• BMB Reports
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• 제54권2호
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• pp.136-141
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• 2021

Thyroid eye disease (TED) is a complex autoimmune disease with a spectrum of signs. we previously reported that trisialoganglioside (GT)1b is significantly overexpressed in the orbital tissue of TED patients, and that exogenous GT1b strongly induced HA synthesis in orbital fibroblasts. However, the signaling pathway in GT1b-induced hyaluronic acid synthase (HAS) expression in orbital fibroblasts from TED patients have rarely been investigated. Here, we demonstrated that GT1b induced phosphorylation of Akt/mTOR in a dose-dependent manner in orbital fibroblasts from TED patients. Both co-treatment with a specific inhibitor for PI3K and siRNA knockdown of TLR2 attenuated GT1b-induced Akt phosphorylation. GT1b significantly induced HAS2 expression at both the transcriptional and translational level, which was suppressed by specific inhibitors of PI3K or Akt/mTOR, and by siRNA knockdown of TLR2. In conclusion, GT1b induced HAS2 in orbital fibroblasts from TED patients via activation of the PI3K-related signaling pathway, dependent on TLR2.

• 대한치과의사협회지
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• 제51권9호
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• pp.511-517
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• 2013

To assess the association between oral health and general health, this study examined the relationship between chewing difficulty and twelve chronic health conditions such as hypertension, hyperlipidemia, diabetes, cerebro- and cardiovascular disease, musculoskeletal disease, respiratory disease, eye/nose/throat disease, stomach/intestinal ulcer, renal dysfunction, thyroid disease, depression, and cancer in Korea. The study population was 3,066 elders aged 65 years old and more from the fourth Korean National Health and Nutrition Examination Survey. Chewing difficulty was measured on a 5-point Likert scale. Chronic conditions were assessed by self-reported questionnaire. Confounders were age, gender, education, income, smoking, drinking, and obesity. Chi-square test, general linear model, and multiple logistic regression model were done with complex sampling design. Musculoskeletal disease (adjusted odds ratio=1.33), respiratory disease (adjusted odds ratio=1.52), and cancer (adjusted odds ratio=1.58) were independently associated with chewing difficulty. Multiple chronic conditions with more than 4 chronic disease showed significant association with chewing difficulty (adjusted odds ratio=1.37).

• Tuberculosis and Respiratory Diseases
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• 제62권5호
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• pp.417-420
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• 2007

저자들은 사르코이드증 환자에서 그레이브스병이 동반된 1예를 경험하였으며 이는 아직 국내에서 보고된 바 없기에 문헌고찰과 함께 보고하는 바이다.

• 한국건강관리협회지
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• 제2권3호
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• pp.73-96
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• 2004

Along with a development of medical technology, a variety of tests, such as laboratory tests, x-ray and endoscopies are being used in health screening tests. As the tests determine the quality of health screening, test items and methods should be carefully selected. This study was to get hold of the test items of major health screening programs in Korea Most of the health screening programmes focused upon detection of risk factors and diagnosis of life - style related diseases (diabetes, hypertension, cardiovascular diseases, hypercholesterolemia, overweight, drinking, smoking, cerebrovascular diseases, osteoporosis) ,cancers (stomach, cervix, lung, breast, liver, colon, prostate, ovary, pancreas, thyroid, esophagus) , infectious diseases (hepatitis, tuberculosis, sexually-transmitted diseases, parasites) , chronic obstructive respiratory diseases, chronic renal diseases (bacteriuria hematuria, proteinuria) , anemia, glaucoma, hearing loss, Alzheimer disease, stress, early psychiatric diseases. The health screening tests were basic physical examination, basic laboratory tests (CBC, urinalysis, liver function tests, lipid tests, glucose, HbAlc, uric acid, electrolytes, serological tests (HBsAg, HBs-Ab, HCV-Ab, HIV-Ab, VDRL) EKG, x-ray (chest PA, CT) , endoscopy (gastroscopy, colonoscopy) , sonography(abdomen, thyroid, pelvis, breast) ,cytology (cervix) , bone density, tumor markets (NMP22, alpha-FP, CEA, CA-19-9, CA12S, PSA) and eye tests. Advanced technologies, like CT, PET, MRI, MRT/Angio, molecular testings) were widely used in hospital health screening programmes .In summary, a variety of tests were utilized in health screening in Korea. Those tests were utilized by stages or according to sex and age in most of health screening programmes, however a few program used tests to excess disregarding health screening subjects.

• 한국건강관리협회지
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• 제2권1호
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• pp.9-25
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• 2004

Along with a development of medical technology, a variety of tests, such as laboratory tests, x-ray and endoscopies are being used in health screening tests. As the tests determine the quality of health screening, test items of major health screening program in Korea. Most, of the health screening programmes focused upon detection of risk factors and diagnosis of life-style related diseases(diabetes, hypertension, cardiovascular diseases, hypercholesterolemia, overweight, drinking, smoking, cerebrovascular diseases, osteoporosis), cancers(stomach, cervix, lung, breast, liver, colon, prostate, ovary, pancreas, thyroid, esophagus), infections diseases(hepatitis, tuberculosis, sexually-transmitted diseases, parasites), chronic obstructive respiratory diseases, chronic renal diseases(bacteriuria, hematuria, proteinuria), anemia, glaucoma, hearing loss, Alzheimer disease, stress and earlypsychiatric diseases. The health screening tests were basic physical examination, basic laboratory tests( CBC, urinalysis, liver function tests, lipid tests, glucose, HbA1c, uric acid, electrolytes, serological tests(HBsAg, HBs-Ab, HCV-Ab, HIV-Ab, VDRL) EKG, x-ray(chest PA, CT) endoscopy(gastroscopy, colonoscopy), sonography (abdomen, thyroid, pelvis, breast), cytology(cervix), bone density, tumor markers(NMP22, alpha-FP, CEA, CA-19-9, CA125, PSA and eye tests. Advanced technologies, like CT, PET, MRI, MRI/Angio, molecular testing were widly used in hospital based health screening programmes. In summary, a variety of tests were untilized in health screening in Korea. Those tests were utilized by stages or according to sex and age in most of health screening programmes, however a few programs used tests excessvely disregarding health screening subjects.

• 한국건강관리협회지
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• 제2권2호
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• pp.215-230
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• 2004

Along with a development of medical technology, a variety of tests, such as laboratory tests, x-ray and endoscopies are being used in health screening tests. As the tests determine the quality of health screening, test items and methods should be carefully selected. This study was to get hold of the test items of major health screening programs in Korea. Most of the health screening programmes focused upon detection of risk factors and diagnosis of life-style related diseases(diabetes, hypertension, cardiovascular diseases, hypercholesterolemia, overweight, drinking, smoking, cerebrovascular diseases, osteoporosis) ,cancers(stomach, cervix, lung, breast, liver, colon, prostate, ovary, pancreas, thyroid, esophagus), infectious diseases (hepatitis, tuberculosis, sexually-transmitted diseases, parasites),chronic obstructive respiratory diseases, chronic renal diseases(bacteriuria, hematuria, proteinuria), anemia, glaucoma, hearing loss, Alzheimer disease, stress, early Psychiatric diseases. The health screening tests were basic physical examination, basic laboratory tests(CBC, urinalysis, liver function tests, lipid tests, glucose, HbAlc, uric acid, electrolytes, serological tests(HBsAg, HBs-Ab, HCV-Ab, HIV-Ab, VDRL) EKG, x-ray(chest PA, CT), endoscopy (gastroscopy, colonoscopy) , sonography(abdormen, thyroid, pelvis, breast) , cytology(cervix) ,bone density, tumor markers(NMP22, alpha-FP, CEA, CA-19-9, CA12S, PSA) and eye tests. Advanced technologies, like CT, PET, MIRI, MIRI/Angio, molecular testings) were widely usedin hospital health screening programmes. In summary, a variety of were utilized by stages or programmes, however a few subjects. tests were utilized in health screening in Korea. Those tests according to sex and age in most of health screening program used tests to excess disregarding health screening subject.

• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2017년도 춘계학술대회
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• pp.175-178
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• 2017

안와 내에서 안구의 상대적 위치는 여러 병적인 상태를 짐작할 수 있는 하나의 기준이 될 수 있다. 특히 안와골절, 갑상선 안질환, 안와 종양 등의 진단과 이에 약물 및 수술적 치료의 결과를 판단하는데 유용하다. 현재 안구 돌출값을 측정하기 위해 주로 사용되는 대표적 측정 기기인 Hertel 안구돌출계와 Naugle 안구돌출계 등은 측정자에 의한 오차가 필연적이다. 본 논문에서는 안구 돌출값의 측정을 3차원 영상 측정기술인 백색광 간섭계를 이용하여 검사 정밀도 및 반복정도를 크게 올릴 수 있는 자동화 측정 방법에 대한 연구를 제안하고자 한다.

• 한국방사선학회논문지
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• 제16권7호
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• pp.843-849
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• 2022

본 연구에서는 감마나이프를 이용한 방사선 수술 시 주변 정상 장기들의 피폭선량을 측정하여 2차 발암확률을 분석하고자 한다. 인체 조직 등가 물질로 구성된 소아 팬텀(Model 706-G, CIRS, USA)에 종양 볼륨은 0.25 cm³, 0.51 cm³, 1.01 cm³, 2.03 cm³ 총 4개로 설정하였으며, 평균 선량은 18.4 ± 3.4 Gy로 하였다. 감마나이프 수술 장비의 테이블위에 Rando phantom을 설치한 후에 OSLD nanoDot 선량계를 Right eye, Left eye, Thyroid, Thymus gland, Right lung, Left lung 에 위치시켜 각각의 피폭선량을 측정하였다. 청신경초종질환의 감마나이프 방사선 수술 시 주변 정상 장기들의 방사선 피폭으로 인한 암 발생확률은 종양 볼륨 2. 03 cm³에서 100,000명 당 4.08명의 암이 발생함을 알 수 있다. 본 연구는 정위적 방사선 수술 시 발생할 수 있는 2차 방사선 피폭선량의 위험성을 연구하여 향후 확률적 영향과 관련하여 유용한 자료로 활용될 것으로 사료된다.

• 한국정보통신학회논문지
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• 제23권1호
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• pp.63-69
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• 2019

안와 내에서 안구의 상대적 위치는 여러 병적인 상태를 짐작할 수 있는 하나의 기준이 될 수 있다. 특히 안와골절, 갑상선 안질환, 안와 종양 등의 진단과 이에 약물 및 수술적 치료의 결과를 판단하는데 유용하다. 현재 안구 돌출 값을 측정하기 위해 주로 사용되는 대표적 측정 기기인 Hertel과 Naugle 안구돌출계 등은 검사자가 다를 경우, 같은 검사자가 반복적으로 측정하더라도 검사할 때마다 안와의 고정부위가 달라지는 현상, 또한 동일한 안구돌출계라고 하더라도 제조 회사가 다르다면 안와의 고정부위 디자인이 달라 검사자에 의한 측정 오차 발생이 필연적이다. 본 논문에서는 백색광 간섭계를 이용한 안구 돌출 측정 장치를 설계 및 제작하고 실제 사람의 안구 돌출을 측정하여 수동식 측정 방법에 비해 정밀도 및 반복 정도가 크게 높아진 것을 확인하였다.

• 한국정보통신학회논문지
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• 제21권12호
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• pp.2341-2346
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• 2017

안와 내에서 안구의 상대적 위치는 여러 병적인 상태를 짐작할 수 있는 하나의 기준이 될 수 있다. 특히 안와골절, 갑상선 안질환, 안와 종양 등의 진단과 이에 약물 및 수술적 치료의 결과를 판단하는데 유용하다. 현재 안구 돌출 값을 측정하기 위해 주로 사용되는 대표적 측정 기기인 Hertel과 Naugle 안구돌출계 등은 검사자가 다를 경우, 같은 검사자가 반복적으로 측정하더라도 검사할 때마다 안와의 고정부위가 달라지는 등 측정자에 의한 오차가 필연적이다. 또한 동일한 안구 돌출 계라고 하더라도 제조 회사가 다르다면 안와의 고정부위 디자인이 달라 검사자에의한 측정 오차가 발생한다. 본 논문에서는 안구돌출값의 측정을 3차원 영상 측정기술인 백색광 간섭계를 이용하여 검사 정밀도 및 반복 정도를 크게 올릴 수 있는 자동 측정 방법에 대한 연구를 제안하고자 한다.