• 동서간호학연구지
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• 제28권1호
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• pp.1-9
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• 2022

Purpose: This descriptive research was conducted to identify the effects of work complexity, role conflict, knowledge of traditional Korean (Hanbang) nursing, and grit on the job satisfaction among traditional Korean nurses. Methods: The survey was conducted from September 7, 2020 to February 10, 2021 on 155 Hanbang nurses. Data were analyzed by t-test, one way ANOVA, Pearson's correlation coefficient, and multiple linear regression with the SPSS statistics 26.0 program. Result: The factors affecting job satisfaction of Hanbang nurses were work complexity, knowledge of Hanbang nursing, age, and experience in traditional Korean medicine hospitals. Conclusions: It is necessary to promote Hanbang nursing related education in regular and clinical area in order to improve the job satisfaction of Hanbang nurses. In addition, an organizational effort is required to increase long-term job satisfaction.

• 동서간호학연구지
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• 제29권1호
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• pp.1-5
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• 2023

Traditional Korean medicine and traditional Korean (Hanbang) nursing are very similar disciplines in terms of philosophy, values, and identity. Traditional Korean medicine views that harmonious and balanced human body and mental state can be formed through the flow of Qi and blood using meridians and acupressure points. This view can be applied to research, practice, theory, and education in Hanbang nursing. The meridian is a pathway through which Qi and blood, the energy necessary for life activities, pass through. Acupressure points are important meridians where physical, mental, and psychological health conditions appear as a response. Pressing and stimulating acupressure points to facilitate and communicate the flow of qi and blood in the meridians can create positive effects and enable the treatment of various symptoms and syndromes of our bodies. Hanbang nursing nursing, which is also based on the use of meridians, may be used to control various symptoms and syndromes and prevent and treat diseases. Currently, Hanbang nursing are growing along with the professionalism of Hanbang nursing practice, vitalization of Hanbang nursing research, and the development of Hanbang nursing education and theory. The growth of Hanbang nursing requires active participation of nursing scholars and efforts to converge beyond the walls of medicine and nursing.

• 대한한의학방제학회지
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• 제32권1호
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• pp.11-28
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• 2024

Objectives : GunRyeong-Tang(GRT) is a traditional herbal prescription that combines Oryeongsan and Sagunja-tang. This study employed network analysis methods on the components of GRT and target genes related to diabetes complications to predict the improvement effects of GRT on diabetes complications. Methods : The collection of active compounds of GRT and related target genes involved the utilization of public databases and the PubChem database. We selected diabetes complication-related genes using GeneCards and confirmed their correlation through comparative analysis with the target genes of GRT. We constructed a network using Cytoscape 3.9.1 and conducted topological analysis. To predict the mechanism, we performed functional enrichment analysis based on Gene Ontology (GO) biological processes and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways. Results : Through network analysis, 234 active compounds and 1361 related genes were collected from GRT. A total of 9,136 genes related to diabetes complications were collected, and 1,039 target genes overlapping with the components of GRT were identified. The core genes of this network were TP53, INS, AKT1, ALB, and EGFR. In addition, GRT significantly reduced the H9c2 cell size and the expression of myocardial hypertrophy biomarkers (ANP, BNP), which were increased by high glucose (HG). Conclusions : Through this study, we were able to predict the activity and mechanism of action of GRT on diabetes and diabetic complications, and confirmed the potential of GRT as a treatment for diabetes complications through the effect of GRT on improving myocardial hypertrophy for diabetic cardiomyopathy.

• 대한한의학방제학회지
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• 제31권3호
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• pp.157-169
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• 2023

Gracilaria Verrucosa (GV), a seaweed used in traditional Korean medicine, was studied for its effects on MI-induced heart failure in rats. MI is caused by a blocked coronary artery, leading to severe cardiac dysfunction. The study used a rat model to assess cardiac changes over time and evaluate the impact of GV on heart failure. Ischemia was induced through LAD ligation surgery, and the extent of ischemic area was measured as a prognostic factor. GV extract administration significantly improved cardiac morphology and reduced cardiac weight compared to the MI group. GV treatment also improved cardiac function, as evidenced by positive effects on chamber dilation during MI-induced heart failure. Parameters such as ejection fraction (EF) and fractional shortening (FS) were measured. The MI group showed decreased EF and FS compared to the sham group, while these parameters improved in the GV group. GV treatment also reduced levels of LDH, CPK, and CK-MB in the serum, indicating reduced myocardial damage. Histological analysis revealed that GV treatment attenuated cardiac hypertrophy and fibrosis, with reduced collagen deposition in the myocardium. Immunohistochemistry analysis showed suppressed expression of TGF-β1 and collagen 1, involved in fibrosis. In conclusion, GV showed potential in improving cardiac function in a rat model of MI-induced heart failure. It alleviated myocardial damage, attenuated cardiac hypertrophy and fibrosis, and suppressed fibrotic markers. Further studies are needed to explore its clinical efficacy and underlying mechanisms in cardiac diseases beyond animal models.

• 한국자원식물학회지
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• 제33권6호
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• pp.696-706
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• 2020

Cordyceps has been used in traditional Chinese medicine more than 2000 year ago. In this study, the new Cordyceps militaris was founded and isolated from O-dae mountain in Korea, and was identified its genetic characteristics. The newly isolation strain HB8 was most closet to Cordyceps militaris W141449 (99.82%), Cordyceps militaris JLCY-LI819 (99.82%) and Cordyceps militaris 4642 (99.81%), respectively. the genotypic result was show that train HB8 was belonging to the Cordyceps militaris genus, therefore, Cordycep militaris HB8 proposed with accession number MT835161. This study we find the optimal condition for production of cordycepin from Cordyceps militaris HB8 was 8 mg/g (200 g of pupa, 1 g of KH₂PO₄, 0.5 g of K₂HPO₄, 20 g of glucose, 1 g of MgSO₄, 0.05 g of vitamin B1, and 1 mg of NAA per liter; light condition 300-700 Lux and day/night was 14 h/10 h) and the optimum condition for the production of adenosine was 2.6 mg/g (15 g of skim milk powder, 1 g of KH₂PO₄, 0.5 g of K₂HPO₄, 20 g of glucose, 1 g of MgSO₄, 0.05 g of vitamin B1, and 1 mg of NAA per liter; light condition 300-700 Lux and day/night was 14 h/10 h).

• 한국한의학연구원논문집
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• 제14권3호
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• pp.23-29
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• 2008

Below are the indications that cultural events in traditional Korean medicine nationwide give to the prospective 2013 DongUiBoGam World traditional Alternative Medicine Expo, especially to the se lection of the Expo's site. If the DongUiBoGam Expo is held as outdoor event, it can secure merits of current local council events' advantages: linking lived experiences to natural and historical resources. As in case of the EXOM and Hanghang EXPO that are held as indoor activivies in metropolitan area, if held the DongUiBoGam Expo can secure easily large-scale academic activities and health lectures. Thus, the key point for the DongUiBoGam Expo's success will he how to combine the good points of currently-held cultural outdoor and indoor activities in the field of traditional Korean medicine nationwide.

• 한국의사학회지
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• 제23권1호
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• pp.77-104
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• 2010

In July 2008, I obtained a copy of "Hanbang Eihak Gangseupseo" through Uibangseowon. It was recorded that the book was compiled by Seong Ju-bong and reviewed by Ji Seok-young. According to previous studies, this book was the lecture book that was used in teaching Traditional Korean Medicine in Daejeon, Chungcheongnam-do. This book gave insight to the system and curriculum of the school for Traditional Korean Medicine in Daejeon, Chungcheongnam-do. It also exhibited the academic characteristics of Traditional Korean Medicine in the Period of Japanese Occupation and the medical viewpoint of Seong Ju-bong. The summary is as follows: First, an independent School for Traditional Korean Medicine was run in Daejeon, Chungcheongnam-do, with reasonable curriculums and systematic textbooks. Second, the medical viewpoint and treatment methods of Huang Yuan-Yu of Qing Dynasty was actively introduced. Then it was reorganized for the society and stimulated the progress of Traditional Korean Medicine. Third, while absorbing Chinese Medicine, it still inherited our heritage of Traditional Korean Medicine Especially, Seong Ju-bong's original opinions and clinical experiences are shown in surgery, gynecology and pediatrics. Fourth, in a break from the past, when Chinese culture could not be introduced due to diplomatic problems between Joseon and Qing, efforts were made to overcome limitations of lagging behind by adopting and educating Warm Disease study. Fifth, while working side by side with Ji Seok-young who introduced the modern Western Medicine through vaccination, it still searched for a traditional Korean medical treatment for chickenpox. I hope that the report of my findings through reading "Eihak Gangseupseo" could make up for the fact that the medical history during the colonial period is scarce.

• 대한한의학회지
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• 제43권4호
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• pp.20-32
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• 2022

Objectives: Kyungok-go (KOG) is a traditional multi-herbal medicine commonly used for enforcing weakened immunity for long time. Recently, there are several reports that KOG has anti-inflammatory and immuno-stimulatory activities in many experimental models. However, the protective effects of KOG on neuronal inflammation are still undiscovered. Thus, we investigated the neuro-protective activity of KOG on lipopolysaccharide (LPS)-stimulated mouse microglia cells. To find out KOG's anti-neuroinflammatory effects on microglial cells, we examined the production of nitrite using griess assay, and mRNA expressions of inducible nitric oxide synthase (iNOS), cyclooxygenase (COX)-2 and interleukin (IL)-1β, IL-6, tumor necrosis factor (TNF)-α using real time RT-PCR. In addition, to examine the regulating mechanisms of KOG, we investigated the protein expression of mitogen-activated protein kinases (MAPKs) and Iκ-Bα by western blot. KOG inhibited the elevation of nitrite, iNOS and COX-2 on LPS-stimulated BV2 cells. Also, KOG significantly inhibited the pro-inflammatory cytokines such as IL-1β, IL-6, and TNF-α on LPS-stimulated BV2 microglial cells. Moreover, KOG inhibited the activation of c-Jun N-terminal kinase (JNK), P38 and degradation of Iκ-Bα but not the activation of extracellular signal regulated kinase (ERK) on LPS-stimulated BV2 microglial cells. These results showed KOG has the anti-inflammatory effects through the inhibition on nitrite, iNOS, COX-2, IL-1β, IL-6, and TNF-α via the deactivation of JNK, p38 and nuclear factor (NF)-κB on LPS-stimulated BV2 microglial cells. Thereby, KOG could offer the new and promising treatment for neurodegenerative disease related to neuroinflammation.

• 고문화
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• 64호
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• pp.47-74
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• 2004

필자는 민속의약에 대한 연구가 일천한 현실에서 이에 대한 이해를 도울 목적으로 350년의 역사와 전통을 갖는 대구약령시(大邱藥令市)를 중심으로 전통의약과 관련한 유$\cdot$무형 전승문화의 존재양상을 유물과 자료, 지식과 기능, 행위전승 등의 측면으로 나누어 고찰해 보고자 하였다. 대구약령시의 유$\cdot$무형 전승문화는 약령시의 고유기능 수행과 관련하여 오래 전부터 전해져 내려온 유형적 문화요소와 기능$\cdot$지식$\cdot$행위양식$\cdot$규범 등의 무형적 은화요소를 총칭한다. 약령시 전승문화는 약령시 사람들의 생업활동과 관련된 물질전승과 기능 지식전승, 행위전승 등으로 대별된다. 물질전승은 한약재의 관리와 유통, 질병 치료를 포함하여 약령시 유지에 필요했던 각종의 물질적 증거들(material evidences)로서 약령시전시관과 한방 관련업소 등에 전시 및 소장되어 있다. 지식$\cdot$기능전승은 한약재를 정선(세척$\cdot$절단$\cdot$건조$\cdot$선별$\cdot$작근) 하여 저장$\cdot$유통시킴은 물론 약으로 제조하거나 치료하는 등의 관련 지식과 기능을 의미한다. 이는 대부분 업소에 오래 동안 종업원으로 근무하면서 형성되는 전인적 인간관계에 기초한 도제시스템에 의해 전승되어 榮다. 대구약령시에는 유구한 역사와 전통 및 전문 인력의 밀집과 수세대에 걸친 비전(秘傳) 등으로 많은 비방과 탁월한 약재 감별지식이 전승되고 있다. 약령시 행위전승은 약령시의 생활경험 및 문화사적 의의와 가치를 발양하고 계승하기 위해 반복되는 행위의 여러 표상들을 제의적$\cdot$기예적$\cdot$오락적 차원으로 정형화한 것으로서 약령시축제와 약령제가 대표적이다. 이상의 사실처럼, 대구약령시는 민속의약 전통에 대한 맥락적 이해를 가능하게 해주는 중요한 삶의 공간이자 민속의약의 저수지이기도 하다. 따라서 약령시 사람들의 생활경험과 기억을 포함하여 관련 물증들을 시$\cdot$공간적 차원에서 수집$\cdot$분류$\cdot$해석하고 효율적으로 보존$\cdot$계승$\cdot$발전시킬 수 있는 방안을 강구할 필요가 있다.

• 생약학회지
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• 제45권1호
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• pp.55-61
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• 2014

Microwaves are non-ionizing electromagnetic waves of frequency between 300MHz to 300GHz and positioned between the X-ray and infrared rays in the electromagnetic spectrum. In recent years, the use of microwave for extraction of ingredient from plant material has shown remarkable research interest and potential. Scutellaria radix has been used as a traditional medicine for a variety of diseases. It has been reported to exert beneficial health effects, such as anti-bacterial, antiviral, anti-inflammatory, and free-radical scavenging. Oxidative stress or the accumulation of reactive oxygen species (ROS) leads neuronal cellular death and dysfunction, and it contributes to neuronal degenerative disease such as Alzheimer's disease, Parkinson's disease and stroke. In this study, we aimed to compare the neuroprotective and antioxidant effect of Scutellaria radix extracted by different methods using hot-water extraction (SBE-DW) or microwave extraction (SBE-DW-MW). As a result, we first examined HPLC analysis of hot-water and microwave extracts of Scutellaria radix. The hot-water and microwave extracts of Scutellaria radix showed the discernible difference patterns of HPLC analysis. Microwave-water extracts of Scutellaria radix increased DPPH radical scavenging activity more than hot-water extraction. Microwave-water extracts of Scutellaria radix also showed neuroprotective effects and ROS inhibition against glutamate-induced oxidative stress in mouse hippocampal HT22 cells, but hot-water extraction not showed. In addition, the phosphorylation of MAPKs induced by glutamate insult was prevented by microwave-water extracts of Scutellaria radix. Thus, these results suggested that microwave extraction can be utilized for improving the extraction efficiency and biological activity of Scutellaria radix.