• Journal of Chest Surgery
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• 제25권7호
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• pp.693-701
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• 1992

Extracorporeal cardiopulmonary bypass[CPB] has been associated with a wide variety of hematologic derangements, including a transient deformation and hemolysis of red blood cells[RBCs], which is supposed to be due to mechanical trauma and/or metabolic alterations. Since membrane integrity is, in part, maintained by energy requiring process, inadequate function of erythrocyte glycolytic pathway, which is inevitalble during CPB, may cause depletion of high energy phosphate pool and result in hemolysis. The authors performed an investigation to assess whether administration of Fructose-l, 6-diphsphate [FDP], which has been known to enhance intracellular glycolytic activities, could counteract erythrocyte hemolytic events caused by CPB. Sixty pateints with cyanotic congenital heart diseases, who underwent open heart surgery under CPB longer than 60 minutes, were randomly divided into two groups depending on whether use of FDP[Group FDP] or not[Group Control]. The age, sex, CPB time, preoperative hemoglobin level, disease entities were all similar[Table 1], and membrane type oxygenators were used in all patients. In Group, FDP, a dose of 250mg/kg body weight of FDP was administered by intravenous dripping every 12 hours from the morning of the operation to postoperative 48 hours, To demonstrate the degree and pattern of hemolysis of erythrocyte, reticulocyte count, indirect /direct bilirubin, haptoglobin, plasma hemoglobin, lactate dehydrogenase were measured every 12 hours from the time of cessation of CPB to 48 hours and RBC morphologic study, osmotic fragility test were done every 24 hours. All parameters revealed less hemolytic in group FDP [Fig. 1~5], though the differences between two groups were not significant, except plasma hemoglobin, lactate dehydrogenase changes. A pattern of sequential changes of plasma hemoglobin, lactate deh-ydrogenase showed the highest level at the time of CPB stop and abrupt decrease in following 24 hours in both groups, and statistically significant differences were demonstrated in group FDP at least for the first 12 hours postoperatively[p<0.05]. The authors conclude that they can expect the benificial effect of FDP on the maintenance of membrane stability of RBC probably by energy enhancement during the shock status of CPB, but FDP could not completely prevent the damaging effect on RBC by cardiopulmonary bypass

• 대한교통학회지
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• 제21권3호
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• pp.97-106
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• 2003

본 연구에서는 운전자의 경로선택과 각 경로에 대한 학습행동이 교통상황에 따라 어떻게 달라지는 가를 살펴보기로 한다. 즉, 주어진 환경 하에서 자신의 효용을 최대화(소요시간의 최소, 비용의 최소)하는 경로를 선택하는 운전자를 가정하여 교통상황에 따른 운전자의 행동을 모델화하고자 한다. 경로선택에 직면한 운전자는 자신이 획득 가능한 정보와 과거의 경험에 근거하여 각 경로의 주행시간 등의 교통조건을 예측하고 반복적인 경로선택 행동을 통해 각 경로의 주행조건 등에 대한 학습을 하게 된다. 이 때, 운전자의 경로선택과 학습 메커니즘은 각 경로의 교통상황에 따라 다르게 형성된다. 즉, 교통류 상황이 정상성(stationarity)을 띄고 있는지 혹은 비정상성(nonstationarity)을 띄고 있는지에 따라 운전자의 경로선택과 학습 메커니즘이 다르게 됨을 확인하였으며, 이 경우 사후적인(ex-post) 정보의 획득가능성이 운전자 학습행동의 수렴에 큰 영향을 미치고 있음도 알 수 있었다. 또한, 랜덤워크와 같은 비정상성을 따르는 교통환경에서 운전자는 경로의 조건에 대한 그들의 학습과정에서 학습계수(적응계수)는 각 경로의 특성에 따라 서로 다른 값으로 수렴함을 확인하였다. 나아가 시뮬레이션을 통해 운전자의 경로 환경에 대한 학습과정과 경로선택 행동을 구현하였으며, 향후 연구방향에 대해 고찰한다.

• Journal of Mechanical Science and Technology
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• 제20권2호
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• pp.251-261
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• 2006

The objective of this work is to apply artificial neural networks for solving inverse problems in the structural optimization of a fiber optic pressure sensor. For the sensor under investigation to achieve a desired accuracy, the change in the distance between the tips of the two fibers due to the applied pressure should not interfere with the phase change due to the change in the density of the air between the two fibers. Therefore, accurate dynamic analysis and structural optimization of the sensor is essential to ensure the accuracy of the measurements provided by the sensor. To this end, a normal mode analysis and a transient response analysis of the sensor were performed by combining commercial finite element analysis package, MSC/NASTRAN, and MATLAB. Furthermore, a parametric study on the design of the sensor was performed to minimize the size of the sensor while fulfilling a number of constraints. In performing the parametric study, the need for a relationship between the design parameters and the response of the sensor was fulfilled by using a neural network. The whole process of the dynamic analysis using commercial finite element analysis package and the parameter optimization of the sensor were automated within the MATLAB environment.

• Nuclear Engineering and Technology
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• 제18권2호
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• pp.107-116
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• 1986

새로이 개발된 망상구조 충전탑에서의 중수증류성능해석 및 설계를 위한 정상 및 비정상상태 모델을 수립하였다. 정상상태 모델은 MESH 방정식에 각단의 압력강하를 고려하여 설정하고, Equation Tearing방법으로 그 해를 구하여 중수중류탄내의 농도, 온도 및 압력구배를 얻었다. 비정상상태 거동해석을 위하여 Cohen의 이상단 모델을 수정한 평형단 전이모델을 세웠으며, 그 모델식의 해석적 해를 구함으로써 시간에 따른 중수 농축과정을 예측할 수 있게 되었다. 설정된 모델들은 전환류 중수증류탑에서의 실험결과와 매우 잘 일치하였으며 개발된 충전물임이 높은 이론단수에 낮은 압력강하, 저체류량을 갖는 우수한 중수농축용 충전물임이 확인되었다.

• The Korean Journal of Physiology and Pharmacology
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• 제25권6호
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• pp.497-506
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• 2021

Besides using for hair removal, depilatory agents have been considered to be used as a penetration enhancer for transepidermal drug delivery. To examine the effect in hair follicles (HFs), two commercially available depilatory creams were tested on the dorsal skin of mice to monitor the effect deep into the skin structure. Fifteen male BALB/c mice were used in this study. Depilatory creams were applied to the dorsal skin of the same animal using shaved and untouched treatments as controls to minimize individual differences. Skin samples were collected at three days, one week and two weeks (n = 5 for each) after the treatment, and subjected for hematoxylin-eosin staining, and immunohistochemical analysis for proinflammatory cytokines. The morphological examination showed an increase in the thickness of epidermal layer of the depilatory cream-treated skin at early time points and in the subcutis at two weeks. Depilatory cream promoted entry of anagen phase and increased the number of hair follicles in the subcutis at one and two weeks. Immunohistochemistry showed elevated percentages of dermal fibroblasts expressing interleukin-6, tumor necrosis factor-α, and tumor necrosis factor-β. Shaving process increased the thickness of epidermis and dermis as depilatory creams did, but did neither induce the expression of proinflammatory cytokines in the dermal fibroblasts nor the number of HFs. The results suggested that the commercially available depilatory creams caused a transient minor inflammatory response of the skin and increased the levels of cytokines that might subsequently affect hair growth.

• 화약ㆍ발파
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• 제37권1호
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• pp.14-23
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• 2019

암석이나 콘크리트와 같은 취성재료의 경우에는 역학적 강도의 하중속도 의존성을 보임에 따라 발파 및 충격해석에 있어 이를 반영코자 하는 노력이 증가하고 있다. 이와 같은 암석의 동적강도의 경우에는 순간적으로 높은 하중이 작용하는 동적하중의 가압특성에 따라 시험편 내의 응력평형상태를 고려한 평가가 수행되어야함이 제안된 바 있다. 본 연구에서는 스플릿 홉킨슨 압력봉 장비를 이용한 포천 화강암의 동적일축압축강도 실험을 통해 응력평형조건의 충족 유무에 따른 암석의 동적파괴과정 및 역학적 강도특성에 대해 고찰하였다. 연구결과 적절한 응력평형상태가 이루어지진 않은 상태에서 평가된 암석의 동적일축압축강도는 상대적으로 과소평가되는 것으로 나타났으며, 이는 하중의 가압면에서 발생하는 조기파괴에 따른 에너지 파괴에너지 손실 및 변형률속도 과대평가에 의한 것으로 판단되었다. 결론적으로 합리적인 동적강도 평가를 위해서는 암석의 변형거동특성에 대한 분석 및 파괴패턴에 대한 검토를 통한 응력평형조건의 세밀한 검증이 수반되어야 할 것으로 판단하였다.

• 한국환경복원기술학회지
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• 제22권1호
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• pp.33-45
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• 2019

Compound disaster is the type that increases the impact affected by two or more hazard events, and attention to compound disaster and multi-hazards risk is growing due to potential damages which are difficult to predict. The objective of this study is to analyze the possible impacts of post-fire landslide scenario quantitatively by using TRIGRS (Transient Rainfall Infiltration and Grid-Based Regional Slope-Stability Analysis), a physics-based landslide model. In the case of wildfire, soil organic material and density are altered, and saturated hydraulic conductivity decrease because of soil exposed to high temperature. We have included the change of soil saturated hydraulic conductivity into the TRIGRS model through literature review. For a case study, we selected the area of $8km^2$ in Pyeongchang County. The landslide modeling process was calibrated before simulate the post-wildfire impact based on landslide inventory data to reduce uncertainty. As a result, the mean of the total factor of safety values in the case of landslide was 2.641 when rainfall duration is 1 hour with rainfall intensity of 100mm per day, while the mean value for the case of post-wildfire landslide was lower to 2.579, showing potential landslide occurrence areas appear more quickly in the compound disaster scenario. This study can be used to prevent potential losses caused by the compound disaster such as post-wildfire debris flow or landslides.

• 접착 및 계면
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• 제19권4호
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• pp.154-162
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• 2018

필름 형태의 Polydimethylsiloxane (PDMS)은 표면 개질을 하기 위해 Plasma 처리 또는 Corona 처리를 하여 표면을 -OH기로 활성화시키는 공정이나, 피착제와 PDMS 필름의 접착 또는 Adhesion promoter와 축합 반응을 통해 PDMS 표면을 다른 작용기로 개질시키는 공정, Grafting polymerization을 이용하는 PDMS 개질 공정이 주로 이용된다. 그러나 Plasma나 Corona 처리 후에 친수성이 오래가지 못하고, 보관에 어려움이 있다. 따라서, 본 연구에서는 코팅 공정을 통하여서 PDMS표면 개질을 하기 위해서, 먼저 새로운 형태의 실란 기능화 아크릴 고분자 전구체를 합성하고 이를 Hydroxyl-terminated PDMS와의 축합 반응을 통해 아크릴 고분자와 PDMS 고분자가 결합된 형태의 표면 개질제를 제조한 후, 이를 PDMS 필름 위에 코팅하였다. 제조한 표면 개질제의 구조와 분자량을 확인하기 위하여 1H-NMR과 GPC를 분석하였고, 표면 개질제가 코팅된 PDMS표면 특성 변화를 확인하기 위하여 XPS, ATR, WCA를 이용하여 표면 특성을 조사하였으며, PDMS 필름과의 부착을 확인하기 위해 Cross cutting test를 진행하였다. 그 결과 PDMS 필름 표면이 아크릴 고분자층이 형성된 것으로 확인하였고, PDMS 필름과 표면 개질제와의 부착성 (4 - 5B) 또한 우수한 것을 확인하였다.

• Geomechanics and Engineering
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• 제29권2호
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• pp.113-131
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• 2022

A rockburst is a common disaster in deep-tunnel excavation engineering, especially for high-geostress areas. An anomalously low friction effect is one of the most important inducements of rockbursts. To elucidate the correlation between an anomalously low friction effect and a rockburst, we establish a two-dimensional prediction model that considers the discontinuous structure of a rock mass. The degree of freedom of the rotation angle is introduced, thus the motion equations of the blocks under the influence of a transient disturbing force are acquired according to the interactions of the blocks. Based on the two-dimensional discontinuous block model of deep rock mass, a rockburst prediction model is established, and the initiation process of ultra-low friction rockburst is analyzed. In addition, the intensity of a rockburst, including the location, depth, area, and velocity of ejection fragments, can be determined quantitatively using the proposed prediction model. Then, through a specific example, the effects of geomechanical parameters such as the different principal stress ratios, the material properties, a dip of principal stress on the occurrence form and range of rockburst are analyzed. The results indicate that under dynamic disturbance, stress variation on the structural surface in a deep rock mass may directly give rise to a rockburst. The formation of rockburst is characterized by three stages: the appearance of cracks that result from the tension or compression failure of the deformation block, the transformation of strain energy of rock blocks to kinetic energy, and the ejection of some of the free blocks from the surrounding rock mass. Finally, the two-dimensional rockburst prediction model is applied to the construction drainage tunnel project of Jinping II hydropower station. Through the comparison with the field measured rockburst data and UDEC simulation results, it shows that the model in this paper is in good agreement with the actual working conditions, which verifies the accuracy of the model in this paper.

• Wind and Structures
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• 제34권5호
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• pp.407-419
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• 2022

Many factors should be considered by architects and designers for designing a tall building. Wind load is one of these important factors that govern the design of tall building structures and can become a serious challenge when buildings tend to be built very tall and slender. On the other hand, through the initial stages of a design process, choosing the design geometry greatly affects the wind-induced forces on a tall building. With this respect, geometric shapes with 3-fold rotational symmetry are one of the applied plan shapes in tall buildings. This study, therefore, aims to investigate the aerodynamic characteristics of 8 different geometrical shapes using Computational Fluid Dynamics (CFD) by measuring the drag and lift forces. A case study approach was conducted in which different building shape models have the same total gross area and the same height of 300 meters. The simulation was an incompressible transient flow that ran 1700 timesteps (85 seconds on the real-time scale). The results show a great difference between wind-induced force performance of buildings with different plan shapes. Generally, it is stated that the shapes with the same area, but with smaller perimeters, are better choices for reducing the drag force on buildings. Applying the lift force, the results show that the buildings with plan shapes that have rounded corners act better in crosswind flow while, those with sharp corners induce larger forces in the same direction. This study delivers more analytical understanding of building shapes and their behavior against the wind force through the parametric modelling.