• 대한방사선기술학회지:방사선기술과학
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• 제16권1호
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• pp.107-115
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• 1993

In this study, to develop highly sensitive radiation sensors, $CaSO_4$ : Tm phosphors and its disc-type TLD elements embedded PTFE(polytetrafluoroethylene) are fabricated. The highest sensitivity of $CaSO_4$ : Tm phosphors is obtained when phosphors have been doped with 0.5mol % Tm and sintered in atmosphere at $600^{\circ}C$ for two hours. Fabricated disc-type elements are made from a homogeneous mixture of phosphors and PTFE powder. They are first cold-pressed and then polymerized at $370^{\circ}C$ in air for one hour. The dose dependence of the prepared $CaSO_4$ : Tm TLD radiation sensors is linear within the range of $100{\mu}Gy{\sim}10Gy$ for X-rays and ${\gamma}-rays$. The response of $CaSO_4$ : Tm to 30keV X-rays is ten times higher than that of 1.25MeV $^{60}Co\;{\gamma}-rays$. The fading rate of the main peak is about 2% per a month. The spectral peaks of TL emission spectrum are at about 350nm and 475nm. The $CaSO_4$ : Tm TLD radiation sensors prepared in this work may be used as radiation dosimeter for personal and environmental monitoring because of their high sensitivity and little fading.

• 대한방사선기술학회지:방사선기술과학
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• 제39권2호
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• pp.157-161
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• 2016

본 연구에서는 자체 제작한 3종의 초음파 TM 팬텀의 음향학적 특성 및 온도 민감도를 측정하였으며, 초음파 영상학적 특성을 관찰, 평가하였다. TM 팬텀은 폴리우레탄을 주재료로 국제전기표준회의(International Electronical Committee, IEC) 기준안에 따라 제작하였으며 외부 온도 변화 따른 초음파 영상학적 특성은 $22^{\circ}C$ 이하에서 온도감소에 따라 휘도 및 영상투과심도가 비례하여 감소하는 것이 확인되었다. 본 연구를 통하여 산란재 특성이 상이한 TM 팬텀을 제작하는 기초자료를 제공하였으며, TM 팬텀의 사용 온도는 $22^{\circ}C$ 이상에서 사용하는 것이 적합한 것으로 판단되었다.

• BMB Reports
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• 제42권1호
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• pp.53-58
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• 2009

The methyl-directed mismatch repair (MMR) mechanism has been extensively studied in vitro and in vivo, but one of the difficulties in determining the biological relationships between the MMR-related proteins is the tendency of MutL to self-aggregate. The properties of a stable MutL homologue were investigated using a thermostable MutL (TmL) from Thermotoga maritima MSB8 and whose size exclusion chromatographic and crosslinking analyses were compatible with a dimeric form of TmL. TmL underwent conformational changes in the presence of nucleotides and single-stranded DNA (ssDNA) with ATP binding not requiring ssDNA binding activity of TmL, while ADPnP-stimulated TmL showed a high ssDNA binding affinity. Finally, TmL interacted with the T. maritima MutS (TmS), increasing the affinity of TmS to mismatched DNA base pairs and suggesting that the role of TmL in the formation of a mismatched DNA-TmS complex may be a pivotal observation for the study of the initial MMR system.

• 혜화의학회지
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• 제19권1호
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• pp.75-86
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• 2010

These days, traditional and complementary/alternative medicine (TM/CAM) becomes more upsurging topics of increasing importance and the use and popularity of TM/CAM is rapidly expanding, Since the tradition and situation on TM/CAM of each country is quite different, the concept and system of TM/CAM expressed by different countries shows the variety of range. Some countries recognize TM/CAM as one part of two branches of medical science and have integrated into national health care system. In these countries, education systems for TM/CAM are also well organized formal education systems, such as the Republic of Korea, DPR Korea, China (including Hong Kong and Macao), and Viet Nam. However, other countries in Asia and the Pacific. still do not have formal and/or informal education system and do not recognize TM/CAM as a kind of health care systems. This paper reviews the current situation of education and training on TM/CAM in the Asia and the Pacific. As a result, fifteen countries (31.3%) of 48 member countries in Asia and the Pacific have formal education systems for TM/CAM, twelve countries (25.0%) do not have formal education system and twenty one countries (43.7%) do not have available information. At least six countries are allocating the curriculum of medical school to the education of both allopathic and traditional medicine. For the proper use and development of TM/CAM, the development of formal education system as well as the integration into the national health care system are needed.

• Advances in concrete construction
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• 제3권1호
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• pp.55-69
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• 2015

Tailing Material (TM) and Fly Ash (FA) are obtained as waste products from the mining and thermal industries. Studies were carried out to explore the possibility of utilizing TM as a part replacement to fine aggregate and FA as a part replacement to cement, in concrete mixes. The effect of replacing fine aggregate by TM and cement by FA on the standard sized specimen for compressive strength, split tensile strength, and flexural strengths are evaluated in this study. The concrete mix of M40 grade was adopted with water cement ratio equal to 0.40. Concrete mix with 35% TM and 65% natural sand (TM35/S65) has shown superior performance in strength as against (TM0/S100, TM30/S70, TM40/S60, TM50/S50, and TM60/S40). For this composition, studies were performed to propose the optimal replacement of Ordinary Portland Cement (OPC) by FA (Replacement levels studied were 20%, 30%, 40% and 50%). Replacement level of 20% OPC by FA, has shown about 0-5% more compressive strength as against the control mix, for both 28 day and 56 days of water curing. Interestingly results of split tensile and flexural strengths for 20% OPC replaced by FA, have shown strengths equal to that of no replacement (control mix).

• International Journal of Computer Science & Network Security
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• 제21권1호
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• pp.84-96
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• 2021

Certainly, the success of the Unified Modeling Language (UML) as the de facto standard for modeling software systems does not imply closing the door on scientific exploration or experimentation with modeling in the field. Continuing studies in this area can produce theoretical results that strengthen UML as the leading modeling language. Recently, a new modeling technique has been proposed called thinging machine (TM) modeling. This paper utilizes TM to further understand UML, with two objectives: (a) Fine issues in UML are studied, including theoretical notions such as events, objects, actions, activities, etc. Specifically, TM can be used to solve problems related to internal cross-diagram integration. (b) TM applies a different method of conceptualization, including building a model on one-category ontology in contrast to the object-oriented paradigm. The long-term objective of this study is to explore the possibility of TM complementing certain aspects in the UML methodology to develop and design software systems. Accordingly, we alternate between UML and TM modeling. A sample UML model is redesigned in TM, and then UML diagrams are extracted from TM. The results clarify many notions in both models. Particularly, the TM behavioral specification seems to be applicable in UML.

• Journal of Applied Biological Chemistry
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• 제64권3호
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• pp.213-216
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• 2021

A gene encoding thermostable cellulase A (TmCelA) was isolated from Thermotoga maritima. The open reading frame of TmCelA gene was 774 bp long which predicted to encode 257 amino acid residues with a molecular weight of 29,732 Da. To examine the biochemical properties, the TmCelA was overexpressed in E. coli BL21, and expressed protein was purified. The optimum temperature of recombinant TmCelA was 90-95 ℃, and the optimum pH of recombinant TmCelA was approximately pH 5.0. Recombinant TmCelA was stable at temperature below 90 ℃.

• Journal of Applied Biological Chemistry
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• 제58권2호
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• pp.97-100
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• 2015

The thermostable pectinase gene TmPec isolated from Thermotoga maritima was introduced into the NdeI site of pRSET-B vector and expressed in its intact form in Escherichia coli BL21. The overexpressed intact form of pectinase (TmPecN protein) was partially purified by heat-denaturation procedure. TmPecN showed the highest activity between 85 and $95^{\circ}C$, and at approximately pH 6.5. Enzyme activity was stably maintained at temperatures below $85^{\circ}C$. In the presence of $Ca^{2+}$, pectinase activity of TmPecN increased to 128.4% of normal level. In contrast, $Ba^{2+}$, $Zn^{2+}$, and $Mn^{2+}$ strongly inhibited TmPecN activity. We conclude that the biochemical properties of the intact form of TmPecN are comparable to those of the recombinant protein TmPec reported previously.

• Journal of mucopolysaccharidosis and rare diseases
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• 제1권1호
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• pp.19-22
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• 2015

In Growth Hormone (GH) therapy, suboptimal adherence is a common problem, reaching up to 82%, and there is a need for interventions to improve adherence and to maximize patients' growth potential eventually. Current studies have demonstrated the association between the rate of non-adherence and reduced height velocity. In order to maximize patients' potential to grow, an auto-injecting/recording device, such as $easypod^{TM}$, may help improve adherence and optimize the treatment effects of GH therapy. The use of $easypod^{TM}$ has contributed to high adherence rates: 87.5% and 93% in Bozzola et al.'s study and the $Easypod^{TM}$ Connect Observational study (ECOS), respectively. Improvement of adherence by $easypod^{TM}$ may lead to higher growth rates of patients receiving GH therapy. Additionally, patients' positive acceptability of $easypod^{TM}$ suggests $easypod^{TM}$ is a preferred device by patients for better adherence.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2003년도 학술회의 논문집 정보 및 제어부문 B
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• pp.959-961
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• 2003

In this paper, we describe implemented DMAC (Direct Memory Access Controller) architecture on Altera's $Excalibur^{TM}$ that includes industry-standard $ARM922T^{TM}$ 32-bit RISC processor core operating at 200 MHz. We implemented DMAC based on AMBA (Advanced Micro-controller Bus Architecture) AHB (Advanced Micro-performance Bus) interface. Implemented DMAC has 8-channel and can extend supportable channel count according to user application. We used round-robin method for priority selection. Implemented DMAC supports data transfer between Memory-to-Memory, Memory-to-Peripheral and Peripheral-to-Memory. The max transfer count is 1024 per a time and it can support byte, half-word and word transfer according to AHB protocol (HSIZE signals). We implemented with VHDL and functional verification using $ModelSim^{TM}$. Then, we synthesized using $LeonardoSpectrum^{TM}$ with Altera $Excalibur^{TM}$ library. We did FPGA P&R and targeting using $Quartus^{TM}$. We can use implemented DMAC module at any system that needs high speed and broad bandwidth data transfers.