• Asian Pacific Journal of Cancer Prevention
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• 제16권10호
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• pp.4363-4368
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• 2015

Background: The tumor-stroma ratio (TSR) represents the percentage of neoplastic cell components compared to the combined area of neoplastic cells and the surrounding tumor-induced stroma. A low TSR (predomination of stromal component) has been demonstrated to be an independent adverse prognostic factor in cancers of several organs. In cervical carcinoma patients, TSR has been evaluated in only one previous study with different histological types. The present study aimed to assess the prognostic value of TSR in early stage cervical cancer patients with adenocarcinoma histology only. Materials and Methods: Histological slides of patients with early stage (IB-IIA) cervical adenocarcinoma who underwent surgical treatment between January 2003 and December 2011 were reviewed. Patients who had received preoperative chemotherapy were excluded. TSR was categorized as low (<50%) and high (${\geq}50%$). Correlations between TSR and clinicopathological variables were evaluated. Prognostic values of TSR and other variables were estimated using Cox's regression. Results: Of 131 patients; 38 (29.0%) had low TSR and 93 (71.0%) had high TSR. The patients with low TSR had significantly higher proportions of deep cervical stromal invasion (outer third of wall, p=0.011; residual stroma less than 3 mm, p=0.008) and parametrial involvement (p=0.026). Compared to the patients with high TSR, those with low TSR tended to have lower 5-year disease-free survival rate (83.8% versus 88.9%) and overall survival rate (85.6% versus 90.3%), although the differences were not statistically significant. Low TSR was significantly associated with decreased overall survival in univariate analysis (HR 2.7; 95% CI 1.0-7.0; p=0.041), but not in multivariate analysis. TSR was not significantly associated with decreased disease-free survival. Conclusions: Low TSR is associated with decreased overall survival in patients with early stage cervical adenocarcinoma treated by surgery. However, it was not found to be an independent prognostic predictor in this study.

• 한국콘텐츠학회논문지
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• 제13권11호
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• pp.306-312
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• 2013

이 연구는 치과감염에 대한 의료소비자들의 인식도를 파악하고자 대구지역 치과병원(3곳)에 내원하는 환자를 대상으로 설문조사하여 회수한 213부를 분석 하였다. 그 결과 가장 중요하게 생각하는 감염관리는 '기구소독'이 64.3%로 많았고, 연령에서 유의한 차이가 있었다(P<0.01). 감염관리 책임여부에 대해서는 72.3%가 '치과의사, 직원'의 책임이라고 답하였고 학력에서 유의하였다(P<0.001). 청결위생중요도에서는 70.0%가 '매우중요하다'고 답하였고, 성별(P<0.05)과 연령(P<0.01)에서 유의하게 나타났다. 치과 감염관리에 관한 정보습득 경험이 있는 사람이 없는 사람보다 손 씻기(P<0.001), 타액 흡입기 교체(P<0.001), 양치컵 교체(P<0.01)여부를 더 유심이 관찰하고, 보안경 착용여부도 더 중요하게 생각하는 것으로 조사되었다(P<0.01). 이상의 연구결과로 치과 의료기관은 보건복지부에서 고지하는 감염관리 평가를 잘 인지하고 일반 의료소비자들의 눈높이에 맞는 감염관리를 실천한다면 병원의 신뢰도는 물론 환자만족도까지 높일 수 있는 바탕이 될 것이라 생각된다.

• 한국대기환경학회지
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• 제7권1호
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• pp.55-65
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• 1991

The study was performed to select a adaptable tree species under stressed field conditions where there are a industrial plants operating with a number of smoke stacks emitting pollutants, such as hydrogen fluoride and sulfur dioxide. As a result of the study, a tree species selected are due to construct a forest belt in a zones near industrial plants to reduce the concentrations of air pollutants. The concentrations of atmospheric hydrogen fluoride and sulfur dioxide were very higher at experimental sites near industrial plants (air-pollution sites) than at control site. The leaves of 7 tree species grown at air pollution sites contained more sulfur and, specially, fluorine than at those control site. Among the tested tree species, Ligustrum japonicum Thunb. and Euonymus japonica Thunb. grown at air pollution sites did not at all break out a foliar injury but appeared to be healthy, as well as those grown at control site. Acer pseudo-sieboldianum Kom., Pinus virginiana Mill., Larix leptolepis Gordon., Pinus koraiensis Sieb. et Zucc., Pinus strobus L., Picea abies Karst and Ligustrum obtusifolium Sieb. et Zucc., however, showed a severe fluoride-type foliar injury such as necrosis on tip or margin of leaves, etc. Fluorine found in leaves was proved to be correlated to sulfur found in leaves whereas index of foliar injury hadn't a good correlation to pollutants found in leaves. It appears that Euonymus japonica Thunb., Ligustrum japonica Thunb., Platanus acerifolia Willd, Chamaecyparis pisifera Endl., Populus tomentiglandulosa T. Lee and Sophora japonica L. grown at both experimental sites had a high value of percent survival whereas Pinus virginiana Mill., Pinus koraiensis Sib. et Zucc., Koelreuteria paniculata Laxm. and Alnus hirsuta Rupr. had an extremely low value of that. In comparison with control site, the percent tree height increments in Chamaecyparis pisifera Endl., Ligustrum japonicum Thunb., Quercus acutissima Carruth., Populus tomentiglandulosa T. Lee, Pinus thunbergii Parl and Euonymus japonica Thunb. and the percent upmost root diameters in Populus tomentiglandulosa T. Lee, Chamaecyparis pisifera Endl., Euonymus japonica Thunb., Ligustrum japonicum Thunb., Betula platyphylla var. japonica Hara and Pinus thunbergii Parl. cultivated at air polluted sites showed very high value above 90%, respectively. A significant negative correlation (r=-0.662) was recognized between the index of foliage injury and the percent collective character, which was the mean of tree characters such as percent survival, percent tree height increment and percent upmost root diameter increment which compared to those at air polluted site with those at control site. Based on the percent collective character Ligustrum japonicum Thunb., Euonymus japonica Thunb., Chamaecyparis pisifera Endl., Populus tomentiglandlosa T. Lee, Betula platyphyla var. japonica Hara and Platanus occidentalis L. have large value about 90%, respectively. Therefore, the results indicate that this tree species are adaptable species in air polluted regions. For better understanding of the adaptable tree species, furthur studies concerning the effects of various air pollutants on the tree growth are required.

• 대한치과교정학회지
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• 제12권2호
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• pp.79-93
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• 1982

The purpose of orthodontic treatment is to achieve normal occlusion and good facial esthetics for individual patients. To produce harmonized facial balance, treatment planning for patient who require orthodontic treatment should include both a hard tissue and soft tissue cephalometric analysis. Author studied to derive the normal standards of soft tissue profile in Koreans by roentgenocephalometric analysis. For this study 12 soft tissue profile landmarks were plotted and 23 linear length, 9 soft tissue thickness, 8 vertical height length, 12 angles of soft tissue profile, and 3 vertical proportion were measured. The subjects consisted of 166 males and 209 females from 7 to 19 years with normal occlusion and acceptable profiles, and were divided into five groups according to age. The obtained results were as follows; 1. From the basis of N-Pog (Nasion-Pogonion) plane, the growth of facial soft tissue in the middle region especially nose area was greater than others facial region. 2. From the basis of G-Pog' (Glabella-soft tissue Pogonion) plane, the values of linear measurement of soft tissue Nasion and Inferior labial sulcus decreased and nose tip grew forward as growing older. 3. The growth of the facial soft tissue thickness was greatest in superior labial sulcus and the thickness of soft tissue nasion gradually became thinner as growing old. 4. The thickness of upper and lower lip was 14.47mm, 14.57mm in adulr male, 12.76mm, 13.78mm in adult female. 5. The soft tissue thickness of the lower lip was thicker than that of upper lip in all age groups and both sexes, 6. The vertical length of the upper and lower lips were 25.04mm, 49.97mm in adult male and 23.50mm, 48.39mm in adult female. 7. By the significant test, there were significant difference between male and female in fifth adult group on all vertical length measurements of lower face. 8. In fifth adult group, the perpendicular distance from LS, LI to Steiner's line and Ricketts' esthetic line were as follow; Steiner line to LS, LI were 7.98mm, 5.84mm in male. Steiner line to LS, LI were 6.71mm, 5.08mm in female. Ricketts' esthetic line to LS, LI were -0.40mm, 1.72mm in male. Ricketts' esthetic line to Ls, LI were -1.38mm 0.65mm in female. 9. In fifth adult group, the facial convexity angle and lower facial component angle were $171.17^{\circ}142.94^{\circ}$ in male and $172.5^{\circ}$, $144.41^{\circ}$ in female.

• 한국잠사곤충학회지
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• 제29권1호
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• pp.7-11
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• 1987

1. 식재당년 비닐 피복은 무피복에 비해 탈포기는 2일, 연구기는 3일 앞당겼다. 2. 피복은 최장 가지 길이를 16.9-25.3cm 더 증가시켰으나, 2,780주 이상 밀식한 경우는 피복의 효과가 떨어졌다. 3. 밀식할수록 엽장과 폭이 작아지고, 가지 기부의 황변된 잎의 수는 증가하였다. 4. 밀식은 주당 가지수와 조장은 감소시켰으며, 정상지에 대한 왜소지의 비율은 증가시켰다. 그러나 10a당 가지수와 총조장은 증가하였다. 5. 식재밀도별 경년적 뽕잎 수량의 변이는 식재후 2년차까지는 계속 증가하였으나, 그 후부터 1,677주구는 926주구에 비해 증가 폭이 둔화되었고, 이보다 밀식한 구에서는 떨어지는 경향이었다. 6. 식재후 5년간 평균 뽕잎 수량은 2,780주구에서 가장 많아서 926주구 대비 46.6% 증수를 보였으며, 3,444주구가 다음으로 40%를, 1,667주구에서 29.9% 증수를 보였다. 7. 식재후 토양의 화학성은 pH, 유기물, Ca, Mg 등이 떨어졌으며, 926주 이상 심을 때는 인산, pH, O.M, Ca, Mg등의 함량이 저하되었다.

• Restorative Dentistry and Endodontics
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• 제22권1호
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• pp.428-446
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• 1997

Restorative procedures can lead to weakening tooth due to reduction and alteration of tooth structure. It is essential to prevent fractures to conserve tooth. The resistance to fracture of the restored tooth may be influenced by many factors, among these are the cavity dimension and the physical properties of the restorative material. The placement of direct composite resin restorations has generally been found to have a strengthening effect on the prepared teeth. It is the purpose of this investigation to study the relationship between the cavity isthmus and the fracture resistance of a tooth in composite resin restorations. In this study, MO cavity was prepared on maxillary first premolar. Three dimensional finite element models were made by serial photographic method and isthmus(1/4, 1/3, 1/2 of intercuspal distance) were varied. Two types of model(B and R model) were developed. B model was assumed perfect bonding between the restoration and cavity wall and R model was left unfilled. A load of 500N was applied vertically at the first node from the lingual slope of the buccal cusp tip. This study analysed the displacement, 1 and 2 direction normal stress and strain with FEM software ABAQUS Version 5.2 and hardware IRIS 4D/310 VGX Work-station. The results were as follows : 1. Displacement of buccal cusp in R model occurred and increased as widening of the cavity, and displacement in B model was little and not influenced by cavity width. 2. There was a significant decrease of stress resulting in increase of fracture resistance in B model when compared with R model. 3. With the increase of the isthmus width, B model showed no change in the stress and strain. In R model, the stress and strain increased both in the area of buccal-pulpal line angle and the buccal side of marginal ridge, therefore the possibility of crack increased. 4. The stress and strain were distributed evenly on the tooth in B model, but in R model, were concentrated on the buccal side of the distal marginal ridge and buccal-pulpal line angle, therefore the possibility of fracture increased.

• 수산해양기술연구
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• 제34권2호
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• pp.117-134
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• 1998

The study on the Assembling Mechanism of the Hairtail, Trichiurus lenpturus, at the Fishing Grounds of the Cheju Strait had been investigated by analyzing the relationship of the oceanographic conditions and the fishing ground of the Hairtail in the Cheju Strait. 1. The fishing grounds of the hairtail at the Cheju Strait are formed at the bottom of a high temperature of the tidal front at the coast. area of northern Cheju Island, the tip of the linguiform is high in salinity at the eastern and western entrances of Cheju Island, low salinity eddy on the surface and its surrounding front, various water masses in the Strait and coastal waters of the South Sea in Korea. 2. The fishing grounds of the Hairtail at the Cheju Strait begins with the sea surface temperature higher than $15^{\circ}C$ and the incoming of low salinity water now from the East China Sea. 3. Estimation of optimum temperature and salinity per season based upon analysis for relationship between temperature of water and salinity of the bottom layer and the catch is : 15.2~$16.4^{\circ}C$, 34.20~34.40${\textperthousand}$ in spring(June); 14.4~ $17.0^{\circ}C$, 33.70~34.30${\textperthousand}$ in summer(July~September); and 15.7~ $18.6^{\circ}C$, 33.70~34.50$\textperthousand$ in autumn(October~December). Hairtail are mostly caught at the Yellow Sea Warm Current and Tsushima Current with temperature over $14.5^{\circ}C$ and salinity over 33.70${\textperthousand}$ at the bottom layers of the Cheju Strait. 4. Considering the relationship between the amount of hairtail catch and the water temperature of bottom layer, when the bottom water being above $14.0^{\circ}C$ flowed into Cheju Strait through the western entrance of the strait in summer, the ca-h appears to have been abundant. In contrast, the catch has been poor when the temperature of such water was recorded to be below $13^{\circ}C$ Therefore, distribution patterns of water at the bottom layer can be used as a forecast index whether the catch of a certain year will be good or poor.

• 약학회지
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• 제58권6호
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• pp.378-386
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• 2014

Topical agents including of steroids are easily exposed to Korean patients in community setting. Those topical agents must be use cautiously because can cause adverse drug reaction unlike other oral medication. We evaluate the using pattern topical agents of Korean in community setting. We performed a questionnaire survey in three different pharmacies (general community pharmacy, dermatology clinic oriented pharmacy, general hospital oriented pharmacy) and in three university town. The survey asked necessity of topical agents, the number of applications per day, application period, site, and exist of steroids ingredient, etc. Total 330 people was participated in the survey from May 1st to July 31st, 2014. We analysed the survey by the frequency of each question and cross-analysis of the compliance between general public and pharmacy groups. In results, Korean people used topical agents for sudden skin diseases (66.9%), was gotten by dermatologist's prescription (89.1%), and did not know their diagnosis (39.2%). The people applied topical agents on face (22.3%), less one half FTU (finger tip unit) per application (61.9%), less than one week (62.9%). Though they was received drug education from pharmacist (52.2%), did not heard about adverse effects (78.4%). And compliance of applied times in pharmacy group was higher than in-non-pharmacy group (56% vs 38%, p=0.002). The highest compliance between 3 pharmacy subgroup was general community pharmacy (76.3% vs 61.6%, 61.2%, p=0.039). Compliance of applied duration was no difference between groups. Majority of respondents did not know diversity of ingredients, potency, application area of topical steroids, and replied to feel some vague reluctance and to think so dangerous about topical steroids. In conclusion, Korean people in community use topical agents well but still some exposed to risk from topical agents.

• The Korean Journal of Pain
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• 제2권1호
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• pp.66-71
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• 1989

It has been standard practice in many institutions to use a combination of a light general anesthesia and an epidural block for lower abdominal and pelvic surgery. This combination of a balanced anesthesia can provide various benefits to the patient such as less bleeding in the surgical field, the use of a lower concentration of general anesthetics, less muscle relaxant, and post operative pain management. However, there are several problems associated with hemodynamics such as bradycardia and hypotension etc. In order to block the pain of the high surgical area with a lumbar epidural puncture postoperatively, a large volume of local anesthetic is required and consequently an extensive blockade of sympathetic, sensory and motor functions can occur causing motor weakness, numbness and postural hypotension. Therefore, the patient is unable to have early ambulation postoperatively. In this study, thoracic epidural catheterization was undertaken to locate the tip of the catheter exactly at the surgical level for upper abdominal surgery, and was followed by general anesthesia. Twenty-one patients scheduled for upper abdominal surgery were selected. Fifteen of them had hepatobiliary operations and the remaining 6 had gastrectomies. Thoracic epidural punctures were performed mostly at T9-T10 (57.1%) and T8-T9. Neuromuscular blocking agents were not used in half of the cases and the, mean doses of relaxant were $3.5{\pm}1.0mg$ in gastrectomies, and $2.7{\pm}0.9mg$ in cases of hepatobiliary operation. Epidural morphine was injected 1 hour before the end of the operation for postoperative pain control. Eight patients did not require additional analgesics and the mean dose of epidural morphine was $2.2{\pm}0.9mg$, and 13 cases were given 0.125% epidural bupivacaine when patients complained of pain. Their initial doses of epidural morphine were $1.9{\pm}0.4mg$ and the mean duration of bupivacaine was 6 hours 20 minutes${\pm}40$ minutes. In conclusion. thoracic epidural analgesia is valuable to reduce postoperative pain in patients with upper abdominal surgery, However, it is not easy to maintain this balanced anesthesia with high epidural analgesia-and light general anesthesia for upper abdominal surgery because of marked hemodynamic changes. Therefore, further practice will be required.

• Imaging Science in Dentistry
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• 제39권3호
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• pp.149-156
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• 2009

Purpose : The purpose of this study was to develop a stent-based image guided surgery system and to apply it to oral and maxillofacial surgeries for anatomically complex sites. Materials and Methods : We devised a patient-specific stent for patient-to-image registration and navigation. Three-dimensional positions of the reference probe and the tool probe were tracked by an optical camera system and the relative position of the handpiece drill tip to the reference probe was monitored continuously on the monitor of a PC. Using 8 landmarks for measuring accuracy, the spatial discrepancy between CT image coordinate and physical coordinate was calculated for testing the normality. Results : The accuracy over 8 anatomical landmarks showed an overall mean of $0.56{\pm}0.16\;mm$. The developed system was applied to a surgery for a vertical alveolar bone augmentation in right mandibular posterior area and possible interior alveolar nerve injury case of an impacted third molar. The developed system provided continuous monitoring of invisible anatomical structures during operation and 3D information for operation sites. The clinical challenge showed sufficient accuracy and availability of anatomically complex operation sites. Conclusion : The developed system showed sufficient accuracy and availability in oral and maxillofacial surgeries for anatomically complex sites.