• Journal of Korean Dental Science
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• 제4권1호
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• pp.20-25
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• 2011

Purpose: To describe the newly developed Film image transfer system (FITS) for proper positioning of the orthodontic mini-implant in the narrow interdental space and considerations for better application. Materials and Methods: A patient who was planning to have orthodontic mini-implant treatment on the posterior maxilla was recruited to assess the feasibility of FITS. Dental radiographic film and bite record was taken. And then the film image was transferred on the photographic emulsion coated model using transfer light through film projector (enlarger). After exposing the photo emulsion coating on the model, the image was developed with a working solution for a paper developer and fixed. The surgical guide for the mini-implant was fabricated from the transported FITS data. Results: The completed surgical guide was easily placed intraorally, and allowed a simple and rapid placement of the mini-implant. The site of the implant placement was accurate as planned position. Conclusion: In the reported case, The FITS technique represents an effort to minimize risk to the patient and produce consistently good results based upon accurate information about the anatomy of the implant site.

• Interaction and multiscale mechanics
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• 제5권1호
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• pp.75-90
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• 2012

This paper investigates the effects of sports ground materials on the transfer characteristics of the landing impact force using a coupled foot-shoe-ground interaction model. The impact force resulting from the collision between the sports shoe and the ground is partially dissipated, but the remaining portion transfers to the human body via the lower extremity. However, since the landing impact force is strongly influenced by the sports ground material we consider four different sports grounds, asphalt, urethane, clay and wood. We use a fully coupled 3-D foot-shoe-ground interaction model and we construct the multi-layered composite ground models. Through the numerical simulation, the landing impact characteristics such as the ground reaction force (GRF), the acceleration transfer and the frequency response characteristics are investigated for four different sports grounds. It was found that the risk of injury, associated with the landing impact, was reduced as the ground material changes from asphalt to wood, from the fact that both the peak vertical acceleration and the central frequency monotonically decrease from asphalt to wood. As well, it was found that most of the impact acceleration and frequency was dissipated at the heel, then not much changed from the ankle to the knee.

• BMB Reports
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• 제55권1호
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• pp.39-47
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• 2022

Adoptive cell transfer (ACT), a form of cell-based immunotherapy that eliminates cancer by restoring and strengthening the body's immune system, has revolutionized cancer treatment. ACT entails intravenous transfer of either tumor-resident or peripheral blood-modified immune cells into cancer patients to mediate anti-tumor response. Although these immune cells control and eradicate cancer via enhanced cytotoxicity against specific tumor antigens, several side effects have been frequently reported in clinical trials. Recently, exosomes, potential cell-free therapeutics, have emerged as an alternative to cell-based immunotherapies, due to their higher stability under same storage condition, lower risk of GvHD and CRS, and higher resistance to immunosuppressive tumor microenvironment. Exosomes, which are nano-sized lipid vesicles, are secreted by living cells, including immune cells. Exosomes contain proteins, lipids, and nucleic acids, and the functional role of each exosome is determined by the specific cargo derived from parental cells. Exosomes derived from cytotoxic effectors including T cells and NK cells exert anti-tumor effects via proteins such as granzyme B and FasL. In this mini-review, we describe the current understanding of the ACT and immune cell-derived exosomes and discuss the limitations of ACT and the opportunities for immune cell-derived exosomes as immune therapies.

• 한국기록관리학회지
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• 제19권2호
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• pp.1-24
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• 2019

본 연구에서는 전자기록물을 전자기록생산시스템에서 기록관리시스템으로 이관할 때 발생되고 있는 디지털컴포넌트의 무결성 훼손 문제를 해결하고자 클라우드 저장소를 활용한 기록물의 논리적 이관방안을 제안하였다. 생산단계에서부터 클라우드 저장소를 활용하여 전자기록물을 생산하고, 이를 기록관으로 이관하는 전자기록물의 논리적 이관 방식은 다음과 같은 장점을 가지고 있다. 첫째, 최근에 점차 확대되고 있는 클라우드 컴퓨팅 기술을 활용하여 공공기관의 업무방식에 효과적으로 적용할 수 있는 기록물관리 방안이다. 둘째, 전자기록물을 복사하여 물리적으로 이관하는 기존의 방식보다 논리적으로 보관권한 만을 이양함으로서 전자기록물의 이관 시 발생할 수 있는 각종 위험 요소를 줄일 수 있다. 셋째, 전자기록물의 물리적인 이관에 따른 디지털컴포넌트의 오류를 미연에 방지할 수 있어 전자기록물의 무결성을 보장할 수 있다. 넷째, 전자기록물의 이관업무 수행을 위해 낭비되고 있는 행정력과 비용을 절감할 수 있다.

• Clinical and Experimental Reproductive Medicine
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• 제51권1호
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• pp.69-74
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• 2024

Objective: The purpose of this study was to identify factors associated with twin pregnancy following day 3 double embryo transfer (DET). Methods: This retrospective cohort study incorporated data from 16,972 day 3 DET cycles. The participants were women aged between 18 and 45 years who underwent in vitro fertilization with intracytoplasmic sperm injection (IVF/ICSI) at My Duc Assisted Reproduction Technique Unit (IVFMD), My Duc Hospital, located in Ho Chi Minh City, Vietnam. Results: Of the 16,972 day 3 DET cycles investigated, 8,812 (51.9%) resulted in pregnancy. Of these, 6,108 cycles led to clinical pregnancy, with 1,543 (25.3% of clinical pregnancies) being twin pregnancies. Factors associated with twin pregnancy included age under 35 years (odds ratio [OR], 1.5; 95% confidence interval [CI], 1.32 to 1.71; p<0.001) and cycles involving the transfer of at least one grade I embryo. Relative to the transfer of two grade III embryos, the risk of twin pregnancy was significantly elevated following the transfer of two grade I embryos (OR, 1.40; 95% CI, 1.16 to 1.69; p<0.001) or a combination of one grade I and one grade II embryo (OR, 1.27; 95% CI, 1.05 to 1.55; p=0.001). Conclusion: By analyzing a large number of IVF/ICSI cycles, we identified several predictors of twin pregnancy. These findings can assist medical professionals in tailoring treatment strategies for couples with infertility.

• Molecules and Cells
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• 제37권11호
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• pp.777-784
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• 2014

Epidemiologic studies have shown that low-density lipoprotein cholesterol (LDL-C) is a strong risk factor, whilst high-density lipoprotein cholesterol (HDL-C) reduces the risk of coronary heart disease (CHD). Therefore, strategies to manage dyslipidemia in an effort to prevent or treat CHD have primarily attempted at decreasing LDL-C and raising HDL-C levels. Cholesteryl ester transfer protein (CETP) mediates the exchange of cholesteryl ester for triglycerides between HDL and VLDL and LDL. We have published the first report indicating that a group of Japanese patients who were lacking CETP had extremely high HDL-C levels, low LDL-C levels and a low incidence of CHD. Animal studies, as well as clinical and epidemiologic evidences, have suggested that inhibition of CETP provides an effective strategy to raise HDL-C and reduce LDL-C levels. Four CETP inhibitors have substantially increased HDL-C levels in dyslipidemic patients. This review will discuss the current status and future prospects of CETP inhibitors in the treatment of CHD. At present anacetrapib by Merck and evacetrapib by Eli Lilly are under development. By 100mg of anacetrapib HDL-C increased by 138%, and LDL-C decreased by 40%. Evacetrapib 500 mg also showed dramatic 132% increase of HDL-C, while LDL-C decreased by 40%. If larger, long-term, randomized, clinical end point trials could corroborate other findings in reducing atherosclerosis, CETP inhibitors could have a significant impact in the management of dyslipidemic CHD patients. Inhibition of CETP synthesis by antisense oligonucleotide or small molecules will produce more similar conditions to human CETP deficiency and may be effective in reducing atherosclerosis and cardiovascular events. We are expecting the final data of prospective clinical trials by CETP inhibitors in 2015.

• 무역상무연구
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• 제12권
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• pp.163-200
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• 1999

The CISG entrusts many problems to trade or practice : for example the problems which can't be compromised between civil law system and common law system ; the problems in which the application of usage or practice in universal ; the problems of rapid change according to trade circumstance. The purpose of this paper is to confirm whether the CISG is accomodating the usage or practice in its Text, and to find which topic is most closely related to usage or practice in CISG. The Article 9 in the CISG is a provision of usages or practices applicable to contract. But the problems of the CISG in the accomodation of usages or practices are that it lacks the definitions of ‘usage’ and ‘practices’, the CISG is not concerned with the validity of any usage according to Article 4, and the application of usage or practice may differ in litigation and arbitration The topics such as delivery of goods, payment of price and the transfer of risk are most closely related to usages and practices. The delivery of goods and the transfer of risk are determined by the trade terms like FOB or CIF. But the method of identification and the risk for the sale of goods in transit can't be determined by the trade terms in INCOTERMS(1990). So the CISG may serve as complementing role. In payment of price, the trade term does not refer to the time and place of payment. So the CISG may be the basis of interpretation. Likewise the usages and practices such as trade terms, UCP and so on, can be expected to play a significant role in complementing and interpreting the CISG.

• 한국환경농학회지
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• 제28권2호
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• pp.146-157
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• 2009

The influence of Pb-citrate complex formation on Pb uptake and the effect of Pb on organic acid exudation were investigated using four plant species, viz., sunflower (Helianthus annuus L), Indian mustard (Brassica juncea), canola (Brassica napus) and vetiver grass (Vetiveria zizanioides) under hydroponic conditions. Seedlings were exposed to different levels of Pb and Pb-citrate for 24 hrs and subsequently Pb distributions in plant shoot, root and hydroponic solution were measured. The dissolved organic carbon (DOC) concentration generally decreased as the concentration of Pb in the hydroponic solution increased. In contrast to DOC, the total organic acid concentrations exuded from Indian mustard roots significantly increased (424 to 6656 mg $kg^{-1}$) with increased Pb treatment, implying that exuding organic acids were involved in Pb accumulation in Indian mustard. The complexation of Pb with citrate enhanced Pb accumulation in the above ground portions. Lead concentration in Indian mustard increased from 2.05 mg $kg^{-1}$ to 6.42 mg $kg^{-1}$ when the concentration of citrate in solution increased from 0 to 50 mg $L^{-1}$. This result showed enhanced translocation of Pb from root to shoot with observation of transfer coefficient ($K_t$) increase from 2.03E-3 to 5.72E-3.

• Journal of Microbiology and Biotechnology
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• 제30권7호
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• pp.974-981
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• 2020

Sequence type 410 (ST410) of Escherichia coli is an extraintestinal pathogen associated with multi drug resistance. In this study, we aimed to investigate the horizontal propagation pathway of a high-risk clone of E. coli ST410 that produces Klebsiella pneumoniae carbapenemase (KPC). blaKPC-encoding E. coli and K. pneumoniae isolates were evaluated, and complete sequencing and comparative analysis of blaKPC-encoding plasmids from E. coli and K. pneumoniae, antimicrobial susceptibility tests, polymerase chain reaction, multilocus sequence typing, and conjugal transfer of plasmids were performed. Whole-genome sequencing was performed for plasmids mediating KPC-2 production in E. coli and K. pneumoniae clinical isolates. Strains E. coli CPEc171209 and K. pneumoniae CPKp171210 were identified as ST410 and ST307, respectively. CPEc171209 harbored five plasmids belonging to serotype O8:H21, which is in the antimicrobial-resistant clade C4/H24. The CPKp171210 isolate harbored three plasmids. Both strains harbored various additional antimicrobial resistance genes. The IncX3 plasmid pECBHS_9_5 harbored blaKPC-2 within a truncated Tn4401a transposon, which also contains blaSHV-182 with duplicated conjugative elements. This plasmid displayed 100% identity with the IncX3 plasmid pKPBHS_10_3 from the K. pneumoniae CPKp171210 ST307 strain. The genes responsible for the conjugal transfer of the IncX3 plasmid included tra/trb clusters and pil genes coding the type IV pilus. ST410 can be transmitted between patients, posing an elevated risk in clinical settings. The emergence of a KPC-producing E. coli strain (ST410) is concerning because the blaKPC-2-bearing plasmids may carry treatment resistance across species barriers. Transgenic translocation occurs among carbapenem-resistant bacteria, which may spread rapidly via horizontal migration.

• 대한한의학회지
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• 제33권1호
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• pp.136-147
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• 2012

Objectives: The purpose of this study was to evaluate work-related risk factors of musculoskeletal disorders (MSDs) in various departments and tasks at an oriental medicine hospital. Methods: 269 hospital workers were selected for the study. The questionnaire survey included general characteristics, work-related characteristics and MSDs. Cross-tabulation analysis, multiple logistic regression, adjusted for age, work time, job demand and workload, were used to evaluate the effects of work-related factors on MSDs. Results: There were differences in MSDs depending on gender, age, occupation, and work-related factors. Prevalence rates of MSDs were 23.79% shoulder, 14.13% back, 10.41% neck. Risk factors for MSDs was packaging of drugs, transfer, and exercise therapy of physical therapist. Shoulder pain was significantly influenced by using power tools, over-reaching, and job demand while back pain was significantly influenced by weight-lifting operations and keyboard typing. Conclusions: The results of this study suggest that consideration of MSDs characteristics of workers in oriental medicine hospital is necessary to change unsuitable work environments and educate on preventing MSDs.