• 전자공학회논문지
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• 제53권4호
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• pp.149-155
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• 2016

본 논문에서는 운전자의 체중 이동을 활용한 메카넘 휠 기반 전방향 전동 보드 제어 방법을 제안한다. 운전을 위한 별도의 운전 장치를 사용하지 않으며, 다수의 센서를 활용하여 측정한 체중 분포로부터 무게 중심의 위치를 구하여 전방향 전동 보드의 병진 운동과 회전 운동의 3 자유도 운전 명령을 생성한다. 체중 이동은 운전 명령으로 반영됨과 동시에 관성력을 극복하기 위한 운전자의 동작과 일치하여 직관적인 장점이 있다. 전체 제어 구조를 제시하며, 실험에 적용하여 제안된 방식의 타당성을 확인한다.

• 대한소아치과학회지
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• 제44권1호
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• pp.72-81
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• 2017

본 연구의 목적은 유치 상아질의 복합레진 술식에서 각 단계별로 치면에 인공타액이 오염되었을 때와 이것을 제거하는 방법이 한 단계 자가부식 접착제와 두 단계 산 부식 접착제의 결합강도에 미치는 영향을 비교 분석하는 것이다. 연구 목적을 달성하기 위해, 건전한 유구치 42개를 선정하여 세 종류의 상아질 접착제인 Scotchbond Universal Adhesive(SBU), All-Bond Universal(ABU)과 Prime & Bond NT(PNT)에 따라 3개의 군으로 분류하였다. 이를 다시 각 접착제에서 7개의 하위 그룹으로 나누었다. 대조군인 1군을 제외한 나머지 군은 인공타액으로 오염시킨 군으로 다음과 같이 분류하였다: 2, 3군 - 접착제 도포 전; 4, 5군 - 접착제 중합 전; 6, 7군 - 접착제 중합 후. 인공타액은 수세, 건조(2, 4, 6군)와 건조(3, 5, 7군)로 제거하였다. 처치된 치면에 복합레진(Filtek, Z-350)으로 수복하고 시편을 제작한 후 미세인장 결합강도(Microtensile bond strength, MTBS)를 측정하였다. One-way ANOVA와 Tukey HSD test를 이용해서 통계분석을 실시하였다(p < 0.05). 대조군에서 MTBS의 평균값은 PNT가 ABU와 SBU에 비해 높게 나타났다(p < 0.001). 세 가지 접착제의 각 오염단계에서 수세와 건조를 시행했을 때(2, 4, 6군)가 건조만 시행했을 때(3, 5, 7군)보다 높은 결합강도를 나타내었다. 그리고 접착제 중합 전 단계에서 인공타액의 오염이 발생했을 때(4, 5군)는 대조군에 비해 낮은 MTBS를 보였다(p < 0.001). 전반적으로 두 단계 산 부식 접착제가 한 단계 자가부식 접착제에 비해 높은 MTBS를 보였다. 접착제를 중합하기 전 단계에서 인공타액에 오염되었을 경우에는 접착 강도가 현저히 감소하였고, 수세와 건조 과정으로 접착강도를 회복할 수 없었다.

• The Korean Journal of Physiology and Pharmacology
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• 제5권5호
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• pp.397-405
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• 2001

The ryanodine receptor, a $Ca^{2+}$ release channel of the sarcoplasmic reticulum (SR), is responsible for the rapid release of $Ca^{2+}$ that activates cardiac muscle contraction. In the excitation-contraction coupling cascade, activation of SR $Ca^{2+}$ release channel is initiated by the activity of sarcolemmal $Ca^{2+}$ channels, the dihydropyridine receptors. Previous study showed that the relaxation defect of diabetic heart was due to the changes of the expressional levels of SR $Ca^{2+}$ATPase and phospholamban. In the diabetic heart contractile abnormalities were also observed, and one of the mechanisms for these changes could include alterations in the expression and/or activity levels of various $Ca^{2+}$ regulatory proteins involving cardiac contraction. In the present study, underlying mechanisms for the functional derangement of the diabetic cardiomyopathy were investigated with respect to ryanodine receptor, and dihydropyridine receptor at the transcriptional and translational levels. Quantitative changes of ryanodine receptors and the dihydropyridine receptors, and the functional consequences of those changes in diabetic heart were investigated. The levels of protein and mRNA of the ryanodine receptor in diabetic rats were comparable to these of the control. However, the binding capacity of ryanodine was significantly decreased in diabetic rat hearts. Furthermore, the reduction in the binding capacity of ryanodine receptor was completely restored by insulin. This result suggests that there were no transcriptional and translational changes but functional changes, such as conformational changes of the $Ca^{2+}$ release channel, which might be regulated by insulin. The protein level of the dihydropyridine receptor and the binding capacity of nitrendipine in the sarcolemmal membranes of diabetic rats were not different as compared to these of the control. In conclusion, in diabetic hearts, $Ca^{2+}$ release processes are impaired, which are likely to lead to functional derangement of contraction of heart. This dysregulation of intracellular $Ca^{2+}$ concentration could explain for clinical findings of diabetic cardiomyopathy and provide the scientific basis for more effective treatments of diabetic patients. In view of these results, insulin may be involved in the control of intracellular $Ca^{2+}$ in the cardiomyocyte via unknown mechanism, which needs further study.

• Asian Pacific Journal of Cancer Prevention
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• 제14권4호
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• pp.2255-2258
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• 2013

The activity of Rb proteins is controlled by post-translational modifications, especially through phosphorylation. Acetylation of Rb2/p130 was reported recently in NIH3T3 cells but its physiological relevance in cell cycle control and tumorigenesis is still unknown. Efforts are underway to investigate possible interplay between Rb2/p130 phosphorylation and acetylation. Here we hypothesized that Rb2/p130 acetylation, like p53 acetylation, may play a role in development of the tumor phenotype. The proposed hypothesis regarding acetylation of Rb2/p130 in tumor VS normal cells was found to be true in our case study of 36 tumor samples. Statistical analysis of results suggest strong correlation among Rb2/p130 acetylation and cancer phenotype.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 1997년도 한국자동제어학술회의논문집; 한국전력공사 서울연수원; 17-18 Oct. 1997
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• pp.175-178
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• 1997

This study was carried out to obtain an analytical expression for the specifications of the Stewart Platform that minimize the maximum force acting on the hydraulic cylinder. The position and orientation of the platform were calculated by means of the inverse kinematic analysis. The maximum force to be exerted on a cylinder was calculated using the Newton's second law for the case when the platform is moved along a horizontal axis with 0.6 g, the maximum translational acceleration possible. This paper suggests a mathematical model to minimize the maximum actuating force using radius and angle ratios as design variables. Finally, a fuzzy set for the minimum actuating force is proposed for this dynamic optimal design problem.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 2003년도 ICCAS
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• pp.2753-2758
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• 2003

Tactile sensation is essential for many manipulation and exploration tasks not only in a real environment but also in a virtual environment. In this paper, we discuss a conceptual design of an integrated tactile display system. The system comprises two parts: a 2 DOF force feedback device for kinesthetic display and a tactile feedback device for displaying the normal stimulation to skin and the skin slip/stretch. Psychophysical experiments measure the effects of fingerpad selection, the direction of finger movements and the texture width on tactile sensitivity. We also investigate characteristics of lateral finger movement while subjects perceive different textures. From the experimental results, the principal parameters for designing a tactile display are suggested. A tactile display device is implemented using eight piezoelectric bimorphs and a linear actuator, and is attached to a 2 DOF translational force feedback device to simultaneously simulate texture and stiffness of the object.

• BMB Reports
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• 제51권11호
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• pp.547-548
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• 2018

Phloem network integrates cellular energy status into post-embryonic growth, and development by tight regulation of carbon allocation. Phloem development involves complicated coordination of cell fate determination, cell division, and terminal differentiation into sieve elements (SEs), functional conduit. All of these processes must be tightly coordinated, for optimization of systemic connection between source supplies and sink demands throughout plant life cycle, that has substantial impact on crop productivity. Despite its pivotal role, surprisingly, regulatory mechanisms underlying phloem development have just begun to be explored, and we recently identified a novel translational regulatory network involving RNA G-quadruplex and a zinc-finger protein, JULGI, for phloem development. From this perspective, we further discuss the role of RNA G-quadruplex on post-transcriptional control of phloem regulators, as a potential interface integrating spatial information for asymmetric cell division, and phloem development.

• 대한인간공학회지
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• 제16권3호
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• pp.11-21
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• 1997

The purpose of this study is to obtain 3-dimensional isocomfort workspace using the robot kinematics, which is based on perceived discomfort in varying postures for manipulating four types of controls. Fifteen healthy male subjects participated in the experiment where their perceived discomfort in the given postures was measured, in which L32 orthogonal array was adopted. The shoulder flexion and adduction-abduction, elbow flexion, types of controls, and right/left hands were selected as experimental variables. The results showed that the shoulder flexion and adduction-abduction, elbow flexion, and types of controls significantly affected the perceived discomfort at .alpha. =0.01. Depending upon the types of control used, regression equations predicting perceived dis- comfort and three dimensional isocomfort workspace were suggested based on the experiemntal cata. Using the equations, driver's isocomfort workspace in his/her cabin for pushing operation was illustrated, in which the robot kinematics was employed to describe the translational relationships between the upper arm and the lower arm/hand. It was ecpected that isocomfort workspace could be used as a valuable guideline to design workplaces ergonomically.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2004년도 추계학술대회 논문집
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• pp.890-893
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• 2004

The ultra precision machining in industrial field are increased day by day. The diamond turning has been used generally, but now is faced with limitation of use, because of higher requirement of production field. The electron beam lithography is alternative in machining area as semiconductor production. For EB lithography, 5 axis vacuum stage is required to duplicate small and large patterns on wafer. The stage is composed of 2 rotational axis and 3 translational axis with 5 DC servo motors. The positioning repeatability and resolution of Z axis feed unit are 3.21$\mu$m and 0.5 $\mu$m/step enough to apply to lithography.

• BMB Reports
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• 제46권1호
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• pp.9-16
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• 2013

In mammalian cells, aberrant transcripts harboring a premature termination codon (PTC) can be generated by abnormal or inefficient biogenesis of mRNAs or by somatic mutation. Truncated polypeptides synthesized from these aberrant transcripts could be toxic to normal cellular functions. However, mammalian cells have evolved sophisticated mechanisms for monitoring the quality of mRNAs. The faulty transcripts harboring PTC are subject to nonsense-mediated mRNA decay (NMD), nonsense-mediated translational repression (NMTR), nonsense-associated alternative splicing (NAS), or nonsense-mediated transcriptional gene silencing (NMTGS). In this review, we briefly outline the molecular characteristics of each pathway and suggest mRNA quality control mechanisms as a means to regulate normal gene expression.