• Journal of Chest Surgery
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• 제27권6호
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• pp.497-501
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• 1994

We have experienced a case of primary thymic carcinoma. A 39 year old female patient admitted with incidentally detected mediastinal mass on chest film.The tumor showed invasion to surrounding tissues and the mediastinal lymphadenopathies were also noted. Invasion to contiguous mediastinal structures made complete surgical extirplation impossible and the biposy findings revealed primary thymic carcinoma. Primary thymic carcinoma is a rare neoplasm originating from the thymic epithelial cells. Clinical behavior of the thymic carcinoma is much different from it`s benign counterpart and several pathologic variants were reported.

• 대한세포병리학회지
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• 제2권1호
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• pp.36-42
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• 1991

We report 4 cases of malignant thymoma which were composed of 2 cases of invasive thymoma and 2 cases of thymic carcinoma. The cytologic findings of invasive thymoma were similar to those of benign thymoma. The distinctive cytologic features of thymic carcinoma were necrotic background, irregular clusters and individually scattered arrangement of anaplastic epithelial cells, and some scattered mature small lymphocytes. These findings may be found in the Hodgkin's lymphoma, seminoma, and metastatic squamous ceil carcinoma, undifferentiated carcinoma, and large ceil carcinoma of the lung. But, the feature of irregular clustering of anaplastic epithelial cell haying scanty cytoplasm was different from Hodgkin's lymphoma and seminoma. Clinical and radiologic findings as well as cytologic finding were helpful in differential diagnosis of thymic carcinoma from metastatic carcinoma.

• Tuberculosis and Respiratory Diseases
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• 제46권5호
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• pp.718-722
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• 1999

14세 여자 환자에서 무증상의 전종격동 낭성 종괴가 있어 절제적 생검을 시행하여 고분화성 흉선암종의 광범위한 낭성 변화로 확진되어 제1기의 흉선종을 완전 적출 후 방사선 치료 혹은 병합화학요법 없이 추후 흉부전산화단층촬영 예정으로 외래에서 경과 관찰 중인 1예를 경험하여 문헌 고찰과 함께 보고하는 바이다.

• 대한두경부종양학회지
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• 제19권1호
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• pp.75-79
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• 2003

Ectopic cervical thymic tumor, first described in 1941 by Boman, is a rare tumor of the neck displaying the same histologic features as mediastinal thymoma. It was classified into benign thymoma, invasive (or malignant) thymoma, thymic carcinoma histopathologically and clinically. The ectopic cervical thymic tumor is misdianosed as the thyroidal mass on radiologic examination and FNA cytology due to its rarity and unusual location. Recently, we have experienced two cases of ectopic cervical thymic tumor misdiagnosed as thyroid mass ; a case of thymic carcinoma;the other of invasive thymoma. So, we report these cases with review of the literature.

• Tuberculosis and Respiratory Diseases
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• 제62권1호
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• pp.67-70
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• 2007

흉선암종은 드문 종격동의 악성 종양으로서 흉선상피세포에서 기원하지만 흉선종과는 조직학적 특징이 다르다. 흉선종이 자가면역질환을 종종 동반하는데 반해 흉선암종에서 자가면역질환이 동반되는 예는 드물다. 국내에서는 흉선암종과 자가면역질환이 동반된 예가 보고된 적이 없는데 저자들은 전신 근육통을 주소로 내원한 49세 남자 환자가 전신홍반루프스와 흉선암종을 동시에 진단받고 항암치료를 시작한 1예를 경험하였기에 문헌 고찰과 함께 보고하는 바이다.

• 대한핵의학회지
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• 제37권4호
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• pp.260-261
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• 2003

Tc-99m methoxyisobutylisonitrile (MIBI) and Tl-201/technetium subtraction scintigraphy have been used for localization of abnormal parathyroid gland. The uptake mechanism of tracers has been postulated to be increased cellular density and vascularity, or dependent on the presence of mitochondria-rich cells. However, the uptake of these tracers was not specific for abnormal parathyroid gland. The author report a case of thymic carcinoma that would have been mistaken for carcinoma of parathyroid because of Tc-99m MIBI and Tl-201 uptake.

• Asian Pacific Journal of Cancer Prevention
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• 제13권6호
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• pp.2745-2748
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• 2012

Aims: To study KIT (CD117) expression in thymic epithelial tumors in China, and investigate diagnostic and clinical significance. Material and Methods: Thymic epithelial tumors (TETs) from 102 patients (3 type A, 29 type AB, 5 type B1, 22 type B2, 29 typeB3 and 16 thymic carcinomas) were examined. Immunohistochemical staining with an antic-kit monoclonal antibody was performed on a tissue microarray. Relationships between KIT positive expression and the TET clinical characteristics (WHO histologic classification and Masaoka stage system) were analysed. Results: The KIT positive expression rate was significantly higher in thymic carcinoma (60%, 9/16) than in thymoma (8%, 7/86), a strong correlation being found with the WHO classification, but not the Masaoka tumor stage. The overall survival for patients with KIT positive lesions was significantly worse. Conclusions: KIT is a good molecule marker to differentially diagnose thymic carcinoma from thymoma, while also serving as a predictor of prognosis for TETs. Further research into KIT mutations in Chinese TETs should be conducted to assess the efficacy of targeted therapy.

• Radiation Oncology Journal
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• 제31권3호
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• pp.131-137
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• 2013

Purpose: We evaluated treatment outcomes of thymic carcinomas to determine prognostic factors for survival. Materials and Methods: Between May 1988 and May 2009, 41 patients had pathologic diagnosis of thymic carcinoma in Seoul National University Hospital, Seoul, Korea. Of these, 40 patients were followed up to 188 months after treatment. The mean age of all patients was 58.3 years and male to female ratio was 23 to 17. Results: Among 30 patients who underwent surgical resection, 26 achieved R0 resection and postoperative radiotherapy (PORT) was performed in 22 patients (73%). Various chemotherapeutic regimens were given with local treatment modalities, surgery and/or radiotherapy, in 12 patients. The 5-year locoregional control (LRC), distant metastasis-free survival, progression-free survival (PFS), and overall survival were 79.4%, 53.0%, 42.6%, and 63.6%, respectively. Patients with Masaoka stage I or II showed excellent prognosis of 5-year PFS around 90%. In advanced stages, invasion of the great vessels or atrium by thymic carcinomas was negative prognostic factor for PFS in univariate analysis. Lymph node involvement was statistically significant factor for LRC and PFS. Local or regional recurrence was infrequent after surgical resection followed by PORT, while distant metastasis was the major component of treatment failure. Conclusion: Complete resection followed by PORT provided remarkable local control without severe acute toxicities in patients with stage II and favorable stage III thymic carcinoma. Invasion of the great vessels or atrium was statistically significant prognostic factor for PFS.

• Nuclear Medicine and Molecular Imaging
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• 제41권3호
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• pp.255-257
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• 2007

A 59-year-old man with thymic carcinoma underwent Tc-99m MIBI myocardial SPECT, and Tc-99m MIBI uptake in the mass was unexpectedly found in a planar image. SPECT images of the thorax showed an increased uptake area with central photon deficiency (a ring-like appearance), which reflected central tumor irreversible ischemia or progressing necrosis with peripheral viable tumor tissue.

• 대한한방내과학회지
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• 제32권3호
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• pp.458-464
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• 2011

Background : Advanced thymic cancer still remains as an intractable disease. The survival rate of advanced thymic cancer could be increased through chemotherapy and radiation, but the results have not been satisfactory. Objectives : To see whether wheel balanced therapy (WBT) has the therapeutic effects or not on advanced thymic cancer patient. Methods : A patient diagnosed with progression of thymic carcinoma with pleura metastasis visited the East-West Cancer Center (EWCC) on Feb 9th, 2011. The patient was treated with WBT for a period of 9 weeks from Feb 9th to Apr 16th. She stayed 6 weeks in hospital and took oriental medicine prescribed by EWCC. Computed tomography (CT) and blood test were used to evaluate the disease progression of the patient. Results : Mass of chest CT was stable for 2 months. The patient's quality of life improved during her hospital stay. Conclusions : This case study supports WBT may have efficacy in treating advanced thymic cancer patients.