• 한국환경농학회지
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• 제34권3호
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• pp.230-237
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• 2015

BACKGROUND: To identify the sources of inaccuracy in LC/MS/MS methods used in the routine quantitation of small molecules are described and discussed. METHODS AND RESULTS: Various UPLC coupled to triple quadrupole mass spectrometer and time of flight (TOF) were used to identify the potential sources of inaccuracy and inducing the pitfalls of qualification and quntitation during the veterinary drug residue analysis. Some of stable isotope labelled veterinary drugs, which were used as internal standards, presented "cross-talk", regardless of manufactures of mass spectrometer and types of spectrometer. Group of sulfonamides also presented inaccuracy qualification and quantitation due to the multi-residue analytical method with the same fragment ions at the close retention times. CONCLUSION: The phenomena of "cross-talk" occurring between subsequently monitored transition from stable isotope labelled and isotope non-labelled authentic chemical were identified. To prevent errors and achieve more accurate data during the analysis of small molecules by LC/MS/MS SRM method, Followings should be taken care of and kept checking; purity and concentration of stable isotope as an internal standard, prevention of carry-over during the separation in column, minimizing the ion suppression by matrix effect, identification of retention time, precursor ion and product ion, and full knowledge of data processing including smoothing and peak integration.

• 산업경영시스템학회지
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• 제39권3호
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• pp.56-63
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• 2016

For air express service providers offering various express delivery services such as overnight delivery and next-business day delivery services, establishing quickly cargo loading plans is one of important issues owing to the characteristics of air express business, i.e., a short amount of time is available to complete all cargo loading operations before flight departure after receiving air express containers, pallets and bulks. On the other hand, one of major concerns in the air cargo loading planning is to make a plan that insures the stability of an aircraft to avoid take-off, flight, and landing accidents. To this end, this paper considers an air cargo loading planning problem, which is the problem of determining locations in the aircraft cargo space where air containers, pallets and bulks to be loaded while insuring the aircraft stability, motivated from DHL and Air Hong Kong. The objective of the problem is to maximize the total revenue gained from loading air express containers, pallets and bulks. To solve the problem, this paper suggests a simulated annealing algorithm to overcome impracticality of the integer programming model developed by a previous study requiring excessive computation time. The results of computational experiments show that the heuristic algorithm is a viable tool for establishing express cargo loading plans as giving robust and good solutions in a short amount of computation time. Scenario analyses are performed to investigate the effect of the current activities of air express carriers on the revenue change and to draw practical implications for air express service providers.

• International Journal of Oral Biology
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• 제34권1호
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• pp.29-36
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• 2009

Cyclosporin A (CsA) has been used clinically as an immunosuppressive drug to prevent organ transplant rejection and in basic research as a mitochondrial permeability blocker. It has been reported that CsA has a protective role in severed neurons and a neurotrophic effect in neuronal cells. However, the molecular mechanisms underlying the stimulation of neuronal cell proliferation by CsA have not yet been elucidated. In our current study, we investigated CsA responsive proteins in PC12 cells using a systematic proteomic approach. The viability of these cells following CsA treatment increased in a dose- and time-dependent manner. Proteins in the CsA-treated PC12 cells were profiled by two-dimensional gel electrophoresis (2-DE) and identified by matrix-assisted laser desorption ionization time-of flight (MALDI-TOF) and electrospray ionization quadupole time-of-flight mass spectrometries (EIQ-TOFMS). This differential expression analysis showed significant changes for 10 proteins (6 up-regulated and 4 down-regulated) upon CsA treatment that were related to cell proliferation, metabolism and the stress response. These proteomics data further our understanding of the proliferation mechanisms of PC12 cells exposed to CsA and demonstrate that our methodology has potential to further elucidate the mechanisms and pathways involved.

• 수면정신생리
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• 제4권1호
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• pp.57-65
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• 1997

누구나 시차가 큰 여행을 할 때 몇일 간 비행시차증이라고 불리우는 증상을 경험하게 된다. 비행시차증은 수면박탈, 비행요인, 지연요인의 복합적인 원인으로 인해 생기는 하나의 증상군이라고 말할 수 있다. 특히 빠른 시차변화로 인한 생리적 지연효과(Jet lag)는 외적 비동조화, 내적 비동조화, 그리고 수면상실의 결과를 낳는다. 인간의 수면을 조절하는 기전에 있어 일중체계가 중요하다. 즉, 평균적인 수면-각성주기는 중심체온의 주기와 내적 비동조화가 일어나더라도 수면경향, 졸리움, 자발적 수면 기간, 그리고 렘수면 경향은 중심체온의 내인성 일중주기에 따라 통제된다. 수면의 구성요소중에서 서파수면은 중심체온의 주기보다는 수면시작시간에 따라 나타나며 이전에 깨어있었던 기간이 길수록 강력하게 나타난다. 따라서 수면은 일중체계와 항상성 기전의 상호작용으로 조절된다. 비행시차 후에 변화되는 수면양상을 이해하는데 있어 일중 체계 이외에 도항상성 기전을 고려하여야한다. 수면에 대한 일중리듬체계의 영향과 수면의 항상성 과정이 비행시차후 도착지에서의 수면양상을 설 명할 수 있을 것이다. 도착지에서의 적응은 통과한 시간대 수, 여행 방향, 일주기 리듬의 부조화에 적응 할 수 있는 개인별 능력에 따라 다르다. 도착지의 시간적 단서에 빨리 노출되어 일중체계의 위상반응곡선에 의한 재동조화를 촉진시키고 수면의 항상성 과정을 고려하여 도착지의 밤 이전까지 충분히 깨어 있는 것이 Jet Lag를 극복하고 적응하는 지름길일 것이다.

• 한국소음진동공학회논문집
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• 제17권5호
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• pp.456-463
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• 2007

It is important to improve the initial launch conditions of golf ball at impact between golf club and ball to get a long flight distance. The flight distance is greatly influenced by the initial launch conditions such as ball speed, launch angle and back spin rate. It is also important to analyze the mechanism of ball spin to improve the initial conditions of golf ball. Back spin rate is created by the contact time and force. Previous studies showed that the contact force is determined as the resultant force of the reaction forces normal and tangential to the club face at the contact point. The normal force causes the compression and restitution of ball, and the tangential force creates the spin. Especially, the tangential force is known to take either positive or negative values as the ball rolls and slides along the club face during impact. Although the positive and negative tangential forces are known to create and reduce the back spin rate, respectively, the mechanism of ball spin creation has not yet been discussed in detail in the literature. In this paper, the influence of the contact force between golf club and ball is investigated to analyze the mechanism of impact. For this purpose, the contact force and time at impact between golf club head and ball are computed using FEM and compared with previous results. In addition, we investigate the impact phenomenon between golf club head and ball by FEM and clarify the mechanism of ball spin creation accurately, particularly focusing on the effect of negative tangential force on ball spin rate.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2007년도 춘계학술대회논문집
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• pp.1017-1022
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• 2007

It is important to improve the initial launch conditions of golf ball at impact between golf club and ball to get a long flight distance. The flight distance is greatly influenced by the initial launch conditions such as ball speed, launch angle and back spin rate. It is also important to analyze the mechanism of ball spin to improve the initial conditions of golf ball. Back spin rate is created by the contact time and force. Previous studies showed that the contact force is determined as the resultant force of the reaction forces normal and tangential to the club face at the contact point. The normal force causes the compression and restitution of ball, and the tangential force creates the spin. Especially, the tangential force is known to take either positive or negative values as the ball rolls and slides along the club face during impact. Although the positive and negative tangential forces are known to create and reduce the back spin rate, respectively, the mechanism of ball spin creation has not yet been discussed in detail in the literature. In this paper, the influence of the contact force between golf club and ball is investigated to analyze the mechanism of impact. For this purpose, the contact force and time at impact between golf club head and ball are computed using FEM and compared with previous results. In addition, we investigate the impact phenomenon between golf club head and ball by FEM and clarify the mechanism of ball spin creation accurately, particularly focusing on the effect of negative tangential force on ball spin rate.

• 한국방사선학회논문지
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• 제13권6호
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• pp.841-846
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• 2019

본 연구에서는 섬광결정과 광센서의 정렬 오차가 TOF-PET 검출기 성능에 미치는 영향성을 정량적으로 평가하였다. 한 쌍 TOF-PET 검출기는 3 mm × 3 mm × 20 mm 체적을 갖는 LYSO 섬광체와 3.07 mm × 3.07 mm 크기의 GAPD 광센서로 구성된다. 아날로그 출력신호는 증폭 및 균일도 보정이 수행되었고, 오실로스코프 기반 데이터 획득 장치에서 신호처리되었다. 각 검출기 정렬 오차는 0.0 mm, 0.5 mm, 1.0 mm, 1.5 mm 를 각각 적용하여 총 16단계의 정렬 오차를 발생시켰다. 검출기 정렬 오차가 증가함에 따라 광절정위치는 약 400 mV에서 약 250 mV로 감소하였다. 또한, 에너지분해능은 11.6%에서 16.2%로, 시간분해능은 477 ps에서 632 ps로 저하되었다. 이 결과는 검출기 정렬 오차가 TOF-PET 검출기 성능저하에 큰 영향성을 내포함을 시사한다.

• 한국항공우주학회지
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• 제30권6호
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• pp.92-100
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• 2002

본 연구에서는 천음속 미소교란 방정식을 이용하여 조종면의 강제 조화 운동을 고려한 전기체 형상에 대하여 천음속/초음속 비선형 플러터 특성을 파악할 수 있는 정밀 해석 시스템을 개발하였다. 본 시스템에는 충격파의 비선형 특성을 고려하기 위해 전산구조동역학, 유한요소해석 및 전산유체역학 기법을 동시에 연계하여 적용하는 연계시간 적분법을 도입하였다. 복잡한 전기체 형상에 대한 효과적인 격자생성을 위해 자체 자동격자 생성프로그램이 개발되었다. 천음속과 초음속 속도 영역에서 전기체 항공기에 대한 정적/동적 공탄성 특성을 고찰하였으며, 시간 영역에서 조종면 강제 조화운동에 대한 플러터 비행시험 시뮬레이션 결과들을 제시하였다.

• 한국소음진동공학회논문집
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• 제21권12호
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• pp.1120-1131
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• 2011

Researches using time reversal acoustics(TRA) for impact localization have been paid attention to recently. Dispersion characteristics of Lamb waves, which restrict the utility of classical nondestructive evaluation based on time-of-flight information, can be compensated through the application of TRA to Lamb waves on a plate. This study investigates the spatial focusing performance of time reversal Lamb waves on a plate using finite element analysis. In particular, the virtual sensor effect caused by multiple wave reflections at the boundaries of a plate is shown to enable the spatial focusing of Lamb waves though a very small number of surface-bonded piezoelectric(PZT) sensors are available. The time window size of forward response signals, are normalized with respect to the number of virtual active sensors. Then their effects on the spatial focusing performance of Lamb waves are investigated.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2011년도 추계학술대회 논문집
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• pp.418-429
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• 2011

Researches using time reversal acoustics (TRA) for impact localization have been paid attention to recently. Dispersion characteristics of Lamb waves, which restrict the utility of classical nondestructive evaluation based on time-of-flight information, can be compensated through the application of TRA to Lamb waves on a plate. This study investigates the spatial focusing performance of time reversal Lamb waves on a plate using finite element analysis. In particular, the virtual sensor effect caused by multiple wave reflections at the boundaries of the plate is shown to enable the spatial focusing of Lamb waves though a very small number of surface-bonded piezoelectric (PZT) sensors are available. The time window size of forward response signals, are normalized with respect to the number of virtual active sensors. Then their effects on the spatial focusing performance of Lamb waves are investigated.