• Journal of Korean Physical Therapy Science
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• v.3 no.1
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• pp.895-905
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• 1996

A whiplash injury of cervical spine is typically caused by a special kind of accident. It usually involves a driver of an automobile who experiences a direct impact from behind. There are no external signs of the injury, but shearing forces from the rapid flexion and extension momement result in segmental lesions. The extent of injury to the tissue depends upon the force of impact, the exact position of head at the moment of impact, the awareness of impending injury in order to "prepare" the musculature, and the normalcy of all the tissues of the neck. Diagnosis demend a carefully detailed history and a through musculo-skeletal--neurological examination. Whenever possible, the symptoms claimed must be verified by a carefule neurological examination.

• The Journal of Advanced Prosthodontics
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• v.4 no.4
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• pp.243-247
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• 2012

The velopharynx is a tridimensional muscular valve located between the oral and nasal cavities, consisting of the lateral and posterior pharyngeal walls and the soft palate, and controls the passage of air. Velopharyngeal insufficiency may take place when the velopharyngeal valve is unable to perform its own closing, due to a lack of tissue or lack of proper movement. Treatment options include surgical correction, prosthetic rehabilitation, and speech therapy; though optimal results often require a multidisciplinary approach for the restoration of both anatomical and physiological defect. We report a case of 56 year old male patient presenting with hypernasal speech pattern and velopharyngeal insufficiency secondary to cleft palate which had been surgically corrected 18 years ago. The patient was treated with a combination of speech therapy and palatal lift prosthesis employing interim prostheses in various phases before the insertion of definitive appliance. This phase-wise treatment plan helped to improve patient's compliance and final outcome.

• The Journal of Korean Physical Therapy
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• v.3 no.1
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• pp.229-250
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• 1991

The study was carried out to investigate and review the principles and practices of immunocytochemical method in light microscopic level. The results were as follows. 1. Immunocytochemistry is the method to search out the intracellular position of the specific meterials using antigen -antibody reaction. 2. The chief items in immunocytochemistry are antigen, antibody and chromogen. 3. The identifical fixation is cardiac perfusion fixation. 4. The tissue slides must be prepared by vibratomy. 5. All stainings are carried out with free floating staining method. 6. There are polyclonal and monoclonal antibodies used in immunocytochemistry.

• The Journal of Internal Korean Medicine
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• v.30 no.1
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• pp.241-248
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• 2009

Object : Liver cirrhosis is a disease of the liver in which normal cells are replaced by scar tissue. The purpose of this case is to report the improvement of liver cirrhosis after herb-med, acupuncture & moxibustion complex therapy. Methods : We provided herb-med, acupuncture & moxibustion complex therapy to a patient who suffered from ascites and fatigue. We examined LFT & Child-Pugh class to evaluate the effectiveness of oriental treatment. Result and Conclusion : We observed that herb-mod. acupuncture & moxibustion complex therapy decreased symptoms of liver cirrhosis and improved general condition of a patient who suffered from ascites and fatigue. In the LFT result, Child-Pugh class was improved.

• Medical Lasers
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• v.10 no.1
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• pp.7-14
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• 2021

In cancer therapy, it is often desirable to use precision medicine that involves treatments of high specificity. One such treatment is the use of photo-triggered theranostic nanoparticles. These nanoparticles make it possible to visualize and treat tumors specifically in a controlled manner with a single injection. Several novel and powerful photo-triggered theranostic nanoparticles have been developed. These range from small organic dyes, semiconducting and biopolymers, to inorganic nanomaterials such as iron-oxide or gold nanoparticles, carbon nanotubes, and upconversion nanoparticles. Using photo-triggered theranostic nanoparticles and localized irradiation, complete tumor ablation can be achieved without causing significant toxicity to normal tissue. Given the great advances and promising future of theranostic nanoparticles, this review highlights the progress that has been made in the past couple of years, the current challenges faced and offers a future perspective.

• Biomedical Science Letters
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• v.22 no.1
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• pp.1-8
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• 2016

Several studies have investigated the various effects of dexamethasone (Dex) on the proliferation and differentiation of mesenchymal stem cells (MSCs). Previously, we reported that co-treatment with L-ascorbic acid 2-phosphate and fibroblast growth factor (FGF)-2 maintained differentiation potential in MSCs through expression of hepatocyte growth factor (HGF). In this study, we investigated the effects of co-treatment with FGF-2 and Dex on the proliferation and differentiation potential of MSCs during a 2-month culture period. Co-treatment with FGF-2 and Dex increased approximately a 4.7-fold higher accumulation rate of MSC numbers than that by FGF-2 single treatment during a 2-month culture period. Interestingly, co-treatment with FGF-2 and Dex increased expression of HGF and maintained adipogenic differentiation potential during this culture period. These results suggest that co-treatment with FGF-2 and Dex preserves the proliferation and differentiation potential during long-term culture.

• Journal of Acupuncture Research
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• v.21 no.4
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• pp.75-84
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• 2004

Objective: To evaluate the treatment effect of Bee-venom Acupuncture on Neck Pain, which is well known for anti-inflammatory effect and function of activating immune system. Methods : We investigated 22 cases of patients with Neck Pain induced by soft tissue injury. One group was treated by Bee-venom Acupuncture therapy (Bee-venom Acupuncture Group :BA), the other group was treated by General Acupuncture therapy (None Bee-venom Acupuncture Group :GA). We evaluated the treatment effect of each group by few statistical analysis such as frequency analysis, Mann Whitney U test and spearman correlation analysis. Results : 1. In the age distribution of both groups, we found the highest frequency at the interval 35 to 45 years old. And in the number of medical treatment, Both groups show the highest frequency at the interval of less than four times. 2. BA was significantly decreased in VAS and clinical grade compared with GA. 3. We found significant correlation between period and number of treatment. So did we between VAS and clinical grade. Conclusion : As a result of thorough investigation, we could come to a conclusion that Bee-venom Acupuncture Group might have a notable effect on VAS and clinic grade.

• CELLMED
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• v.2 no.3
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• pp.23.1-23.7
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• 2012

The healing properties of medicinal maggots (larval stage of Lucilia sericata) are widely used in the chirurgical debridement of non-healing wounds including diabetic foot ulcers, venous and pressure ulcers, where classical approaches have failed. Several kinds of wounds are prone to complications coming out of a specific wound bed environment. There are multi-resistant bacterial species present, their pathogenic impact is multiplied by their ability to form a biofilm. Moreover, immunological events in chronic wounds differ from those in acute wounds. Non-healing wounds are cycled in the early inflammation phase with increased levels of inflammation attributes like inflammation cytokines and matrix metalloproteinases produced by inflammation phase cells. Application of larval therapy promotes progress in the healing process to the next stages involving tissue granulation and re-epithelisation. Larval debridement is an effective method of cleaning the wound of cell debris, necrotic tissue and bacterial load. This happens in a mechanical and biological manner, but the whole complex mechanism of the maggot healing activity is still not fully elucidated. Centuries of clinical practice brings noticeable proof of the maggots' beneficial effect in wound healing management. This long history led to the investigation of the bioactive components of the larval body and its extracts in vitro. We introduce a review which describes the immunomodulation impact of maggot body components on the cellular and molecular levels of the wound healing process.

• Journal of Biomedical Engineering Research
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• v.37 no.4
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• pp.147-151
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• 2016

Tibial defect, or fracture is very routine musculoskeletal case which brings fully uncomfortable and painful situations to patient. Moreover, it has long hospitalization period because of its risk of non-union. There are many studies using ultrasound, vibration, and laser for bone regeneration to figure out fast bone healing. Among them, Low Level Laser Therapy (LLLT) is already known that it is very easy to treat and may have positive effect for bone regeneration. However, LLLT has uncertain energy dose because of scattering and absorption of laser in tissue. In this study, we used interstitial LLLT to treat tibial defect in animal study. The Interstitial LLLT can overcome some limitations caused by laser scattering or absorption in tissue medium. The results were evaluated using u-CT which can calculate X-ray attenuation coefficient and bone volume of bone defect area. These results showed that interstitial LLLT may affect fast bone healing process in early phase.

• The Journal of the Korean bone and joint tumor society
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• v.7 no.1
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• pp.36-40
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• 2001

Kimura's disease is a mass producing uncommon chronic inflammatory process of unknown cause. It is more common among Orientals and affects particularly the young male. Sites of predilection include the head and neck regions, primarily the subcutaneous tissue and dermis. It's clinical course is benign in nature. The treatment modalities for this disease are surgical excision, steroid therapy and radiation therapy. We experienced a case of soft tissue mass in the right upper arm. It was painless and relatively movable. We performed marginal excision of the mass, which was turned out to be Kimura's disease on microscopic examination. In this case, disease recurrence was not found fifteen months after the operation.