• 대한한방내과학회지
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• 제40권3호
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• pp.390-408
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• 2019

Objectives: Several pattern diagnosis questionnaires have been developed to objectify the process of pattern diagnosis in Korean medicine. In this context, this study aimed to develop a food retention questionnaire for functional dyspepsia (FRQ-FD) by modifying the previously developed food retention questionnaire (FRQ) and to verify its reliability and validity. Furthermore, this study aimed to identify the optimal cut-off value of the FRQ-FD for standardization and use in clinical situations. Methods: To develop the FRQ-FD, we extracted the major symptoms of food retention pattern for functional dyspepsia from Chinese/Korean medicine textbooks and requested an importance survey from experts using the Delphi method. The first draft of the FRQ-FD was composed of 25 questions comprising 8 questions from the textbooks and the Delphi method and 17 questions from the FRQ already developed in 2013. To analyze its reliability, validity, and optimal cut-off value, 60 subjects were enrolled in this study from June 25 to August 13, 2018. Thirty patients were diagnosed as both functional dyspepsia and food retention pattern, and 30 healthy participants were not. All participants were requested to fill up the FRQ-FD, Stomach Qi Deficiency Questionnaire (SQDQ), Scale for Stomach Qi Deficiency pattern (SSQD), visual analog scale (VAS) for dyspepsia, Nepean Dyspepsia Index-Korean version (NDI-K), and functional dyspepsia-related quality of life (FD-QoL). Results: No statistically significant differences were found in sex distribution, age, and body mass index between the patient group and the control group. As five questions affected the reliability negatively and three questions affected the clinical validity negatively, we decided to exclude the eight questions upon further investigation. The Cronbach's ${\alpha}$ coefficient of the revised FRQ-FD (17 items) was 0.899, and its clinical validity was verified. Construct validity was analyzed by factor analysis and produced five factors. Statistically significant positive correlations were found between the revised FRQ-FD and the other dyspepsia scales, namely, SQDQ, SSQD, VAS, NDI-K, and FD-QoL. VAS and NDI-K especially had strong positive correlations with FRQ-FD. Conclusions: The FRQ-FD developed in this study can provide fundamental reliability and validity for a pattern diagnosis questionnaire. FRQ-FD can help to diagnose food retention pattern in functional dyspepsia patients. Further studies are required to inspect several statistical factors.

• Interdisciplinary Bio Central
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• 제4권3호
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• pp.9.1-9.7
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• 2012

Filamentous phages have been in the limelight as a new type of nanomaterial. In this study, genetically and chemically modified fd phage was used to generate a biomimetic phage self-assembly product. Positively charged fd phage (p8-SSG) was engineered by conjugating 3-aminopropyltriethoxysilane (APTES) to hydroxyl groups of two serine amino acid residues introduced at the N-terminus of major coat protein, p8. In particular, formation of a phage network was controlled by changing mixed ratios between wild type fd phage and APTES conjugated fd-SSG phage. Assembled phages showed unique bundle and network like structures. The bacteriophage based self-assembly approach illustrated in this study might contribute to the design of three dimensional microporous structures. In this work, we demonstrated that the positively charged APTES conjugated fd-SSG phages can assemble into microstructures when they are exposed to negatively charged wild-type fd phages through electrostatic interaction. In summary, since we can control the phage self-assembly process in order to obtain bundle or network like structures and since they can be functionalized by means of chemical or genetic modifications, bacteriophages are good candidates for use as bio-compatible scaffolds. Such new type of phage-based artificial 3D architectures can be applied in tuning of cellular structures and functions for tissue engineering studies.

• 대한약학회:학술대회논문집
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• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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• pp.296.2-296.2
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• 2002

Our previous study demonstrated that 2.3', 4.4'. 5- Pentachlorobiphenyl (PCB 118) showed an antiestrogenic activity in vitro and in vivo. In the present study. we examined the effect of PCB 118 on postnatal reproductive development in female rats. PCB 118 (0.001. 0.01 or 0.1 mg/kg/day) was administered to pregnant female SD rats from gestation day (GO) 6 to 18 via subcutaneous injection. and developmental parameters such as vaginal opening were determined. PCB 118 significantly delayed vaginal opening of female offsprings at dose of 0.1 ${\mu}g$/kg/day. whereas had no effects on body weights. In addition. in utero treatment of PCB 118 caused significant decreases in serum levels of E2, T3 and T4 in female oftsprings at certain doses on postnatal day (PND) 22. Our data of results indicate that in utero exposure to PCB 118 may postnatal reproductive development in female rat through its antiestrogenic activity.

• 한국정보통신학회:학술대회논문집
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• 한국해양정보통신학회 2003년도 추계종합학술대회
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• pp.105-108
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• 2003

이기종의 망과 다양한 종류의 사용자 단말 보급으로 디지털 영상 컨텐츠를 효과적으로 제공하는 기술이 요구되고 있고, 이를 위한 한 가지 접근 방법으로서 트랜스코딩 기법에 대한 연구가 활발히 진행되고 있다. 특히, FD(Frame Dropping)/CD(Coefficient Dropping)기법은 VLC영역에서 트랜스코딩을 수행하여 계산량을 절감하고, 가장 손쉽게 구현할 수 있는 기법으로 고려되고 있다. 그러나, 이기법에 근거한 기존의 연구 결과는 이전 프레임의 CD로 인해 현재 프레임에 전파되어 오는 왜곡 특성을 적절히 분석하지 않고 적용되고 있다. 본 논문에서는 VLC영역에서 수행되는 CD에 따른 왜곡의 특성 및 관계를 수식적으로 유도하고, 또한, 각 왜곡의 특성을 실험적으로 분석한다. 모의실험을 통하여 본 논문에서 분석된 결과들은 VLC영역에서의 효과적인 FD/CD기법을 구하는데 효과적으로 사용될 수 있을 것이다.

• 한국인터넷방송통신학회논문지
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• 제16권6호
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• pp.311-318
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• 2016

최근의 자동차 내부에는 차량의 제어, 진단기능 및 ECU 프로그램 업그레이드 등의 다양한 목적으로 차량 내부 네트워크를 사용하고 있는데 현재 CAN과 FlexRay가 가장 대표적인 네트워크이며 차세대 네트워크로는 CAN FD와 차량용 이더넷의 사용이 적극 연구되고 있다. 본 논문에서는 진단기능 및 ECU 프로그램 업그레이드 관점에서 CAN, CAN FD, 그리고 FlexRay 네트워크 적용시의 각 네트워크별 다운로드 시간과 관련된 특성에 대해서 상호 비교 평가를 하는 것을 목적으로 하였다. 시뮬레이션 결과 CAN FD 네트워크가 현재 실질적인 사용가능 속도인 500Kbps, 2Mbps 조건에서도 가격대비 성능측면에서 다른 네트워크들을 제치고 차세대 네트워크로 가장 적합함을 판단할 수 있었다.

• 천문학회보
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• 제37권2호
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• pp.120.1-120.1
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• 2012

The Lunar Reconnaissance Orbiter (LRO) launched on June 16, 2009 has six experiments including of the Cosmic Ray Telescope for the Effects of Radiation (CRaTER) onboard. The CRaTER instrument characterizes the radiation environment to be experienced by humans during future lunar missions. The CRaTER instrument measures the effects of ionizing energy loss in matter specifically in silicon solid-state detectors due to penetrating solar energetic protons (SEP) and galactic cosmic rays (GCRs) after interactions with tissue-equivalent plastic (TEP), a synthetic analog of human tissue. The CRaTER instrument houses a compact and highly precise microdosimeter. It measures dose rates below one micro-Rad/sec in silicon in lunar radiation environment. Forbush decrease (FD) event is the sudden decrease of GCR flux. We use the data of cosmic ray and dose rates observed by the CRaTER instrument. We also use the CME list of STEREO SECCHI inner, outer coronagraph and the interplanetary CME data of the ACE/MAG instrument.We examine the origins and the characteristics of the FD-like events in lunar radiation environment. We also compare these events with the FD events on the Earth. We find that whenever the FD events are recorded at ground Neutron Monitor stations, the FD-like events also occur on the lunar environments. The flux variation amplitude of FD-like events on the Moon is approximately two times larger than that of FD events on the Earth. We compare time profiles of GCR flux with of the dose rate of FD-like events in the lunar environment. We figure out that the distinct FD-like events correspond to dose rate events in the CRaTER on lunar environment during the event period.

• 한국유체기계학회 논문집
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• 제4권3호
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• pp.53-61
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• 2001

Vortex type Fluidic Device(FD) which is installed at the bottom of Safety Injection Tank(SIT) controls the discharge flow rate from the tank. In case of loss of coolant accident the injection water flows into primary system in two steps; initial high flow rate for certain period of time and subsequent low flow rate. By two-step control of the discharge flow rate, FD can ensure the effective use of water in the tank. A small-scale FD has been tested to obtain a required flow characteristics maintaining full pressure and height of prototype, which are the major contributing parameters. Through the testing of many different arrangements of internal geometry of FD, most appropriate one was selected and its performance data was obtained. As characteristics of FD, time dependent Euler number, flow rate and pressure are presented and discussed. Also a method to predict the full size FD is presented.

• 대한한방내과학회지
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• 제41권4호
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• pp.563-582
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• 2020

Objectives: The aim of this study was to develop a Phlegm Pattern Questionnaire for Functional Dyspepsia (PPQ-FD) by modifying a previously developed Phlegm Pattern Questionnaire (PPQ) and to verify its reliability and validity. Further objectives were to obtain the optimal cut-off value for the PPQ-FD for standardization and for clinical use. Methods: The PPQ-FD was developed by extracting the major symptoms of the phlegm pattern in functional dyspepsia and by using the Delphi method to administer a requested importance survey to experts. The reliability, validity, and optimal cut-off value of the PPQ-FD were analyzed by enrolling a total of 60 subjects in this study. Thirty patients were diagnosed with both functional dyspepsia and phlegm pattern and thirty patients were diagnosed with only functional dyspepsia. All participants were requested to fill out the PPQ-FD. Results: No statistically significant differences were detected in the two groups for sex distribution, age, or body mass index. Five of the survey questions negatively affected its reliability; therefore, we decided to exclude those five questions on further inspection. The Cronbach's α coefficient of the revised PPQ-FD was 0.853, and clinical validity was verified. Construct validity was analyzed by factor analysis and identified four factors. Statistically significant positive correlations were found between the revised PPQ-FD and other dyspepsia scales, such as the SQDQ, SSQD, VAS, NDI-K, and FD-QoL scales. The VAS had particularly strong positive correlations with the PPQ-FD. Conclusions: The PPQ-FD developed in this study has fundamental reliability and validity for use as a pattern-diagnosis questionnaire. The PPQ-FD can help to diagnose the phlegm pattern in patients with functional dyspepsia.

• Korean Journal of Radiology
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• 제22권3호
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• pp.297-307
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• 2021

Objective: To compare the performance of simulated abbreviated breast MRI (AB-MRI) and full diagnostic (FD)-MRI in distinguishing between benign and malignant lesions detected by MRI and investigate the features of discrepant lesions of the two protocols. Materials and Methods: An AB-MRI set with single first postcontrast images was retrospectively obtained from an FD-MRI cohort of 111 lesions (34 malignant, 77 benign) detected by contralateral breast MRI in 111 women (mean age, 49.8. ± 9.8; range, 28-75 years) with recently diagnosed breast cancer. Five blinded readers independently classified the likelihood of malignancy using Breast Imaging Reporting and Data System assessments. McNemar tests and area under the receiver operating characteristic curve (AUC) analyses were performed. The imaging and pathologic features of the discrepant lesions of the two protocols were analyzed. Results: The sensitivity of AB-MRI for lesion characterization tended to be lower than that of FD-MRI for all readers (58.8-82.4% vs. 79.4-100%), although the findings of only two readers were significantly different (p < 0.05). The specificity of AB-MRI for lesion characterization was higher than that of FD-MRI for 80% of readers (39.0-74.0% vs. 19.5-45.5%, p ≤ 0.001). The AUC of AB-MRI was comparable to that of FD-MRI for all readers (p > 0.05). Fifteen percent (5/34) of the cancers were false-negatives on AB-MRI. More suspicious margins or internal enhancement on the delayed phase images were related to the discrepancies. Conclusion: The overall performance of AB-MRI was similar to that of FD-MRI in distinguishing between benign and malignant lesions. AB-MRI showed lower sensitivity and higher specificity than FD-MRI, as 15% of the cancers were misclassified compared to FD-MRI.

• 대한임베디드공학회논문지
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• 제12권6호
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• pp.351-358
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• 2017

The most common communication interface for automotive electronic control devices is CAN (Controller Area Network). Sine CAN was first adopted to Daimler vehicles in 1991, all of automobile manufacturers use the CAN communication for in-vehicle networks. However, as the number of electronic control devices connected to the CAN network rapidly increases, the CAN protocol reaches the limit of technology. To overcome this limitation, Bosch introduced the new communication protocol, that is CAN-FD (Flexible Data-rate). In this paper, we analyze the characteristics and limitations of CAN-FD communication according to the topology under the in-vehicle wiring harness environment designed based on the existing classic CAN communication.