• 한국보건간호학회지
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• 제20권1호
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• pp.87-94
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• 2006

Purpose: To explore the effect of lavender fragrance on depression and anxiety of nursing students intending to take the national licensing examination. Methods: Twenty-four nursing students were studied for one week during which they underwent lavender fragrance treatment using a necklace. All subjects were in the department of nursing in 'K' college. Before and after treatment, the severity of depression and anxiety was evaluated by questionnaire. Results: After treatment, the severity of depression had not decreased significantly (p=.139) but the severity of anxiety had (p=.030). Conclusion: According to the study results, it can be concluded that lavender fragrance showed an effect on anxiety among nursing students intending to take the national licensing examination and choose a job.

• 생물정신의학
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• 제13권3호
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• pp.162-169
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• 2006

Objective : Since some studies have shown that the brain-derived neurotrophic factor(BDNF) has an important role in the pathophysiology of depression, this study investigated the relationship between BDNF genetic polymorphism and the long-term outcome of the antidepressant treatment. Method : One hundred and eight patients with major depressive disorder were evaluated for the long-term outcome(up to 3 years) of antidepressant treatment. The severity and improvement of depression were assessed with the Clinical Global Impression(CGI) Scale. The genotypes of BDNF 196A/G polymorphism in the patients were determined using Restriction Fragment Length Polymorphism(RFLP). Result : The genotypes of 128 patients were investigated and 95 patients of those have been evaluated for 3 years. No significant differences were noted comparing three-genotype groups for CGI scales at baseline, 4 weeks, 8 weeks, 1 year, 2 years and 3 years. Conclusion : This result shows that BDNF polymorphism investigated in this study was not associated with the long-term outcome of the antidepressant treatment. However, further studies with another BDNF polymorphism should be needed.

• 대한한방부인과학회지
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• 제27권3호
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• pp.175-188
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• 2014

Objectives: The study was implemented to observe how Oriental Medicine Music Therapy (Korean Medicine Music Therapy) influences on curing the symptoms of anger and depression. Methods: Study conducted an experiment with an age of 43 female who usually suffers from headache and dizziness, and frequently gets angry at her daughter. The Study was conducted for an hour, 1 times a week. In the present study, the whole program consisted of 7 sessions. Other than the Oriental Medicine Music Therapy, the patient had never been cured by other treatments. Results: 1. According to the result of STAXI analysis, the patient with anger scale of 36 (before treatment) became to have anger scale of 31 after the treatment, indicating that the therapy had positive effect on curing the anger symptom. 2. Moreover, the analysis result of BDI showed that the patient with depression scale of 17 (before treatment) turned out to be non-depression state, which he had the depression scale of 8. Regarding the results above, it was observed that the treatment cured the depression symptom. 3. Based on the result of SEI analysis, the patient with a SEI score of 139 (higher the SEI score, more the self-esteem one has) became to have score of 142 after the treatment. Conclusions: From the research, it was observed that Korean Medicine Music Therapy has positive influence on improving one's anger or depression control and self-esteem. Clinical trial is needed to verify statistical significance.

• 아동학회지
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• 제31권2호
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• pp.197-207
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• 2010

The aim of this study was to examine the effectiveness of a Laughter Therapy Group Counseling Program on overcoming anxiety, depression, and improving the self-esteem of mothers. The State-Trait Anger Scale, the Beck Depression Inventory, and the Self-Esteem Scale were used as a pre-test, post-test, and follow-up test respectively. The test results were analyzed using a t-test, a one-way analysis of variance. Twelve mothers suffering from anxiety and depression participated in eight sessions of the program, and were then compared with twelve mothers in the control group who did not receive the treatment. The treatment group showed statistically significant improvements in self-esteem, and reduced levels of anxiety and depression, in comparison to the control group. It was concluded that the program was effective in overcoming anxiety, depression, and improving self-esteem in mothers.

• 동의신경정신과학회지
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• 제34권4호
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• pp.445-452
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• 2023

Objectives: The purpose of this study is to report the efficacy of using Korean medicine treatment for depression induced by Plica syndrome operation and worsen by a traffic accident. Methods: We treated a patient's depression with Korean medicine treatments (Uwhangchungsimwon, acupuncture, pharmacoacupuncture, cupping, moxibustion, interferential current therapy). To evaluate the results of this treatment, we measured Beck Depression Inventory (BDI), EuroQol-Five Dimensions (EQ-5D), Numeric Rating Scale (NRS), Oswestry Disability Index (ODI), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Results: Improvements of BDI, EQ-5D, NRS, ODI and WOMAC were observed after the treatments. Conclusions: This study suggests that Korean medicine treatment for depression may be effective.

• Journal of Yeungnam Medical Science
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• 제36권3호
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• pp.249-253
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• 2019

There is considerable overlap in the clinical presentations of apathy and depression. However, differential diagnosis between apathy and other psychiatric conditions, including depression and dementia, is important. In this report, we present the case of a 67-year-old woman with a history of receiving selective serotonin reuptake inhibitor (SSRI) treatment for depression. Differential diagnosis between treatment-resistant depression and SSRI-induced apathy syndrome was required. The symptoms of her apathy syndrome were relieved after the discontinuation of SSRIs and the addition of olanzapine, methylphenidate, and modafinil. Furthermore, we briefly review related literature in this article.

• 대한불안의학회지
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• 제6권1호
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• pp.55-64
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• 2010

Objective : Depression is a significant and growing problem among college students. Depression contributes to numerous academic, social, and health problems, including suicide. This study surveyed depression awareness and the need for establishing a depression support program through Kyunghee University. Methods : We used the Kyunghee University Mail delivery system for college students to conduct this survey on depression and depression. Results : All of the students who responded to the survey, 41.86% reported that they had experienced depression. Among students experiencing depression, 27.27% experienced suicidal ideation, and 56.56% said they wanted to receive mental health counseling or treatment. All the respondents, 47.04% of respondents said they would to go to the external medical center, not school's internal counseling center of school, for such treatment. All the respondents, 73.75% said the student depression/suicide problem was serious. In addition, 71.34% of respondents required a depression support program. Conclusion : The university's depression support program needs to improve its accessibility by developing content focused on the early detection of, and improved awareness of, depression.

• 생물정신의학
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• 제13권4호
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• pp.226-233
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• 2006

Depression is one of the most common mental disorders. Some characteristics of depression in Korea were elucidated. The tendency to express depressive feeling through somatic complaints is more prominent in Korea than in Western countries. Careful studies on depressive symptoms suggest that guilt and suicidal idea are apparent among Korean depressive patients as well as among Western subjects. But most depressive patients in Korea are reluctant to express suicidal idea, which is hidden under the somatic complaints. We should remember the possibility of research artifacts or cultural bias with regard to the evaluation of depressive symptoms of a country in comparison with other countries. Non-pharmacological treatment of depression includes dynamic psychotherapy, cognitive behavioral therapy, interpersonal psychotherapy, self-care treatment, etc. Some kinds of Korean culture relevant psychotherapies are introduced: Tea therapy, Imago therapy, Tao psychotherapy, and combined approach. Interest in the aged people is growing recently, and the research about the factors which affect the depressive disorders in older patients and treatment strategy for them is ongoing.

• International Journal of Advanced Culture Technology
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• 제12권3호
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• pp.427-433
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• 2024

This study aims to develop a personalized music digital therapeutic based on MBTI personality types and apply it to depression treatment. In the data collection stage, participants' MBTI personality types and music preferences were surveyed to build a database, which was then preprocessed as input data for the KNN model. The KNN model calculates the distance between personality types using Euclidean distance and recommends music suitable for the user's MBTI type based on the nearest K neighbors' data. The developed system was tested with new participants, and the system and algorithm were improved based on user feedback. In the final validation stage, the system's effectiveness in alleviating depression was evaluated. The results showed that the MBTI personality type-based music recommendation system provides a personalized music therapy experience, positively impacting emotional stability and stress reduction. This study suggests the potential of nonpharmacological treatments and demonstrates that a personalized treatment experience can offer more effective and safer methods for treating depression.

• Biomolecules & Therapeutics
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• 제31권2호
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• pp.161-167
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• 2023

Despite the various medications used in clinics, the efforts to develop more effective treatments for depression continue to increase in the past decades mainly because of the treatment-resistant population, and the testing of several hypotheses- and target-based treatments. Undesirable side effects and unresponsiveness to current medications fuel the drive to solve this top global health problem. In this study, we focused on neuroinflammatory response-mediated depression which represents a cluster of depression etiology both in animal models and humans. Several meta-analyses reported that proinflammatory cytokines such as interleukin 6 (IL-6) and tumor necrosis factor-α (TNF-α) were increased in major depressive disorder patients. Inflammatory mediators implicated in depression include type-I interferon and inflammasome pathways. To elucidate the molecular mechanisms of neuroinflammatory cascades underlying the pathophysiology of depression, we introduced hycanthone, an antischistosomal drug, to check whether it can counteract depressive-like behaviors in vivo and normalize the inflammation-induced changes in vitro. Lipopolysaccharide (LPS) treatment increased proinflammatory cytokine expression in the murine microglial cells as well as the stimulation of type I interferon-related pathways that are directly or indirectly regulated by Janus kinase-signal transducer and activator of transcription (JAK-STAT) activation. Hycanthone treatment attenuated those changes possibly by inhibiting the JAK-STAT pathway and inflammasome activation. Hycanthone also ameliorated depressive-like behaviors by LPS. Taken together, we suggest that the inhibitory action of hycanthone against the interferon pathway leading to attenuation of depressive-like behaviors can be a novel therapeutic mechanism for treating depression.