• Proceedings of the Korean Society of Toxicology Conference
• /
• 2001.10a
• /
• pp.29-30
• /
• 2001

MAP kinase/ AP-1 signal transduction components are rapidly initiated by many extracellular stimuli, especially environmental carcinogens. We have investigated the role of MAP kinases (Erks, JNKs, and p38 kinases) and AP-1 signal transduction pathways in the process of cell transformation and carcinogenesis. Incubation of Cl 41 cells with tumor promoters such as TPA, EGF, arsenic, or TNF-$\alpha$ led to cell transformation and activation of MAP kinases.(omitted)

• Proceedings of the Microbiological Society of Korea Conference
• /
• 1998.04a
• /
• pp.49.1-49.1
• /
• 1998

• Journal of Life Science
• /
• v.12 no.1
• /
• pp.33-42
• /
• 2002

In several species, a short period of ischemic preconditioning protects the heart by reducing the size of infarcts resulting from subsequent prolonged bouts of ischemia. The mechanism by which activation of ATP-sensitive $K^+$($K_ATP$) channels could provide the memory associated with ischemic preconditioning is still under debate. Several signal transduction pathways have been implicated in the mechanisms of protection induced by ischemic preconditioning. The exact receptor-coupled pathways involved in preconditioning remain to be identified. Likely extracellular agonists are those whose circulating levels increase under conditions that activate $K_ATP$ channels; these conditions include ischemia and ischemic preconditioning. Potential physiological agonists include the following: (1) nitric oxide; (2) catecholamine; (3) adenosine; (4) acetylcholine; (5) bradykinin and (6) prostacycline. The purpose of this review was to understand the mechanism by which biological signal transduction mechanism acts as a link in one or more known receptor-mediated pathways to increase $K_ATP$ channel activity during ischemic preconditioning.

• Journal of Industrial Technology
• /
• v.40 no.1
• /
• pp.1-6
• /
• 2020

In the process of protein transcription and translation, various protein complexes bind to DNA, and all processes are precisely controlled. Among the proteins constituting this complex, a peptide derived from eukaryotic initiation factor (eIF) 2 was synthesized. In addition, in order to increase the efficiency of transduction of this peptide into cells, peptides with polyarginine, one of the protein transduction domains (PTD), were synthesized. Cell growth inhibition was confirmed in HER2 positive breast cancer (SK-Br-3) and HER2 negative breast cancer (MDA-MB-231), and cardiomyocytes (H9c2). The peptide with polyarginine had high transduction efficiency in all cells, and had excellent cancer cell growth inhibitory effects. The peptide used in this study might be useful peptide therapeutics for the treatment of cancer through future research.

• Proceedings of the KSME Conference
• /
• 2003.11a
• /
• pp.1413-1418
• /
• 2003

In this study, the topology optimization is applied to the design of a piezoelectric microactuator satisfying the specific mean transduction ratio(MTR). The optimization problem is formulated to minimize the difference between the specified and the current mean transduction ratio. In order to analyze the response of the piezoelectric-structure coupled system, both the structural and the electric potential are considered in the finite element method. The optimization problem is resolved by using Sequential Linear Programming(SLP) and the results of test problems show that the design of a piezoelectric microactuator with specified mean transduction ratio can be obtained.

• Archives of Pharmacal Research
• /
• v.21 no.5
• /
• pp.487-495
• /
• 1998

Gorwth factors such as TGF-beta, PDGF and FGF are thought to play important roles in wound healing. However, thier biological activity and signal transduction during wound repair remain poorly understood. Growth factors are often ligands for receptor tyrosine kinase and receptor serine/threonine kinases. With recent advances in signal transduction by receptor kinases, we are beginning to understand the underlying mechanism of how growth factors may regulate cutaneous wound repair. In this paper, we will describe the pharmacological effects of growth factors on wound healing, and dscuss the potential underlying signaing mechanisms. thus, we hope to provide the basis for designing more specific therapeutics for wound healing in the near future.

• Proceedings of the Ginseng society Conference
• /
• 2005.05a
• /
• pp.7-7
• /
• 2005

• Transactions of the Korean Society of Mechanical Engineers A
• /
• v.28 no.2
• /
• pp.206-213
• /
• 2004

In this study, the topology optimization is applied to the design of a piezoelectric microactuator satisfying the specific mean transduction ratio(MTR). The optimization problem is formulated to minimize the difference between the specified and the current mean transduction ratio. In order to analyze the response of the piezoelectric-structure coupled system, both the structural and the electric potential are considered in the finite element method. The optimization problem is resolved by using Sequential Linear Programming(SLP) and the results of test problems show that the design of a piezoelectric microactuator with the specified mean transduction ratio can be obtained.

• Bulletin of the Korean Chemical Society
• /
• v.29 no.1
• /
• pp.252-254
• /
• 2008

• Journal of Microbiology
• /
• v.42 no.4
• /
• pp.328-335
• /
• 2004

The human immunodeficiency virus type 1 (HIV-I) Tat protein transduction domain (PTD), which con­tains rich arginine and lysine residues, is responsible for the highly efficient transduction of protein through the plasma membrane. In addition, it can be secreted from infected cells and has the ability to enter neighboring cells. When the PTD of Tat is fused to proteins and exogenously added to cells, the fusion protein can cross plasma membranes. Recent reports indicate that the endogenously expressed Tat fusion protein can demonstrate biodistribution of several proteins. However, intercellular transport and protein transduction have not been observed in some studies. Therefore, this study exam­ined the intercellular transport and protein transduction of the Tat protein. The results showed no evi­dence of intercellular transport (biodistribution) in a cell culture. Instead, the Tat fusion peptides were found to have a significant effect on the transduction and intercellular localization properties. This sug­gests that the HIV-1 PTD passes through the plasma membrane in one direction.