• Proceedings of the Korean Society of Precision Engineering Conference
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• 2005.06a
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• pp.915-918
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• 2005

Advances in Information Technology and in Biomedicine have created new uses for CAD technology with many novel and important biomedical applications. Such applications can be found, for example, in the design and modeling of orthopedics, medical implants, and tissue modeling in which CAD can be used to describe the morphology, heterogeneity, and organizational structure of tissue and anatomy. CAD has also played an important role in computer-aided tissue engineering for biomimetic design, analysis, simulation and freeform fabrication of tissue scaffolds and substitutes. And all the applications require precision geometry of the organs or bones of each patient. But the geometry information currently used is polygon model with none solid geometry and is so rough that it cannot be utilized for accurate analysis, simulation and fabrication. Therefore a case study is performed to deduce a transformation method to build free form surface from a rough polygon data or medical images currently used in the application. This paper describes the transformation procedure in detail and the considerations for accurate organ modeling are discussed.

• Journal of the Korean Society for Precision Engineering
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• v.21 no.8
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• pp.188-195
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• 2004

In this paper we analyzed the mechanical behavior with respect to the thickness variation of elastic foundation(fatty tissue) in end-to-end anastomosis. This study considered the preliminary deformed shape induced by suturing in the anastomosis of coronary artery and PTFE with different diameters using simplified suturing model and the fatty tissue surrounding heart and coronary artery for more accurate result using finite element method. Area compliance(CA) was used to analyze the final deformed shape of the anastomotic part with respect to the thickness variation of fatty tissue under mean blood pressure, 100mmHg(13.3㎪). And Equivalent and circumferential stresses in the anastomosis were also analyzed with respect to the change of initial diameter ratio( $R_1$) and fatty tissue thickness( $T_{F}$). The results obtained were as follows : 1 When the elastic foundation, assumed to be incompressive material, surrounded the grafts in anastomosis, the compliance mismatch of artery and PTFE was reduced by 47 -72%. 2. As the initial diameter ratio( $R_1$) became larger, the higher difference of compliance was induced in spite of elastic foundation surrounding grafts. 3. The maximum nondimensional circumferential stress is twice or three times as high as the maximum nondimensional equivalent stress in the anastomotic part.t.

• Journal of Biomedical Engineering Research
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• v.14 no.1
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• pp.31-40
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• 1993

It is well known that nonlinear propagation characteristics of the wave in the tissue may give very useful information for the medical diagnoisis. In this paper, a new method to detect nonlinear propa gation characteristics of the internal vibration in the tissue for the low frequency mechanical vibra lion by using bispectral analysis is proposed. In the method, low frequency vibration of $f_0(=100Hz)$ is applied on the surface of the object, and the waveform of the internal vibration ${\times}{\;}(t)$ is measured from Doppler frequency modulation of silmultaneously transmitted probing ultrasonic waves. Then, the bispectra of the signal ${\times}{\;}(t.)$ at the frequencies ($f_0,{\;}f_0$) and ($f_0,{\;}2f_0$) are calculated to estimate the nonlinear propagation characteristics as their magnitude ratio, where since bispectrum is free from the gallssian additive noise we can get the value with high S/N. Basic experimental system is con structed by using 3.0 MHz probing ultrasonic waves and the several experiments are carried out for some phantoms. Results show the superiority of the proposed method to the conventional method using power spectrum and also its usefulness for the tissue characterization.

• Journal of Biomedical Engineering Research
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• v.10 no.2
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• pp.165-172
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• 1989

In this paper, the temperature dependence of tissue is estimated by measuring the attenuation coefficient and the propagation velocity of ultrasonic reflection signal. And, on the basis of expeiments, the possibility of non- invasive temperature estimation is considered. Specimens in the experiment are acryl 1)late. muscle, fat and liver of pig. The temperature of specimen is controlled by water bath which is able to adjust temperature a quarter of a degree. Through the series of experiments, we conformed that the ultrasonic parameters have lin earity to a certain extents with the change of tissue's temperature. And we expect that noninvasive temperature estimation of tissue can be realized after several preconditions be satisfied with the standard experiment conditions and a great number of base data.

• Journal of the Institute of Electronics Engineers of Korea SC
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• v.42 no.3 s.303
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• pp.53-62
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• 2005

This paper proposes a method of measuring and visualizing the elasticity distribution of the human soft tissue to detect tumors or cancers which have been difficult to diagnose in conventional medical ultrasonic B-mode images. To measure the stiffness of soft tissue, first, pressure is applied to deform the tissue being imaged, and then the amount of mechanical displacement is determined from correlation coefficients obtained from ultrasonic data downconverted into the baseband. We confirmed the feasibility of imaging tissue stiffness by computer simulation and experiment.

• Journal of the Korean Institute of Telematics and Electronics T
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• v.36T no.2
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• pp.70-76
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• 1999

With the recent increase in the use among young children of portable telephone public concern regarding potential health hazards due to a hot spot appearing inside the infant head, has been growing. Since the biological hazards due to RF exposure are caused mainly by a temperature-rise in tissue, the effect of localized SAR for portable telephones should also be related to the temperature-rise in the human head. In this paper, it was measured that in the actual use of portable telephone the temperature of the local tissue in the human-head change. As a result, it should be noted that the mean temperature of human-body and localized tissue is rising from beginning call. However the temperature variation of localized tissue is recovered rapidly as normal temperature, although the mean temperature of human-body rising continuously at ending call of portable telephone.

• Journal of the Korean Society for Industrial and Applied Mathematics
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• v.18 no.2
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• pp.77-105
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• 2014

Medical imaging techniques have evolved to expand our ability to visualize new contrast information of electrical, optical, and mechanical properties of tissues in the human body using noninvasive measurement methods. In particular, electrical tissue property imaging techniques have received considerable attention for the last few decades since electrical properties of biological tissues and organs change with their physiological functions and pathological states. We can express the electrical tissue properties as the frequency-dependent admittivity, which can be measured in a macroscopic scale by assessing the relation between the time-harmonic electric field and current density. The main issue is to reconstruct spectroscopic admittivity images from 10 Hz to 1 MHz, for example, with reasonably high spatial and temporal resolutions. It requires a solution of a nonlinear inverse problem involving Maxwell's equations. To solve the inverse problem with practical significance, we need deep knowledge on its mathematical formulation of underlying physical phenomena, implementation of image reconstruction algorithms, and practical limitations associated with the measurement sensitivity, specificity, noise, and data acquisition time. This paper discusses a number of issues in electrical tissue property imaging modalities and their future directions.

• Journal of Biomedical Engineering Research
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• v.27 no.3
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• pp.117-124
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• 2006

Recently, active research has been going on to measure the elastic modulus of human soft tissue with medical ultrasound imaging systems for the purpose of diagnosing cancers or tumors which have been difficult to detect with conventional B-mode imaging techniques. In this paper, a real-time ultrasonic elasticity imaging system is implemented in software on a Pentium processor-based ultrasonic diagnostic imaging system. Soft tissue is subjected to external vibration, and the resulting tissue displacements change the phase of received echoes, which is in turn used to estimate tissue elasticity. It was confirmed from experiment with a phantom that the implemented elasticity imaging system could differentiate between soft and hard regions, where the latter is twice harder than the former, while operating at an adequate frame rate of 20 frames/s.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.3 no.1
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• pp.7-18
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• 1970

The present paper deals with mortality and pathogenetic investigation of the oysters Crassostrea gigas cultured by tile coventional bamboo and hanging method in Kimhae and Koje-Do in 1969. The results of the investigation may be summarized as follows: 1. Mortality of the oysters by the bamboo method in Kimhae was $9.5\%$ in June, $10.2\%$ In July, $12.3\%$ in August and $12.1\%$ in September, respectively, 2. Mortality of the oysters cultured by the hanging method in Koje-Do was $2.4\%$ in June, $2.9\%$ in July, $30.7\%$ in October, $37.3\%$ in November and $30.0\%$ in December, respectively 3. The diseased oysters had severe inflammation, necrosis and multiple abscess in the epithelia of stomach, mid-gut, digestive tubules, blood vessels and gonads, mucous membrane and surrounding tissue. 4. From August gram negative bacteria were found in the nodules of connective tissue and multiple abscess of the diseased oysters. Particularly the connective tissue of the diseased oysters contained more bacteria than epithelia. 5. Since the bacteria are less abundant in the region of digenerated tissue, mortality of the oysters is not caused only by the infectious bacteria but seems that is also caused by other environmental factors such as extreme temperatures and salinities.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.45 no.4
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• pp.180-185
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• 2019

Masson's tumor or intravascular papillary endothelial hyperplasia is an inflammatory soft tissue lesion that rarely occurs in the maxillofacial region and skeletal system. Precise clinical and para-clinical investigation is necessary for the accurate diagnosis and correct treatment of this lesion. This paper presents a massive intravascular papillary endothelial hyperplasia lesion in the bony tissue of the mandible. Histopathology features, clinical appearance, and suitable management are discussed, with a complete review of the literature. The patient underwent composite resection of the lesion as well as reconstruction. No recurrence was observed during 6 years of follow-up. To the best of our knowledge, this is the fourth case of Masson's tumor in mandibular skeletal tissue, which has unique and distinctive features due to its size and location. A rare occurrence in skeletal tissue, complex clinical presentations, and complicated histopathologic findings present diagnostic challenges for treatment of this lesion.