• Clinical and Experimental Pediatrics
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• 제65권5호
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• pp.214-221
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• 2022

Diagnosing and treating latent tuberculosis infection (LTBI) is an important part of efforts to combat tuberculosis (TB). The Korean guidelines for TB published in 2020 recommend 2 LTBI regimens for children and adolescents: 9 months of daily isoniazid (9H) and 3 months of daily isoniazid plus rifampicin. Isoniazid for 6-12 months has been used to effectively treat LTBI in children for over 50 years. However, a long treatment period results in poor patient compliance. This review summarizes pediatric data on the treatment completion rate, safety, and efficacy of 4 months of daily rifampicin (4R) and evaluates the pharmacokinetics and pharmacodynamics of rifampicin in children. The 4R regimen has a higher treatment completion rate than the 9H regimen and equivalent safety in children. The efficacy of preventing TB is also consistent with that of 9H when summarizing reports published to date. A shorter treatment period could increase patient compliance and, therefore, prevent TB in more patients. By using an effective, safe, and highly compliant regimen for the treatment of children with LTBI, we would become one step closer to our goal of eradicating TB.

• Animal Bioscience
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• 제37권6호
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• pp.1121-1129
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• 2024

Objective: Objective of the study was to reduce heat stress in Murrah buffaloes and maintain their milk production and other vital functions during heat stress. Methods: A total of 21 dyads of calf-mother Murrah buffalo were selected for the study and equally divided in 3 treatment groups. First treatment group was restricted calf contact (RCC), second treatment group was fence line calf contact (FCC) and third treatment groups fence line calf contact and heat stress protection (FCC-HSP [time-controlled fan-fogger system] in the shed). Present study was conducted from April to mid-September 2021. Results: Maximum temperature and temperature humidity index in FCC-HSP shed were significantly (p<0.05) lower than that in FCC and RCC shed. Higher (p<0.05) mean daily milk yield in both the treatment groups FCC (10.36±0.30) and FCC-HSP (10.97±0.31) than RCC (8.29±0.41) was recorded. Though no significant difference between FCC and FCC-HSP in daily milk yield but FCC-HSP yielded 600 gm more milk than FCC. Pulse rate (PR) and respiration rate (RR) were lowest in FCC-HSP followed by FCC and RCC, respectively. Cortisol and prolactin levels were lower (p<0.05) in FCC-HSP followed by FCC and RCC, respectively. Conclusion: Hence, FCC along with heat stress ameliorative measures helped the buffaloes to be free of stress and maintain milk yield during heat stress period of the year in tropical conditions.

• 동의생리병리학회지
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• 제37권6호
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• pp.185-192
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• 2023

The purpose of this study is to analyze trends in domestic and international clinical research studies on pharmacopuncture treatment for fractures. We searched five online databases (PubMed, CNKI, RISS, KISS, and OASIS), and selected a total of 13 clinical research studies from Korea and China. Selected studies were analyzed according to publication year, subject, intervention, treatment method, evaluation scale, adverse event, risk of bias, etc. A total of 10 case studies and 3 randomized controlled trials were included. The study subjects were more often female, and the most common type of fracture was vertebral compression fracture. In Korea, herbal medicine preparations and bee venom were used for pharmacopuncture solution, whereas in China, both herbal medicine preparations and Western medicine preparations were used. All studies commonly used local acupoint needling, and in most cases, the treatment period for case study was less than 1 month, and the observation period of randomized controlled trials was diverse. The most frequently used evaluation scale was numeric rating scale, adverse events were mentioned in only three studies, and no adverse events were reported. Overall risk of bias of all included randomized controlled trials was judged "some concerns". According to this study, pharmacopuncture treatment for fractures was found to be relatively effective and safe, but research that complements the limitations of this study is needed.

• 한국농공학회:학술대회논문집
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• 한국농공학회 2001년도 학술발표회 발표논문집
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• pp.451-455
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• 2001

This study was performed to examine water and nutrient balance during rice cropping period using difference fertilization paddy plot in ground water irrigation region. The experimental rice paddy consist of three plot, Treatment of Excess fertilization(TEF) and Treatment of Standard Fertilization(TSF) and Treatment of Reduce Fertilization(TRF). As result, input amount to rice paddy was almost rainfall and output was direct runoff through drainage. nutrient input amount was upper paddy in case COD and fertilization in case Total nitrogen and total phosphorus, and output was drainage in all nutrient.

• 대한한방소아과학회지
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• 제27권3호
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• pp.20-28
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• 2013

Objectives The purpose of this study is to report the clinical effects of Korean medical treatments on peripheral facial palsy. Methods In this study, 5 children were treated with peripheral facial palsy with Korean medical treatments, such as herb medicines, acupunctures, electro-acupuncture, and infrared therapy. Results As a result of the treatment, 5 children were almost recovered. The average treatment period was 42.17 days, with average recovery period of 9 weeks. Conclusions This study shows that Korean medical treatments on childhood peripheral facial palsy could be one of the viable options for this patient kind.

• 대한두경부종양학회지
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• 제14권2호
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• pp.220-227
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• 1998

The clinical and pathological features of 35 cases of anaplastic thyroid cancer were studied. These tumors occurred in 12 men and 23 women ranging in age from 19 to 83 years(mean age; 61.7 years). A rapidly enlarging thyroid mass was the most common presentation. The duration of the presence of mass varied from 20 days to 12 months with an average of 2.7 months. Systemic metastasis at the time of initial examination was found in 14 patients(40.0%) and the lung was the most common site of involvement. The overall rate of distant metastasis was about 65.7%. The tumors were subdivided morphologically into giant cell type of 10 cases, spindle cell type of 7 cases, epidermoid cell type of 1 cases, and mixed giant cell and spindle cell type of 5 cases. The mean survival period of 6 among 35 patients who had biopsy alone was 1.4 months. The 22 patients underwent the incomplete combined treatment modalities (palliative surgery with or without chemotherpy or radiation therapy) survived for a mean period of 3.0 months, among them, 7 patients who had surgery combined with chemotherapy and radiation therapy showed mean survival period of 3.7 months. The mean survival of 7 patients who had complete combined treatment modality(curative surgery combined with chemotherapy and hyperfractionated radiation therapy) was 6.6 months, only one patient survived for 21 months and one patient has been alive for 1 month after operation, and the others survived for a mean period of 4.8 months. So far, as of July 31, 1998, 34 patients among 35 were died(one has been survived for 1 month) despite the various treatment modalities, and the main cause of death were failure of local control and systemic metastasis. None of the various treatment modalities gave consistently favourable results. However, a combination of surgery, radiation therapy and chemotherapy seemed to have a slight positive effect on survival. Furthermore, the aggressive treatment modalities will be indicated only in the early diagnosed and minimal cases.

• 한국식생활문화학회지
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• 제36권3호
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• pp.325-332
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• 2021

This study sought to investigate the effects of heat-moisture treatment (HMT) and ethanol treatment (EOH) for improving the quality and storage stability of Tteokbokki Tteok. The quality characteristics were evaluated by moisture, pH, color, texture profile analysis, and observing the microbial properties after the heat-moisture treatment or ethanol treatment. As the storage period increased, the moisture content of Tteokbokki Tteok tended to decrease except for the HMT group (p<0.05) while the pH did not show significant variation except for the EOH group (p<0.05). While measuring the color, the L-value tended to increase in all groups during the storage period. The a-value and the b-value showed the highest values in the HMT group and the control (CON) group, respectively. In the texture profile analysis, all groups showed a significant tendency to increase levels of hardness and chewiness as the storage period increased (p<0.05). The HMT group showed an increase in hardness and adhesiveness, which are characteristics of the HMT treatment. The results of examining the microbial properties of Tteokbokki Tteok showed that the total microbial count in the HMT group was 4.52 on the 8^th day of storage, which was lower than the level in the CON group and the EOH group on the 4^th day of storage. Yeast and mold were not measured during the storage period. Thus the results of this study showed that when manufacturing Tteokbokki Tteok, the heat-moisture treatment of rice powder increased the storage stability by delaying microbial growth and also had positive effects on quality.

• 생태와환경
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• 제51권4호
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• pp.259-267
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• 2018

온도상승에 대한 낙엽성 목본식물종의 식물계절반응을 알아보기 위하여 동일지역에서 채종된 종자를 기반으로 야외(대조구)와 온도가 최저생육온도(약 $4.8^{\circ}C$) 이상으로 유지되는 온실(처리구)에서 우리나라 주요 낙엽수 39종을 재배하며, 잎의 식물계절변화를 1년 동안 관찰하고, 이를 식물의 현재 분포범위와 관련지어 설명하였다. 잎이 돋는 개엽기는 평균적으로 야외에서 5월 1~3일이었고, 온실처리구에서는 12월 13일~1월 7일이었으며, 잎이 지는 낙엽기는 평균적으로 야외에서 10월 11~26일이었고, 온실에서는 10월 30일~11월 13일이었다. 이처럼 온도상승으로 개엽기는 119~140일 빨라졌으며, 낙엽기는 3~32일 늦춰졌다. 그리고 잎의 생육기간은 야외대조구보다 온실에서 평균 148일 증가하였다. 온도상승조건인 온실에서 재배된 신갈나무와 졸참나무는 1년 동안 낙엽기가 없이 생육기만 지속되는 상록성으로 변하였으며, 또한 팥배나무의 개엽기는 야외보다 빨라졌으나 그 폭은 가장 적었고, 낙엽기는 오히려 앞당겨져 생육기간의 증가폭이 가장 적었다. 그러나 온도상승에 대한 낙엽수 잎의 식물계절학적 반응은 식물의 현재 분포범위와는 연관성이 없었다. 이는 낙엽수 잎의 표현형이 과거의 환경보다 현재의 생육조건에 더 민감하게 반응한 것으로 사료된다.

• Journal of Korean Neurosurgical Society
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• 제44권6호
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• pp.364-369
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• 2008

Objective : The aim of this study was to evaluate the efficacy of endovascular therapy as a primary treatment for spinal dural arteriovenous fistula (DAVF). Methods : The authors reviewed 18 patients with spinal DAVFs for whom endovascular therapy was considered as an initial treatment at a single institute between 1993 and 2006. NBCA embolization was considered the primary treatment of choice, with surgery reserved for patients in whom endovascular treatment failed. Results : Surgery was performed as the primary treatment in one patient because the anterior spinal artery originated from the same arterial pedicle as the artery feeding the fistula. Embolization was used as the primary treatment modality in 17 patients. with an initial success rate of 82.4%. Two patients with incomplete embolization had to undergo surgery. One patient underwent multiple embolizations, which failed to completely occlude the fistula but relieved the patient's symptoms. Spinal DAVF recurred in two patients (one collateral development and one recanalization) during the follow-up period. The collateral development was obliterated by repeated embolization, but the patient with recanalization refused further treatment. The overall clinical status improved in 15 patients (83.3%) during the follow-up period. Conclusion : Endovascular therapy can be successfully used as a primary treatment for the majority of patients with spinal DAVFs. Although it is difficult to perform in some patients, endovascular embolization should be the primary treatment of choice for spinal DAVF.

• 한방안이비인후피부과학회지
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• 제30권4호
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• pp.142-152
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• 2017

Objectives : The purpose of this study is to report the effectiveness of Korean Medicine Treatment on 101 psoriasis patients for 6 months. Methods : Psoriasis Area and Severity Index(PASI) is used for measuring the degree of psoriasis with photos of total 101 psoriasis patients who have visited Korean medical clinic from October 11, 2013 to August 31, 2017. And we analyzed the PASI score according to gender, age, period of treatment, being used steroid or not. Results : 1. The ratio of male to female was 44.55 : 55.45. The mean age of patients was 34.65 years old(All patients were constituted with 9.9% of 10~19 year-old group, 31.7% of 20~29 year-old group, 26.7% of 30~39 year-old group, 12.9% of 40~49 year-old group, 15.8% of 50~59 year-old group and 3.0% of 60~69 year-old group). 2. PASI score was significantly higher in men than in women before treatment, but there was no significant difference of PASI score improvement after 2, 4 and 6 months treatment in both men and women. 3. PASI score improvement according to age after 2, 4 and 6 months treatment was no significant difference. 5. In initial visit, the steroid group patients were 61 and non-steroid group patients were 40. PASI score in initial visit between steroid group and non-steroid group was no significant difference. And PASI score after 2, 4 and 6 months treatment was no significant difference. Conclusions : PASI score was significantly decreased after 2, 4 and 6 months treatment compared with before treatment. PASI score improvement was significantly increased in proportion to the period of treatment.