• Clinical and Experimental Pediatrics
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• v.55 no.2
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• pp.35-41
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• 2012

Passive exposure to tobacco smoke significantly contributes to morbidity and mortality in children. Children, in particular, seem to be the most susceptible population to the harmful effects of environmental tobacco smoke (ETS). Paternal smoking inside the home leads to significant maternal and fetal exposure to ETS and may subsequently affect fetal health. ETS has been associated with adverse effects on pediatric health, including preterm birth, intrauterine growth retardation, perinatal mortality, respiratory illness, neurobehavioral problems, and decreased performance in school. A valid estimation of the risks associated with tobacco exposure depends on accurate measurement. Nicotine and its major metabolite, cotinine, are commonly used as smoking biomarkers, and their levels can be determined in various biological specimens such as blood, saliva, and urine. Recently, hair analysis was found to be a convenient, noninvasive technique for detecting the presence of nicotine exposure. Because nicotine/cotinine accumulates in hair during hair growth, it is a unique measure of longterm, cumulative exposure to tobacco smoke. Although smoking ban policies result in considerable reductions in ETS exposure, children are still exposed significantly to tobacco smoke not only in their homes but also in schools, restaurants, child-care settings, cars, buses, and other public places. Therefore, more effective strategies and public policies to protect preschool children from ETS should be consolidated.

• Proceedings of the Korea Air Pollution Research Association Conference
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• 2000.04a
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• pp.344-345
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• 2000

인류가 흡연을 시작하면서 담배는 보편적인 사람들의 기호식품으로 이용되기도 했으나, 보건학적으로 인간의 건강을 위협하는 가장 위협적인 존재로 인식되고 있다. 흡연자의 담배연기에 비흡연자가 무저항적으로 노출되는 간접흡연의 문제는 생활수준의 향상과 생활활동 양식의 변화, 건강에 대한 관심의 증대로 현대인들에게 매우 중요한 문제가 되고 있다. 환경중 담배연기(Environmental Tobacco Smoke; ETS)는 흡연자의 입, 비강에서 품어내는 주류연(mainstream smoke)과 담배가 자연 연소되면서 발생하는 부류연(sidestream smoke)이 환경공기 중에 확산된 상태의 담배연기를 일컫는 용어로 실내공기의 주요오염원이다. (중략)

• Bulletin of the Korean Chemical Society
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• v.34 no.8
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• pp.2394-2398
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• 2013

Nicotine is the main component of environmental tobacco smoke, and its presence in indoor air is widely used as a secondhand-smoke indicator. Environmental tobacco smoke is a major source of indoor air pollution, but sufficient investigation of the uncertainty of its measurement, which mirrors the reliability of nicotine measurement, has not been performed. We calculated the uncertainty of measurement of indoor air nicotine concentration at low, medium, and high concentrations of 11.3798, 10.1977, $98.3768{\mu}g/m^3$, respectively, and we employed the Guide to the Expression of Uncertainty in Measurements (GUM), proposed by the International Organization for Standardization (ISO). The factors considered in determining the uncertainty were uncertainty of the calibration curve (calibration curve and repeated measurements), desorption efficiency, extraction volume, and sampling airflow (accuracy and acceptable limits of flowmeter). The measurement uncertainty was highest at low concentrations; the expanded measurement uncertainty is $0.9435{\mu}g/m^3$ and is represented as a relative uncertainty of 63.38%. At medium and high (concentrations, the relative uncertainty was 13.1% and 9.1%, respectively. The uncertainty of the calibration curve was largest for low indoor nicotine concentrations. To increase reliability of measurement in assessing the effect of secondhand smoke, measures such as increasing the sample injection rate ($1{\mu}L$ or more), increasing sampling volume to increase collected nicotine, and using gas chromatography-mass spectrometry (GC/MS) or GC/MS/MS, which has a lower quantitation threshold, rather than gas chromatography with nitrogen phosphorous detector, should be considered.

• Clinical and Experimental Pediatrics
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• v.59 no.8
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• pp.319-327
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• 2016

Allergic diseases such as asthma, allergic rhinitis, atopic dermatitis, and food allergy, are most common chronic, noncommunicable diseases in childhood. In the past few decades, the prevalence has increased abruptly worldwide. There are 2 possible explanations for the rising prevalence of allergic diseases worldwide, that an increased disease-awareness of physician, patient, or caregivers, and an abrupt exposure to unknown hazards. Unfortunately, the underlying mechanisms remain largely unknown. Despite the continuing efforts worldwide, the etiologies and rising prevalence remain unclear. Thus, it is important to identify and control risk factors in the susceptible individual for the best prevention and management. Genetic susceptibility or environments may be a potential background for the development of allergic disease, however they alone cannot explain the rising prevalence worldwide. There is growing evidence that epigenetic change depends on the gene, environment, and their interactions, may induce a long-lasting altered gene expression and the consequent development of allergic diseases. In epigenetic mechanisms, environmental tobacco smoke (ETS) exposure during critical period (i.e., during pregnancy and early life) are considered as a potential cause of the development of childhood allergic diseases. However, the causal relationship is still unclear. This review aimed to highlight the impact of ETS exposure during the perinatal period on the development of childhood allergic diseases and to propose a future research direction.

• Journal of the Korean Society of Tobacco Science
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• v.20 no.1
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• pp.124-130
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• 1998

This study was conducted to evaluate the ability of anion generating air cleaner to remove gases, vapor and particles from closed room contaminated with environmental tobacco smoke (ETS). The measurements covered particle sizes of 13.8-542.5nm, particle concentration, surface area, volumes UVPM, FPM, solanesol, and the following gases and vapor; carbon dioxide, carbon monoxide, nicotine, and 3-ethenylpyridine. Tobacco smoke was generated and mixed in a closed room in which the airflow rates were in the range of 0.00-0.04 m/s. The anion generating air cleaner was startedl and the decay rates for the gases, vapor and particles were measured, When the use of anion generating air cleaner, solid components of ETS, such as respirable suspended particle (RSP), utraviolet particulate matter (UVPM, fluorescent particulate matter (FPM) and solanesol was sharply decreased, and vapor phase components of ETS, such as nicotines 3-ethenylpyidine were modelately decreased by time elapse. Even the use of anion generation air cleaner, the decreasing rate of carbon dioxide concentration was similar with control, and the decreasing rate of carbon monoxide was slower than that of control. Our results indicated that the use of anion generting air cleaner had an effect on reduction of solid and vapor components from ETs, but it had no effect on gaseous components of ETS.

• Proceedings of the Korea Air Pollution Research Association Conference
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• 2000.11a
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• pp.43-44
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• 2000

흡연 당사자의 직접흡연이 이와 관련한 발병률과 사망률의 주요 원인이 되어 왔다는 것은 여러 연구조사자료에 보고되어 왔다. 그러나 최근 들어 담배연기에 대한 비흡연자의 비자의적인 노출 즉, 환경담배연기(Environmental Tobacco Smoke, 이하 ETS)로 인한 보건학적 위해성에 대한 논란이 제기되면서 간접흡연은 새로운 사회문제로 대두되고 있다(Surgeon General, 1986). 1986년에 미국 National Research Council은 미국 내에서 연간 3000명에 달하는 폐암의 발생이 ETS에 대한 노출에서 기인한다고 발표한 바 있으며(NRC, 1986), 이를 근거로 1990년대 초에 미국 EPA와 NIOSH에서는 세계최초로 ETS를 인체발암성물질로 규정한 바 있다(NIOSH, 1991; USEPA, 1992). (중략)

• Tuberculosis and Respiratory Diseases
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• v.76 no.4
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• pp.188-191
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• 2014

Acute eosinophilic pneumonia (AEP) is a disease characterized by an acute febrile onset, eosinophilia in bronchoalveolar lavage fluid, and a dramatic response to corticosteroids. Although many studies have reported a close relationship between direct cigarette smoking and AEP, few studies have identified an association between passive smoking and AEP. Here, we report a case of AEP in a 19-year-old female with cough, fever, and dyspnea after 4 weeks of intense exposure to secondhand smoke for 6 to 8 hours a day in an enclosed area.

• Journal of the Korean Society of Tobacco Science
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• v.21 no.1
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• pp.102-108
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• 1999

This study was conducted to evaluate the ventilation to remove gases, vapor and particles of environmental tobacco smoke(ETS) in a closed room. The ventilation rate choosed were 0.445 ㎥/min, 0.528 ㎥/min, and 0.625 ㎥/min. ETS components measured were total suspended particle(TSP), ultraviolet particulate matter(UVPM), fluorescent particulate matter(FPM), solanesol, carbon dioxide($CO_2$), carbon monoxide(CO), nicotine, and 3-ethenylpyri-dine(3-EP). The concentration of ETS components measured rapidly decreased as increasing ventilation rate, but the removal efficiency by ventilation was different from each ETS compounds. The $CO_2$, and CO, gaseous components of ETS, were dominant components to be removed from the room by ventilation. The ventilation with 0.528 ㎥/min for 1 hr was enough to remove over 99% of those gaseous components. Nicotine and 3-EP needed the ventilation for 2 hrs to reduce over 95 % of those components. As the same ventilation rate, 99 % of TSP and solanesol concentration were removed from the room within 2 hrs, UVPM and FPM concentration decreased 90 %.

• Tuberculosis and Respiratory Diseases
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• v.73 no.4
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• pp.210-218
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• 2012

Background: The level of urine cotinine is an indicator of tobacco smoke exposure. The purpose of this study is to investigate urine cotinine for the purpose of assessing the smoking status of Korean smokers and non-smokers exposed to tobacco smoke. Methods: The subjects were identified from the 2007-2009 and the 2010 data sets of the Korea National Health and Nutrition Examination Survey (KNHANES). They were assigned as non-smokers, current smokers and ex-smokers. Non-smokers were also divided into three subset groups according to the duration of smoke exposure. Each group was stratified by gender prior to analysis. Results: The median value of urine cotinine in the male current smokers was 1,221.93 ng/mL which was the highest among all groups. The difference between levels of urine cotinine for male and the female groups was statistically significant (p<0.01). In the female group, passive smoke exposure groups reported higher urine cotinine levels than non-exposure groups (p=0.01). The cutoff point for the discrimination of current smokers from non-smokers was 95.6 ng/mL in males and 96.8 ng/mL in females. The sensitivity and specificity were 95.2% and 97.1%, respectively, in males, 96.1% and 96.5% in females. However, the determination of urine cotinine level was not useful in distinguishing between passive smoke exposure groups and non-exposure groups. Conclusion: Urine cotinine concentration is a useful biomarker for discriminating non-smokers from current smokers. However, careful interpretation is necessary for assessing passive smoke exposure by urine cotinine concentration.

• Proceedings of the Korea Air Pollution Research Association Conference
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• 1999.10a
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• pp.143-144
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• 1999

1950년대 이후 구미 각국에서 수집된 대부분의 독성학적, 역학적 연구조사자료에 따르면 흡연과 관련한 발병률 및 사망률의 주요 원인이 흡연 당사자의 직접흡연에 의한 것으로 보고되어 왔다. .그러나 최근 들어 담배연기에 대한 비흡연자의 비자의적인 노출 즉, 환경담배연기(Environmental Tobacco Smoke, 이하 ETS)로 인한 보건학적 위해성에 대한 논란이 제기되면서 간접흡연은 새로운 사회문제로 대두되고 있다(Repace, 1980; Surgeon General, 1986).(중략)