• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제36권4호
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• pp.270-274
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• 2010

Introduction: Limited mouth opening is a representative clinical symptom of temporomandibular disorders (TMD) with anterior disc displacement without reduction (ADDWOR). Various treatment methods have been proposed for patients with ADDWOR. This study examined the clinical effectiveness of template therapy for patients with mouth opening difficulty due to the ADDWOR. Material and Methods: A total of 14 patients (female 12, male 2, average age: $29.1{\pm}14.4$), who had been treated in the template clinic, Sooncheonhyang University Bucheon Hospital, from January of 2006 to December of 2008, were enrolled in this study. The subjects were selected according to the following criteria: more than 2 weeks after the onset of locking, mouth opening range <35 mm, and confirmed ADDWOR without a synovial pathology by magnetic resonance imaging (MRI). All patients were treated with the template appliance, instructed to wear it while sleeping and exercise for at least 10 hours per day. The maximum mouth opening (MMO) range and pain recognition scores before and after template therapy were recorded and compared. A paired t-test and Wilcoxon's signed rank test were used for statistical analysis. Results: After the periodical follow up, significant improvement in the opening range was observed in the template treatment group. The average MMO range before treatment was $30.2{\pm}3.5mm$ and the average MMO after treatment and follow up was $47.1{\pm}4.7mm$. The mean amount of mouth opening increment was $16.9{\pm}5.4mm$ (P<0.01) and the pain recognition scores before and after treatment was also improved.(P=0.001) Conclusion: The template appliance proved to be efficient for the treatment of TMD with a closed lock and painful joint due to ADDWOR.

• Journal of Korean Neurosurgical Society
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• 제46권2호
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• pp.144-151
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• 2009

Objective: To compare two testing protocols for evaluating range of motion (ROM) changes in the preloaded cadaveric spines implanted with a mobile core type Charite$^{TM}$ lumbar artificial disc. Methods: Using five human cadaveric lumbosacral spines (L2-S2), baseline ROMs were measured with a bending moment of 8 Nm for all motion modes (flexion/extension, lateral bending, and axial rotation) in intact spine. The ROM was tracked using a video-based motion-capturing system. After the Charite$^{TM}$ disc was implanted at the L4-L5 level, the measurement was repeated using two different methods: 1) loading up to 8 Nm with the compressive follower preload as in testing the intact spine (Load control protocol), 2) loading in displacement control until the total ROM of L2-S2 matches that when the intact spine was loaded under load control (Hybrid protocol). The comparison between the data of each protocol was performed. Results: The ROMs of the L4-L5 arthroplasty level were increased in all test modalities (p < 0.05 in bending and rotation) under both load and hybrid protocols. At the adjacent segments, the ROMs were increased in all modes except flexion under load control protocol. Under hybrid protocol, the adjacent segments demonstrated decreased ROMs in all modalities except extension at the inferior segment. Statistical significance between load and hybrid protocols was observed during bending and rotation at the operative and adjacent levels (p< 0.05). Conclusion: In hybrid protocol, the Charite$^{TM}$ disc provided a relatively better restoration of ROM, than in the load control protocol, reproducing clinical observations in terms of motion following surgery.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제25권4호
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• pp.337-349
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• 1999

The extracellular matrix(ECM) is a complex network of different combination of collagens, glycosaminoglycans, laminin, fibronectin, and many other glycoproteins including proteolytic enzymes. The composition and organization of the ECM contributes to the uniques physical or biomechanical properties of a tissue. Fibronectins(FN) are dimeric glycoproteins located on cell surfaces, in the matrix of connective tissue, and in blood. Fibronectins mediate cell attachment to collagen substratum and have been implicated in a variety of important biological processes, including embryogenesis and cell differentiation. The purpose of this study was to determine the effects of surgical induction of anterior disk displacement(ADD) on distribution of fibronectin in the rabbit temporomandibular joint(TMJ) tissues included the articular cartilage, disc, retrodiscal tissue, articular eminence using an immunohistochemical technique. The left TMJ was exposed surgically, and all discal attachments were severed except for the posterior attachment. The disk was then repositioned anteriorly and sutured to the zygomatic arch. The right TMJ served as a shamoperated control. Normal joints were used as a nonoperated control. Fourty-five rabbits were used for experiments in total. For fibronectin immunohistochemical study, eighteen rabbits (one normal group and 5 experimental groups, each group consists of 3 rabbits) were used. The experimental rabbits were sacrified after operation period of 2, 3, 4, 6 and 8 weeks on fibronectin. The obtained results were as follows ; 1. Fibronectin immunoreaction on all TMJ tissues(mandibular condyle, articular disc, retrodiscal tissue, articular eminence) in the normal rabbit was observed. Especially the reverse cell layer and proliferation zone of articular cartilage of condyle show strong positive reaction. 2. Depletion of fibronectin in the all TMJ tissues except hypertrophic zone of articular cartilage occurred at 2 weeks following induction of ADD. 3. The restoration of immunoreaction at 4 weeks was observed and a progressive increasing reaction at 6 weeks, 8 weeks also was found. Our study generally showed degenerative changes in TMJ tissues after ADD although TMJ tissues adapted or degenerated to abnormal loads and stress distribution according to the remodeling capacity of TMJ tissues.

• 대한의용생체공학회:의공학회지
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• 제28권3호
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• pp.397-409
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• 2007

Owing to needs of biomechanical comprehension and analysis to obtain various medical treatment designs which are related with the spine in order to cure and diagnose LBP patients, the FE modeling and nonlinear analysis of lumbosacrum including a partial ilium and iliolumbar ligaments, were carried out. First, we investigated whether the geometrical configuration of vertebrae displayed by DICOM slice files is regular and normal condition. After constructing spinal vertebrae including a partial ilium, a sacrum and five lumbars (from L1 to L5)with anatomical shape reconstructed using softwares such as image modeler and CAD modeler, we added iliolumbar ligaments, lumbar ligaments, discs and facet joints, etc.. And also, we assigned material property and discretized the model using proper finite element types, thus it was completely modeled through the above procedure. For the verification of each segment, average sagittal ROM, average coronal ROM and average transversal ROM under various loading conditions(${\pm}10Nm$), average vertical displacement under compression(400N), ALL(Anterior Longitudinal Ligament) and PLL(Posterior Longitudinal Ligament) force at L12 level, strains of seven ligaments on sagittal plane at L45 level and maximal strain of disc fibers according to various loading conditions at L45 level, etc., they were compared with experimental results. For the verification of multilevel-lumbosacrum spine including partial ilium and iliolumbar ligaments, the cases with and without iliolumbar ligaments were compared with ROM of experiment. The results were obtained from analysis of the verified FE model as follows: I) Iliolumbar ligaments played a stabilizing role as mainly posterior iliolumbar ligaments under flexion and as both posterior and anterior iliolumbar ligaments of one side under lateral bending. 2) The iliolumbar ligaments decreased total ROM of 1-8% in total model according to various motion conditions, which changed facet contact forces of L5S level by approximately 0.8-1.4 times and disc forces of L5S level by approximately 0.8-1.5 times more than casewithout ilioligaments, under various loading conditions. 3) The force of lower discs such as L45 and L5S was bigger than upper discs under flexion, left and right bending and left and right twisting, except extension. 4) It was predicted that strains of posterior ligaments among iliolumbar ligaments would produce the maximum 16% under flexion and the maximum 10% under twisting. 5) It's expected that this present model applies to the development and design of artificial disc, since it was comparatively in agreement with the experimental datum.

• 한방재활의학과학회지
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• 제29권3호
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• pp.1-13
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• 2019

Objectives This review aims to analyze the current research trend in the usage of bee venom (BV) acupuncture for spinal diseases. Methods We collected 80 articles on BV acupuncture clinical study for spinal diseases by searching Korean web databases 'Journal of Korean Medicine Rehabilitation', 'Oriental Medicine Advanced Searching Integrated System', 'Korean Traditional Knowledge Portal' from 1999 to 2018. Results We summarized the most frequent clinical treatment methods of BV acupuncture. 1. Herniated intervertebral disc was treated for 40% and the treated spinal diseases were various. 2. '1:10,000' in the type of BV was chosen for 21%. 3. 29% of studies used 6-7 acupoints per session and 23% of studies used 'BL' as the injection site. 3. The highest volume of injected BV into each acupoint was 0.1 cc for 34% and the highest total volume of injected BV was 1.0 cc for 39%. Conclusions We found the limited evidence on the lack of consensus and detailed description in the reported experimental design. The results in this review suggest that future works should focus on more consistent and systematic study for the reproducible and standardized treatment methods.

• Journal of Oral Medicine and Pain
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• 제32권3호
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• pp.293-303
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• 2007

목적 : 비정복성 관절원판변위와 연관되어 전치부 개교합이 발생하는 원인과 교합장치 치료가 개교합 발생과 연관이 있는 지를 살펴보고자 한다. 재료 및 방법 : 2년간 경북대학병원 구강내과에 턱관절 질환으로 내원한 환자 중에 임상적으로 비정복성 관절원판변위로 진단된 환자를 대상으로 파노라마, 측방 횡두개상 그리고 측방 두부방사선 사진을 촬영하였다. 환자는 3군으로 나누었으며 1군은 처음 병원에 내원할 때 개교합이 있거나 교합장치 치료를 제외한 치료도중에 갑자기 개교합이 유발된 군(22명), 2군은 교합장치 치료 도중에 개교합이 발생한 군과 이 기간동안 예전에 이미 교합장치 치료도중 개교합이 발생한 후 정기적 관찰 환자를 포함한 군(16명). 그리고 3군은 교합장치 치료 후에도 개교합이 발생하지 않은 군(20명)으로 구성되었다. 측방 두부방사선 계측으로 개교합 발생과 안면부 골격 형태의 연관성을 한국인 정상 교합자들의 평균치와 각 3군 간의 t-test 비교와 ANOVA를 이용해 3군 간의 골격 형태를 비교 조사하였다. 결과 : 1. 1군과 2군은 정상 교합자들의 평균치와 비교했을 때 대부분의 경우에서 유의한 차이가 있었으며, 1, 2, 3군 모두에서 하악의 크기와 형태를 나타내는 변수들과 더 작은 ANB, 더 큰 FMA 값을 보였다. 2. 세군 간의 비교에서 1군과 2군은 3군에 비해 더 큰 하악하연각 (a larger FMA, a larger SN to mandibular plane angle), 짧은 하악지, 더 큰 하악각을 가졌으며, 1군과 2군 간은 통계학적 유의한 차이가 없어 비슷한 수직적 부조화가 큰 골격형태를 가졌으며, 3군은 1, 2군과는 달랐다. 결론 : 이상의 결과로 미루어 1군과 2군은 수직적 부조화가 큰 안모 형태를 보여 저작근의 작용 방향과 저작근 부착 위치에 따른 하악의 후하방 회전의 결과로 전치부 개교합이 발생하는 것으로 생각된다. 그리고 수직적 부조화가 큰 경우일 때는 수직 고경의 변화를 일으키는 것은 좀 더 주의가 필요하리라 생각한다.

• 구강회복응용과학지
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• 제17권4호
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• pp.245-256
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• 2001

The purpose of this study is to analyze the mechanical stress and displacement on the jaws during the simulated bilateral clenching task on the three-dimensional finite element model of the dentated skull with unilateral molar loss. For this study, the computed tomography(G.E.8800 Quick, USA) was used to scan the total length of human skull in the frontal plane at 2.0mm intervals. The fully assembled finite element model consists of the articular disc, maxilla, mandible, teeth, periodontal ligament and cranium. The FE model was used to simulate the bilateral clenching in intercuspal position. The loading condition was the force of the masseter muscle exerted on the mandible as reported by Korioth et al. degrees of freedom of the zygomatic region where the masseter muscle is attached were fixed as restraints. In order to reflect the actual action of the muscles force, the displacement of the region was attached where the muscle is connected to the temporal bone and restraint conditions were given values identical to values at the attachment region of the masticatory muscle but with the opposite direction of the reaction from when the muscle force is acted on the mandible. Although the mandible generally has higher displacement and von Mises stress than the maxilla, its mandibular corpus on the molar-loss side has a higher stress and displacement than the molar-presence side. Because the displacement and von Mises Stress was the highest on the lateral surface of mandibular corpus with molar loss, the stress level of the condyle on the molar-loss side is greater than that of the molar-presence side, which in turn caused the symphysis of the mandible to bend. In conclusion, the unilateral posterior bite collapse with molar loss under para-functional activities such as bruxism and clenching can affect the stress concentration on the condyle and mandibular corpus. It is therefore necessary to consider the biomechanical function of dento-skeleton under masticatory force while designing the occlusal scheme of restoration on alveolar bone with the posterior collapse.

• Journal of Korean Neurosurgical Society
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• 제63권1호
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• pp.108-118
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• 2020

Objective : This study aimed to determine the incidence and analyze trends of the herniated lumbar disc (HLD) based on a national database in the Republic of Korea (ROK) from January 2008 to December 2016. Methods : This study was a retrospective analysis of data obtained from the national health-claim database provided by the National Health Insurance Service for 2008-2016 using the International Classification of Diseases. The crude incidence and age-standardized incidence of HLD were calculated, and additional analysis was conducted according to age and sex. Changes in trends in treatment methods and some treatments were analyzed using the Korean Classification of Diseases procedure codes. Results : The number of patients diagnosed with HLD was 472245 in 2008 and increased to 537577 in 2012; however, it decreased to 478697 in 2016. The pattern of crude incidence and the standardized incidence were also similar. Overall, the incidence of HLD increased annually for the 30s, 40s, 50s, and 70s until 2012 and then decreased. However, the incidence of HLD for the 80s continued to increase. The crude incidence of HLD in female patients exceeded that of male patients in their middle age (30s or 40s) and was 1.5-1.6 times higher than in male patients in their 60s. The total number of open discectomy (OD) increased from 71598 in 2008 to 93942 in 2012 and then decreased to 85846 in 2016. The rate of younger patients (the 20s, 30s, and 40s) who underwent OD was decreased, and the rate of younger patients who underwent percutaneous endoscopic lumbar discectomy was increased. However, the rate of older patients (the 70s and 80s) who underwent OD was continuously increased. Conclusion : This nationwide data on HLD from 2008 to 2016 in the ROK demonstrated that the crude incidence and the standardized incidence increased until 2012 and then decreased. The annual crude incidence was different according to age and sex. These findings may be considered when deciding future health policy, especially in countries with a similar national health insurance system (or with plans to adopt).

• Journal of Korean Neurosurgical Society
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• 제38권4호
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• pp.265-268
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• 2005

Objective : With the increasing popularity of pedicle screw fixation devices for several indications, the safety and reliability of screw insertion in the small pedicle has become a major issue. Many studies have investigated the accuracy of screw placement after pedicle screw fixation using various method. The reported displacement rates have been very different. The purpose of the study is to investigate the proper placement of pedicle screw insertion in the lumbar spine on 26 consecutive patients. Methods : Between September and December 2003, 26 consecutive patients [16women and 10men] were analyzed after transpedicular screw fixation of the lumbar and lumbosacral spine. After pedicle screw fixation in this study, 2-mm slices of CT scan were performed in all patients to detect caudal and cranial deviation of screw and medial and lateral deviation. Pedcile screw placement related complication was evaluated clinically. Results : A total of 144 inserted pedicle were analyzed in 26patients, and 58pedicle screws [40.3%] were detected to be improper placement. There were 14level [9.0%] of caudal or cranial deviation and 44level [30.6%] of medial or lateral deviation to the pedicle. Extra-pedicle placement was found on 4levels [2.7%] with only lease of neurologic injury. Conclusion : Proper screw placement, though complication rate is low, is important not only for clinical symptom but also for biomechanics. Further study for screw placement related biomechanical changes is needed.

• 한국수산과학회지
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• 제17권5호
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• pp.353-360
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• 1984

유전가열을 이용한 내부가열로서 어육연제품을 조리${\codt}$살균함과 동시에 내부수분을 확산${\codt}$이탈시켜 제품의 수분활성을 조절하여 상온보장이 가능한 보장성 어묵을 가공하는 방법과 제품개발을 위한 원료첨가물의 배합 및 가공조건을 검토한 실험결과를 요약하면 다음과 같다. (1) 고등어 연육의 첨가물 배합조건은 고기풀 100에 대하여 전분(옥수수 전분) $10\%$, 소금 $1.5%$, MSG $0.6\%$, sorbitol $3.0\%$, 설탕 $2.0\%$일 때가 가장 적당하였다. (2) 연제품의 형상과 크기는 두께 0.8cm, 직경 8cm의 원반형이 균일한 가열과 팽화 및 표면경화를 막는데 가장 적당하였고, 이것은 연육을 8cm 직경의 원주형으로 충전하여 이것을 열탕중에서 $2{\sim}3$분간 가열처리하여 gel시킨 후 0.8cm 두께로 절단하여 만들수 있으므로 조작이 매우 편리하였다. 동시에 열탕처리는 유전 가열시간을 단축시키는 효과도 있었다. (3) 유전가열은 $5{\sim}6$분간을 2분, $1{\codt}5$분, $1{\codt}5$분 및 1분씩으로 간헐적으로 행하는 것이 제품의 성상과 수분활성 조절 및 살균효과가 좋았다. 1단계 가열에 의하여 확산${\codt}$이탈된 수분은 $60^{\circ}C$, 3m/sec의 열풍으로 2분간 건조하고 계속적으로 600 W 전열기로 $5{\sim}6$분간 가열 표면배소와 함께 최종적으로 수분활성을 조절할 수 있었다. (4) (3)과 같은 조건으로 가공한 연제품은 수분활성 0.84{\sim}0.86, 생균수 $3{\times}10^2/g$이하, TI함량 27.6mg/g였고 texture 시험성적은 hardness 42, cohesiveness 0.53, toughness 4.6, elasticity 0.8, folding test AA였다. (5) 연제품의 일반성분 조성은 수분 $40.1\%$, 단백질 $20.8\%$, 지방 $17.4\%$, 탄수화물 $16.2\%$ 및 회분$5.5\%$였다.