• 한국재료학회지
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• 제9권5호
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• pp.460-466
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• 1999

The deep level electron traps in AP-MOCVD GaAs/undoped Al\ulcornerGa\ulcornerAs/n-type GaAs heterostructures have been investigated by means of Deep Level Transient Spectroscopy DLTS). In terms of the experimental procedure, GaAs/undoped Al\ulcornerGa\ulcornerAs/n-type GaAs heterostructures were deposited on 2" undoped semi-insulating GaAs wafers by the AP-MOCVD method at $650^{\circ}C$ with TMGa, AsH3, TMAl, and SiH4 gases. The n-type GaAs conduction layers were doped with Si to the target concentration of about 2$\times$10\ulcornercm\ulcorner. The Al content was targeted to x=0.5 and the thicknesses of Al\ulcornerGa\ulcornerAs layers were targeted from 0 to 40 nm. In order to investigate the electrical characteristics, an array of Schottky diodes was built on the heterostructures by the lift-off process and Al thermal evaporation. Among the key results of this experiment, the deep level electron traps at 0.742~0.777 eV and 0.359~0.680 eV were observed in the heterostructures; however, only a 0.787 eV level was detected in n-type GaAs samples without the Al\ulcornerGa\ulcornerAs overlayer. It may be concluded that the 0.787 eV level is an EL2 level and that the 0.742~0.777 eV levels are related to EL2 and residual oxygen impurities which are usually found in MOCVD GaAs and Al\ulcornerGa\ulcornerAs materials grown at $630~660^{\circ}C$. The 0.359~0.680 eV levels may be due to the defects related with the al-O complex and residual Si impurities which are also usually known to exist in the MOCVD materials. Particularly, as the Si doping concentration in the n-type GaAs layer increased, the electron trap concentrations in the heterostructure materials and the magnitude of the C-V hysteresis in the Schottky diodes also increased, indicating that all are intimately related.ated.

• 대한기계학회논문집A
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• 제41권4호
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• pp.263-270
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• 2017

조선소에서 사용되는 대형 셧오프 밸브의 개폐를 위한 용기의 경우, 저압의 고정식 대형 공기탱크가 사용되고 있는데, 이는 먼 거리에 있는 밸브에 공압을 공급해야 할 경우, 추가 배관이 필요하며 수송도중 압력 강하가 발생하는 문제점이 있다. 이에 본 논문에서는 작업자들의 편의성을 증대시키고, 공기누설로 인한 폭발 방지를 위하여 고압의 휴대형 용접식 질소용기(11 kg, 10 L 및 50 bar)의 설계를 수행하였다. 구조적으로 취약한 용접부를 최소화하기 위하여 용기의 외형을 타원형으로 설계하였으며, 기준 무게 및 용적 충족과 사용압력에 대한 구조안전성을 확립하기 위하여 용기의 두께와 장단축 비를 설계하였다. 또한 용접 잔류응력 예측을 위해 APDL(ANSYS Parametric Design Language)을 이용하여 과도 열-구조 연성해석을 수행하였으며, 내압에 의한 구조안전 및 피로수명을 검증하였다.

• 정보처리학회논문지A
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• 제8A권4호
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• pp.319-330
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• 2001

가상 메모리 시스템에서 프로세스가 현재 물리 메모리에 없는 페이지에 접근하게 되면 페이지 폴트가 발생하고, 이를 처리하기 위하여 예측할 수 없는 지연을 초래하는 페이지 폴트 핸들러가 동작하게 된다. 따라서 가상 메모리 시스템은 실시간 태스크의 제한 시간 실패율을 높여주는 요인이 될 수 있으므로 실시간 시스템에서 사용하기 어렵다. 뿐만 아니라, 새로운 태스크가 동적으로 유입되는 범용 운영체제 환경에서 가상 메모리 시스템은 태스크의 집중적인 페이지 폴트로 인하여 일시적인 과부하 상태에 빠질 수 있다. 본 논문에서는 집중적으로 발생하는 페이지 폴트에 의한 일시적인 과부하를 효율적으로 처리할 수 있는 RBPFH(Rate-Based Page Fault Handling) 알고리즘을 제시하고 있다 알고리즘의 특징은 현재 시스템의 자원을 모니터링하면서 페이지 폴트가 제한된 범위를 초과하지 않도록 분산시키는 방법을 사용하고 있으며, 페이지 폴트 처리 비율을 조정해줌으로써 동적으로 시스템의 부하가 변하는 상황을 고려하고 있다. RBPFH 알고리즘은 리눅스 운영체제에서 구현하였으며, 실험을 통하여 멀티미디어와 같은 연성 실시간 태스크를 지원하는데 있어서 유용하게 사용될 수 있음을 확인하였다. 실험 결과 RBPFH는 태스크의 제한 시간 실패율을 10%∼20% 감소시키고, 평균 지연 시간을 50%∼60% 감소시켜주었다.

• Journal of Pharmaceutical Investigation
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• 제25권3호spc1호
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• pp.7-20
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• 1995

Taurine, a ${\beta}-amino$ acid, plays an important role as a neuromodulator and is necessary for the normal development of the brain. Since de novo synthesis of taurine in the brain is minimal and in vivo studies suggest that taurine dose not cross the blood-brain barrier, we examined whether the choroid plexus, the blood-cerebrospinal fluid (CSF) barrier, plays a role in taurine transport in the central nervous system. The uptake of $[^3H]-taurine$ into ATP depleted choroid plexus from rabbit was substantially greater in the presence of an inwardly directed $Na^+$ gradient taurine accumulation was negligible. A transient in side-negative potential gradient enhanced the $Na^+-driven$ uptake of taurine into the tissue slices, suggesting that the transport process is electrogenic, $Na^+-driven$ taurine uptake was saturable with an estimated $V_{max}$ of $111\;{\pm}\;20.2\;nmole/g/15\;min$ and a $K_M\;of\;99.8{\pm}29.9\;{\mu}M$. The estimated coupling ratio of $Na^+$ and taurine was $1.80\;{\pm}\;0.122.$ $Na^+-dependent$ taurine uptake was significantly inhibited by ${\beta}-amino$ acids, but not by ${\alpha}-amino$ acids, indicating that the transporter is selective for ${\beta}-amino$ acids. Since it is known that the physiological concentration of taurine in the CSF is lower than that in the plasma, the active transport system we characterized may face the brush border (i.e., CSF facing) side of the choroid plexus and actively transport taurine out of the CSF. Therefore, we examined in vivo elimination of taurine from the CSF in the rat to determine whether elimination kinetics of taurine from the CSF is consistent with the in vitro study. Using a stereotaxic device, cannulaes were placed into the lateral ventricle and the cisterna magna of the rat. Radio-labelled taurine and inulin (a marker of CSF flow) were injected into the lateral ventricle, and the concentrations of the labelled compounds in the CSF were monitored for upto 3 hrs in the cisterna magna. The apparent clearance of taurine from CSF was greater than the estimated CSF flow (p<0.005) indicating that there is a clearance process in addition to the CSF flow. Taurine distribution into the choroid plexus was at least 10 fold higher than that found in other brain areas (e. g., cerebellum, olfactory bulb and cortex). When unlabelled taurine was co-administered with radio-labelled taurine, the apparent clearance of taurine was reduced (p<0.0l), suggesting a saturable disposition of taurine from CSF. Distribution of taurine into the choroid plexus, cerebellum, olfactory bulb and cortex was similarly diminished, indicating that the saturable uptake of taurine into these tissues is responsible for the non-linear disposition. A pharmacokinetic model involving first order elimination and saturable distribution described these data adequately. The Michaelis-Menten rate constant estimated from in vivo elimination study is similar to that obtained in the in vitro uptake experiment. Collectively, our results demonstrate that taurine is transported in the choroid plexus via a $Na^+-dependent,saturable$ and apparently ${\beta}-amino$ acid selective mechanism. This process may be functionally relevant to taurine homeostasis in the brain.

• 멤브레인
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• 제28권5호
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• pp.351-360
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• 2018

본 연구에서는 NaY 제올라이트 분리막의 프로필렌/프로판 분리 메카니즘을 규명하고자 하였다. 투과온도 증가 시에 프로필렌과 프로판 투과도는 증가하다 최고점을 보이고 감소하였고 약 $50-60^{\circ}C$ 부근에서 최대 선택도를 보였다. 혼합가스 프로판 투과도는 단일가스 투과도 보다 작았고, 프로필렌/프로판 혼합가스 선택도는 단일가스 투과선택도보다 우수하였다. 시간에 따른 혼합가스 투과거동 실험에서, 투과시간이 증가함에 따라서 프로필렌 투과도는 증가하는 반면, 프로판의 투과도는 감소하였고 선택도는 증가하였다. 위의 모든 실험결과는 NaY 제올라이트 분리막을 통한 프로필렌/프로판 분리는 선택적으로 흡착된 프로필렌의 프로판 투과 억제에 의해 일어나며 프로필렌 투과는 표면확산에 의해 지배된다는 것을 나타낸다. 프로필렌/프로판(89 : 11) 혼합가스에 대하여 분리막은 $50^{\circ}C$, 4 bar에서 선택도 12, 프로필렌 투과도 497 GPU를 나타내었다. 따라서 본 연구에서 제조된 NaY 제올라이트 모세관 분리막은 가격이 저렴하고 우수한 분리성능을 보이기 때문에 프로필렌/프로판 분리를 위한 유망한 분리막 소재임을 확인할 수 있었다.

• Korean Chemical Engineering Research
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• 제55권2호
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• pp.180-189
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• 2017

난용성 약물의 용해도를 증가시키고 안정성을 향상하기 위한 제약 공결정은, 미국 FDA가 지난 2016년 8월에 공결정을 solvate의 특별한 경우라고 정의를 수정하면서, 개량신약의 개발에 더욱 박차를 가할 것으로 추측된다. 본 연구에서는 모델 조합으로 잘 알려진 indomethacin-saccharin 공결정을 반용매 방법으로 제조할 때, 인라인 모니터링 기법을 적용하여, 반용매의 주입속도에 따른 indomethacin 준 안정상의 일시적인 생성 및 indomethacin-saccharin 공결정의 생성을 관찰하고 메커니즘을 제안하고자 하였다. 그간 인라인 모니터링을 위해서 매우 다양한 분석도구가 연구되어 왔는데, 본 연구에서는 PVM (particle vision measurement)와 FBRM (focused beam reflectance measurement)를 조합하여 공결정화 공정에서의 변화를 실시간으로 측정하였다. 공결정화 결과물의 오프라인 분석은 PXRD (powder x-ray diffraction)와 DSC (Differential scanning calorimeter)를 이용하여 수행하였다. 반용매의 주입 속도에 따라서 공결정이 생성되는 경로에 분명한 차이가 있음을 관찰하였으며, 이러한 상관 관계의 이해를 통해서 제약학적 특성이 더욱 일정하고 품질이 보증된 indomethacin-saccharin Co-crystal을 얻는 조건을 확립하였다. 본 연구결과, PVM과 FBRM을 조합한 인라인 모니터링은 제약 공결정 제조공정에서 활용성이 매우 높은 기술이라고 할 수 있다.

• Journal of Information Display
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• 제13권2호
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• pp.73-82
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• 2012

In this paper, a light-emitting diode (LED) backlight driver integrated circuit (IC) for medium-sized liquid crystal displays (LCDs) is proposed. In the proposed IC, a linear current regulator with matched internal resistors and an adaptive phase-shifted pulse-width modulation (PWM) dimming controller are also proposed to improve LED current uniformity and reliability. The double feedback loop control boost converter is used to achieve high power efficiency, fast transient characteristic, and high dimming frequency and resolution. The proposed IC was fabricated using the 0.35 ${\mu}m$ bipolar-CMOS-DMOS (BCD) process. The LED current uniformity and LED fault immunity of the proposed IC were verified through experiments. The measured power efficiency was 90%; the measured LED current uniformity, 97%; and the measured rising and falling times of the LED current, 86 and 7 ns, respectively. Due to the fast rising and falling characteristics, the proposed IC operates up to 39 kHz PWM dimming frequency, with an 8-bit dimming resolution. It was verified that the phase difference between the PWM dimming signals is changed adaptively when LED fault occurs. The experiment results showed that the proposed IC meets the requirements for the LED backlight driver IC for medium-sized LCDs.

• Journal of Power Electronics
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• 제15권3호
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• pp.730-740
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• 2015

This paper presents model reference adaptive system speed estimators based on Type-1 and Type-2 fuzzy logic controllers for the speed sensorless direct torque and flux control of an induction motor drive (IMD) using space vector pulse width modulation. A Type-1 fuzzy logic controller (T1FLC) based adaptation mechanism scheme is initially presented to achieve high performance sensorless drive in both transient as well as in steady-state conditions. However, the Type-1 fuzzy sets are certain and cannot work effectively when a higher degree of uncertainties occurs in the system, which can be caused by sudden changes in speed or different load disturbances and, process noise. Therefore, a new Type-2 FLC (T2FLC) - based adaptation mechanism scheme is proposed to better handle the higher degree of uncertainties, improve the performance, and is also robust to different load torque and sudden changes in speed conditions. The detailed performance of different adaptation mechanism schemes are performed in a MATLAB/Simulink environment with a speed sensor and sensorless modes of operation when an IMD is operates under different operating conditions, such as no-load, load, and sudden changes in speed. To validate the different control approaches, the system is also implemented on a real-time system, and adequate results are reported for its validation.

• Asian Pacific Journal of Cancer Prevention
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• 제13권9호
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• pp.4827-4834
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• 2012

Tumor suppressor genes have received much attention for their roles in the development of human malignancies. Gelsolin has been found to be down-regulated in several types of human cancers, including leukemias. It is, however, expressed in macrophages, which are the final differentiation derivatives for the monocytic myeloid lineage, implicating this protein in the differentiation process of such cells. In order to investigate the role of gelsolin in leukaemic cell differentiation, stable clones over-expressing ectopic gelsolin, and a control clone were established from U937 leukaemia cells. Unlike the control cells, both gelsolin-overexpressing clones displayed retarded growth, improved monocytic morphology, increased NADPH and NSE activities, and enhanced surface expression of the ${\beta}$-integrin receptor, CD11b, when compared with the parental U937 cells. Interestingly, RT-PCR and western blot analysis also revealed that gelsolin enhanced p21CIP1 mRNA and protein expression in the overexpressing clones. Moreover, transient transfection with siRNA silencing P21CIP1, but not the control siRNA, resulted in a reduction in monocytic differentiation, accompanied by an increase in proliferation. In conclusion, our work demonstrates that gelsolin, by itself, is capable of inducing monocytic differentiation in U937 leukaemia cells, most probably through p21CIP1 activation.

• Nuclear Engineering and Technology
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• 제52권9호
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• pp.1955-1962
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• 2020

In a sudden shutdown of primary pump or coolant loss accident in a marine nuclear power plant, the primary flow decreases rapidly in a transition process from forced circulation (FC) to natural circulation (NC), and the lower flow enters the steam generator (SG) causing reverse flow in the U-tube. This can significantly compromise the safety of nuclear power plants. Based on the marine natural circulation steam generator (NCSG), an experimental loop is constructed to study the characteristics of reverse flow under middle-temperature and middle-pressure conditions. The transition from FC to NC is simulated experimentally, and the characteristics of SG reverse flow are studied. On this basis, the experimental loop is numerically modeled using RELAP5/MOD3.3 code for system analysis, and the accuracy of the model is verified according to the experimental data. The influence of the flow variation rate on the reverse flow phenomenon and flow distribution is investigated. The experimental and numerical results show that in comparison with the case of adjusting the mass flow discontinuously, the number of reverse flow tubes increases significantly during the transition from FC to NC, and the reverse flow has a more severe impact on the operating characteristics of the SG. With the increase of flow variation rate, the reverse flow is less likely to occur. The mass flow in the reverse flow U-tubes increases at first and then decreases. When the system is approximately stable, the reverse flow is slightly lower than obverse flow in the same U-tube, while the flow in the obverse flow U-tube increases.