• Journal of Gastric Cancer
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• v.16 no.3
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• pp.141-151
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• 2016

Purpose: The aim of the present study was to elucidate the clinicopathological significance and diagnostic accuracy of immunohistochemistry (IHC) for determining the mesenchymal epidermal transition (c-MET) expression in patients with gastric cancer (GC). Materials and Methods: The present meta-analysis investigated the correlation between c-MET expression as determined by IHC and the clinicopathological parameters in 8,395 GC patients from 37 studies that satisfied the eligibility criteria. In addition, a concordance analysis was performed between c-MET expression as determined by IHC and c-MET amplification, and the diagnostic test accuracy was reviewed. Results: The estimated rate of c-MET overexpression was 0.403 (95% confidence interval [CI], 0.327~0.484) and it was significantly correlated with male patients, poor differentiation, lymph node metastasis, higher TNM stage, and human epidermal growth factor receptor 2 (HER2) positivity in IHC analysis. There was a significant correlation between c-MET expression and worse overall survival rate (hazard ratio, 1.588; 95% CI, 1.266~1.992). The concordance rates between c-MET expression and c-MET amplification were 0.967 (95% CI, 0.916~0.987) and 0.270 (95% CI, 0.173~0.395) for cases with non-overexpressed and overexpressed c-MET, respectively. In the diagnostic test accuracy review, the pooled sensitivity and specificity were 0.56 (95% CI, 0.50~0.63) and 0.79 (95% CI, 0.77~0.81), respectively. Conclusions: The c-MET overexpression as determined by IHC was significantly correlated with aggressive tumor behavior and positive IHC status for HER2 in patients with GC. In addition, the c-MET expression status could be useful in the screening of c-MET amplification in patients with GC.

• The Korean Journal of Community Living Science
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• v.23 no.1
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• pp.17-30
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• 2012

This study is targeted on children's parks in Seogu, Daejeon with the goal of maximizing the usage and versatility of existing parks in the area by the survey and analysis of the general status of children's parks, land use near the parks, population, users, and traits of usage. For the purposes of this thesis this study has selected 65 of the children's parks in the Seogu District to monitor. It also focused on a number of these parks located in areas which underwent a lot of changes and needed an increase in usage and versatility. Based on the selection criteria, the four target parks, Wojeong, Meongwhack, Dosan and Wicdunjimi children's park were selected. The Survey shows that 55.9% of park visitors visited a park to 'rest and take a walk' and used 'main facilities' meaning resting facilities like pergola and benches. In the nighttime, the number of park visitors is so few because of safety problems. 50% of users were satisfied with parks. It shows that there are many respondents who want to recompose these parks as places for light exercise, resting, meeting, and as community symbols. Generally, these target parks don't reach their full potential and they also do not play their proper roles because they are hampered by the constriction of the law. These stick to an outdated idea of what a park should be like without considering the actual and practical needs of city dwellers. When it comes to the remodeling and refurbishing of these parks we have to rethink the planning process so that these parks may be more versatile and practical in order to accommodate the radical changes of users and patterns of usage.

• Journal of the Korean Institute of Telematics and Electronics S
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• v.35S no.10
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• pp.175-185
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• 1998

In this paper, we studied some design methodologies of typical FIR filters based on the peak-error constrained least square criterion which was first introducedd by Adams in 1991. This method is a mixed type of the classical least squared error method(LSM) and the so-called min-max error method (MMM). And by considering both the least squared error as well as the maximum error, the solution, i.e. the impulse response of the filter, can be found only when the restrictions on maximum gain, transition bandwidth, and the squared error are satisfied simultaneously under some trade-off conditions. We used the multiple exchange algorithms for optimization procedure and applied the design methodology to the cases of the multiband filter, the differentiator, and the Hilbert transformer by taking the balance of two design criteria into account. The results show that the peak-error constrained least weighted square error design method(PLEM) is superior in performance to the existing LSM and MMM from both the squared error and the maximum error standpoints. And it is verified that PLEM can be applied to not only the case of simple low pass filter, but also to various types of FIR filters.

• KCI Concrete Journal
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• v.12 no.1
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• pp.57-68
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• 2000

The effect of structure size on the nominal strength of unidirectional fiber-polymer composites, failing by propagation of a kink band with fiber microbuckling, is analyzed experimentally and theoretically. Tests of novel geometrically similar carbon-PEEK specimens, with notches slanted so as to lead to a pure kink band (without shear or splitting cracks), are conducted. The specimens are rectangular strips of widths 15.875, 31.75. and 63.5 mm (0.625, 1.25 and 2.5 in and gage lengths 39.7, 79.375 and 158.75 mm (1.563, 3.125 and 6.25 in.). They reveal the existence of a strong (deterministic. non-statistical) size effect. The doubly logarithmic plot of the nominal strength (load divided by size and thickness) versus the characteristic size agrees with the approximate size effect law proposed for quasibrittle failures in 1983 by Bazant This law represents a gradual transition from a horizontal asymptote, representing the case of no size effect (characteristic of plasticity or strength criteria), to an asymptote of slope -1/2 (characteristic of linear elastic fracture mechanics. LEFM) . The size effect law for notched specimens permits easy identification of the fracture energy of the kink bandand the length of the fracture process zone at the front of the band solely from the measurements of maximum loads. Optimum fits of the test results by the size effect law are obtained, and the size effect law parameters are then used to identify the material fracture characteristics, Particularly the fracture energy and the effective length of the fracture process zone. The results suggest that composite size effect must be considered in strengthening existing concrete structural members such as bridge columns and beams using a composite retrofitting technique.

• Proceedings of the KOSOMBE Conference
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• v.1996 no.05
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• pp.335-338
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• 1996

We attempted to reconstruct basement membrane (BM) in between the epidermal compartment and dermal compartment in the artificial skin preparation and examine its effect on the skin architecture as well as on the epidermal differentiation. Laminin, one of the component of BM, stimulate the migration of the basal cells but type IV collagen which is a major component of the mechanical network of BM did not stimulate epidermal migration. However laminin in the presence of type IV collagen at a 1:1 molar ratio did not stimulate epidermal migration but provide nice demarcation between epidermis and dermis. This mixture of laminin and type IV collagen enhanced epidermal differentiation in the artificial skin based on the morphological observation as well as biochemical criteria. The epidermal acquirement of migratory ability on the laminin-rich substrate suggest that this type of unbalance in the expression of the components of BM may prevail in the area of healing tissue and the invasive transition of the tumor. The result in this study provide the technical improvement in the artificial skin preparation and further application of this technique for the reconstruction of other bio-artificial organ.

• Journal of Korean Society of Steel Construction
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• v.15 no.6 s.67
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• pp.629-637
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• 2003

This s paper presented the results of the three phases of fatigue tests to determine the fatigue strength of in-plane welded gusset joints, which are the most common details inevitably existing in the region of high stress range. A total of 57 fatigue specimens with varying thickness and strengths were made and tensile fatigue tests performed. One full-scale beam fatigue test was also performed. The validity of the fatigue strength of those details in the specification was confirmed, with the effects of thickness of flanges and welded attachments, length of attachments, and strength of applied steel examined. The characteristics of crack initiation and propagation were also observed. The test result was evaluated by comparing it with other test data and fatigue criteria of other countries. To determine the degree of stress concentration in the weld toe depending on geometric configuration such as attachment length and transition radius, analyses were performed. Compared to the present specification, analytical results indicate the need to revise and subdivide the detail categories.

• Journal of the Korean Society for Railway
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• v.10 no.5
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• pp.546-553
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• 2007

The objective of the present paper is to evaluate the effect of the evolution of contact surface profile by fretting wear on the contact stress distribution and fatigue crack initiation site of press-fitted shaft by means of an analytical method based on experimental data. A finite element analysis was performed to analyze the stress states of press-fitted shaft, considering the worn contact surface profiles of shaft. The evolutions of contact stress as wearing of contact surface were analyzed by finite element analysis and fatigue crack nucleation sites were evaluated by fretting fatigue damage parameter (FFDP) md multiaxial fatigue criteria. It is found that the stress concentration of a contact edge in press-fitted sha손 decreases rapidly at the initial stage of total fatigue life, and its location shifts from the contact edge to the inside due to fretting wear as increasing of fatigue cycles. Thus the transition of crack nucleation position in press-fitted shaft is mainly caused by stress change of a contact edge due to the evolution of contact surface profile by fretting wear. Therefore, it is suggested that the nucleation of multiple cracks on fretted surface of press fits is strongly related to the evolution of surface profile at the initial stage of total fatigue life.

• Nuclear Engineering and Technology
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• v.23 no.1
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• pp.56-65
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• 1991

The LOFT LOCE L2-3 was simulated using the RELAP5/MOD2 Cycle 36.04 code to assess its capability in predicting the thermal-hydraulic phenomena in LBLOCA of a PWR. The reactor vessel was simulated with two core channels and split downcomer modeling for a base case calculation using the frozen code. The result of the base calculation showed that the code predicted the hydraulic behavior, and the blowdown thermal response at high power region of the core reasonably and that the code had deficiencies in the critical How model during subcooled-two-phase transition period, in the CHF correlation at high mass flux and in the blowdown rewet criteria. An overprediction of coolant inventory due to the deficiencies yielded the poor prediction of reflood thermal response. Improvement of the code, RELAP5 / MOD2 Cycle 36.04, based on the sensitivity study increased the accuracy of the prediction of the rewet phenomena.

• Journal of Soil and Groundwater Environment
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• v.23 no.3
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• pp.27-42
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• 2018

It is important to identify the contaminant sources and to evaluate the fate and transport of heavy metals to crops in agricultural lands. This study was conducted to evaluate metal sources and its transfer and accumulation to crop in agricultural soils. Pollution indices were calculated and multivariate analysis was performed to identify metal sources. To evaluate transfer and accumulation of metals to crops, the contents of phytoavailable metals were evaluated by using single extraction method and the correlation between metal content and soil properties was analyzed. Also the BCF was quantitatively evaluated for investigating the metal transition to each crop grown in the research area. As a result, Cr, Ni, and Co were expected to be mainly derived from geologic factors due to weathering of certain parent rocks. The content of nickel in soils of the research area was slightly higher than that of the concern level criteria based on total concentration, but the amount transferred and accumulated in the crops was actually low. Understanding the contamination characteristics by investigating the pollution sources of heavy metals and its transfer and accumulation to crops through various evaluation techniques could provide important information for proper management of the agricultural land.

• Convergence Security Journal
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• v.19 no.2
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• pp.129-136
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• 2019

The main tasks of commander and staffs in ground operations are a continuation performing the process of making decisions in various situations. Since the current decision-making process is largely dependent on qualitative methods, it is difficult to integrate with the decision-making tools associated with the 4th Industrial Revolution. The purpose of this study is to suggest the process of deriving the relative importance of the evaluation factors using the AHP with focusing on assessing the avenues of approach in IPB related to the ground operation plan. The most important aspect of IPB is the evaluation of the avenues of approach. Evaluation factors include target accessibility, observation and seasons, concealment and cover-up, ease of maneuverability, and ease of transition to adjacent access roads. The existing methods are the comparison method with evaluation factors and the analysis with the advantages and disadvantages. However, it has been criticized that they regard evaluation factors as equal importance. The results show that target accessibility has the highest score related with priority when considering the criteria.