• Title/Summary/Keyword: Trial registration

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Single Cross Maize Hybrid 'Hwangdaok' for High Grain Yield (다수성 종실용 옥수수 단교잡 신품종 '황다옥')

  • Son, Beom-Young;Baek, Seong-Bum;Kim, Jung-Tae;Lee, Jin-Seok;Bae, Hwan-Hee;Go, Young-Sam;Kim, Sun-Lim
    • Korean Journal of Breeding Science
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    • v.51 no.2
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    • pp.105-109
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    • 2019
  • 'Hwangdaok', a new maize F1 hybrid (Zea mays L.), was developed by the maize breeding team at the National Institute of Crop Science (NICS), RDA in 2016. The high-yielding yellow dent hybrid named 'Hwangdaok' was obtained by crossing between two inbred lines, 'KS203' and 'KS190'. After advanced yield trial in Suwon in 2012, regional yield trial was subsequently carried out to evaluate the growth and yield of 'Hwangdaok' at three different locations from 2014 to 2016. The number of days to silking of 'Hwangdaok' is 76. The plant height is 262 cm and ear height ratio is 51%, which are similar to those of 'Jangdaok'. It has resistance to lodging. The number of ears per 100 plants is 95. The ear length is 21.3 cm and weight of 100 seeds is 34.7 g, similar to those of 'Jangdaok'. It has moderate resistance to southern leaf blight (Bipolaris maydis) and European corn borer (Ostrinia nubilalis). The grain yield (10 ton/ha) of 'Hwangdaok' is 6% higher than that of 'Jangdaok'. The seed production rate of 'Hwangdaok' is acceptable due to good synchronization of flowering period during crossing between the seed parent, KS203, and the pollen parent, KS190, in Yeongwol. F1 seed yield was 1.68 ton/ha. 'Hwangdaok' can be a suitable cultivar to plain areas in Korea. (Variety registration No. 7502).

Multi-Source/Multi-Use Model of Storytelling Related to Patent (특허 연계 스토리텔링의 멀티소스/멀티유즈 모델)

  • Lee, Ga-Hee;Lee, Sang-Zee
    • The Journal of the Korea Contents Association
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    • v.15 no.10
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    • pp.447-456
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    • 2015
  • In this paper a new model of storytelling related to patent in the field of business as a sort of Intellectual Property(IP) was proposed. The patent related storytelling is investigated in the view points of variety of customers, purposes and applications which is different from the conventional OSMU, transmedia or crossmedia storytelling. In business there are several stages related to patent such as the initial conceptualization and development of technology, apply for and registration of patent, legal conflict like patent invalidation trial and action for infringement of patent and damages, and the commercialization stage like development of product based on patent, advertisement and marketing. Multiple sources optimized to the purpose in each stage of patent related business as well as to multiple convergence application of a patent. Similarly, multi-use refers to the fact that storytelling can be applied in each stage of patent oriented business. The effectiveness and usefulness of proposed MSMU model is also investigated.

A Study on the Need for Arbitration and Agreement in Sports Disputes (스포츠중재의 필요성과 중재합의에 관한 고찰)

  • Jeon, Hong-Gu
    • Journal of Arbitration Studies
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    • v.26 no.1
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    • pp.3-27
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    • 2016
  • There is a need for disputes in sports to be settled by arbitration rather than a court ruling, taking the unique characteristics of sports into consideration. Arbitration is a form of alternative dispute resolution (ADR). A dispute resolution system is regarded as: an arbitrator is selected by the agreement between the parties, and a binding decision is made, which the parties obey, consequently resulting in a final resolution. To resolve a dispute upon arbitration, there must be an arbitration agreement upon the free will of the parties. In relation to the arbitration agreement, however, there are some cases in which sports organizations have an arbitration clause in the articles of association, regulations or player registration application that call for settling disputes by arbitration. In such cases, the validity of the arbitration agreement may create doubt whether or not this sort of arbitration has been made by mutual agreement. Consequently this is required to be legally examined. The activities of a sports organization are recognized as part of private autonomy, and they include even the rights that establish regulations or rules. Nonetheless, the powers that such sport organizations are able to establish are not allowed without limit. However, sports activities and autonomy shall be protected as themselves. Therefore, if we give priority to arbitration upon the independent arbitrator and fair process by establishing an independent arbitral organization in charge of sports disputes to handle the effective resolution of disputes and protect sports autonomy and ask for a court decision if one party disobeys the arbitration, or the sports arbitration prepositive principle, it seems helpful to resolve the unfairness of compulsory jurisdiction and the clause for sports arbitration and protect the player's right of choice and of claims for trial.

The Development of a Trial Curriculum Classification and Coding System Using Group Technology

  • Lee, Sung-Youl;Yu, Hwa-Young;Ahn, Jung-A;Park, Ga-Eun;Choi, Woo-Seok
    • Journal of Engineering Education Research
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    • v.17 no.4
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    • pp.43-47
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    • 2014
  • The rapid development of science & technology and the globalization of society have accelerated the fractionation and specialization of academic disciplines. Accordingly, Korean colleges and universities are continually dropping antiquated courses to make room for new courses that better meet societal demands. With emphasis placed on providing students with a broader range of choices in terms of course selection, compulsory courses have given way to elective courses. On average, 4 year institutions of higher learning in Korea currently offer somewhere in the neighborhood of 1,000 different courses yearly. The classification of an ever growing list of courses offered and the practical use of such data would not be possible without the aid of computers. For example, if we were able to show the pre/post requisite relationship among various courses as well as the commonalities in substance among courses, such data generated regarding the interrelationship of different courses would undoubtedly greatly benefit the students, as well as the professors, during course registration. Furthermore, the GT system's relatively simple approach to course classification and coding will obviate the need for the development of a more complicated keyword based search engine, and hopefully contribute to the standardization of the course coding scheme in the future..Therefore, as a sample case project, this study will use GT to classify and code all courses offered at the College of Engineering of K University, thereby developing a system that will facilitate the scanning of relevant courses.

Smoking Relapse and Related Factors Within One Year Among Successes of the Smoking Cessation Clinics of Public Health Centers (보건소 금연클리닉 금연성공자의 1년내 재흡연과 관련요인)

  • Kim, Mi-Jag;Jeong, Ihn-Sook
    • Journal of Preventive Medicine and Public Health
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    • v.44 no.2
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    • pp.84-92
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    • 2011
  • Objectives: This study aimed to investigate smoking relapse and the related factors within 1 year after discharge from the smoking cessation clinics (SCCs) of public health centers (PHCs). Methods: Data were collected with a structured questionnaire from 395 people who success fully stopped smoking at 4 SCCs in Busan between May and June 2009, and this data were analyzed by Kaplan-Meier survival curves and the Cox proportional hazard model. Results: The rate of smoking relapse within 1 year after discharge from SCCs was 39.2% and this decreased rapidly over 6 months after discharge. The factors related to smoking relapse within 1 year after discharge from SCCs were being female (HR, 2.11; 95% CI, 1.17 to 3.82), a trial of smoking cessation with any assistants (HR, 1.95; 95% CI, 1.19 to 3.19), more than 7 ppm of exhaled CO2 on the SCCs' registration (HR, 1.81; 95% CI, 1.24 to 2.64), use of pharmacotherapy after discharge from SCCs (HR, 2.00; 95% CI, 1.36 to 2.93), alcohol drinking more than once a week after discharge from SCCs (HR, 3.32; 95% CI, 2.15 to 6.78), and a perceived barrier (HR, 1.21; 95% CI, 1.14 to 1.30) after discharge from the SCCs. Conclusions: According to the results, at least 6 months follow-up after discharge from SCCs of public health centers is recommended to reduce the rate smoking relapse. It is also recommended to strengthen the education on how to overcome barriers such as drinking in the course of smoking cessation clinics.

Optimal Timing of Zoster Vaccination After Shingles: A Prospective Study of the Immunogenicity and Safety of Live Zoster Vaccine

  • Lee, Eunyoung;Chun, June Young;Song, Kyoung-Ho;Choe, Pyoeng Gyun;Bang, Ji Hwan;Kim, Eu Suk;Kim, Hong Bin;Park, Sang Won;Kim, Nam Joong;Park, Wan Beom;Oh, Myoung-don
    • Infection and chemotherapy
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    • v.50 no.4
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    • pp.311-318
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    • 2018
  • Background: Zoster vaccination is recommended for people with a history of herpes zoster (HZ), but the most effective timing of vaccine administration after zoster illness is unresolved. This prospective observational study compared the immunogenicity and safety of administering HZ vaccine at 6-12 months and 1-5 years after zoster illness. Materials and Methods: Blood samples were collected before the administration of live zoster vaccine and 6 weeks after vaccination. Varicella-zoster virus (VZV) IgG concentrations and T-cell responses were assessed by glycoprotein enzyme-linked immunosorbent assay and interferon-${\gamma}$ enzyme-linked immunospot assay (ELISPOT), respectively. Results: The baseline geometric mean value (GMV) of VZV IgG was higher in the 6-12 months group than in the 1-5 years group (245.5 IU/mL vs. 125.9 IU/mL; P = 0.021). However, the GMV increased significantly in both groups (P = 0.002 in the 6-12 months group; P <0.001 in the 1-5 years group). The results of the ELISPOT assay were not significant for differences of the GMV between baseline and 6-week post-vaccination groups, while the GMV increased significantly in both groups (P = 0.001 in the 6-12 months group; P <0.001 in the 1-5 years group). Conclusion: The immunogenicity of zoster vaccine may be similar whether administered 6-12 months, or >1 year after zoster illness. Trial Registration: ClinicalTrials.gov Identifier: NCT02704572

Quality Over Volume: Modeling Centralization of Gastric Cancer Resections in Italy

  • Lorenzon, Laura;Biondi, Alberto;Agnes, Annamaria;Scrima, Ottavio;Persiani, Roberto;D'Ugo, Domenico
    • Journal of Gastric Cancer
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    • v.22 no.1
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    • pp.35-46
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    • 2022
  • Background: The correlation between hospital volume and postoperative outcomes has led to the centralization of complex procedures in several countries. However, the results reported in relation to gastric cancer (GC) are contradictory. This study aimed to analyze GC surgical volumes and 30-day postoperative mortality in Italy and to provide a simulation for modeling centralization of GC resections based on district case volumes. Methods: A national registry was used to identify all GC resections, record mortality rates, and track the national in-border GC resection health travel. Hospitals were grouped according to caseload. Centralization of all GC procedures performed within the same district was modeled. The outcome measures were a minimal volume of 25 GC resections/year and the 30-day postoperative mortality. Results: In 2018, 5,873 GC resections were performed in 498 Italian hospitals (mean resections per hospital per year: 11.8); the postoperative mortality rate (5.51%) was tracked from 2016-2018. GC resection health travel ranged from 2% to 50.5%, with a significant (P<0.001) difference between northern and central/southern Italy. The mean mortality rate was 7.7% in hospitals performing one to 3 GC resections per year, compared with 4.7% in those with >17 GC resections/year (P≤0.01). Most Italian districts achieved 25 procedures/year after centralization; however, 66.3% of GC cases in southern Italy vs. 42.2% in central and 52.7% in the northern regions (P<0.001) required reallocation. Conclusion: Postoperative mortality after GC resection correlated with hospital volume. Despite health travel, most Italian districts can reach a high-volume threshold, but discrepancies in mortality rates are alarming.Trial RegistrationResearch Registry Identifierresearchregistry6869

Development of Sports Events Management Process and Conformance Assessment (스포츠이벤트 매니지먼트 프로세스 개발 및 적합성 평가)

  • Kim, Joo-Hak;Kim, Joo-Yong;Cho, Sun-Mi
    • Asia-pacific Journal of Multimedia Services Convergent with Art, Humanities, and Sociology
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    • v.7 no.7
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    • pp.691-700
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    • 2017
  • International sports events is one of the core products in the sports industry the scale of sports event business is steadily increasing. However, In terms of sports event management, knowledge and experience generated through sports events are ineffective and non-systematically managed. For this reason, unnecessary resources are wasted and trial and error are repeated in hosting, preparing and operating in sports event management. The purpose of this study is to develop a sports event management process and evaluate conformance. To accomplish the purpose of this study, developed the core processes of sports events in step by step and then applied and conformance evaluated of the designed process. Developed and evaluated sports events management processes are five Functional Area of registration, accommodation, transport, broadcasting, and food and beverage. Of these FA, 63 activities were selected and analyzed. The modeling was used as IDEF method, the conformity analysis was used as Fuzzy logic, analysis tool was used ProM.

The Comorbidity of Anxiety Disorder in Depressed Patients : A CRESCEND(Clinical Research Center for Depression in Korea) Cohort Study (우울증 환자에서 불안장애의 동반이환 : 우울증 임상연구센터 코호트연구)

  • Sakong, Jeong-Kyu;Lee, Do-Yun;Suh, Ho-Suk;Sung, Hyung-Mo;Kim, Jung-Bum;Jung, Young-Eun;Lee, Min-Soo;Kim, Jae-Min;Jo, Sunjin
    • Mood & Emotion
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    • v.9 no.1
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    • pp.30-36
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    • 2011
  • Purpose : Anxiety disorder and depressive disorder are often comorbid with each other, and the comorbidity is associated with poorer psychiatric outcome, resistance to treatment, increased risk for suicide, greater chance for recurrence. We aimed to investigate the comorbidity of anxiety disorder in Korea. Method : Subjects were total of 867 depressed patients recruited CRESCEND-K multicenter trial. We used SCID (Structured Clinical Interview for DSM - IV) to find comorbidity of anxiety disorders in depressed patient. Results : Of 867 patients, total 8.2% had anxiety disorder. Proportion of anxiety disorder Not Otherwise Specified was 3.5%, panic disorder was 1.7%, generalized anxiety disorder was 1.1%, post traumatic stress disorder was 0.9%, obsessive compulsive disorder was 0.6%, social phobia was 0.4%. Conclusion : In this study, anxiety disorder in depression were measured at a low comorbidity rate in compare to previous studies. Selection bias, use of antidepressants at registration, severity of depression symptoms, and point of SICD administration seems to have affected these results. It is probable that comorbidity evaluation would be more precise if shorter, structured interviews such as M. I.N.I.-Plus were used during first clinical interview for depression diagnosis.

A Single Center Study on the Evaluation of Safety after Single Oral Administration of Peony Root Extract Tablets (작약엑스정 1회 경구 투여의 안전성 평가에 관한 연구)

  • Su-Hak Kim;Jeong-Su Park;Tae-Seong Jeong;Seung-Hyun Oh;Young-Dal Kwon
    • Journal of Korean Medicine Rehabilitation
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    • v.34 no.3
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    • pp.89-96
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    • 2024
  • Objectives This study is designed to evaluated the safety of peony root extract tablet in healthy male volunteers. Methods 12 healthy male volunteers were recruited, and this study was conducted by a single center. The safety was evaluated by collecting laboratory test and vital signs of volunteers. As the registration process, 12 subjects were assigned by serial number. To evaluate safety, vital signs were checked and blood samples were collected 4 times during the screening period, pre & post-administration (after 8 hours) and post-administration (after 7 days). The difference in variables was summarized by the mean±standard deviation. The normality test was carried out using the Shapiro-Wilk test and Kolmogorov-Smirnov test. When normality is fulfilled, a paired t-test is applied and the significance level was p<0.05. And the incidence of all adverse effects and serious adverse effects are shown in percentage. Results In the case of vital sign, body temperature (BT) (℃) was 0.06±0.05 ℃ (p=0.008), and there was a statistically significant difference in before and after administration. However, clinical symptoms were not occurred and BT (℃) of all subjects before and after administration showed values within the normal reference value. There was no significant difference from the control group in all other vital signs and laboratory test data. And no side-effects associated to clinical trial drugs were followed. Conclusions The peony root extract tablet was considered to be safe for healthy male volunteers.