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The Neuroprotective Activities of the Sam-Hwang-Sa-Shim-Tang in the Transient Ischemic Model in Rats.

  • Kim, Min-Sun;Hwang, Young-Sun;Ryu, Jong-Hoon
    • Proceedings of the Korean Society of Applied Pharmacology
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    • 2001.11a
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    • pp.85-85
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    • 2001
  • Sam-Hwang-Sa-Shim-Tang(SHSST), a traditional Chinese medicine, composed of Rhei rhizoma, Scutellaria radix, and Coptidis rhizoma were used in the several disease including hypertension, constipation, and hemorrhage. In the present study, we investigated the neuroprotective effects of SHSST and its ingredients on the ischemia/ reperfusion-induced brain injury was evaluated in the rat brain. Ischemia was induced by intraluminal occlusion of the right middle cerebral artery for 120 min and reperfusion was continued for 22 h. SHSST (450 mg/kg), Rhei rhii oma (100 mg/kg), Coptidis rhizoma (100 mg/kg), and Scutellaria radik (100 mg/kg) were orally administered twice, promptly prior to reperfusion and 2 h after the repefusion. Total infarction volume in the ipsilateral hemisphere of ischemia/ reperfusion rats was significantly lowed by the treatments of SHSST (39.2%) and Scutellaria radix (66.5%). However, Coptidis rhizoma did not show any significant effects on the total infarct volume. The inhibiting effect of Scutellaria radix on the total infarct volume was more potent than that of SHSST. In addition, Scutellaria radix significantly inhibited myeloperoxidase (MPO) activity, an index of neutrophil infiltration in ischemic brain tissue. However, there was marked mismatch between total infarct volume and MPO activity in the Scutellaria radix-treated rats. Our findings suggest that Scutellaria radix as an ingredient of SHSST plays a protective role in ischemia-induced brain injury by inhibiting neutrophil infiltration. The effects of Rhei rhizoma on transient brain ischemia-induced neuronal injury are under study.

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Pore-Controlled Synthesis of Mesoporous Silica Particles by Spray Pyrolysis from Aqueous Silicic Acid (규산 수용액으로부터 분무열분해법에 의한 기공 특성이 제어된 메조기공의 다공성 실리카 분말 합성)

  • Chang, Han Kwon;Lee, Jin Woo;Oh, Kyoung Joon;Jang, Hee Dong;Kil, Dae Sup;Choi, Jeong Woo
    • Particle and aerosol research
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    • v.8 no.2
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    • pp.89-95
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    • 2012
  • Spherical mesoporous silica particles, of which main pore diameter was 3.8 nm, were successfully prepared by spray pyrolysis from aqueous silicic acid. The effect of precursor concentration, reaction temperature, and the addition of urea and PEG on the particle diameter and pore properties such as pore diameter, total pore volume, and specific surface area were investigated by using FE-SEM, particle size analyzer, and nitrogen absorption-desorption analysis. With an increase of the precursor concentration from 0.2 M to 0.7 M, the average particle diameter, total pore volume, and specific surface area of the porous silica particles increased from 0.56 to $0.96\;{\mu}m$, 0.434 to $0.486\;cm^3/g$, 467.8 to $610.4\;m^2/g$, respectively. Within the temperature range $(600\;^{\circ}C{\sim}800\;^{\circ}C)$, there was no significant difference in the pore diameter, total pore volume, and specific surface area. In addition, the addition of urea as an expansion aid led to slight increases in particle diameter, pore diameter, and specific surface area. However, when the polyethylene glycol (PEG) as an organic template was used, the total pore volume of porous particles increased dramatically.

Loading Rates and Characteristics of Litter from Highway Stormwater Runoff (강우로 인해 고속도로로부터 유출되는 폐기물의 성상, 부하량 및 유출 특성)

  • Kim, Lee-Hyung;Kang, Joohyon
    • Journal of Korean Society on Water Environment
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    • v.20 no.5
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    • pp.415-421
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    • 2004
  • Litter wastes on highway runoff are gradually being considered one of the major pollutants of concern in protecting the integrity of receiving waters for beneficial use. The California State Water Resources Control Board has identified in their 303(d) list at least 36 water bodies where trash or litter is considered a pollutant of concern. The first TMDL adopted by the Region 4 (Los Angeles area) of the California State Water Quality Control Board was for trash in the Los Angeles River. The first flush characteristic study was developed to obtain first flush water quality and litter data from representative stormwater runoff from standard highway drainage outfalls in the Los Angeles area. Total captured gross pollutants in stormwater runoff were monitored at six Southern California highway sites over two years. The gross pollutants were 90% vegetation and 10% litter. Approximately 50% of the litter was composed of biodegradable materials. The event mean concentrations show an increasing trend with antecedent dry days and a decreasing trend with total runoff volume or total rainfall. Event mean concentrations were ranged 0.0021 to 0.259g/L for wet gross pollutants and 0.0001 to 0.027g/L for wet litters. The first flush phenomenon was evaluated and the impacts of various parameters such as rainfall intensity, drainage area, peak flow rate, and antecedent dry period on litter volume and loading rates were evaluated. First flush phenomenon was generally observed for litter concentrations, but was not apparent with litter mass loading rates. Litter volume and loading rates appear to be directly related to peak storm intensity, antecedent dry days and total flow volume.

Acquisition of Evidential Information to Control Total Volume in accordance with Degradation Trends of Green Space (녹피율 훼손추세 평가를 통한 총량규제 근거자료 학보방안)

  • Um, Jung-Sup
    • Spatial Information Research
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    • v.14 no.3 s.38
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    • pp.299-319
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    • 2006
  • This research is primarily intended to investigate the potential of estimating green space threshold in terms of total volume control using degradation trends of green space derived from remote sensing and GIS. An empirical study for a case study site was conducted to demonstrate how a standard remote sensing and GIS technology can be used to assist in estimating the total control volume for green space in terms of area-wide information, spatial resolution and change detection etc. Guidelines for a replicable methodology are presented to provide a strong theoretical basis for the standardization of factors involved in the estimation of the green space threshold; the meaningful definition of land mosaic, redefinition of degradation trends for green space. It was demonstrated that the degradation trends of green space could be used effectively as an indicator to restrict further development of the sites since the visual maps generated from remote sensing and GIS can present area-wide visual evidences by permanent record. It is anticipated that this research output could be used as a valuable reference to support more scientific and objective decision-making in introducing aggregate control of green space.

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Optimal design and performance test of thermally controlled superconducting switch (열 제어형 초전도 스위치의 최적화 설계 및 특성 평가)

  • 고락길;배준한;권영길;조영식
    • Proceedings of the Korea Institute of Applied Superconductivity and Cryogenics Conference
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    • 2002.02a
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    • pp.207-210
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    • 2002
  • We had designed thermally controlled superconducting switches using a general nonlinear optimized algorithm with constraints and tested its performance. Objective function was to minimize the total volume of the superconducting switch. And constraints were to have designed resistance in normal status and temperature. In order to compare performance of the optimized superconducting switch, we made another one which had geometrically different parameters but had same structure and resistance value when the superconductor part is normal status by heater. Objective function converged very rapidly. As result, volume of the adiabatic part and total volume of the switch were reduced to more than 70% and 30% respectively. Also, even if same heater power was supplied with NiCr wire heater, the optimized superconducting switch had very fast On-OFF switching performance comparing with unoptimized switch.

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Change of Craniovertebral Angle(CVA) and Respiration on Application Correction Method of Posture and Breathing Accessory Muscle Exercise in Forward Head Posture(FHP) (두부전방전위자세에 자세교정법과 호흡보조근운동의 적용 시 CVA와 호흡의 변화)

  • Cho, hyunrae
    • Journal of The Korean Society of Integrative Medicine
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    • v.3 no.3
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    • pp.89-94
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    • 2015
  • Purpose : This study was analyzed to researched the improvement of the posture and breathing ability on correction method of posture and breathing exercise in Forward Head Posture(FHP) Method : Eighten forward head posture subjects participated in this study. The control group applied to correction method of posture and the experiment group applied to correction method of posture with breathing exercises. Results : The results showed significant improvement in Craniovertebra-Angle on each two group(P<0.05). All the other result showed non-significant in respiratory(Tidal volume, Expiratory residual volume, Inspiratory residual volume) But value of result is slightly improved in after exercise. Conclusion : CVA angle is increased in each group but not increased between experiment group and control group. Total Volume(TV), Inspiratory Reserve Volume(IRV) and Expiratory Reserve Volume(ERV) are a little increased.

Wear Analysis of Engine Bearings at Constant Shaft Angular Speed during Firing State - Part II: Calculation of the Wear on Journal Bearings (파이어링 상태의 일정 축 각속도에서 엔진베어링의 마모 해석 - Part II: 저어널베어링 마모 계산)

  • Chun, Sang Myung
    • Tribology and Lubricants
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    • v.34 no.4
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    • pp.146-159
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    • 2018
  • This paper presents a wear analysis procedure for calculating the wear of journal bearings of a four-strokes and four-cylinder engine operating at a constant angular crank shaft speed during firing conditions. To decide whether the lubrication state of a journal bearing is in the possible region of wear scar, we utilize the concept of the centerline average surface roughness to define the most oil film thickness scarring wear (MOFTSW) on two rough surfaces. The wear volume is calculated from the wear depth and wear angle, determined by the magnitude of each film thickness on a set of oil films with thicknesses lower than the MOFTSW at every crank angle. To calculate the wear volume at one contact, the wear range ratio during one cycle is used. The total wear volume is then determined by accumulating the wear volume at every contact. The fractional film defect coefficient, asperity load sharing factor, and modified specific wear rate for the application of the mixed-elasto-hydrodynamic lubrication regime are used. The results of this study show that wear occurs only at the connecting-rod big-end bearing. Thus, simulation results of only the big-end bearing are illustrated and analyzed. It is shown that the wear volume of each wear scar group occurs consecutively as the crank angle changes, resulting in the total accumulated wear volume.

The Yields of Volume, Thiamin and Riboflavin from the Milk of Cesarian-Section Women, and Their Ingestion in Infants (제왕절개 분만 수유부의 모유, 티아민, 리보플라빈의 분비량과 영아의 섭취량)

  • 김을상
    • Journal of Nutrition and Health
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    • v.32 no.1
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    • pp.83-89
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    • 1999
  • The present study was conducted to investigate the yields of volume, thiamin and riboflavin from the milk of twenty-five Cesarean-section women, and their ingestion in infants. We measured the consumed volume of human milk of infants by the test-weighing method, and thiamin riboflavin contents were determined by fluorescence spectroscopy during the first 7 days postpartum. Thiamin contents of the milk averaged 24.3, 24.0, 27.4 and 30.2ug/100g. Thiamin and riboflavin contents of the milk both increased during the lactation ps mod(p<0.05). The first secretion of breast milk occurred from the 4th to 5th day postpartum in Cesarean-section women. The consumed volume of human milk was 63, 81, 104 and 133g/day at 4, 5, 6 and 7 days postpartum and the consumed volume of formula milk was 58, 176, 292, 323, 308, 321 and 318g/day at 1, 2, 3, 4, 5, 6 and 7 days postpartum and the consumed volume of formula from the human and formula milk were 26.6, 91.0, 151.0, 172.5, 169.2, 175.9 and 172.9ug/day. Total daily riboflavin ingestion from the human and formula milk were 26.6, 91.0, 151.0, 172.5, 169.2, 175.9 and 172.9ug/day. Total daily riboflavin ingestion from the human and formula milk was 48.7, 166.8, 277.6, 318.2, 312.0, 327.0 and 335.7ug/day at 1, 2, 3, 4, 5, 6 and 7 postpartum. These results suggest that the milk secretion of Cesarean-section women is delayed a few days and the yield volume of milk is less than that of normal delivery women, but thiamin and riboflavin contents of the milk are not different from those of milk of normal-delivery women.

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An Evaluation by CT scanning of Intracranial Volume after Correction of Craniosynostosis (두개골 조기유합증 환자의 술후 CT Scan을 이용한 두개강내 용적의 평가)

  • Kim, Seok Kwun;Lee, Jang Ho;Han, Jae Jung;Jung, Ki Hwan;Lee, Keun Cheol;Park, Jung Min
    • Archives of Plastic Surgery
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    • v.32 no.1
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    • pp.29-36
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    • 2005
  • Craniosynostosis is the premature fusion of one or more sutures of either cranial vault or base. Fused sutures may impede normal growth of the calvaria, leading to characteristic skull deformities; Morphological craniosynostosis is classified descriptively. Being craniosynostosis uncorrected the deformity progresses continuously and causes an increase of intracranial pressure. The surgical involvement aims at the expansion of intracranial space as well as satisfactory achievement of craniofacial shape. Early surgical correction in infancy prevents the deformity from the further progression and possible associated complication of high intracranial pressure. A long period of follow-up is essential to asses the outcome of an effectiveness of the surgery. measurement of intracranial volume has been concerned in medical personnel and anthropologists for many years. A reliable and accurate measurements of the intracranial volume facilitates to make a diagnosis and treatment of craniosynostosis. Pre-and postoperative change of intracranial volume was evaluated with 3D CT scanning in 12 cases of craniosynostosis who underwent frontal advancement and total cranial vault remodeling. Increased intracranial volume is attributed to surgical release of craniosynostosis and natural growth. We conceive that the intracranial volume is significantly increased after surgical correction of fused cranial sutures and along with natural growing. A procedure of frontal advancement and total cranial vault remodeling is very useful to correct such a deformity as craniosynostosis. And also 2 cases out of five mentally retarded patients improved remarkably and Forehead retrusion or temporal depression followed in another two cases.

Studies on Bread-Baking Properties of Naked Barley Flour and Naked Barley-Wheat Flour Blends - I. Variations of loaf volume of naked barley bread and mixed naked barley-wheat bread prepared by lactic acid method - (쌀보리 및 쌀보리-밀 복합분(複合粉)의 제빵 적성에 관한 연구 - 제 1 보 : 젖산 발효법에 의(依)한 쌀보리 가루 및 복합분(複合粉) 빵의부피(loaf volume)의 변화(變化) -)

  • Rhee, Chul;Bae, Song-Hwan;Yang, Han-Chul
    • Korean Journal of Food Science and Technology
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    • v.14 no.4
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    • pp.370-374
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    • 1982
  • Bread-baking properies of naked barley flour and naked barley-wheat flour blends were investigated, and changes of loaf volume of naked barley bread prepared by straight method and by lactic acid method were observed. Specific loaf volume of naked barley flour bread made by straight method was only 1.11 ml/g bread, while that of barley bread made by lactic acid method was more than 1.50 ml/g bread. No significant increase of loaf volume was noted in mixed naked barley-wheat bread. The increase of loaf volume of barley bread appeared to be due to total titratable acidity of barley dough. Loaf volume of what bread made by lactic acid method decreased sharply as the total titratable acidity of wheat flour dough increased.

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