• Maxillofacial Plastic and Reconstructive Surgery
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• 제21권1호
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• pp.69-73
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• 1999

Toxic Shock Syndrome(TSS)은 1978년 Todd등에 의해 처음 보고된 이래 젊은 여성에서 월경과 연관된 질환으로 생각되어 왔으나 최근에는 코수술을 비롯한 두경부수술 및 기타 소수술후 합병증으로 많은 증례가 발표되고 있다. 이의 진단은 주로 임상적 진단, 즉 갑작스런 술후 고열, 설서, 저혈압 및 홍피증과 혈액배양등에서 검출되는 포도상구균등으로 가능하다. TSS은 대부분 수액공급 및 혈압의 유지, 전신적인 항생제 투여등으로 쉽게 치료가 가능하지만, 경과가 좋지 않은 경우 면역글로불린의 사용도 시도되어 좋은 결과를 얻고 있으며 조기 발견 및 처치가 가장 중요하다고 할 수 있다. 이에 저자는 상악골 및 비골, 안와근심벽 골절을 지닌 48세 남자환자에서 골절부에 대한 관혈적 정복고정술후 발생된 TSS의 처치에 대해 문헌고찰과 함께 보고하는 바이다.

• 한국응용곤충학회지
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• 제23권3호
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• pp.166-171
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• 1984

가. 해충과 거미에 대한 반치사약량및 상대독성 조사 (1) BPMC와 MIPC는 벼멸구와 황산적거미에 대한 상대독성치가 각각 $18.4\~29.6,\;8.0\~10.3$으로 비교적 높은 선택독성을 보였다. (2) 이화명충과 황산적거미에서는 thiocyclam, chlorpyrifos-methyl이 각각 727, 14의 상대독성치를 보였으며 벼밤나방에서는 thiocyclam이 189.3으로 선택독성이 높았다. (3) 끝동매미충과 황산적거미에 대해서도 BPMC의 상대독성치가 8.2로 양호하였다. 나. 약제형성 및 처리회구가 해충 및 천적밀도에 미치는 영향(폿트시험) (1) 이화명충 방제약제중 cartap이 이화명충 방제효과도 높고, 거미밀도도 높았으며, 제형간에서는 유제가 분제보다 거미에 미치는 영향이 적었다. (2) MIPC 처리구에서 끝동매미충 방제효과가 높고 거미 밀도에 미치는 영향도 적었다. (3) pyridaphenthion 1회 처리구가 2회 처리구에 비하여 거미밀도에 미치는 영향이 적었으나 혹명나방 방제효과는 비슷하였다.

• 대한안전경영과학회지
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• 제14권1호
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• pp.43-51
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• 2012

This study was carried out to observe the impacts of a mouse's inhalation of toxic gas SO2 generated from combustion on its organs by different concentrations. As for research methods: First, after concentrations of SO2 generation from combustion had been set to three: low (10.4 ppm), middle (24.9 ppm) and high (122 ppm) through Gas Toxicity Testing Method (KS F 2271) and SO2 combustion gas was exposed to eight mice in each concentration. Five mice that were able to move based on LD50, a criterion, which sets the down time of a mouse's average behaviors to over 9 minutes, were randomly selected in each concentration, and they were set up as the subjects of the study on toxicity bio-markers. Second, tissues were taken from heart, liver, lungs, spleen and the thymus gland of the mice selected in each concentration and a pathological examination of them was carried out. As a result, microvascular congestion appeared in the heart, and cell necrosis, cortex congestion and tubule medulla congestion, etc. in each concentration were observed in addition to vascular congestion in liver, lungs, spleen and the thymus gland. Also, it was found that the higher the concentrations of SO2 exposure is, the greater, the changes in the organs get. Through this study, SO2 of various toxic gases generated from fire turned out to affect the tissues of each organ of a mouse, it is expected that the toxic gases may greatly affect human body in case of actual fire, and this study is evaluated as having a significance as a basic data on inhalation toxicity assessment of toxic substances generated in combustion.

• 한국가스학회지
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• 제23권1호
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• pp.54-61
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• 2019

휴대용 전자기기의 시장이 성장함에 따라서 Lithium Ion Battery(LIB)의 수요 또한 증가하고 있다. LIB는 다른 2차 전지에 비해 높은 효율성을 보이지만 열 폭주(Thermal runaway)로 인한 폭발/화재의 위험성이 있다. 특히나 대용량 LIB cell을 탑재한 Electric Vehicle(EV)의 경우 화재로 발생하는 대량의 독성 가스로 인한 위험성 또한 존재한다. 따라서 사고 피해를 최소화하기 위한 EV 화재로 발생하는 독성 가스의 위험성 분석이 필요하다. 이 연구에서는 EV의 화재로 발생하는 독성 가스의 유동을 전산유체역학(Computational Fluid Dynamic; CFD)을 이용하여 해석하였다. 문헌 조사 결과와 국내 EV 자료를 기반으로 시나리오를 설정하여 시나리오 발생 경과시간에 따른 독성 가스의 확산을 수치 해석하여 위험성에 대하여 분석 하였다. 이 연구는 EV 화재로 인한 독성 가스의 위험성을 분석하여 사고 발생에 의한 인명, 재산피해를 최소화하는데 의의를 가진다.

• 한국초지조사료학회지
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• 제42권3호
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• pp.201-207
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• 2022

Fescues, which are widely cultivated as grasses and forages around the world, are often naturally infected with the endophyte, Epichloë. This fungus, transmitted through seeds, imparts resistance to drying and herbivorous insects in its host without causing any external damage, thereby contributing to the adaptation of the host to the environment and maintaining a symbiosis. However, some endophytes, such as E. coenophialum synthesize ergovaline or lolitrem B, which accumulate in the plant and impart anti-mammalian properties. For example, when livestock consume excessive amounts of grass containing toxic endophytes, problems associated with neuromuscular abnormalities, such as convulsions, paralysis, high fever, decreased milk production, reproductive disorders, and even death, can occur. Therefore, pre-inoculation with non-toxic endogenous fungi or management with endophyte-free grass is important in preventing damage to livestock and producing high-quality forage. To date, the diagnosis of endophytes has been mainly performed by observation under a microscope following staining, or by performing an immune blot assay using a monoclonal antibody. Recently, the polymerase chain reaction (PCR)-based molecular diagnostic method is gaining importance in the fields of agriculture, livestock, and healthcare given the method's advantages. These include faster results, with greater accuracy and sensitivity than those obtained using conventional diagnostic methods. For the diagnosis of endophytes, the nested PCR method is the only available option developed; however, it is limited by the fact that the level of toxic alkaloid synthesis cannot be estimated. Therefore, in this study, we aimed to develop a triplex real-time PCR diagnostic method that can determine the presence or absence of endophyte infection using DNA extracted from seeds within 1 h, while simultaneously detecting easD and LtmC genes, which are related to toxic alkaloid synthesis. This new method was then also applied to real field samples.

• 한국위험물학회지
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• 제2권1호
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• pp.12-17
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• 2014

With a rapid growth of domestic industry in korea, now about 25,000 kinds of chemicals are being distributed, and it has been known that just about 15% of them has toxic substances. Recently, South Koreans have an anxiety about the stability and accidents of chemicals because chemical accidents like Gumi hydrofluoric acid accident have occurred. The U.S. has adopted the systems like EPCRA (Emergency Planning and Community Right-to-Know Act), TRI (Toxic Release Inventory) and TSCA (Toxic Substances Control Act), and is also managing the hazardous chemicals by providing the information about them to its people and site workers. Japan's Ministry of Health, Labor and Welfare also has adopted J-CHECK system and is implementing it to let Japanese people know the information of safety of chemicals about REACH. However, the Korean government has a difficult situation to mediate the different idea with the Korean industry to make lower statute of Pre-legislation registration & evaluation of chemicals that will be implemented and Chemical Material Control Association that is being implemented. Especially city and country areas located in the industrial areas need political improvement focusing on vulnerable area through the check about current situation of hazardous chemicals of jurisdiction and management method, but the information about the management situation of small scale work places is insufficient. Therefore this study set up the urgent management area in Ansan Smart Hub through NFPA code according to the types of accident and dander characteristics of each chemical being used in the companies that have less than 50 workers and deal with chemicals located in Ansan Smart Hub in Gyeonggi-do.

• 대한화장품학회지
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• 제15권1호
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• pp.37-50
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• 1989

The in Vitro chemosensitivity of fibroblast cell strains was determined using a semiautomated tetrazolium-based colorimetric assay(MTT assay) to 16 cosmetic materials. This assay is useful method to evaluate toxic effects of the chemicals. From assay results, we determined that the preservatives are more toxic than moisteurizers. The chemicals in the same group have a different toxicity. That is, in preservatives, Germall -115 is more toxic than Danisol -M, -p, and in surfactant sodium laurel sulfate than Myrj 52, and in moisteurizers, 1, 3-butylene glycol is more safe than the others. When the results from this assay for preservatives were compared with patch test results, good correlation was observed. Forthemore, this assay method can be used together with Patch test for the evaluation of the chemical toxicity, particularly in cosmetic field.

• 한국전기전자재료학회:학술대회논문집
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• 한국전기전자재료학회 2009년도 하계학술대회 논문집
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• pp.247-247
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• 2009

In this work, Ga-doped ZnO (GZO) thin films for toxic gas sensor application were deposited on low temperature co-fired ceramic (LTCC) substrates, by RF magnetron sputtering method. LTCC is one of promising materials for integration with heater, low cost production and high manufacturing yields than silicon substrate. The LTCC substrates with thickness of $400\;{\mu}m$ were fabricated by laminating 12 greentapes which consist of alumina and glass particle in an organic binder. The GZO thin films deposited on the substrates and were analyzed by X-ray diffraction method (XRD) and field emission scanning electron microscope (FESEM). The films are well crystallized in the hexagonal (wurzite) structure with increasing thickness. The fabricated sensors showed good sensitivity and fast response time to common types of toxic gases (NOx, COx).

• 대한본초학회지
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• 제20권4호
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• pp.53-60
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• 2005

Objectives : This study was carried out to determine if Dendrobii Herba have protective effect against cell injury induced by various toxic agents in rat kidney slices. Water(DWe) and methanol(DMe) extracts were prepared for this experiment. Methods : Cell injury was estimated by measuring lactate dehydrogenase(LDH). Lipid peroxidation was examined by measuring malondialdehyde, a product of lipid peroxidation. Results : DMe prevented the LDH release by $CCl_4$, menadione, tert-butyl hydroperoxide and mercury treatment in vitro in kidney slices, but DWe prevented the LDH release by $CCl_4$ and mercury. DMe also prevented reduction in GSH and lipid peroxidation induced by $CCl_4$ and mercury. Conclusion : Thus, DMe may have more powerful efficacy on anti-oxidative effects when compared with DWe. And further studies have to be followed concerned with extraction of Dendrobii Herba and its change of effects.

• Toxicological Research
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• 제28권2호
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• pp.123-127
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• 2012

Voltammetric detection of the toxic Zn ion was investigated using a fluorine-doped graphite pencil electrode (FPE). It is notable from the study that pencils were used as reference and working electrodes. In all the experiments, a clean seawater electrolyte solution was used to yield good results. The analytical working range was attained to 10 ${\mu}gL^{-1}$. The optimized voltammetric condition was examined to maximize the effect of the detection of trace Zn. The developed sensor was applied to an earthworm's tissue cell. It was found that the methods can be applicable to in vivo fluid or agriculture soil and plant science.