• Proceedings of the Korean Society for Bioinformatics Conference
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• 2005.09a
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• pp.51-56
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• 2005

There are many sources of systematic variations in cDNA microarray experiments which affect the measured gene expression levels like differences in labeling efficiency between the two fluorescent dyes. Print-tip lowess normalization is used in situations where dye biases can depend on spot overall intensity and/or spatial location within the array. However, print-tip lowess normalization performs poorly in situation where error variability for each gene is heterogeneous over intensity ranges. We proposed the new print-tip normalization methods based on support vector machine regression(SVMR) and support vector machine quantile regression(SVMQR). SVMQR was derived by employing the basic principle of support vector machine (SVM) for the estimation of the linear and nonlinear quantile regressions. We applied our proposed methods to previous cDNA micro array data of apolipoprotein-AI-knockout (apoAI-KO) mice, diet-induced obese mice, and genistein-fed obese mice. From our statistical analysis, we found that the proposed methods perform better than the existing print-tip lowess normalization method.

• International Journal of Fluid Machinery and Systems
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• v.3 no.3
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• pp.260-270
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• 2010

Reducing the losses of the tip clearance flow is one of the keys in an unshrouded centrifugal compressor design and development because tip clearances are large in relation to the span of the blades and also centrifugal compressors produce a sufficiently large pressure rise in single stage. This problem is more acute for a low flow high-pressure ratio impeller design. The large tip clearance would cause flow separations, and as a result it would drop both the efficiency and surge margin. Thus a design of a high efficiency and wide operation range low flow coefficient centrifugal compressor is a great challenge. This paper describes a recent development of high efficiency and wide surge margin low flow coefficient centrifugal compressor. A viscous turbomachinery optimal design method developed by the authors for axial flow machine was further extended and used in the centrifugal compressor design. The compressor has three main parts: impeller, a low solidity diffuser and volute. The tip clearance is under a special consideration in this design to allow impeller insensitiveness to the clearance. A patented three-dimensional low solidity diffuser design method is used and applied to this design. The compressor test results demonstrated to be successful to extend the low solidity diffusers to high-pressure ratio compressor. The compressor stage performance showed the total to static efficiency of the compressor being about 85% and stability range over 35%. The test results are in good agreement with the design.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.23 no.5
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• pp.661-669
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• 1999

The evolutionary structure of a tip vortex in the initial period have been investigated by the two-dimensional LDV system. Circumferential and axial components of mean velocities, their turbulences and Reynolds stresses were measured by the phase averaging technique at seven different wake ages within one revolution of the rotor. Core growth was also analyzed. It was resulted that circumferential velocity components showed a Rankine combined vortex shape and their circulation profiles viewed in the radial direction were close to the n = 2 model of Vatistas' algebraic formula, while axial velocity components seemed to have the Gaussian profiles In these measured ranges with the base width of three times of core radii. Peaks of circumferential velocities and core radii showed distinct asymmetric behaviors before the wake age of $150^{\circ}$ over inboard and outboard sides of the slipstream, but they became symmetric afterwards. Turbulence profiles which had two peaks Inside the core radii in the earlier wake age were also changed to single peaks after $150^{\circ}$. These trends imply that the tip vortex was barely mature at this wake age.

• Transactions of the Korean Society of Automotive Engineers
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• v.5 no.1
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• pp.87-100
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• 1997

The ability of turbulence model to accurately describe the complex characteristics of the flow field and the fuel spray is of great importance in the optimum design of diesel engine. The numerical simulations of the flow field and the spray characteristics within the combustion chamber of direct injection model entgine are performed to examine the applicability of turbulence model. The turbulence models used are the RNG $\varepsilon$ model and the modified $\varepsilon$ model which included the compressibility effect due to the compression/expansion of the charges. In this study, the predicted results in the quiescent condition of direct injection model engine show reasonable trends comparing with the experimental data of spray characteristics, i. e., spray tip penetration, spray tip velocity. The results of eddy viscosity obtained using the $\varepsilon$ model in the spray region is significantly larger than that obtained using the RNG $\varepsilon$ model. The application of the RNG model seems to have some potential for the simulations of the spray characteristics, e. g., spray tip penetration, spray tip velocity, droplets distribution over the $\varepsilon$ model.

• Archives of Plastic Surgery
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• v.45 no.3
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• pp.253-258
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• 2018

Background The nasolabial flap is ideal for reconstruction of the nasal alar subunit due to its proximity, color and contour match, and well-placed donor scar. When raised as a random-pattern flap, there is a risk of vascular compromise to the tip with increased flap length and aggressive flap thinning. Surgical delay can greatly improve the chances of tip survival, allowing the harvest of longer flaps with greater reach. Methods We describe our technique of lengthening the nasolabial flap through multiple delay procedures. A bipedicled flap was first raised and then transferred as a unipedicled flap with a 6:1 length-to-width ratio. During the delay process, the flap tip was thinned to the subdermal layer. Results In our case series of seven patients, defects as far as the medial canthal area and contralateral ala were reconstructed successfully with no incidence of tip necrosis or flap loss. The resultant flaps were thin enough to be folded over for the reconstruction of alar rim defects. Conclusions We highlight the success of our surgical technique in creating thin and robust nasolabial flaps for the reconstruction of full-thickness defects around the nose.

• Korean Journal of Metals and Materials
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• v.48 no.1
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• pp.71-76
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• 2010

The use of advanced high-strength steels (AHSS) in automotive applications has steadily increased over the past few years. Two different failure modes are generally observed in shear-tension tests for resistance spot welds of AHSS. interfacial fractures and full button pullout. Despite high load-carrying capacity. the resistance spot welds in AHSS cue prone to interfacial fractures. To improve the load carrying ability of welds during shear-lap and cross tension tests. the tip surface of the electrode was grooved in a round shape. The electrode tip surface was modified so as to concentrate the current now in the central and circumferential portion of the electrode force. The results showed that the interfacial fracture was suppressed in welds using the modified electrode. In a comparison of failure mode during mechanical tests. the welds made with the modified electrode showed a higher tendency to fail via full button pullout fracture.

• Proceedings of the KSME Conference
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• 2007.05b
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• pp.2573-2578
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• 2007

In order to investigate the vortex body frame interaction around the side mirror of a passenger car, velocity vector fields in the wake, pressure distributions and boundary layer flows over both the mirror surface and the mirror housing, have been measured by several experimental tools. It was resulted that only within an half downstream distance of the mirror span there appears the recirculation zone, and also found that vortex trail towards to the driver side window between A and B pillars, making the acoustic noise and vibration. Wake vortex rolls up after this recirculating zone and makes the trail of the vortex center towards the driver side window, which was also confirmed by measurements of wake velocity vectors in the vertical sections of the trail and visualization over the side mirror surfaces as well. It was also observed that total pressure distribution over the mirror surface has the minimum peak near the lower tip region which can be considered as the origin of the vortex center. It can be concluded that the geometrical modification of the lower tip and the upper root area of the mirror housing is the key to control the wake vortex.

• Journal of Welding and Joining
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• v.3 no.1
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• pp.22-31
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• 1985

Hot straining embrittlement is one of the most important factors which cause the brittle fracture initiation even in the service temperature in the case of mild steel and high tensile steel. Therefore it is necessary to analyze thoroughly the hot straining embrittlement occurred in weld HAZ of the structural steels. The behaviors of plastic deformation and fracture toughness at the notch tip of the hot strained weld HAZ in structural steels (SB 41 KS, SA 588-Grade A ASTM) have been studied by the recrystallization technique and crack opening displacement (COD) test method. The obtained results are summarized as follows; 1. The plastic zone is formed at the notch tip of weld HAZ owing to nomotonic and cyclic hot stran, and the maximum plastic strain increases with the accumulated hot straining amounts. 2. The distribution of the effective strain at the plastic deformed zone in HAZ can be determined as follows; (.epsilon. over bar $_{p}$ )$_{\chi}$=.epsilon. over bar $_{cr}$ ( $R_{/chi}$/.chi.)$^{m}$ where, .epsilon. over bar $_{cr}$ : (SB 41; .epsilon. over bar $_{cr}$ = 0.2, SA 588; .epsilon. over bar $_{cr}$ = 0.1) 3. The embrittlement of weld HAZ in SB 41 and SA 588 is influenced by hot strain, and the degree of embrittlement becomes deeper with hot straining amounts. 4. The embrittlement of weld HAZ of SB 41 is not influenced by the hot straining amounts until .epsilon. over bar $_{max}$ = 0.36, $R_{\chi}$ = 0.065mm, however the embrittlement of structure in SA 588 is considerably influenced even by a small quantity of the hot straining amounts.s.

• Environmental Engineering Research
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• v.19 no.3
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• pp.229-240
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• 2014

Rain events are extremely important for phosphorus (P) dynamics in rivers since large portions of annual river P loads can be transported in particulate forms during only a few major events. Despite their importance, a precise estimation of P contribution in river sediments after rainy seasons has rarely been reported. This study estimated the longitudinal variation in the concentrations of different inorganic P fractions in bed sediments of the South Han River over a rainy season, through using the sequential extraction method. Non-apatite P was the dominant form, representing more than 60% of total inorganic P (TIP) content in sediments. Although no significant variation of TIP contents was observed, the proportion of bioavailable P in TIP pools decreased after the rainy season. The concentrations of individual inorganic P fractions ($NH_4Cl-P$, $NH_4F-P$, NaOH-P, and $H_2SO_4-P$) were significantly different across sites and after the rainy season (p < 0.05, two-way ANOVA). $NH_4F-P$ and NaOH-P concentrations in sediments increased in a downstream direction. After the rainy season, $NH_4Cl-P$ concentrations in sediments decreased whereas $NH_4F-P$ and $H_2SO_4-P$ concentrations increased. The redistribution of individual P fractions in sediments observed after rainy seasons were possibly due to the changing contribution of various sources of runoff and the variation in flow related particle size. Current estimation of P in bed sediments of the South Han River suggests a lower potential of internal P loading from sediments after the rainy season.

• Molecules and Cells
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• v.19 no.2
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• pp.289-293
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• 2005

BAF53 is an actin-related protein that shuttles between nucleus and cytoplasm. In the nucleus, it constitutes an integral component of many chromatin-modifying complexes such as the SWI/SNF, TIP60, TRRAP, and TIP48/49 complexes. BAF53 is essential for growth, but its function remains elusive. BAF53 homologues from yeast to humans have a conserved N-terminal motif, MS_(G/A)(G/A)__(V/L)YGG, which is unique to these proteins. Previously we showed that over-expression of an N-terminal deletion mutant of BAF53 ($BAF53_-{\Delta}N$) reduced the viability of HEK293 and HeLa cells. When we replaced the serine 2 and tyrosine 6 of this N-terminal motif with alanine, over-expression of the alanine-replaced BAF53 strongly impaired the growth of HEK293 cells whereas replacement with aspartate/glutamate had no effect. The alanine-replaced BAF53 mutants also stimulated p53-dependent transcription, in which the SWI/SNF and TRRAP complexes are involved. Our results demonstrate that serine 2 and tyrosine 6 play important roles in BAF53 activity.