• 한방안이비인후피부과학회지
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• 제35권2호
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• pp.28-48
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• 2022

Objectives : The purpose of this study is to investigate the trend of traditional Chinese medicine for sudden sensorineural hearing Loss(SSHL) in Chinese journals. Methods : Chinese National Knowledge Infrastructure(CNKI) and Wanfang med online were used to search randomized controlled trials(RCTs) on SSHL which were published from January, 2017 to December, 2021. Results : Among Chinese studies, Tonifying and Replenishing medicinal(補益藥) and Exterior-releasing medicinal(解表藥) were the most frequently used medicine in treating SSHL. Acori Graminei Rhizoma(石菖蒲) was the most frequently used herb excluding Glycyrrhizae Radix(甘草). All studies reported that using Traditional Chinese Medicine alone or combining western medicne(WM) is more effective for treating SSHL than using WM alone, although one study reported the result is not statistically significant. Conclusions : In analysis of selected studies, co-treatment of traditional chinese medicine and WM can be more effective way for treating SSHL than using WM alone. Side effects of treating SSHL can also be reduced by co-treatment of traditional chinese medicine and WM.

• 대한한의학원전학회지
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• 제26권4호
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• pp.89-94
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• 2013

Objective : To collect cosmetology text in Shang Han Za Bing Lun(伤寒杂病论), to analyze theory and prescription about cosmetology before HAN(漢) dynasty, so to allow records for modern cosmetology of Traditional Chinese Medicine. Method : Through the systematize for all terms about cosmetology, to reveal the regularity about cosmetology before HAN(漢) dynasty. Result : There were damage-appearance disease in HAN(漢) dynasty, there are lots of ideas about cosmetology in Shang Han Za Bing Lun(伤寒杂病论). Conclusion : Shang Han Za Bing Lun(伤寒杂病论) is a monograph about pattern identification and treatment, and is an important ancient book for research of cosmetology of Traditional Chinese Medicine. In the further, we will research in knowledge discovery about cosmetology of Traditional Chinese Medicine. to strengthen the guidance of the theory of Zhang Zhongjing(张仲景) for clinical practice of cosmetology of Traditional Chinese Medicine.

• Journal of Microbiology and Biotechnology
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• 제26권8호
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• pp.1358-1366
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• 2016

The purpose of the present study was to investigate the immune-enhancing activity of selenizing Codonopsis pilosula polysaccharide (sCPPS₅) in nonspecific immune response. In in vitro experiment, the results showed that sCPPS₅ could promote the phagocytic uptake, NO production, and TNF-α and IL-6 secretion of RAW264.7 cells. sCPPS₅ could also strongly increase the IκB-α degradation in the cytosol and the translocation of NF-κB p65 subunit into the nucleus of RAW264.7 cells. In the vivo experiment, sCPPS₅ at medium doses could significantly improve the phagocytic index of peritoneal macrophages and induce the secretion of TNF-α and IL-6. Moreover, the effect of sCPPS₅ was significantly better than Codonopsis pilosula polysaccharide (CPPS). These results indicated that selenylation modification could significantly enhance the immune-enhancing activity of CPPS in the nonspecific immune response.

• Journal of Ginseng Research
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• 제42권3호
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• pp.270-276
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• 2018

Background: Notoginsenoside Ft1 is a promising potential candidate for cardiovascular and cancer disease therapy owing to its positive pharmacological activities. However, the yield of Ft1 is ultralow utilizing reported methods. Herein, an acid hydrolyzing strategy was implemented in the acquirement of rare notoginsenoside Ft1. Methods: Chemical profiles were identified by ultraperformance liquid chromatography coupled with quadruple-time-of-flight and electrospray ionization mass spectrometry (UPLC-Q/TOF-ESI-MS). The acid hydrolyzing dynamic changes of chemical compositions and the possible transformation pathways of saponins were monitored by ultrahigh-performance LC coupled with tandem MS (UHPLC-MS/ MS). Results and conclusion: Notoginsenoside Ft1 was epimerized from notoginsenoside ST4, which was generated through cleaving the carbohydrate side chains at C-20 of notoginsenosides Fa and Fc, and vinaginsenoside R7, and further converted to other compounds via hydroxylation at C-25 or hydrolysis of the carbohydrate side chains at C-3 under the acid conditions. High temperature contributed to the hydroxylation reaction at C-25 and 25% acetic acid concentration was conducive to the preparation of notoginsenoside Ft1. C-20 epimers of notoginsenoside Ft1 and ST4 were successfully separated utilizing solvent method of acetic acid solution. The theoretical preparation yield rate of notoginsenoside Ft1 was about 1.8%, which would be beneficial to further study on its bioactivities and clinical application.

• 척추신경추나의학회지
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• 제7권1호
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• pp.15-20
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• 2012

Objectives : The aims of this study were to introduce the theory of traditional Chinese orthopedic theory(整脊理論) and to analyze the guideline of diagnosis and treatment of common spinal disorders by treating Chinese spinal manipulation technique(常見病中醫整脊指南). Methods : We have searched the web sites of traditional Chinese orthopedics association (整脊學會), a branch of the China academy of traditional Chinese medicine (TCM), and related articles. Additionally, we analyzed the guideline of diagnosis and treatment of common spinal disorders by treating Chinese spinal manipulation technique which was introduced by that association at 7th academic conference in China in 2011. Results : The guideline was prepared by 2 year project leaded by professor Yi-zhong Wei who was a person in charge of the spinal manipulation guideline of national standardization committee of TCM in China. It was a summary of the whole theory of China spinal manipulation therapy in TCM and contained 22 common spinal disorders by the treatment of traditional Chinese Tuina methods. Spinal manipulation theory was summarized by one doctrine, two theories, and two important view points. The treatment method was abstracted as 8 major Tuina techniques. Conclusions : The guideline will be a way of advance of Chinese spinal manipulation technique. This will be a good reference to Korea Chuna manipulation for improving their techniques.

• 셀메드
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• 제2권2호
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• pp.16.1-16.5
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• 2012

Fever in cancer patients is often due to the following causes: evil qi and toxity stagnancy, disorders of qi and blood, deficiencies of zang and fu organs, and the disorder of yin and yang. The treatments given to cancer patients with a fever are according to five: (a) Excessive inner heat and toxicants: remove heat and the toxicant, induce purgation. We use Cheng-Qi-Tang plus Qing-Wen-Bai-Du-Yin. (b) Tangle of damp and heat, and qi stagnancy: remove damp and heat, smooth the qi channel. We use Gan-Lu-Xiao-Du-Dan or San-Ren-Tang. (c) Obvious blood and heat stagnancy: remove heat and blood stasis. We use Xue-Fu- Zhu-Yu-Tang. (d) Deficiency of spleen qi, inner heat caused by a yin deficiency: nourish spleen qi and yin to remove the inner heat. We use Bu-Zhong-Yi-Qi-Tang or Xiao-Jian-Zhong-Tang. (e) Prominent yin deficiency and hectic fever: replenish yin and remove inner heat. We use Qing-Hao-Bie-Jia-Tang or Chai- Qian-Mei-Lian-San. The pathogenesis of fever in cancer patients is complicated. We can see both deficiency and excess in one differentiation. Therefore, we must make sure of it, then we can get the most effective treatment.

• 한국의사학회지
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• 제27권1호
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• pp.77-86
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• 2014

The paper describes the practice and purpose of the medical missionaries research on the traditional Chinese drugs(中藥). Searches were made using the journal of the China Medical Missionary Association. The China Medical Missionary Association established the committee of the Chinese Materia Medica in 1890. This committee aimed to research on the traditional Chinese drugs. Then why did the medical missionaries study traditional Chinese drugs? This is because the western drugs(西洋藥）was not easy to acquire, especially in land areas. Also, some western drugs have poor quality and expensive. Therefore they need to understand that Chinese drugs will help in the production of the western drugs. But from around 1920, the main purpose of the research was changed. The scientific and systematic investigation on the Chinese medicine itself became more important. And this change partly influenced that medical missionaries' views on traditional Chinese drugs.

• 동의신경정신과학회지
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• 제22권4호
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• pp.21-30
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• 2011

Objectives : This study was performed to review the research trends in treatment for acute alcohol intoxication in traditional Chinese medicine. Methods : 19 studies were selected by searching CNKI(China National Knowledge Infrastructure) from 2006 to 2011, and we performed a systemic review of them. Results : All studies are controlled clinical trials using pharmacopuncture therapy. Each experimental group was given various kinds of pharmacopuncture therapy, whereas each control group was given another western medicine or treatment. Emergent treatment was used in both groups. The results of 15 studies showed that pharmacopuncture therapy has an effect on the treatment of acute alcohol intoxication. However the quality of these clinical trials wasn't high. Conclusions : It seems that the researches for acute alcohol intoxication have been performed actively in traditional Chinese medicine. We hope that our study can activate clinical research for this disorder in Korean traditional medicine.

• IMMUNE NETWORK
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• 제22권3호
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• pp.21.1-21.21
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• 2022

As far the current severe coronavirus disease 2019 (COVID-19), respiratory disease is still the biggest threat to human health. In addition, infectious respiratory diseases are particularly prominent. In addition to killing and clearing the infection pathogen directly, regulating the immune responses against the pathogens is also an important therapeutic modality. Sirtuins belong to NAD+-dependent class III histone deacetylases. Among 7 types of sirtuins, silent information regulator type-1 (SIRT1) played a multitasking role in modulating a wide range of physiological processes, including oxidative stress, inflammation, cell apoptosis, autophagy, antibacterial and antiviral functions. It showed a critical effect in regulating immune responses by deacetylation modification, especially through high-mobility group box 1 (HMGB1), a core molecule regulating the immune system. SIRT1 was associated with many respiratory diseases, including COVID-19 infection, bacterial pneumonia, tuberculosis, and so on. Here, we reviewed the latest research progress regarding the effects of SIRT1 on immune system in respiratory diseases. First, the structure and catalytic characteristics of SIRT1 were introduced. Next, the roles of SIRT1, and the mechanisms underlying the immune regulatory effect through HMGB1, as well as the specific activators/inhibitors of SIRT1, were elaborated. Finally, the multitasking roles of SIRT1 in several respiratory diseases were discussed separately. Taken together, this review implied that SIRT1 could serve as a promising specific therapeutic target for the treatment of respiratory diseases.

• Journal of Ginseng Research
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• 제45권2호
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• pp.211-217
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• 2021

The treatments of nervous system diseases (NSDs) have long been difficult issues for researchers because of their complexity of pathogenesis. With the advent of aging society, searching for effective treatments of NSDs has become a hot topic. Ginseng polysaccharides (GP), as the main biologically active substance in ginseng, has various biological properties in immune-regulation, anti-oxidant, anti-inflammation and etc. Considering the association between the effects of GP and the pathogenesis of neurological disorders, many related experiments have been conducted in recent years. In this paper, we reviewed previous studies about the effects and mechanisms of GP on diseases related to nervous system. We found GP play an ameliorative role on NSDs through the regulation of immune system, inflammatory response, oxidative damage and signaling pathway. Structure-activity relationship was also discussed and summarized. In addition, we provided new insights into GP as promising neuroprotective agent for its further development and utilization.