• Translational and Clinical Pharmacology
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• 제25권2호
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• pp.67-73
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• 2017

Glimepiride, a third generation sulfonylurea, is an antihyperglycemic agent widely used to treat type 2 diabetes mellitus. In this study, an untargeted urinary metabolomic analysis was performed to identify endogenous metabolites affected by glimepiride administration. Urine samples of twelve healthy male volunteers were collected before and after administration of 2 mg glimepiride. These samples were analyzed by liquid chromatography-tandem mass spectrometry (LC-MS/MS), and then subjected to multivariate data analysis including principal component analysis and orthogonal partial least squares discriminant analysis. Through this metabolomic profiling, we identified several endogenous metabolites such as adenosine 3', 5'-cyclic monophosphate (cAMP), quercetin, tyramine, and urocanic acid, which exhibit significant metabolomic changes between pre- and posturine samples. Among these, cAMP, which is known to be related to insulin secretion, was the most significantly altered metabolite following glimepiride administration. In addition, the pathway analysis showed that purine, tyrosine, and histidine metabolism was affected by pharmacological responses to glimepiride. Together, the results suggest that the pharmacometabolomic approach, based on LC-MS/MS, is useful in understanding the alterations in biochemical pathways associated with glimepiride action.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2004년도 춘계학술대회논문집
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• pp.438-441
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• 2004

Reduction of a ship's rolling is the most important performance requirement for improving the safety of the crew on board and preventing damage to cargos as well as improving the comfort of the ride. A mass driving anti-rolling system (MD-ARS) might be one candidate of several systems against the ship's rolling. In this paper, a sea-trial test on a pendulum-type MD-ARS passively operated is carried out in Suyoung, Busan. After the system is installed on the cabin of the small leisure boat, a series of test is conducted before and after operating the system. Through the test, it is confirmed that the roll rate of the ship is pretty well reduced by the system.

• 한방비만학회지
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• 제17권2호
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• pp.87-95
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• 2017

Objectives: This study was conducted to evaluate efficacy and safety of Punica granatum L. Actinidia chinensis Planch. mixed extract on body fat. Methods: Thirty women were recruited ($25kg/m^2{\leq}body$ mass index [BMI]${\leq}29.9kg/m^2$) ($19yr{\leq}age{\leq}38yr$) and randomized to receive Punica granatum L. Actinidia chinensis Planch. mixed extract or placebo for 8 weeks. During the test, they visited four times including screening. Body fat mass, body fat rate, anthropometric dimensions at waist and hip, waist-hip ratio, total cholesterol, triglyceride, low density lipoprotein-cholesterol (LDL-C), and high density lipoprotein-cholesterol (HDL-C) were measured at screening and 8 weeks after screening. Adverse reaction were also checked each visit. Results: There were no significant differences in all index. But when divide experimental group by BMI index, age, and compliance, less than BMI $27kg/m^2$ group decreased body weight, body fat mass and more than BMI $27kg/m^2$ group also decreased body weight, body fat mass and waist circumference. Less than age 30 years group showed decline of waist circumference, fat free rate and T-cholesterol and more than age 30 years group showed decline of fat free mass. Group with compliance more than 95% was decreased BMI, fat free mass, and hip circumference. Conclusions: There was no significant efficacy as compared with placebo group, but as divide experimental group according to BMI index, age, compliance, mixed extract might be effective to reduce obesity index.

• 한방재활의학과학회지
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• 제20권2호
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• pp.63-77
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• 2010

Objectives : It is known that abdominal obesity increases the possibility of cardiovascular diseases, early death, and metabolic syndrome including dyslipidemia and insulin resistance. Clinical trials have been under way to verify the effectiveness of treatment for abdominal obesity. The objective of this study is to set criteria about how effective oriental medicine and acupuncture are in abdominal obesity. Methods : I manually search "www.clinicaltrial.gov", 4 Korean medical databases and 4 Korean medical journals of abdominal obesity. Search terms used were "abdominal obesity" or "visceral obesity". In order to see detail review, searching was performed from 01, 01, 2005 to 11, 31, 2009. And I classified all the searched studies into design, intervention, purpose, end point, diseases, condition and etc. Results : 1. I could search total 67 trials in "www.clinicaltrial.gov". I found 9, 10, 13, 8, 6 clinical trial from 2005 to 2009 every year. 2. Test on both gender and adult or adult and senior have been most frequent. 3. Randomization clinical trial is 51 cases that occupied 96.2%. 38 cases use control group. 4. Body mass index(BMI) and waist circunference(WC) are major criteria of abdominal obesity clincal trial. WC, BMI, abdominal fat mass, body weight are measured at end point of abdominal obesity clincal trial. 5. I could search total 86 cases in domestic study. I found 15, 23, 23, 20, 5 cases from 2005 to 2009 every year. 6. Test on female and adult have been most frequent in domestic study. 7. Randomization clincal trial is only 2 cases that occupied 2.3%. 62 cases use control group in domestic study. 8. BMI, body fat percent, WC, visceral-subcutaneous fat ratio(VSR), waist-hip ratio(WHR) are criteria of abdominal obesity clincal trial in domestic study. WC, BMI, abdominal fat mass, body weight are measured at end point of abdominal obesity clincal trial in domestic study. Conclusions : To improve abdominal obesity study in traditional korean medicine, it is need to activate clinical trial, meta analysis, develope of clinical practice guidelines, co-works with conventional medicine and etc.

• Bulletin of the Korean Chemical Society
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• 제33권5호
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• pp.1681-1685
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• 2012

A sensitive liquid chromatography-tandem mass spectrometric (LC-MS/MS) method was developed to determine valproic acid in human red blood cell (RBC). It is important to measure the drug concentration of the RBC as well as that of the plasma because of drug partitioning for pharmacokinetic and pharmacodynamic study. The method was linear over the dynamic range of 1-100 ${\mu}g$/mL with a correlation coefficient $r$ = 0.9997. The linearity of this method was established from 1 to 100 ${\mu}g$/mL for valproic acid in red blood cell with accuracy and precision within 15% at all concentrations. The intra-run and inter-run assay accuracy and coefficient of variations are all within 15% for all QC samples prepared in plasma and red blood human samples. Then, valproic acid amount by protein precipitation in plasma was quantified by LC-MS/MS mass spectrometry. The distribution ratio of VPA in RBC and plasma was analyzed by clinical samples. Based on measurement of the valproic acid in human red blood cell, this method has been applied to clinical research for study of distribution ratio of valproic acid in blood.

• 대한조선학회논문집
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• 제49권6호
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• pp.478-483
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• 2012

The speed performances of ice sea trial on the Arctic(2010 & 2011) area were shown different results depend on the ice floe size. Penetration phenomena of level ice was not happened on medium ice floe and tore up by the impact force because the mass of medium ice floe is similar to the mass of Araon which is Korean ice breaking research vessel and did not shut up by the ice ridge or iceberg. The sea trial on the Amundsen sea was performed at the big floe which is classified by WMO(World Meteorological Organization). Three measurements of ice properties and five results of speed trial were obtained with different ice thicknesses and engine powers. To evaluate speed of level ice trial and model test results at the same ice thickness and engine power, the correction method of HSVA(Hamburg Ship Model Basin) was used. The thickness, snow effect, flexural strength and friction coefficient were corrected to compare the speed of sea trial. The analyzed speed at 1.03m thickness of big floe was 5.85 knots at 10MW power and it's 6.10 knots at 1.0m ice thickness and the same power. It's bigger than the results of level ice because big floe was also slightly tore up by the impact force of vessel based on the observation of recorded video.

• 복식
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• 제66권8호
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• pp.33-45
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• 2016

This study classified respondents by degree of obesity using Body Mass Index(BMI) and investigated the differences in self-esteem, food lifestyle, social-cultural attitudes towards appearance, and diet-related attitude and behavior such as trial number of diet, exercise time and period, use of diet information, interest in weight control, diet motivation, and dietetic therapy. A survey was conducted with 258 adults between the ages of 20 and 29 who lived in Daegu and Uijeongbu from November $17^{th}$ to December $14^{th}$ 2014. Data collected from the respondents were analyzed using descriptive statistics, factor analyses, analyses of variance and chi-square tests. This study divided the respondents into three groups (the underweight, the normal weight, the overweight) according to Body Mass Index. The results showed that there were significant differences in food lifestyle (health-conscious, popularity-seeking, taste-seeking), social-cultural attitudes towards appearance, exercise time and period, use of diet information, interest in weight control, diet motivation, and dietetic therapy among groups classified by degree of obesity. However, there were no differences in self-esteem, convenience-seeking, and trial number of diet among them.

• 한국양식학회지
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• 제11권1호
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• pp.91-97
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• 1998

이 연구에서는 해산어의 종묘 생산에 필요한 대량 배양용 로티퍼, Brachionus rotundiformis의 종 보존 방법으로서 무균 로티퍼의 이용을 검토했다. 로티퍼는 개량형 항생제 혼합액 AM9을 사용하여 무균 처리한후, 무균 Nannochloropsis oculata를 먹이로 공급하여 연속 유지 배양했다. 각각 다른 시기의 3회 (trial 1, 2 and 3)에 걸친 로티퍼 배양결과, 무균 배양 (axenic culture)에서는 비교적 안정적인 증식을 보인 반면, 유균 배양 (non-axenic culture)에서 로티퍼의 증식은 불안정적으로 각 시기에 따라서 심한 증식의 차이가 관찰되었다. 이 결과는 유균 배양에서 로티퍼의 증식에 직접적으로 악영향을 미치는 박테리아가 무균 처리과정을 통해서 제거되었음을 증명한다. 로티퍼 무균 배양 방법의 일반화 또는 대량 배양용 로티퍼의 씨앗으로서의 무균 로티퍼의 이용은 로티퍼의 안정 배양은 물론 유용 수산 생물의 대량 폐사를 일으키는 원인 생물을 사전에 제거할 수 있는 유효한 방법이 될 수 있다고 생각된다.

• 한국공작기계학회:학술대회논문집
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• 한국공작기계학회 1996년도 추계학술대회 논문
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• pp.167-172
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• 1996

A Dual Mass Flywheel system is a evolution to the reduction of torsional vibration and impact noise occuring in powertrain when a vehicle is eit-her moving or idling. The name already explains what it is : The mass of the conventional single mass flywheel is divided. One section continues to belong to the mass moment of inertia of the engine-side. The ot-her section increass the mass moment of inertia of the transmission-side. The two masses are connected via a spring /damping system. This reduces the speed at which the dreaded resonance occurs to below idle speed. Since 1984 Dual Mass Flywheel has been de-veloped again and again. But the prosidures of de-velopment of D.M.F system didn't have had differe-nce from conventional clutch system's trial and err-or This paper presents the method for systematical design of D.M.F system with demensionless design variables of D.M.F system mass ratio between two flywheels λ. natual frequency rate of two flywheel s, ${\gamma}$and viscosity coefficient ζ. And experimental re-sults are used to prove these theoretical results.

• 한방재활의학과학회지
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• 제30권1호
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• pp.105-113
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• 2020

Objectives Excess weight and obesity are a crucial public health problem worldwide and are considered as the main cause of many chronic diseases. The present study evaluated the effects of Aronia melanocarpa extract (AMEX) supplementation on body compositions in overweight or obese people. Methods This randomized, double-blind, placebo-controlled clinical trial was carried out on 66 healthy overweight or obese peoples. The eligible subjects were divided into AMEX and placebo supplement treatment for 12 weeks. Anthropometrics, body composition (dual-energy X-ray absorptiometry), and blood analysis were performed preand post intervention. Results We observed significant reductions in the body weight and body mass index in both groups; however, the decrease was higher in the AMEX group. Body fat mass and percent body fat showed a tendency to decreases after AMEX supplementation. No clinically significant changes were observed for any safety parameter. Conclusions In conclusion, the data of this trial indicate that AMEX were not effective in reducing body compositions, but as a safe supplement, it may help weight loss in overweight or obese people.