• Title/Summary/Keyword: Tolerance factor

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분열효모 SpHMT1을 세포질 파이토킬레이트를 생성하지 않는 효모에서 발현으로 인한 카드뮴에 대한 저항성 증가 (Heterologous Expression of Fission Yeast Heavy Metal Transporter, SpHMT-1, Confer Tolerance to Cadmium in Cytosolic Phytochelatin-Deficient Saccharomyces cerevisiae)

  • 이상만
    • 생명과학회지
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    • 제19권12호
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    • pp.1685-1689
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    • 2009
  • 파이토킬레이트(PC)는 PCS에 의해 생성되는 작은 폴리펩타이드로서 여러 생물에서 발견되고 있다. PC의 역할은 카드뮴과 같은 중금속을 세포질에서 결합하며 이는 액포막에 존재하는 HMT에 의해서 액포 안으로 이동된다. HMT1은 분열효모에서 처음으로 알려졌으며 이후 선충, 초파리 등에서도 발견되었으며 세포 내 역할은 카드뮴 같은 중금속 해독에 관여를 하고 있다. 하지만 액포가 존재하지 않고 PC를 생성하지 않는 초파리에서의 HMT1의 발견은 그 동안 알려진 HMT1의 역할을 재 조명하게 된다. 따라서 PC를 생성하지 못하는 출아효모에 PC를 생성하는 분열효모 유래 SpHMT1을 발현시켜 카드뮴에 대한 저항성을 분석하였다. SpHMT1을 발현하는 출아효모는 카드뮴에 대한 저항성이 현저하게 증가되었고 이는 SpHMT1이 PC가 존재하지 않는 조건에서도 카드뮴에 대한 해독작용을 하는 것을 암시한다. 또한 SpHMT1을 발현하는 출아효모는 GSH에 대한 저항성을 보였고 카드뮴에 대한 저항성도 GHS에 의해서 더 증가되는 결과를 보였다. 이러한 결과는 HMT1이 PC와 결합된 카드뮴을 액포안으로 이동시키는 가능성보다 GSH와 결합된 카드뮴을 액포 안으로 이동시켜 카드뮴에 대한 해독작용을 한다는 것을 암시한다.

Overexpresssion of the OsbZIP66 transcription factor enhances drought tolerance of rice plants

  • Lee, Ho Suk;Yoon, Suin;Yu, In Jeong;Kim, Youn Shic;Choi, Yang Do;Kim, Ju-Kon
    • 한국작물학회:학술대회논문집
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    • 한국작물학회 2017년도 9th Asian Crop Science Association conference
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    • pp.160-160
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    • 2017
  • Drought stress is a major constraint of crop development and productivity. Plants have evolutionally developed several mechanisms at the molecular, cellular, and physiological levels to overcome drought stress. The basic Leucine zipper (bZIP) transcription factor (TF) family members are starting to be concerned about their roles in drought stress responses. In this study, we functionally characterized OsbZIP66, a rice group-E bZIP TF, to be associated with rice drought tolerance mechanisms. Expression of OsbZIP66 was significantly induced upon treatments of rice plants with drought, high salinity, and ABA. These observations and the fact that the OsbZIP66 promoter contains ten ABA-responsive elements suggest that OsbZIP66 is up-regulated by drought stress in an ABA-dependent manner. Overexpression of both OsbZIP66 in a whole plant body and specifically in roots enhanced drought tolerance of rice plants, indicating that the rice drought tolerance positively correlates with the expression levels of OsbZIP66. Thus, our results demonstrated that OsbZIP66 has a potential for use in biotechnological development of high-yielding rice plants under drought conditions.

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플렉시블 허용오차법을 이용한 예압된 금형 설계에 관한 연구 (A Study on the Design of Prestressed Die using Flexible Tolerance Method)

  • 허관도;최영;여홍태
    • 소성∙가공
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    • 제12권2호
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    • pp.116-122
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    • 2003
  • In the Prestressed die design for cold working, many constraining conditions should be considered to insure the die safety and to improve the dimension accountancy products. Among the constraining conditions, yielding conditions, diameter ratios and interferences between rings are very important. . In this paper, therefore, flexible tolerance method was used in order to search the optimum values of design variables. The maximum inner pressure is used as objective function in this numerical analysis. In the design Process, it was also involved the safety factor to the yield strength of each ring by considering the allowable tensile or compressive hoop stress in each ring. The proposed technique has been applied to the die design of backward extrusion process, and it's analytical results have been compared with that of the conventional design method.

원전 안전등급 저전압계전기 설정시 오차함수 검토 (Review on tolerance factors for 1E UVR setting at NPPs)

  • 문수철;김건중
    • 전기학회논문지
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    • 제61권3호
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    • pp.367-372
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    • 2012
  • In nuclear plants, UVR (under voltage relay, 27r) of 1E bus, which protected and supplied power to essential loads, to safety trip of reactor and supplied to starting signal of EDG (emergency diesel generators) automatically. therefore UVR tolerances setting and calculation method has been important to nuclear facility. If calculation and tolerances values differ or ignore, may induced power loss and economical loss by protective failure. This paper show results for calculation methods, and whether dependant or independent methods for factors. included whether PT (potential transformer/voltage transformer) tolerance or not adapted, and based on UVR setting method within a difference minimum and maximum of rated voltage to safety operation in nuclear plants.

Changes of Plasma Tumor Necrosis Factor α and C-Reactive Protein Levels in Patients with Hypertension Accompanied by Impaired Glucose Tolerance and their Clinical Significance

  • Xiao, Qiang;Wang, Lan-Ping;Ran, Zhang-Shen;Zhang, Xin-Huan
    • Asian Pacific Journal of Cancer Prevention
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    • 제16권8호
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    • pp.3389-3393
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    • 2015
  • Background: Chronic inflammation could affect the occurrence and development of malignant tumors. To explore the levels of tumor necrosis factor ${\alpha}$ (TNF-${\alpha}$) and C-reactive protein (CRP) in patients accompanied by impaired glucose tolerance (IGT) and their clinical significance. Materials and Methods: A total of 210 patients hospitalized in Affiliated Hospital of Taishan Medical University from Jun., 2013 to Dec., 2014 were selected, in which 92 cases were accompanied by IGT. Meanwhile, 80 randomly-selected healthy people by physical examination were as the control. The levels of routine biochemical indexes, plasma TNF-${\alpha}$ and CRP in all subjects were measured. Results: Both systolic and diastolic pressures in hypertension group and hypertension plus IGT group were significantly higher than in control group (p<0.01), but there was no statistical significance between these two groups (p>0.05). The levels of fasting plasma glucose (FPG) and blood glucose 2 h after taking glucose in hypertension plus IGT group were markedly higher than other groups (p<0.01). Homeostasis model assessment-insulin resistance (HOMA-IR), TNF-${\alpha}$ and CRP contents were on the progressive increase in control, hypertension and hypertension plus IGT groups, but significant differences were presented among each group (P<0.01). Hypertension accompanied by IGT had a significantly-positive association with CRP, TNF-${\alpha}$, FPG and blood glucose 2h after taking glucose. Conclusions: The levels of plasma TNF-${\alpha}$ and CPR in patients with hypertension accompanied by IGT increase significantly, indicating that inflammatory reaction in these patient increases, thus suggesting that these patients should be focused regarding cancer prevention.

고속 주축베어링의 볼 접촉각 변동을 고려한 주축 설계공차 (Design Tolerance of High Speed Spindle considering the Variation of Ball Contact Angle in the Angular Contact Ball Bearings)

  • 이찬홍
    • 한국생산제조학회지
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    • 제19권5호
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    • pp.609-615
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    • 2010
  • Angular contact ball bearings in a high speed spindles are under the extreme conditions, such as high temperature, big centrifugal force and thrust cutting forces. So, the assembly contacts between spindle shaft and inner ring bearings, bearing housing and outer ring of bearings are occasionally unstable at high speed revolution. Furthermore, the ball contact angle of a bearing, which influence stiffness and lifetime of bearings, are changed according to loads and rotational speed. To analyze internal forces of a bearing under high speed revolution, the ball contact are calculated using nonlinear equations in consideration of rotational speed, thrust loads and raceway form. Diameter increase of inner and outer ring by influence factors, such as internal forces to inner and outer ring, centrifugal force and temperature of inner and outer rings are calculated to establish stable state in bearing assembly in high speed spindle. Finally, contribution ratio of influence factor to assembly design tolerance of inner and outer rings are shown and the stable assembly design tolerance are proposed.

Evaluation of Chloroplast Genotypes of Korean Cucumber Cultivars (Cucumis sativus L.) Using sdCAPS Markers Related to Chilling Tolerance

  • Ali, Asjad;Yang, Eun Mi;Lee, Sun Young;Chung, Sang-Min
    • 원예과학기술지
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    • 제31권2호
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    • pp.219-223
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    • 2013
  • DNA markers can determine the genotype of many species. Single nucleotide polymorphism (SNP) detection is difficult without sequencing but it becomes easier with sdCAPS method. Here an experiment was performed for developing molecular markers using two SNPs, CSatpB-SNP and CSycf1-SNP, of chloroplast in cucumber plants. Properly designed primers with nucleotide sequences for restriction enzymes proved success of PCR and efficacy of digestion by the restriction enzymes. Then these markers were used to study the genotyping of cucumber breeding lines and cultivars obtained from various sources in respect of their chilling stress response. We confirmed that a U.S. cucumber line, 'NC76' known to possess a nuclear factor for the chilling tolerance showed the chloroplast genotypes related to chilling tolerance. However all Korean cucumber cultivars tested in this study showed the chloroplast genotypes related to chilling susceptibility. In conclusion, to develop chilling tolerant cucumber, both maternal and a nuclear factors related to chilling tolerance should be transferred from 'NC76' when 'NC76' is used as a female source and other elite lines as recurrent parents.

그레이 큐브의 고장 지름(Fault Diameter)과 고장 허용도(Fault Tolerance) (Fault Diameter and Fault Tolerance of Gray Cube)

  • 이형옥;주낙근;임형석
    • 한국정보처리학회논문지
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    • 제4권8호
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    • pp.1930-1939
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    • 1997
  • 본 논문에서는 최근에 [12]에 제시된 그레이 큐브의 고장 지름(fault diameter)과 고장 허용도(fault tolerance)를 분석한다. 상호 연결망의 고장 지름은 연결망을 평가하기 위한 중요한 척도중 하나로서 노드들이 고장인 경우 노드를 사이에 최장 거리를 나타낸다. $2^n$개의 노드를 가지는 n-차원 그레이큐브의 고장 지름이 지름 +2임을 보인다.($n{\ge}3$). 이는 노드들이 고장인 환경에서도 노드들 사이의 최장 거리가 단지 상수 요소밖에 증가하지 않음을 나타낸다. 이 결과를 널리 알려진 하이퍼큐브의 고장 지름과 비교하면 노드 고장인 환경에서도 메시지의 최장 전달 거리가 하이퍼큐브의 그것에 비해 약 절반 정도임을 보이고 있다.

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추락착륙 하중배수에 대한 고찰 (Review of Crash Landing Load Factor)

  • 배효길;김도형;박재성
    • 항공우주시스템공학회지
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    • 제15권1호
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    • pp.47-55
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    • 2021
  • 항공기의 비정상적인 착륙 상황에서도 조종사의 생존을 보장하고 탈출에 방해되지 않도록 구조물이 설계되어야 한다. 추락 시, 화재의 원인을 찾는 연구를 시작으로 과거 수많은 고정익 항공기 추락시험이 수행되었다. 동역학적 분석을 통한 구조물의 거동특성을 이해하고, 가속도 상태에서 인체의 허용한계를 조사하여 적절한 추락하중배수가 설정되었다. 또한 화물기 사고 데이터를 확률론적 방법으로 분석하여 승객의 안전과 운용비용이 합리적으로 반영된 화물고정용 추락하중배수도 제시되었다. 과거 사례를 바탕으로 현재 적용되고 있는 추락하중배수의 물리적, 의학적, 경제적 의미를 살펴 보았다.