• 대한수의학회지
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• 제37권1호
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• pp.15-24
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• 1997

This study was undertaken to obtain basic data on the histological changes in the tracheal cartilage of the embryos and fetuses of the Korean native cattle. Twenty-two embryos and fetuses of the Korean native cattle, ranging from 30mm(peesumptive fetal age 44 days) to 440mm(presumptive fetal age 168 days) in crown-nump(C-R) length, were used for present study. The results were summerized an follows; 1. Mesenchymal cells differentiated as chondroblasts were condensed into tracheal cartilage in the CRL 30mm of the Korean native cattle embryo, and the chondrocytes begun to appear in the tracheal cartilage in the CRL 40mm fetus. 2. The tracheal cartilage in the CRL 70mm fetus was composed of the large number of chondrocytes. The histochemi8cal reactions for glycosaminoglycans showed strong positive reaction in the CRL 380mm, and for collagen substance showed mildly in the 6th experimental group.

• 대한기관식도과학회:학술대회논문집
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• 대한기관식도과학회 2003년도 제3차 추계학술대회
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• pp.107-107
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• 2003

Purpose; Tracheal transplantation is necessary in patients with extensive tracheal stenosis, congenital lesions and many oncologic conditions but bears many critical problems compared with other organ transplantations. The purpose of this study was to make an intestine-cartilage composite graft for potential application for tracheal reconstruction by free intestinal graft. Methods; Hyaline cartilage was harvested from trachea of 2 weeks old New Zealand White Rabbits. Chondrocytes were isolated and cultured for 8 weeks. Cultured chodrocytes were seeded in the PLGA scaffolds and mixed in pluronic gel. Chondrocyte bearing scaffolds and gel mixture were embedded in submucosal area of stomach and colon of 3kg weighted New Zealand White Rabbits under general anesthesia. 10 weeks after implantation, bowels were harvested for evaluation. Results; We could identify implantation site by gross examination and palpation. Developed cartilage made a good frame for shape memory Microscopic examinations include special stain showed absorption of scaffold and cartilage formation even though not fully matured Conclusion; Intestine-cartilage composite graft could be applicable to future tracheal substitute and needs further Investigations.

• Journal of Chest Surgery
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• 제27권5호
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• pp.407-412
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• 1994

Congenital long-segment tracheal stenosis which involves nearly entire trachea and carina is very rare disease, but leads to life threatening obstruction in infancy and childhood. Symptoms are ranged from stridor and wheezing to severe cyanosis and respiratory failure. Routine chest X-ray is somewhat helpful to diagnose it, but definitive diagnosis can be made by bronchoscopy or tracheogram for severely narrowed tracheal lumen.Recently, we experienced a case of congenital tracheal stenois, type 1 by Cantrell classification with carinal involvement. After costal cartilage was designed as oval shaped flap and covered with pericardium, anterior and posterior augmentation was done with prepared costal cartilage.This patient died of respiratory failure at 13 days postoperatively, probably due to sustaining obstruction in association in with failure to make a sufficient widening at carinal level.Important issues in the management of congenital tracheal stenosis are rapid diagnosis, selection of appropriate surgical procedure, and detailed anesthetic schedule.In the future, more biocompatible material and more effective surgical procedures should be studied to reduce the surgical mortality and morbidity of the complicated tracheal stenosis.

• 대한기관식도과학회:학술대회논문집
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• 대한기관식도과학회 1983년도 제17차 학술대회연제순서 및 초록
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• pp.14.3-14
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• 1983

최근 급속히 증가 추세에 있는 각종 산업재해와 교통사고로 인한 심한 신체적 손상, 심혈관계수술 및 호흡계수술등을 받은 환자에서 기도유지를 위해 사용되는 기관내삽관과 기관절개위의 후유증 또는 두부외상으로 발생하는 외상성 기관협착의 빈도가 점차 높아짐에 따라서 이에 대한 치료로 기관성형술이 주목할만한 관심을 보여주고 있다. 기관성형술의 방법으로는 손상된 기관의 위치나 크기에 따라 여러 가지가 있으나 부분절제 및 단단문합술, 경부피변과 자가이식물질등을 이용한 재건술을 들 수 있다. 1965년 Grillo가 개에서 환상절제후 기관성형술을 시행한 이래 환상기관협착의 경우에는 부분절제및 단단문합술이 많이 이용되고 있다. 또한 자가이식물질로는 비중격, 늑골, 이개의 연골이 많이 사용되고 있으며, Consiglio와 Caputo가 이개연골을 이용하여 기관성형술을 시행한 이래 Morgenstein은 기관결손이 있는 환자에서 이개연골을 사용하여 혼합이식을 시행하여 성공적인 재건을 보고하였다. 이개연골이식은 이비인후과의사에게는 쉽게 채취하여 활용할 수 있고 친근감이 있는 장점이 있다. 최근 본교실에서는 5예의 기관협착증 환자에서 이개연골이식(2예), 부분절제후 단단문합술(3예)에 의한 기관성형술을 시행하여 좋은 결과를 얻었기에 문헌고찰과 함께 보고하는 바이다.

• 대한기관식도과학회지
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• 제3권1호
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• pp.148-153
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• 1997

Laryngotracheal stenosis is one of the most troublesome diseases in the Em field. Subglottic stenosis can be treated by a cricoid augmentation with rib cartilage. In case of tracheal stenosis, the treatment of choice is by tracheal end-to-end anastomosis after resection of the stenotic site. However, in case of subglottic stenosis combined with tracheal stenosis, it is hard to manage. Even though several methods(such as thyrotracheal anastomosis) have been tried, they have some limitations too much excision of normal trachea and too much pulling up of the trachea after resection of the stenotic lesion. The authors have managed two cases of laryngotracheal stenosis as an anterior and posterior subglottic augmentation with an autologous cartilage graft and laryngotracheal anastomosis. The first few weeks after the operation, we could do a decannulation successfully, but in one case the patient developed restenosis. Even though one case was unsuccessful, the authors believe that this method could be used in the treatment of laryngotracheal stenosis.

• 한국임상수의학회지
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• 제17권1호
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• pp.129-133
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• 2000

Based on pathological findings, 5 German shepherds, revealed a mean age of 7.6 years, showing no clinical signs were diagnosed as tracheopathia osteochondroplastica(TOC). Grossly, multiple small-sizecd nodules, appeared as cobble-stones, on the cartilage rings situated in the anterior trachea and the mucosal surface of the epiglottis were showed. Numerous tiny nodules were scattered on the pleural surface of the lung. The vascular walls of the heart were irregular and coarse apearance with calcification. Histopathologically, nodules in the trachea represented an irregular expansion of the underlying tracheal ring with protrusion into the submucosa and consisted of proliferated and calcified cartilage and bone with marrow spaces containing numbers of hematopoietic cells. Pulmonary calcinosis and calcification of the vascular walls of the heart were observed. Our observations suggested that TOC arises form eccondroses and exostoses of the tracheal cartilage rings.

• Journal of Chest Surgery
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• 제37권6호
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• pp.474-481
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• 2004

배경: 암이나 협착 등의 각종 기관질환으로 광범위한 기관절제가 필요한 경우에는 기관 이식이 필요하나, 다른 장기의 이식술과 비교하여 많은 어려움이 있다. 이에 본 연구에서는 이상적인 기관 대체물을 개발하기 위한 노력의 일환으로, 조직 공학적 기법을 통하여 기관 재건에 적용할 수 있는 소장-연골 복합 이식판의 개발이 가능한가를 알아보고자 하였다. 대상 및 방법: 생후 2주 된 토끼의 기관과 이개로부터 각각 연골세포를 채취하여 8주간 배양하였다. 배양된 초자 연골세포와 탄성 연골세포를 담체(PLGA)에 심거나 플루로닉 겔에 혼합한 후에, 4 종류의 혼합체를 토끼의 위장과 대장의 점막하 조직에 이식하고 10주 후에 연골 형성 여부를 평가하였다. 결과: 육안과 촉진으로 이식 부위를 판별할 수 있었으며, 현미경적 소견상 담체의 흡수와 연골의 형성을 확인할 수 있었다. 특히 초자 연골세포-담체 혼합체에서 연골의 형태를 잘 갖추고 있었다. 결론: 장-연골 복합 이식판 개발의 전망은 밝으며, 이상적인 기관 대체물로서 기관 재건에 기여할 가능성이 있다고 사료된다.

• 대한두경부종양학회지
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• 제37권1호
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• pp.63-66
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• 2021

Supracricoid partial laryngectomy (SCPL) with cricohyoidoepiglottopexy (CHEP) or cricohyoidopexy (CHP) involves the removal of the whole thyroid cartilage, both true and false vocal cords, the ventricles, and the paraglottic spaces, sparing the cricoid cartilage, hyoid bone, and at least one functional and mobile cricoarytenoid unit. Reconstruction is performed by suturing of the cricoid cartilage up tightly to the hyoid bone, so trachea-releasing procedures are needed to prevent leakage at anastomosis site. In case of advanced tranglottic cancer invading tracheal tracheal wall, we need to perform additional circumferentrial circumferential tracheal wall resection. However, when we perform SCPL, circumferential resection of tracheal wall is limited because SCPL procedure itself needs releasing of tracheal length. We report a case of advanced transglottic cancer involving tracheal wall treated with induction chemotherapy and SCPL including tracheal wall resection with reconstruction of tracheal defect by sternocleidomastoid muscle flap covered with skin graft.

• Journal of Chest Surgery
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• 제28권2호
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• pp.156-161
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• 1995

Although there are many kinds of method in treatment of tracheal stenosis, tracheal resection and primary anastomosis can be performed for management of various kinds of tracheal stenosis because it is considered the most anatomical ideal therapeutic modality. During a 10-year period we performed 18 tracheal resection on 18 patients with no operative mortality and some morbidity. 13 patients had tracheal stenosis caused by endotracheal intubation [eight patients or tracheostomy [five patients ; and five patients caused by a variety of neoplastic lesions [four primary and one secondary . The length of tracheal stenosis were various from 1.5cm to 5.5cm and site of tracheal stenosis were cervical[17patients and thoracic [one patient . Operative techniques were tracheal resection and primary anastomosis[18 patients and additional procedures were cricoid cartilage reconstruction with costal cartilage [one patient , primary repair of esophagus[one patient and suprahyoid laryngeal release technique[eight patients without any complications. We have eight complications; tracheal restenosis were developed in five patients[growth of grannulation tissue at anastomotic site in three patients, delayed restenosis in two patients , anastomotic disruption in one patient, hoarseness and pneumonia in each of two patients. We managed tracheal complications with T-tube insertion in two patients, permanent tracheostomy in three patients and insertion of Gianturco tracheal stent in one patient, but tracheal stent did not reveal good result because it caused persistent production of sputum. We concluded that it is necessary to access full length of normal trachea including suprahyoid laryngeal release technique to avoid anastomotic tension in tracheal surgery and develope new ideal techniques to manage postoperative tracheal complications, because we suppose tracheal complications are developed due to anastomotic tension.

• 대한수의학회지
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• 제19권1호
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• pp.1-8
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• 1979

Detailed human gross anatomic structures have been characterized. No similar data are available in nonhuman primate species in spite of close phylogenic similarity found between man and nonhuman primates. The ever increasing incidence of lung cancer and air pollution related respiratory ailments found in man emphasizes the need for an ideal animal model for studying pathogenesis of these various human pulmonary diseases. Thus, detailed investigation of pulmonary structures found in various species of nonhuman primates is warranted. For determining primate gross pulmonary anatomic structure, published works concerning the number of tracheal cartilage, angle of tracheal bifurcation, caliber of trachea, lung lobe and bifurcation position of trachea recorded for several species of nonhuman pimates, were reviewed. Limited information is available concerning the number of tracheal cartilage, width of tracheal cartilage, angle of bronchus, caliber of trachea and bronchus, and the bifurcation position of the trachea including the length of bronchus on nonhuman primates. Since scanty data have been gathered with no specific reference to their age, sex and body weight, they have no comparative values.