• 상하수도학회지
• /
• 제26권6호
• /
• pp.871-881
• /
• 2012

This study suggested a model that can predict a degradation condition over time of two plastic pipes, PE and PVC, which are currently used in the country. This study was analyzed physical characteristics change of plastic pipes by comparison with initial physical characteristics (on the case of new pipes). Since this is dependent on accidents that already occurred, there are limitations that it only decides a priority on improvement based on relative corrosion status rather than precautionary aspects. The comparison results between physical degradation by the deducted performance rating and a conventional numerical scoring method showed that correlation coefficient was 0.67 for PE pipes and 0.86 for PVC pipes, indicating a high correlation. According to this result, it has been decided that the performance rating suggested herein can be applied naturally to the criterion of an improvement decision, which was based on Scoring System. From results of the research, it is expected that a reliable result can be provided to an improvement decision process related to degradation of plastic pipes by comprehensively comparing and evaluating a condition of pipe materials(direct factors) and an environmental impact(indirect factors).

• Membrane and Water Treatment
• /
• 제5권4호
• /
• pp.235-250
• /
• 2014

The impacts of membrane degradation due to chlorine attack on the rejection of inorganic salts and trace organic contaminants by nanofiltration (NF) and reverse osmosis (RO) membranes were investigated in this study. The rejection of trace contaminants was examined at environmentally relevant concentrations. Changes in the membrane surface morphology were observed as a result of chlorine exposure. A small increase in rejection was consistently observed with all four membranes selected in this study after being exposed to a low concentration of hypochlorite (100 ppm). In contrast, a higher concentration of hypochlorite (i.e., 2000 ppm) could be detrimental to the membrane separation capacity. Membranes with severe chlorine impact showed a considerable decrease in rejection over filtration time, possibly due to rearrangement of the polyamide chains under the influence of chlorine degradation and filtration pressure. The reported results indicate that loose NF membranes are more sensitive to chlorine exposure than RO membranes. The impact of hypochlorite exposure (both positive and negative) on rejection is dependent on the strength of the hypochlorite solution and is more significant for the neutral carbamazepine compound than the negatively charged sulfamethoxazole.

• 대한한의학회지
• /
• 제22권3호
• /
• pp.63-73
• /
• 2001

Objectives : The objective of the current study is to determine the protective effect of Ukyium(Yougui-yin) on the apoptosis induced by zinc. Methods : Zinc is known to generate reactive oxygen species (ROS), including superoxide anion ($O_2$) and hydrogen peroxide ($H_2O_2$), which eventually contribute to cytotoxicity in a variety of cell types. We investigated the viablity of cells, $H_2O_2$ generation, chromatin condensation and nuclear fragmentation in Hoechst dye staining and $IkB-{\alpha}$ degradation in C6 glial cells of $ZnCl_2$ between pretreatment- and not pretreatment-group with Ukyium. The former methods were researched by Time- and Dose-dependent manners. Results : We demonstrated that pretreatment with Ukyium prevented zinc-induced cell death of C6 glial cells and apoptotic characteristics including chromatin condensation and nuclear fragmentation. Ukyium also prevented $H_2O_2-induced$ cell death. We further confirmed that Ukyium decreased zinc-induced generation of $H_2O_2$ and inhibited degradation of $IkB-{\alpha}$ by zinc in C6 glial ceHs. Conclusions : These data indicated that Ukyium (Yougui-yin) prevents zinc-induced apoptotic death of C6 glial cells via inhibition of ROS generation, such as $H_2O_2$ as well as inhibition of $IkB-{\alpha}$ degradation.

• 대한구강악안면병리학회지
• /
• 제41권1호
• /
• pp.1-7
• /
• 2017

Lycorine, a natural alkaloid extracted from the Amaryllidaceae plant family, was reported to various physiological and pharmacological effects including anti-cancer activity. Nevertheless, there is no report of the anticancer effect of lycorine in oral cancer cells. The effects of lycorine on cell proliferation and apoptosis were examined through trypan blue exclusion assay, 4'-6-diamidino-2-phenylindole (DAPI) stain, Live/Dead assay, Western blot analysis and RT-PCR. Lycorine suppressed cell viability and induced apoptosis in MC3 and HSC-3 cell lines. Lycorine decreased survivin protein but did not affect its mRNA. It regulated survivin through accelerating protein degradation in a time-dependent manner although neither proteasome nor lysosome was not associated with lycorine-mediated protein degradation. Collectively, our results suggest that lycorine may be a potential therapeutic anti-cancer drug candidate for the treatment of human oral cancer.

• Structural Engineering and Mechanics
• /
• 제34권2호
• /
• pp.189-211
• /
• 2010

The behaviour of a reinforced concrete tension member is governed by the contribution of concrete between cracks, tension stiffening effect. Under highly repeated loading, this contribution is progressively reduced and the member response approximates that given by the fully cracked member. When focusing on the unloaded state, experiments show deformations larger than those of the naked reinforcement. This has been referred to as negative tension stiffening and is due to the fact that concrete carries compressive stresses along the crack spacing, even thought the tie is subjected to an external tensile force. In this paper a cycle-dependent approach is presented to reproduce the behaviour of the axially loaded tension member, paying attention to the negative tension stiffening contribution. The interaction of cyclic bond degradation and time-dependent effects of concrete is investigated. Finally, some practical diagrams are given to account for the negative tension stiffening effect in reinforced concrete elements.

• Journal of the Korean Physical Society
• /
• 제73권11호
• /
• pp.1675-1678
• /
• 2018

Methylammonium lead halide ($MAPbI_3$) perovskites are considered as promising materials owing to their excellent optical and electrical properties. However, perovskite materials suffer from degradation in air, which limits their practical applications. Here, we demonstrate successful passivation of the $MAPbI_3$ photodetectors through monochloro-para-xylylene (Parylene-C) deposition. The time-dependent photocurrent characteristics were systematically investigated, and we achieved significantly improved device performance and stability with Parylene-C passivation. Based on the excitation-power-dependent photoluminescence (PL) data, we confirmed that Parylene-C can reduce the carrier losses in $MAPbI_3$, leading to the enhancement of photocurrent and PL in $MAPbI_3$ photodetectors.

• International Journal of Naval Architecture and Ocean Engineering
• /
• 제6권3호
• /
• pp.507-528
• /
• 2014

In the ship and offshore structure design, age-related problems such as corrosion damage, local denting, and fatigue damage are important factors to be considered in building a reliable structure as they have a significant influence on the residual structural capacity. In shipping, corrosion addition methods are widely adopted in structural design to prevent structural capacity degradation. The present study focuses on the historical trend of corrosion addition rules for ship structural design and investigates their effects on the ultimate strength performance such as hull girder and stiffened panel of double hull oil tankers. Three types of rules based on corrosion addition models, namely historic corrosion rules (pre-CSR), Common Structural Rules (CSR), and harmonised Common Structural Rules (CSR-H) are considered and compared with two other corrosion models namely UGS model, suggested by the Union of Greek Shipowners (UGS), and Time-Dependent Corrosion Wastage Model (TDCWM). To identify the general trend in the effects of corrosion damage on the ultimate longitudinal strength performance, the corrosion addition rules are applied to four representative sizes of double hull oil tankers namely Panamax, Aframax, Suezmax, and VLCC. The results are helpful in understanding the trend of corrosion additions for tanker structures.

• Advances in materials Research
• /
• 제1권4호
• /
• pp.245-268
• /
• 2012

Results of isothermal torsional oscillation tests are reported on melts of linear low density polyethylene and isotactic polypropylene. Prior to rheological tests, specimens were annealed at various temperatures ranging from $T_a$ = 180 to $310^{\circ}C$ for various amounts of time (from 30 to 120 min). Thermal treatment induced degradation of the melts and caused pronounced decreases in their molecular weights. With reference to the concept of transient networks, constitutive equations are developed for the viscoelastic response of polymer melts. A melt is treated as an equivalent network of strands bridged by junctions (entanglements and physical cross-links). The time-dependent response of the network is modelled as separation of active strands from and merging of dangling strands with temporary nodes. The stress-strain relations involve three adjustable parameters (the instantaneous shear modulus, the average activation energy for detachment of active strands, and the standard deviation of activation energies) that are determined by matching the dependencies of storage and loss moduli on frequency of oscillations. Good agreement is demonstrated between the experimental data and the results of numerical simulation. The study focuses on the effect of molecular weight of polymer melts on the material constants in the constitutive equations.

• Structural Engineering and Mechanics
• /
• 제19권5호
• /
• pp.581-602
• /
• 2005

In this paper the accumulation of local damage during the cyclic loading in reinforced high-strength concrete columns is experimentally investigated. Two identical column specimens with annular cross-section and spiral reinforcement were designed and two tests, up to failure, under the action of a constant vertical concentrated force and a time-dependent concentrated horizontal force, were carried out at the LNEC shaking tables facility. Sine type signals, controlled in amplitude, frequency and time duration were used for these experiments. The concept of local damage based on local stiffness degradation is considered in detail and illustrated by experimental results. The specimens were designed and reinforced in such a way that the accumulation of damage was predicted by dominating deformations (cracking and crushing of the concrete) while the increasing of the loading values was a dominating factor of damage. It was observed that the local damage of HSC columns has exposed their anisotropic local behaviour. The damage accumulation was slightly different from the expected in accordance with the continuum damage concept, and a partial random character was observed.

• Archives of Pharmacal Research
• /
• 제28권1호
• /
• pp.68-72
• /
• 2005

Pseudolaric acid B is a major compound found in the bark of Pseudolarix kaempferi Gordon. In our study, pseudolaric acid B inhibited growth of human melanoma cells, A375-S2 in a time and dose-dependent manner. A375-S2 cells treated with pseudolaric acid B showed typical characteristics of apoptosis including morphologic changes, DNA fragmentation, sub-diploid peak in flow cytometry, cleavage of poly-ADP ribose polymerase (PARP) and degradation of inhibitor of caspase-activated DNase (ICAD). P53 protein expression was upregulated while cells were arrested at the $G_2/M$ phase of the cell cycle. There was a decrease in the expression of anti-apoptotic Bcl-2 and Bcl-xL proteins, whereas pro-apoptotic Bax was increased. The two classical caspase substrates, PARP and ICAD, were both decreased in a time-dependent manner, indicating the activation of downstream caspases.