• The Korean Journal of Applied Statistics
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• v.20 no.1
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• pp.39-52
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• 2007

Crossover trials of new drugs in the treatment of angina pectoris, which frequently use treadmill exercise test for the assessment of its efficacy, produce censored survival times. In this paper we consider analysis approaches for censored survival times from crossover trials. Previously, a stratified Cox model for paired observation and nonparametric methods have been presented as possible analysis methods. On the other hand, the differences of two survival times would produce interval-censored survival times and we propose a Cox model for interval-censored data as n alternative analysis method. Example data is analyzed in order to compare these different methods.

• Journal of The Korean Society of Integrative Medicine
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• v.4 no.4
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• pp.13-19
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• 2016

PURPOSE : The purpose of this study was to determine whether tredmill exercise increases pulmonary function and decreases body mass index of the 20s obesity. METHOD : Thirty obesity in their 20s were randomly assigned to on experimental group (n=15) or control group (n=15). Over the course of four weeks, the experimental group participated in tredmill exercise for 30 minutes three times per week and the control group participated in auto-med exercise for 30 minutes three times per week. Subjects were assessed pre-test and post-test by measurement of pulmonary function (tidal volume, inspiration reserve volume, expiratory reserve volume, vital capacity) and body mass index. RESULT : Our findings show that the experimental group had significant difference in expiratory reserve volume and vital capacity and body mass index (p<.05). In the comparison of the two groups, the experimental group had higher pulmonary function and lower body mass index than the control group. CONCLUSION : In this study, the experimental group showed greater improvement in pulmonary function than the control group, which indicates that the tredmill exercise is effective at increasing the pulmonary function and body mass index 20s obesity.

• Physical Therapy Korea
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• v.14 no.1
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• pp.1-10
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• 2007

This study was designed to examine the effects of electroacupuncture and treadmill exercise on the improvement of muscle atrophy and Brain-Derived Neurotrophic Factor (BDNF) expression in an ischemic stroke model induced by middle cerebral artery occlusion. This study selected 120 Sprangue-Dawley rats, divided them into six groups, and assigned 5 rats to each group. Experiments were conducted for 1, 3 days and 1, 8 weeks, respectively. In each group, changes in weight of muscle and relative muscle of tibialis anterior muscle, histologic observations, and BDNF expression were observed and analyzed. For the changes in muscle weight of unaffected and affected sides of tibialis anterior, muscle atrophy was expressed in an affected side 3 days after ischemic stroke was induced. There was a statistically significant difference in Group VI 1 and 8 weeks after ischemic stroke was induced, compared to Group II (p<.05). For the changes in relative muscle weight of unaffected and affected sides of tibial anterior muscle, there was significant decrease in each group 3 days after ischemic stroke was induced, compared to Group I, while there was a statistically significant increase in Group VI 1 week after ischemic stroke was induced, compared to Group II (p<.05). For neurologic exercise behavior test, Group VI generally had the highest score, compared to other groups. The results of the behavior test suggests that 8 weeks after ischemic stroke was induced, Group VI improved in degeneration and inflammation of muscle fiber and decreased in destruction of nerve cells and cerebral infarction, thus indicating a similar state of muscle fiber and brain tissue in Group I. In immunohistochemical observations, Group 1 week showed increase in BDNF. Based on these results, electroacupuncture and treadmill exercise may improve muscle atrophy and change in BDNF expression of ischemic stroke rats and contribute to the improvement of exercise function.

• Journal of Life Science
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• v.19 no.11
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• pp.1651-1657
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• 2009

Physical activity and exercise can promote sensorimotor recovery from central nerve injury. It has been suggested that the functional recovery promoted by exercise training after spinal cord injury might be associated with insulin-like growth factor-I in the inflicted muscle. To investigate morphological and biochemical change of the soleus muscle after spinal cord injury, all tissues were used for H&E, immunofluorescence staining and Western blot. Also, BBB-test was used to evaluate behavioral improvement after spinal cord contusion. Thirty male Sprague-Dawley rats ($230{\pm}10\;g$; 7week in age) were assigned equally to three different groups; Normal (n=10), SCI (n=10), SCI+TMT (n=10). Every rat in SCI and SCI+TMT groups underwent laminectomy at T9 level and then contusion on the exposed spinal cord site in anesthetized condition. After one week-recovery from contusion, every rat in the SCI+TMT group exercised on a motorized treadmill for 30min/d, 5d/wk for 7wks. TMT followed by injury increased IGF-I induction levels in the soleus muscle and inhibited muscle atrophy. Behavioral scales for 4 and 8 weeks after spinal cord injury were improved in the SCI+TMT group compared to the SCI group. These results suggest that treadmill exercise after spinal cord injury might promote functional recovery along with muscle regrowth through the up-regulation of IGF-1 in muscle tissue.

• Proceedings of the ESK Conference
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• 1996.10a
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• pp.33-40
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• 1996

본 연구의 목적은 작업생리학적 접근방법(physiological approach)을 이용하여 생리학적 작업 능력(PWC; physiological work capacity)을 추정할 경우 작업형태와 작업방법에 따른 차이점을 비교분석해 보고자 함이다. 작업유형으로는 자전거 에르고미터(cycle ergometer)와 트레드밀 (treadmill)을 사용하였고, 작업방법으로는 각각의 작업유형에 대하여 램프 테스트(ramp test 와 인크리멘탈 테스트(increemntal test)의 차이점을 비교하였다. 또한 외국인들의 생리학적 작업능력(PWC)과 한국인들의 생리학적 작업능력(PWC)을 비교,검토하여 NIOSH(National Institute of Safety and Healty)기준치를 사용하는데 문제점이 없는가를 검토해 보고자 하였다. 작업방법 에 따른 차이점은 자전거 에르고미터의 경우 램프 테스트(ramp test )253.63 ml/min로서 인크리 멘탈 테스트(increemental test) 2859.74ml/min 의 87.70 % 정도로 나타났으며, 트레드 밑의 경우 ramp test 2859.22ml/min로서 incremental test 289.46ml/min의 98.77%정도로 나타났다. 작업유형 에 따른 결과는 자전거 에르고미터의 ramp test 트레드밀의 ramp test 는 ramp test는 트레드밀의 ramp test의 88.72% 정도로 나타났으며, 자전거 에르고미터의 incremental tests는 트레이드밀 작 업의 98.% 정도로 나타났다.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.12 no.10
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• pp.4459-4466
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• 2011

The purpose of this study was to compare the lower extremity muscle activities according to the different longitudinal arch and treadmill inclination and to provide basic data on treadmill walking exercise. The selected 17 subjects who had not lower extremity injury and ROM limitation were recruited in this study. The longitudinal arch was divided into normal foot and flat foot. The inclinations of the treadmill were $0^{\circ}$, up hill $5^{\circ}$, $10^{\circ}$, $15^{\circ}$, down hill $5^{\circ}$, $10^{\circ}$ and $15^{\circ}$. The electromyography was used to analyze the muscle activity of rectus femoris, biceps femoris, tibialis anterior, gastrocnemius lateralis and medialis. There were significant differences between the inclination $0^{\circ}$ and down hill $15^{\circ}$. There was no interactive effect of treadmill inclination on the longitudinal arch. The activity difference of lower extremity muscle was not conspicious. There existed the interactive effect between the longitudinal arch and muscle activity. The contrast test within subjects showed positively in the rectus femoris and gastrocnemius medialis, biceps femoris and gastrocnemius medialis. The different longitudinal arch did not influence on the effect(p>.05). There was significant difference between the normal foot and the flat foot. So it is necessary to carry out the long term study.

• Food Science of Animal Resources
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• v.23 no.2
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• pp.180-185
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• 2003

Rats(Sprague-Dawley) were randomly assigned to the following four groups, control, exercise only, exercise and the intake of DNA, exercise, and the intake of DNA plus crude catechin. 0.4% of DNA from salmon egg and 0.1% crude catechins from Puerariae thunbergiana roots were fed to the rats. The exercise group was exercised in a treadmill at 20 m/min speed for 6 wks. Body weight and body fat weight of 4 groups were investigated, and the body fat composition and antioxidant activity were evaluated by measuring the weight of organs and biochemical test. After 6 wks, body weight did not show any significant differences among those 4 groups, but body fat weight in exercised groups was significantly decreased. The weight of liver, epididymal adipose tissue(E.A.T) and perirenal adipose tissue(P.A.T) were significantly decreased in groups of exercise only, exercise and the intake of DNA, exercise and the intake of DNA plus crude catechin(p<0.05). Phospholipid, cholesterol and triglyceride levels of serum were decreased by exercise, but HDL-cholesterol level of serum was significantly increased(p<0.05). GOT, GPT and glucose levels in serum were slightly decreased by crude catechin, but serum NEFA levels were significantly increased by crude catechin(p<0.05). Results indicated that excercise with the intake of crude catechin would be helpful for the functional development of the compositions in blood lipid.

• 한국체육학회지인문사회과학편
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• v.58 no.4
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• pp.481-492
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• 2019

The purpose of this study was to investigate the effects of treadmill exercise on cerebellar astrocyte activation and purkinje cells, neurotrophic factors expression, and motor function in aged rats. Sprague-Dawley (SD) rats were used and divided into three groups; (1) Young Control Group (YCG; 3months aged, n=10); (2) Old Control Group; (OCG; 24months aged, n=10); (3) Old Exercise Group (OEG; 24months aged, n=10). Rats were then subjected to treadmill exercise for 5 days per week for 12 weeks during which time the speed of the treadmill was gradually increased. The results revealed that in the rota-rod test, motor function was significantly increased in the OEG compared to the OCG (p<.05), and similarly YCG. Number of calbindin-positive purkinje cell expression significantly increased in the cerebellar vermis of OEG compared to the OCG (p<.05), and similarly YCG. GFAP-, NMDAR-positive cell expression significantly increased in the OEG (respectively p<.001), GFAP and GLAST protein levels were significantly increased in the cerebellum of OEG compared to the OCG (p<.05, p<.001) and similarly YCG. BDNF and NGF protein levels were highest in the YCG, increased in the OEG compared to OCG (p<.001, p<.05). These result show that regular exercise not only improved astrocyte activation, but also increased purkinje cell expression in the cerebellum and motor function by increasing the neurotrophic factors in aged rats.

• Journal of the Korean Society of Food Science and Nutrition
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• v.40 no.12
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• pp.1700-1707
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• 2011

This study evaluated the effect of multigrain supplementation on exercise-related changes in running time and glycogen storage capacity of male SD rats engaged in treadmill exercise. Thirty-six 6-week-old rats were divided into six groups: normal (Nor) fed normal feed, control (Con) fed with 20% normal feed and 80% milled rice, test group one (GI) fed with multigrain feed I, test group two (GII) fed with multigrain feed II, test group three (GIII) fed with multigrain feed III, and test group four (GIV) fed with multigrain feed IV. Endurance tests by treadmill machine were administered after 24 days of multigrain feed supplementation and adaptive training. Running time was extended and glycogen storage capacity increased in the multigrain-treated group compared to the non-treated group. Also, the fatigue indicators of inorganic phosphorous, CPK, and lactate concentration were all reduced in the multigrain feed group compared to the control group after 25 min and/or exhausted exercise. But there was no difference in GOP, GTP, lactate, or LDH concentrations between the groups. Our results demonstrated that endurance improved with multigrain feed in rats. Specifically, running time, glycogen storage capacity, inorganic phosphorous, CPK, and lactate serum concentration increased. Importantly, the improvements in endurance brought about in the GII group fed with waxy barley was the greatest among the experimental groups.

• Physical Therapy Korea
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• v.15 no.4
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• pp.50-58
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• 2008

The purpose of this study was to investigate the effects of the task-oriented training according to the application time with the change of motor and cognition function. Focal ischemic brain injury was produced in Sprague-Dawley rats (20 rats, $250{\pm}50$ g) through middle cerebral artery occlusion (MCAo). Before MCAo induction, all rats were trained in treadmill training and Morris water maze training for 1 week. Then they were randomly divided into groups: Group I : MCAo induction ($n_1$=5), Grop II: the application for simple treadmill task training after. MCAo induction ($n_2$=5). Group III: the application for Morris water maze cognitive task training after MCAo induction ($n_3$=5). Group IV: the application for progressive treadmill task training and Morris water maze cognitive task training after MCAo induction ($n_4$=5). Modified limb placing tests (MLPTs) and motor tests (MTs) were performed to test motor function and then Morris water maze acquisition test (MWMAT) and Morris water maze retention test (MWMRT) were performed to test cognitive function. For MTs, there were significant interactions among the groups with the time (p<.001). Group IV showed the steeper increasing pattern than those in other Groups on the 7th and 14th day. For MLPTs, there were significant interactions among the groups with the time (p<.001). The scores in Group III. IV had showed the more decreasing pattern than those in Group I, II since the 7th day and 14th day. For MWMAT, there were significant interactions among the groups with the time (p<.001). Group II found the Quadrant circular platform showed the steeper decreasing pattern than that in Group I on the 9th, 10th, 11th and 12th day. Group III. IV found the quadrant circular platform showed the slower decreasing pattern than that in Group I, II, For MWMRT, there were significant differences among the four groups (p<.001). The time to dwell on quadrant circular platform in Group IV on the 13th day was the longest compared with other groups. These results suggested that the combined task training was very effective to improve the motor and cognition function for the rats affected on their focal ischemic brain injury.