• Asian-Australasian Journal of Animal Sciences
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• v.33 no.3
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• pp.382-389
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• 2020

Objective: This study was conducted to test the efficiency of genomic selection for milk production traits in a Korean Holstein cattle population. Methods: A total of 506,481 milk production records from 293,855 animals (2,090 heads with single nucleotide polymorphism information) were used to estimate breeding value by single step best linear unbiased prediction. Results: The heritability estimates for milk, fat, and protein yields in the first parity were 0.28, 0.26, and 0.23, respectively. As the parity increased, the heritability decreased for all milk production traits. The estimated generation intervals of sire for the production of bulls (L_SB) and that for the production of cows (L_SC) were 7.9 and 8.1 years, respectively, and the estimated generation intervals of dams for the production of bulls (L_DB) and cows (L_DC) were 4.9 and 4.2 years, respectively. In the overall data set, the reliability of genomic estimated breeding value (GEBV) increased by 9% on average over that of estimated breeding value (EBV), and increased by 7% in cows with test records, about 4% in bulls with progeny records, and 13% in heifers without test records. The difference in the reliability between GEBV and EBV was especially significant for the data from young bulls, i.e. 17% on average for milk (39% vs 22%), fat (39% vs 22%), and protein (37% vs 22%) yields, respectively. When selected for the milk yield using GEBV, the genetic gain increased about 7.1% over the gain with the EBV in the cows with test records, and by 2.9% in bulls with progeny records, while the genetic gain increased by about 24.2% in heifers without test records and by 35% in young bulls without progeny records. Conclusion: More genetic gains can be expected through the use of GEBV than EBV, and genomic selection was more effective in the selection of young bulls and heifers without test records.

• Journal of Korean Society of Environmental Engineers
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• v.38 no.9
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• pp.521-527
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• 2016

Nanoscale zero valent iron (nZVI) has been intensively studied for the treatment of a plethora of pollutants through reductive reaction, however, the nano size should be of concern when nZVI is considered for water treatment, due to difficulties in recovery. The loss of nZVI causes not only economical loss, but also potential risk to human health and environment. Thus, the immobilization onto coarse or structured support is essential. In this study, two representative processes for nZVI immobilization on granular activated carbon (GAC) were evaluated, and optimized conditions for synthesizing Fe/GAC composite were suggested. Both total iron content and $Fe_0$ content can be significantly affected by preparation processes, therefore, it was important to avoid oxidation during preparation to achieve higher reduction capacity. Synthesis conditions such as reduction time and existence of intermediate drying step were investigated to improve $Fe_0$ content of Fe/GAC composites. The optimal condition was two hours of $NaBH_4$ reduction without intermediate drying process. The prepared Fe/GAC composite showed synergistic effect of the adsorption capability of the GAC and the degradation capability of the nZVI, which make this composite a very effective material for environmental remediation.

• Journal of Korea Technology Innovation Society
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• v.14 no.4
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• pp.833-859
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• 2011

This study aims to draw the characteristics of the regional operation system of the shared research instrument service, which contributes to the R&D investment efficiency by the avoidance of duplicated research instrument investment and the enhancement of the network collaboration. So from the perspective of technology infrastructure policy and regional innovation system, Gyeonggi region of Korean metropolitan area has been analyzed for the case study. The case study has been conducted by 2 step process of within-case analysis and cross-case analysis. Firstly, the characteristics of operation system of the shared research instrument have been examined through various research methods. Secondly, in the cross-case analysis, the examined issues and problems have been organized by the matrix of 3 organizational governance characteristics and 4 issues to facilitate the regional policy approach. The issues deducted by the cross-case analysis have been deducted as (1) 'usage fee charge system', 'relevant method for the performance index and measurement of the instrument service management' for the regional policy led case, (2) 'performance management issue', 'financial and managerial accounting system for the instrument operating division', and 'change of budget support scheme' for the joint operation case and lastly (3) 'usage facilitation after the expiration of research lab support project' for the university led case.

• Nutrition Research and Practice
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• v.14 no.5
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• pp.438-452
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• 2020

BACKGROUND/OBJECTIVES: Brain senescence causes cognitive impairment and neurodegeneration. It has also been demonstrated that curcumin (Cur) and hesperetin (Hes), both antioxidant polyphenolic compounds, mediate anti-aging and neuroprotective effects. Therefore, the objective of this study was to investigate whether Cur, Hes, and/or their combination exert anti-aging effects in D-galactose (Dg)-induced aged neuronal cells and rats. MATERIALS/METHODS: SH-SY5Y cells differentiated in response to retinoic acid were treated with Cur (1 μM), Hes (1 μM), or a combination of both, followed by 300 mM Dg. Neuronal loss was subsequently evaluated by measuring average neurite length and analyzing expression of β-tubulin III, phosphorylated extracellular signal-regulated kinases, and neurofilament heavy polypeptide. Cellular senescence and related proteins, p16 and p21, were also investigated, including their regulation of antioxidant enzymes. In vivo, brain aging was induced by injecting 250 mg/kg body weight (b.w.) Dg. The effects of supplementing this model with 50 mg/kg b.w. Cur, 50 mg/kg b.w. Hes, or a combination of both for 3 months were subsequently evaluated. Brain aging was examined with a step-through passive avoidance test and apoptosis markers were analyzed in brain cortex tissues. RESULTS: Cur, Hes, and their combination improved neuron length and cellular senescence by decreasing the number of β-gal stained cells, down-regulated expression of p16 and p21, and up-regulated expression of antioxidant enzymes, including superoxide dismutase 1, glutathione peroxidase 1, and catalase. Administration of Cur, Hes, or their combination also tended to ameliorate cognitive impairment and suppress apoptosis in the cerebral cortex by down-regulating Bax and poly (ADP-ribose) polymerase expression and increasing Bcl-2 expression. CONCLUSIONS: Cur and Hes appear to attenuate Dg-induced brain aging via regulation of antioxidant enzymes and apoptosis. These results suggest that Cur and Hes may mediate neuroprotective effects in the aging process, and further study of these antioxidant polyphenolic compounds is warranted.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.16 no.3
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• pp.1699-1706
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• 2015

The purpose of this study is to induce a indicator related to the response, handling and management which are appeared on each step of business enforcement in housing reconstruction projects. Then, it aims to appropriately and reasonably resolve the conflicts of reconstruction business with relevant subjects. These projects physician satisfaction and continual business was going to have the impact that any analysis of the structure in an evaluation. In addition, this study analyzes the impact structure on the business satisfaction and a intention for continuous business through this evaluation. This study sets a operational hypothesis in order to verify the relationship between the variables. then, it creates the structural model by using the Smart PLS 3.0. After analyzing the impact structure by using total 252 samples, this study adopts the final hypothesis which shows (+) path coefficient as set in the hypothesis and test statistic above 1.65. In result, six out of the nine hyphothesis are adopted. then, The 'Response to conflict' which affects the 'Management to conflict(H1)' has a path coefficient of 0.618. In addition, the 'Handling to conflict' which affects the 'Management to conflict(H2)' has a path coefficient of 0.150. The 'Handling to conflict' which affects the satisfaction of 'business' has a path coefficient of 0.101. and the 'management to conflict' which affects the satisfaction of 'business(H7)' has a path coefficient of 0.644. In addition, the 'Intention for continuous business(H8)' shows a path coefficient of 0.258. Finally, The satisfaction of 'business' which affects the 'intention for continuous business(H9)' has a path coefficient of 0.391.

• The Journal of Industrial Distribution & Business
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• v.8 no.6
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• pp.97-109
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• 2017

Purpose - This study aimed to investigate the effect of entrepreneurial temperament (ET) such as innovativeness, risk-taking, and proactiveness in entrepreneur's lifetime before start-up and the effect of social capital (SC) such as network ties and trustworthiness on entrepreneurial intention. Research design, data, and methodology - We examined the components of ET (innovativeness, risk-taking, and proactiveness) and components of SC (network ties and trustworthiness) through existing prior research and investigated the factors that affected entrepreneurial intention. The first hypothesis of this study was that entrepreneurial temperament will have a significant impact on network ties of social capital, and the second hypothesis assumed that entrepreneurial temperament will have a significant effect on the trustworthiness of social capital. Finally, the second hypothesis assumed that social capital will have a significant impact on entrepreneurial intentions. We collected 175 data using questionnaires for people who have not yet started a start-up. And we used the Structure Equation Modeling (SEM) to evaluate the collected data and to test the research model by the two step research procedure. Results - As a result, the innovativeness and proactiveness of ET have a significant effect on network ties and trustworthiness of SC, but the effect of risk-taking on risk-taking of SC is not significant. On the other hand, network ties and network ties of SC was revealed a significant effect on the EI. Conclusions - The implications of this article could be observed as mentioned in this paper. First, we found that entrepreneurial innovativeness and proactiveness are helpful in constructing SCs, but not risk-taking. These results demonstrated that ET of entrepreneurs is important factor in the formation of social capital. Second, the SC that an entrepreneur built before the start-up has a meaning for EI. In conclusion, ET was affected partially to EI mediated SC. It is academic in that ET and SC are independent from each other and have a mediating role between ET and EI, unlike those directly affecting EI. Although some important implications were found in this study, this study had some limitations and we hope that future research will be complemented.

• The Journal of the Korea Contents Association
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• v.15 no.4
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• pp.500-509
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• 2015

The purpose of this study is to induce a indicator related to the response, handling and management which are appeared on each step of business enforcement in Reconstruction projects. Then, it aims to appropriately and reasonably resolve the conflicts of reconstruction business with relevant subjects. These projects physician satisfaction and continual business was going to have the impact that any analysis of the structure in an evaluation. In addition, this study analyzes the impact structure on the business satisfaction and a intention for continuous business through this evaluation. This study sets a operational hypothesis in order to verify the relationship between the variables. then, it creates the structural model by using the Smart PLS 3.0. After analyzing the impact structure, this study adopts the final Five hypothesis which shows (+) path coefficient as set in the hypothesis and test statistic above 1.65. then, The 'Approval for union establishment(H1)' has a path coefficient of 0.127. In addition, the 'Approval for business enforcement(H2)' has a path coefficient of 0.343. The 'Management and disposition plan(H4)' has a path coefficient of 0.145. and the 'External Factors(H6)' has a path coefficient of 0.124. Finally, The 'satisfaction of business' which affects the 'intention for continuous business(H7)' has a path coefficient of 0.727.

• Journal of Microbiology and Biotechnology
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• v.20 no.9
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• pp.1331-1338
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• 2010

This study was designed to investigate the potentially protective effects of Curcuma longa Linn. extract (CLE) on carbon tetrachloride ($CCl_4$)-induced hepatotoxicity in rats. Male Sprague-Dawley rats were pretreated with 50 or 100mg/kg of CLE or 100mg/kg of butylated hydroxytoluene(BHT) for 14 days before $CCl_4$ administration. In addition, the CLE control group was pretreated with 100mg/kg CLE for only 14 days. Three hours after the final treatment, a single dose of $CCl_4$ (20mg/kg) was administrated intraperitoneally to each group. After the completion of this phase of the experiment, food and water were removed 12 h prior to the next step. The rats were then anesthetized by urethane and their blood and liver were collected. It was observed that the aspartate aminotransferase and alanine aminotransferase activities of the serum, and the hepatic malondialdehyde levels had significantly decreased in the CLE group when compared with the $CCl_4$-treated group. The antioxidant activities, such as superoxide dismutase, catalase, and glutathione peroxidase activities, in addition to glutathione content, had increased considerably in the CLE group compared with the $CCl_4$-treated group. Phase II detoxifying enzymes, such as glutathione S-transferase, were found to have significantly increased in the CLE group as opposed to the $CCl_4$-treated group. The content of Nrf2 was determined by Western blot analysis. Pretreated CLE increased the level of nuclear translocated Nrf2, and the Nrf2 then increased the activity of the antioxidant and phase II detoxifying enzymes. These results indicate that CLE has protective effects against $CCl_4$-induced hepatotoxicity in rats, via activities of antioxidant and phase II detoxifying enzymes, and through the activation of nuclear translocated Nrf2.

• Journal of Korea Multimedia Society
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• v.14 no.9
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• pp.1165-1174
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• 2011

In data broadcasting systems, servers continuously disseminate data items through broadcast channels, and mobile client only needs to wait for the data of interest to present on a broadcast channel. However, because broadcast channels are shared by a large set of data items, the expected delay of receiving a desired data item may increase. This paper explores the issue of designing proper data allocation on multiple broadcast channels to minimize the average expected delay time of all data items, and proposes a new data allocation scheme named two level bin-packing(TLBP). This paper first introduces the theoretical lower-bound of the average expected delay, and determines the bin capacity based on this value. TLBP partitions all data items into a number of groups using bin-packing algorithm and allocates each group of data items on an individual channel. By employing bin-packing algorithm in two step, TLBP can reflect a variation of access probabilities among data items allocated on the same channel to the broadcast schedule, and thus enhance the performance. Simulation is performed to compare the performance of TLBP with three existing approaches. The simulation results show that TLBP outperforms others in terms of the average expected delay time at a reasonable execution overhead.

• Korean Chemical Engineering Research
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• v.47 no.6
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• pp.715-719
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• 2009

The phase change electrode board for the bio-information detection through electrical property response of phase change material was developed in this study. We manufactured the electrode board using Aluminum first that is widely used in conventional semiconductor device process. Without further treatment, these aluminum electrodes tend to contain voids in PETEOS(plasma enhanced tetraethyoxysilane) material that are easily detected by cross-sectional SEM(Scanning Electron Microscope). The voids can be easily attacked and transformed into holes in between PETEOS and electrodes after etch back and washing process. In order to resolve this issue of Al electrode board, we developed a electrode board manufacturing method using low resistivity TiN, which has advantages in terms of the step-coverage of phase change($Ge_2Sb_2Te_5$, GST) thin film as well as thermodynamic stability, without etch back and washing process. This TiN material serves as the top and bottom electrode in PRAM(Phase-change Random Access Memory). The good connection between the TiN electrode and GST thin film was confirmed by observing the cross-section of TiN electrode board using SEM. The resistances of amorphous and crystalline GST thin film on TiN electrodes were also measured, and 1000 times difference between the amorphous and crystalline resistance of GST thin film was obtained, which is well enough for the signal detection.