• Journal of Ginseng Research
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• v.37 no.2
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• pp.201-209
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• 2013

Ginsenoside, one of the active ingredients of Panax ginseng, has a variety of physiologic and pharmacologic effects. The purpose of this study was to explore the effects of ginsenoside Rd (G-Rd) on melastatin type transient receptor potential 7 (TRPM7) channels with respect to the proliferation and survival of AGS and MCF-7 cells (a gastric and a breast cancer cell line, respectively). AGS and MCF-7 cells were treated with different concentrations of G-Rd, and caspase-3 activities, mitochondrial depolarizations, and sub-G1 fractions were analyzed to determine if cell death occurred by apoptosis. In addition, human embryonic kidney (HEK) 293 cells overexpressing TRPM7 channels were used to confirm the role of TRPM7 channels. G-Rd inhibited the proliferation and survival of AGS and MCF-7 cells and enhanced caspase-3 activity, mitochondrial depolarization, and sub-G1 populations. In addition, G-Rd inhibited TRPM7-like currents in AGS and MCF-7 cells and in TRPM7 channel overexpressing HEK 293 cells, as determined by whole cell voltage-clamp recordings. Furthermore, TRPM7 overexpression in HEK 293 cells promoted G-Rd induced cell death. These findings suggest that G-Rd inhibits the proliferation and survival of gastric and breast cancer cells by inhibiting TRPM7 channel activity.

• 전기의세계
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• v.24 no.2
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• pp.71-77
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• 1975

This paper describes the results of a study for the stability of power system when the Kori Nuclear #1 P/P is operated with existing system. First, a transient disturbance, which effects the stability of entire power system, was analysed and to cope with the problem a load shedding method was studied to recover the fluctuation of the power system. Second, transient stability problem was studied when three phase fault occurs in 345 Extra High Voltage power System, and from this result, it was found to be highly effective that high speed protecting device should be provided and operated to recover the fault.

• Journal of the Korean Society of Manufacturing Technology Engineers
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• v.7 no.3
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• pp.79-84
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• 1998

It is very difficult to analyze the transient temperature distribution during quenching of the steel because of coupled effects among temperature, structures and stresses. In this paper, using Inoue's equation of evolution and mixture rule, transient temperature distribution is calculated by the finite element method considering latent heat of transformation structure and temperature dependence of physical and mechanical prperties for the 0.45% carbon cylindrical steel bar with 40mm diameter and 20mm height during end-quenching.

• Journal of the Korean Institute of Telematics and Electronics A
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• v.30A no.11
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• pp.122-131
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• 1993

In this paper, we have developed a submicron Si MOSFET simulator, which is physically based on the hydrodynamic energy transport mode. The simulator was used to investigate the nonstationary transport effects and the transient phenomena in submicron Si MOSFET's. It is found that the velocity overshoot and the carrier heating are dominant transport mechanism near the drain end of the channel and the transient phenomena is more retained in a long channel MOSFET.

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.18 no.10
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• pp.1024-1032
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• 2008

The vibration characteristics of a rotating cantilever beam undergoing impulsive force are investigated using wavelet transformation. The transient response induced by the impulsive force and the rigid body motion of the beam are calculated using hybrid deformation variable modeling along with the Rayleigh-Ritz assumed mode methods. The vibration characteristics of the beam can be analyzed in time-frequency domain with the wavelet transform method. Therefore, the effects of the impulsive force on the transient vibration characteristics of the beam can be investigated more effectively.

• Journal of the Korean Society for Precision Engineering
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• v.25 no.8
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• pp.65-71
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• 2008

This paper presents a transient heat transfer analysis of a drum brake shape. The transient heat transfer analysis of automotive drum brakes with frictional contact is performed by using the finite element method. The drum brake type studied in the page is the internally expanding one in which two shoes fitted externally with frictional material are forced outward against surface a rotating drum on the wheel unit. In this case, the braking power is produced by the friction force between a drum and a lining, and is converted into heat. The brake drum has constant material properties. The air inside the drum has temperature-dependent thermal conductivity and enthalpy. Radiation effects are ignored. The result explains the reason why hair crack and cause of drum failure occur. The temperature of drum is in proportion to the drum thickness and nonlinear changes at every points of drum. It's necessary for the decrease of the drum temperature to make the air inside drum flow.

• 제어로봇시스템학회:학술대회논문집
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• 2003.10a
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• pp.2016-2021
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• 2003

This paper deals with a control technique of eliminating the transient vibration with respect to a waist axis of an articulated robot. This control technique is based on a model-based control in order to establish the damping effect on the driven mechanical part. The control model is composed of reduced-order electrical and mechanical parts related to the velocity control loop. The parameters of the control model can be obtained from design data or experimental data. This model estimates a load speed converted to the motor shaft. The difference between the estimated load speed and the motor speed is calculated dynamically, and it is added to the velocity command to suppress the transient vibration. This control method is applied to an articulated robot regarded as a time-invariant system. The effectiveness of the model-based control integrated into the position control loop is verified by simulations. Simulations show satisfactory control results to reduce the transient vibration at the end-effector.

• 제어로봇시스템학회:학술대회논문집
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• 2003.10a
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• pp.1392-1397
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• 2003

This paper deals with a control technique of eliminating the transient vibration of a twin-drive geared mechanical system. This technique is based on a model-based control in order to establish the damping effect at the driven machine part. The control model is composed of reduced-order electrical and mechanical parts. This control model estimates a load speed converted to the motor shaft. The difference between the estimated load speed and the motor speed is calculated dynamically and it is added to the velocity command to suppress the transient vibration generated at the load. This control technique is applied to a twin-drive geared system with backlash. In the previous work, the performance of this control method is examined by simulations. In this paper, the effectiveness of this control technique is verified by experiments. The settling time of the residual vibration generated at the loading inertia can be shortened down to about 1/2 of the uncompensated vibration level.

• Advances in materials Research
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• v.6 no.1
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• pp.27-43
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• 2017

The transient thermo-mechanical behavior of a simply-supported beam made of a functionally graded material (FGM) under the effect of a moving heat source is investigated. The FGM consists of a ceramic part (on the top), which is the hot side of the beam as the heat source motion takes place along this side, and a metal part (in the bottom), which is considered the cold side. Grading is in the transverse direction, with the properties being temperature-dependent. The main steps of the thermo-elastic modeling included deriving the partial differential equations for the temperatures and deflections in time and space, transforming them into ordinary differential equations using Laplace transformation, and finally using the inverse Laplace transformation to find the solutions. The effects of different parameters on the thermo-mechanical behavior of the beam are investigated, such as the convection coefficient and the heat source intensity and speed. The results show that temperatures, and hence the deflections and stresses increase with less heat convection from the beam surface, higher heat source intensity and low speeds.

• Steel and Composite Structures
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• v.18 no.4
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• pp.889-907
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• 2015

This paper aims to present an alternative analytical method for transient vibration analysis of doubly-curved laminated shells subjected to dynamic loads. In the method proposed, the governing differential equations of laminated shell are derived using the dynamic version of the principle of virtual displacements. The governing equations of first order shear deformation laminated shell are obtained by Navier solution procedure. Time-dependent equations are transformed to the Laplace domain and then Laplace parameter dependent equations are solved numerically. The results obtained in the Laplace domain are transformed to the time domain with the help of modified Durbin's numerical inverse Laplace transform method. Verification of the presented method is carried out by comparing the results with those obtained by Newmark method and ANSYS finite element software. Also effects of number of laminates, different material properties and shell geometries are discussed. The numerical results have proved that the presented procedure is a highly accurate and efficient solution method.