the proposed scheme.

• The Journal of Engineering Geology
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• v.28 no.1
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• pp.47-59
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• 2018

At present, there has been a wide range of studies on debris flow in Korea, more specifically, on rainfall characteristics that trigger debris flow including rainfall intensity, rainfall duration, and preceding rainfall. the prediction of landslide / debris flow relies on the criteria for landslide watch and warning by the Korea Forest Service (KFS, 2012). Despite this, it has been found that most incidents of debris flow were caused by rainfall above the level of landslide watch, maximum hourly rainfall, extensive damage was caused even under the watch level. Under these circumstances, we calculated a rainfall triggering index (RTI) using the main factors that trigger debris flow-rainfall, rainfall intensity, and cumulative rainfall-to design a more sophisticated watch / warning criteria than those by the KFS. The RTI was classified into attention, caution, alert, and evacuation, and was assessed through the application of two debris flow incidents that occurred in Umyeon Mountain, Seoul, and Cheongju, Inje, causing serious damage and casualties. Moreover, we reviewed the feasibility of the RTI by comparing it with the KFS's landslide watch / warning criteria (KFS, 2012).

• Molecules and Cells
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• v.39 no.4
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• pp.286-291
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• 2016

Epstein-Barr virus (EBV) is the prototypical ${\gamma}$-herpesvirus and an obligate human pathogen that infects mainly epithelial cells and B cells, which can result in malignancies. EBV infects these target cells by fusing with the viral and cellular lipid bilayer membranes using multiple viral factors and host receptor(s) thus exhibiting a unique complexity in its entry machinery. To enter epithelial cells, EBV requires minimally the conserved core fusion machinery comprised of the glycoproteins gH/gL acting as the receptor-binding complex and gB as the fusogen. EBV can enter B cells using gp42, which binds tightly to gH/gL and interacts with host HLA class II, activating fusion. Previously, we published the individual crystal structures of EBV entry factors, such as gH/gL and gp42, the EBV/host receptor complex, gp42/HLA-DR1, and the fusion protein EBV gB in a postfusion conformation, which allowed us to identify structural determinants and regions critical for receptor-binding and membrane fusion. Recently, we reported different low resolution models of the EBV B cell entry triggering complex (gHgL/gp42/HLA class II) in "open" and "closed" states based on negative-stain single particle electron microscopy, which provide further mechanistic insights. This review summarizes the current knowledge of these key players in EBV entry and how their structures impact receptor-binding and the triggering of gB-mediated fusion.

• Asian Journal of Business Environment
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• v.5 no.3
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• pp.5-15
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• 2015

Purpose - This paper aims to identify and rank factors that influence impulse buying behavior among shoppers in Dubai. Research design, data, and methodology - Questionnaires were collected from 168 Dubai shoppers using non-probability quota sampling. Factor Analysis was completed to identify factors triggering impulse buying traits. Results - Six antecedent factors were identified: hedonism, in-store influences, product related influences, socialization, promotional activities, and convenience. Surprisingly, product related influences were the most significant in stimulating impulse buying behavior. Conclusions - This research suggests that a multitude of factors affect shopper propensity for impulse buying, with non-economic factors like product and in-store related influences having a significant impact. Hence, retail managers should concentrate on these in merchandising and promotional efforts. Against the backdrop of Dubai, one of the biggest retail destinations, this study contributes to present knowledge on impulse buying behavior. In terms of shopper inclinations and likeliness to purchase products, it highlights how shoppers respond to special in-store displays and discount offerings. For marketers, the findings regarding relative significance of various factors may help in strategies to attract consumers.

• Korean Security Journal
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• no.15
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• pp.89-105
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• 2008

The aim of this study is to examine the primary causes of security guard's stress by conducting a survey of 50 guards engaging in security companies in Seoul and Gyeonggido. The following results are attained by an inductive content analysis of conviction interview data through in-depth interview of qualitative study method. 1. Factors of stress related to personal problems. The stress by personal problems is resulted from two factors. One is the physical strength inferiority, which leads to negative thoughts, dismay, mental conflict and tension. The other is complex about not-specializing security, which causes discord with his/her supervisor or co-workers and a feeling of uneasiness. 2. Factors of stress related to human relationship. The stress due to human relations is constantly resulted from discord with his/her supervisor and inclined to be accumulated. The mental conflict is elated in feeling that the manager's instructions are not right. So this factor makes them want change of occupation. Also working conditions are different from those of their friends, which causes them not to spend a lot of time with their friends. 3. Factors of stress related to domestic life It appears that most security guards are under stress due to their spouses' discontent with a small number of wages. Also it is reported that male guards are under stress in case of unhappy conjugal relations. And security guard's life is restricted much more than that of workers in a general occupation because of standing ready for mobilization and 24-hour service. So some of male guards experienced an early symptoms of a morbid suspicion about their wife's chastity and are suffering from insomnia as an occupational disease.